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Research Article

Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation

Mohammed Almaghrabia Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Medina, Saudi ArabiaView further author information
,
Arafa Musab Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi ArabiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0979-556XView further author information
ORCID Icon,
Ahmed K. B. Aljohania Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Medina, Saudi ArabiaView further author information
,
Hany E. A. Ahmedc Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8898-8452View further author information
ORCID Icon,
Marwa Alsulaimanya Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Medina, Saudi ArabiaView further author information
,
Samar F. Miskid Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Medina, Saudi ArabiaView further author information
,
Ehab M. Mostafab Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi ArabiaView further author information
,
Shaimaa Husseine Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi ArabiaView further author information
,
Della Grace Thomas Parambif Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi ArabiaView further author information
,
Mohammed M. Ghoneimg Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi ArabiaView further author information
,
Walid E. Elgammalh Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, EgyptView further author information
,
Ahmed H. Halawah Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, EgyptView further author information
,
Ali Hammadc Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, EgyptView further author information
&
Ahmed M. El-Agrodyh Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, EgyptView further author information
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Received 13 Jun 2023, Accepted 20 Aug 2023, Published online: 03 Sep 2023

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