Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy

Jessica Ann Chacon Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center; Houston, TX USA

Shari Pilon-Thomas Immunology Program; H Lee Moffitt Cancer Center and Research Institute; Tampa, FL USA

Amod A Sarnaik Immunology Program; H Lee Moffitt Cancer Center and Research Institute; Tampa, FL USA

Laszlo G Radvanyi Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center; Houston, TX USACorrespondence[email protected]

Article: e25581 | Received 25 Jun 2013, Accepted 28 Jun 2013, Published online: 03 Jul 2013

Cite this article
https://doi.org/10.4161/onci.25581

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

References

Radvanyi LG, Bernatchez C, Zhang M, Fox PS, Miller P, Chacon J, et al. Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients. Clin Cancer Res 2012; 18:6758 - 70; http://dx.doi.org/10.1158/1078-0432.CCR-12-1177; PMID: 23032743
PubMed Web of Science ®Google Scholar
Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res 2011; 17:4550 - 7; http://dx.doi.org/10.1158/1078-0432.CCR-11-0116; PMID: 21498393
PubMed Web of Science ®Google Scholar
Dudley ME, Wunderlich JR, Shelton TE, Even J, Rosenberg SA. Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. J Immunother 2003; 26:332 - 42; http://dx.doi.org/10.1097/00002371-200307000-00005; PMID: 12843795
PubMed Web of Science ®Google Scholar
Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH. A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo. J Immunol 2004; 172:981 - 8; PMID: 14707071
PubMed Web of Science ®Google Scholar
Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005; 23:23 - 68; http://dx.doi.org/10.1146/annurev.immunol.23.021704.115839; PMID: 15771565
PubMed Web of Science ®Google Scholar
Habib-Agahi M, Jaberipour M, Searle PF. 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol 2009; 256:39 - 46; http://dx.doi.org/10.1016/j.cellimm.2009.01.003; PMID: 19217084
PubMed Web of Science ®Google Scholar
Li Y, Liu S, Hernandez J, Vence L, Hwu P, Radvanyi L. MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro. J Immunol 2010; 184:452 - 65; http://dx.doi.org/10.4049/jimmunol.0901101; PMID: 19949105
PubMed Web of Science ®Google Scholar
Chacon JA, Wu RC, Sukhumalchandra P, Molldrem JJ, Sarnaik A, Pilon-Thomas S, et al. Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy. PLoS One 2013; 8:e60031; http://dx.doi.org/10.1371/journal.pone.0060031; PMID: 23560068
PubMed Web of Science ®Google Scholar
Hernandez-Chacon JA, Li Y, Wu RC, Bernatchez C, Wang Y, Weber JS, et al. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother 2011; 34:236 - 50; http://dx.doi.org/10.1097/CJI.0b013e318209e7ec; PMID: 21389874
PubMed Web of Science ®Google Scholar
Sluijter BJ, van den Hout MF, Stam AG, Lougheed SM, Suhoski MM, van den Eertwegh AJ, et al. 4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes. Clin Immunol 2010; 137:221 - 33; http://dx.doi.org/10.1016/j.clim.2010.07.009; PMID: 20708974
PubMed Web of Science ®Google Scholar

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date