Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

Thomas S. Corrigana Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USAView further author information

Leilani M. Lotti Diaza Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USAView further author information

Sarah E. Bordera Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USAView further author information

Steven C. Ratiganb Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USAView further author information

Kayla Q. Kaspera Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USAView further author information

Daniel Sojkac Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech RepublicView further author information

Pavla Fajtovad Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USAView further author information

Conor R. Caffreyd Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USAView further author information

Guy S. Salvesene Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USAView further author information

Craig A. McElroyb Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USAView further author information

Christopher M. Hadada Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USAView further author information

Özlem Doğan Ekicia Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA;f Department of Chemistry and Biochemistry, The Ohio State University at Newark, Newark, OH, USACorrespondence[email protected]
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Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

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Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

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