Senescence and NFκB

References

• d’Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426:194 - 8; http://dx.doi.org/10.1038/nature02118; PMID: 14608368
   PubMed Web of Science ®Google Scholar
• Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, et al. Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J 2012; 31:2839 - 51; http://dx.doi.org/10.1038/emboj.2012.132; PMID: 22569128
   PubMed Web of Science ®Google Scholar
• Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 1999; 59:3761 - 7; PMID: 10446993
   PubMed Web of Science ®Google Scholar
• Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5:99 - 118; http://dx.doi.org/10.1146/annurev-pathol-121808-102144; PMID: 20078217
   PubMed Web of Science ®Google Scholar
• Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6:2853 - 68; http://dx.doi.org/10.1371/journal.pbio.0060301; PMID: 19053174
   PubMed Web of Science ®Google Scholar
• Prieur A, Peeper DS. Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 2008; 20:150 - 5; http://dx.doi.org/10.1016/j.ceb.2008.01.007; PMID: 18353625
   PubMed Web of Science ®Google Scholar
• Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109:335 - 46; http://dx.doi.org/10.1016/S0092-8674(02)00734-1; PMID: 12015983
   PubMed Web of Science ®Google Scholar
• Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008; 133:1019 - 31; http://dx.doi.org/10.1016/j.cell.2008.03.039; PMID: 18555778
   PubMed Web of Science ®Google Scholar
• Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A 2009; 106:17031 - 6; http://dx.doi.org/10.1073/pnas.0905299106; PMID: 19805069
   PubMed Web of Science ®Google Scholar
• Acosta JC, O’Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008; 133:1006 - 18; http://dx.doi.org/10.1016/j.cell.2008.03.038; PMID: 18555777
   PubMed Web of Science ®Google Scholar
• Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008; 134:657 - 67; http://dx.doi.org/10.1016/j.cell.2008.06.049; PMID: 18724938
   PubMed Web of Science ®Google Scholar
• Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007; 445:661 - 5; http://dx.doi.org/10.1038/nature05541; PMID: 17251932
   PubMed Web of Science ®Google Scholar
• Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007; 445:656 - 60; http://dx.doi.org/10.1038/nature05529; PMID: 17251933
   PubMed Web of Science ®Google Scholar
• Soriani A, Zingoni A, Cerboni C, Iannitto ML, Ricciardi MR, Di Gialleonardo V, et al. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood 2009; 113:3503 - 11; http://dx.doi.org/10.1182/blood-2008-08-173914; PMID: 19098271
   PubMed Web of Science ®Google Scholar
• Crescenzi E, Pacifico F, Lavorgna A, De Palma R, D’Aiuto E, Palumbo G, et al. NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells. Oncogene 2011; 30:2707 - 17; http://dx.doi.org/10.1038/onc.2011.1; PMID: 21278794
   PubMed Web of Science ®Google Scholar
• Ouaaz F, Li M, Beg AA. A critical role for the RelA subunit of nuclear factor kappaB in regulation of multiple immune-response genes and in Fas-induced cell death. J Exp Med 1999; 189:999 - 1004; http://dx.doi.org/10.1084/jem.189.6.999; PMID: 10075983
   PubMed Web of Science ®Google Scholar
• Bretz JD, Arscott PL, Myc A, Baker JR Jr.. Inflammatory cytokine regulation of Fas-mediated apoptosis in thyroid follicular cells. J Biol Chem 1999; 274:25433 - 8; http://dx.doi.org/10.1074/jbc.274.36.25433; PMID: 10464273
   PubMed Web of Science ®Google Scholar
• Fluhr H, Krenzer S, Stein GM, Stork B, Deperschmidt M, Wallwiener D, et al. Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis. J Cell Sci 2007; 120:4126 - 33; http://dx.doi.org/10.1242/jcs.009761; PMID: 18003704
   PubMed Web of Science ®Google Scholar
• Kühnel F, Zender L, Paul Y, Tietze MK, Trautwein C, Manns M, et al. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J Biol Chem 2000; 275:6421 - 7; http://dx.doi.org/10.1074/jbc.275.9.6421; PMID: 10692445
   PubMed Web of Science ®Google Scholar
• Freund A, Patil CK, Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011; 30:1536 - 48; http://dx.doi.org/10.1038/emboj.2011.69; PMID: 21399611
   PubMed Web of Science ®Google Scholar
• Hardy K, Mansfield L, Mackay A, Benvenuti S, Ismail S, Arora P, et al. Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell 2005; 16:943 - 53; http://dx.doi.org/10.1091/mbc.E04-05-0392; PMID: 15574883
   PubMed Web of Science ®Google Scholar
• Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev 2007; 21:3244 - 57; http://dx.doi.org/10.1101/gad.1588507; PMID: 18055696
   PubMed Web of Science ®Google Scholar
• Penzo M, Massa PE, Olivotto E, Bianchi F, Borzi RM, Hanidu A, et al. Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1. J Cell Physiol 2009; 218:215 - 27; http://dx.doi.org/10.1002/jcp.21596; PMID: 18803232
   PubMed Web of Science ®Google Scholar
• Rovillain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema RH, et al. Activation of nuclear factor-kappa B signalling promotes cellular senescence. Oncogene 2011; 30:2356 - 66; http://dx.doi.org/10.1038/onc.2010.611; PMID: 21242976
   PubMed Web of Science ®Google Scholar
• Wang J, Jacob NK, Ladner KJ, Beg A, Perko JD, Tanner SM, et al. RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair. EMBO Rep 2009; 10:1272 - 8; http://dx.doi.org/10.1038/embor.2009.197; PMID: 19779484
   PubMed Web of Science ®Google Scholar
• Gapuzan ME, Schmah O, Pollock AD, Hoffmann A, Gilmore TD. Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene 2005; 24:6574 - 83; PMID: 16027734
   PubMed Web of Science ®Google Scholar
• Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev 2011; 25:2125 - 36; http://dx.doi.org/10.1101/gad.17276711; PMID: 21979375
   PubMed Web of Science ®Google Scholar
• Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell 2011; 145:92 - 103; http://dx.doi.org/10.1016/j.cell.2011.02.023; PMID: 21458669
   PubMed Web of Science ®Google Scholar