Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments

Elena KrayukhinaGraduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan;U-Medico Inc., Yamadaoka, Suita, Osaka, Japan

Masanori NodaGraduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan;U-Medico Inc., Yamadaoka, Suita, Osaka, Japan

Kentaro IshiiOkazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Higashiyama, Myodaiji, Okazaki, Aichi, Japan

Takahiro MarunoGraduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan;U-Medico Inc., Yamadaoka, Suita, Osaka, Japan

Hirotsugu WakabayashiGraduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan

Minoru TadaDivision of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo, Japan

Takuo SuzukiDivision of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo, Japan

Akiko Ishii-WatabeDivision of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo, Japan

Masahiko KatoSysmex Corporation, Murotani, Nishi-ku, Kobe-shi, Hyogo, Japan

Susumu UchiyamaGraduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan;U-Medico Inc., Yamadaoka, Suita, Osaka, Japan;Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Higashiyama, Myodaiji, Okazaki, Aichi, JapanCorrespondence[email protected]

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Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments

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Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments

Supplemental_Material.docx

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