1,451
Views
98
CrossRef citations to date
0
Altmetric
Research Paper

Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response

, , , , &
Pages 22-29 | Published online: 01 Jan 2011

References

  • Seemungal T, Harper-Owen R, Bhowmik A, Moric I, Sanderson G, Message S, et al. Respiratory viruses, symptoms and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164:1618 - 1623
  • Micillo E, D'Auria D, Mazzarella G, Abbate GF. Respiratory infections and asthma. Allergy 2000; 55:42 - 45
  • Tsolia MN, Psarras S, Bossios A, Audi H, Paldanius M, Gourgiotis D, et al. Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections. Clin Infect Dis 2004; 39:681 - 686
  • Hayden FG. Rhinovirus and the lower respiratory tract. Rev Med Virol 2004; 14:17 - 31
  • Akira S. Toll-like receptors and innate immunity. Adv Immunol 2001; 78:1 - 56
  • Akira S. Hemmi H. recognition of pathogen associated molecular patterns by TLR family. Immunol Lett 2003; 85:85 - 95
  • Kurt-Jones EA, Popova L, Kwinn L, Haynes M, Jones LP, Tripp RA, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytia virus. Nat Immunol 2000; 1:398 - 401
  • Triantafilou K, Triantafilou M. Coxsackievirus B4-induced cytokine production in pancreatic cells is mediated through TLR4. J Virol 2004; 78:11313 - 11320
  • Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like Receptor 2. J Virol 2003; 77:4588 - 4596
  • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NFkappaB by Toll-like receptor 3. Nature 2001; 413:732 - 738
  • Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004; 10:1366 - 1373
  • Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. TLR9 mediated recognition of Herpes Simplex 2 by plasmacytoid dendritic cells. J Exp Med 2003; 198:513 - 520
  • Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, Akira S, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001; 98:9237 - 9242
  • Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, et al. Recognition of single stranded RNA viruses by Toll like receptor 7. Proc Natl Acad Sc USA 2004; 101:5598 - 5603
  • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303:1529 - 1531
  • Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. Species specific recognition of single stranded RNA via Toll like receptor 7 and 8. Science 2004; 303:1526 - 1529
  • Triantafilou K, Orthopoulos G, Vakakis E, Ahmed MAE, Golenbock DT, Lepper PM, et al. Human cardiac inflammatory responses triggered by Coxsackie B Viruses are mainly Toll-like receptor (TLR) 8-dependent. Cellular Microbiol 2005; 7:1117 - 1126
  • Triantafilou K, Vakakis E, Orthopoulos G, Schumann E, Lepper PM, Triantafilou M. TLR8 and TLR7 are involved in the host's immune response to Human Parechovirus 1. Eur J Immunol 2005; 35:2416 - 2423
  • Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005; 23:19 - 28
  • Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5 and LGP2 in antiviral innate immunity. J Immunol 2005; 175:2851 - 2858
  • Johnson CL, Gale M Jr.. CARD games between virus and host get a new player. Trends in Immunol 2006; 27:1 - 4
  • Melchjorsen J, Jensen SB, Malmgaard L, Rasmussenm SB, Weber F, Bowie AG, et al. Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J Virol 2005; 79:12944 - 12951
  • Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA, et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA 2006; 103:8459 - 8464
  • Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 2006; 314:997
  • Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science 2006; 314:994
  • Abraham G, Colonno RJ. Many rhinovirus serotypes share the same cellular receptor. J Virol 1984; 51:340 - 345
  • Alexander HE, Koch G, Mountain IM, Sprunt K, Van Damme O. Infectivity of ribonucleic acid of poliovirus on Hela cell monolayers. Virology 1958; 5:172 - 173
  • Smull CE, Ludwig EH. Infectivity of Poliovirus and its nucleic acid for dehydrated Hela Cell monlayers. J Bacteriol 1965; 89:52 - 57
  • Boczkowski D, Nair SK, Snyder D, Gilboa E. Dendritic cells pulsed with RNA are potent antigen presenting cells in vitro and in vivo. J Exp Med 1996; 184:465 - 472
  • Bastiaens PI, Jovin TM. Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta1. Proc Natl Acad Sci USA 1996; 93:8407 - 8412
  • Kenworthy AK, Edidin M. Imaging fluorescence resonance energy transfer as probe of membrane organisation and molecular associations of GPI-anchored proteins. Methods Mol Biol 1999; 116:37 - 49
  • Triantafilou K, Fradelizi D, Wilson KM, Triantafilou M. GRP78 a co-receptor for Coxsackievirus A9, interacts with MHC-class-I molecules which mediate virus internalisation. J Virol 2002; 76:633 - 643
  • Kato H, Takeuchi O, Sato S, Yoneyama M, Matsui K, Uematsu S, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441:101 - 105
  • Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117:979 - 987
  • Takeuchi O, Akira S. Innate immunity to virus infection. Immunol Rev 2009; 227:75 - 86
  • Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441:101 - 105
  • Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, et al. Distinct Rig-I and MDA5 signaling by RNA viruses in innate immunity. J Virol 2008; 82:335 - 345
  • Pichlmair A, Schulz O, Tan CP, Näslund TI, Liljeström P, Weber F, et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 2007; 314:997 - 1001
  • Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008; 205:1601 - 1610
  • Savolainen C, Mulders MN, Hovi T. Phylogenetic analysis of rhinovirus isolates collected during successive epidemic seasons. Virus Res 2002; 85:41 - 46
  • Hewson CA, Jardine A, Edwards MR, Laza-Stanca V, Johnston SL. Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells. J Virol 2005; 79:12273 - 12279
  • Saito T, Gale M Jr.. Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity. J Exp Med 2008; 205:1523 - 1527