mAbs, Volume 9, Issue 4 (2017)

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mAbs, Volume 9, Issue 4 (2017)

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Meeting Report

Meeting Report
MAbDelivery: Administration routes for antibody therapy Third LabEx MAbImprove industrial workshop, July 2, 2015 Tours, France
Elsa Bodier-Montagutelli, Renaud Respaud, Hervé Watier & Audrey Guillon-Munos
Pages: 579-585
Published online: 27 Mar 2017
AbstractforMAbDelivery: Administration routes for antibody therapy Third LabEx MAbImprove industrial workshop, July 2, 2015 Tours, France | Full Text | References | PDF (365.5 KB)
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Review

Review
Glycation of antibodies: Modification, methods and potential effects on biological functions
Bingchuan Wei, Kelsey Berning, Cynthia Quan & Yonghua Taylor Zhang
Pages: 586-594
Published online: 07 Apr 2017
AbstractforGlycation of antibodies: Modification, methods and potential effects on biological functions | Full Text | References | PDF (546 KB)
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Brief Reports

Article
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1
Salvatore Santamaria, Oleg Fedorov, John McCafferty, Gillian Murphy, Jayesh Dudhia, Hideaki Nagase & Kazuhiro Yamamoto
Pages: 595-602
Published online: 12 Apr 2017
AbstractforDevelopment of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1 | Full Text | References | PDF (832.4 KB)
  • 1620 Views
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Article
TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets
Devin B. Lowe, Camille K. Bivens, Alexis S. Mobley, Christian E. Herrera, Amanda L. McCormick, Timea Wichner, Manoj K. Sabnani, Laurence M. Wood & Jon A. Weidanz
Pages: 603-614
Published online: 27 Apr 2017
AbstractforTCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets | Full Text | References | PDF (1,021.1 KB) | Supplemental
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Reports

Report
Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity
Jillian M. Prendergast, Ana Paula Galvao da Silva, David A. Eavarone, Darius Ghaderi, Mai Zhang, Dane Brady, Joan Wicks, Julie DeSander, Jeff Behrens & Bo R. Rueda
Pages: 615-627
Published online: 10 Mar 2017
AbstractforNovel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity | Full Text | References | PDF (1.5 MB) | Supplemental
  • 6613 Views
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Report
Epitope mapping reveals the binding mechanism of a functional antibody cross-reactive to both human and murine programmed death 1
Dong Li, Jianqing Xu, Zhuozhi Wang, Zhen Gong, Jieying Liu, Yong Zheng, Jian Li & Jing Li
Pages: 628-637
Published online: 16 Mar 2017
AbstractforEpitope mapping reveals the binding mechanism of a functional antibody cross-reactive to both human and murine programmed death 1 | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2525 Views
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Report
Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches
Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla & Albert J. R. Heck
Pages: 638-645
Published online: 10 Mar 2017
AbstractforResolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches | Full Text | References | PDF (973.1 KB) | Supplemental
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Report
Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies
Rong Yang, Tushar Jain, Heather Lynaugh, R. Paul Nobrega, Xiaojun Lu, Todd Boland, Irina Burnina, Tingwan Sun, Isabelle Caffry, Michael Brown, Xiaoyong Zhi, Asparouh Lilov & Yingda Xu
Pages: 646-653
Published online: 10 Mar 2017
AbstractforRapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies | Full Text | References | PDF (684.3 KB) | Supplemental
  • 4378 Views
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Report
A modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell protein clearance
Donald E. Walker, Feng Yang, Joseph Carver, Koman Joe, David A. Michels & X. Christopher Yu
Pages: 654-663
Published online: 07 Apr 2017
AbstractforA modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell protein clearance | Full Text | References | PDF (1.1 MB) | Supplemental
  • 3211 Views
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Report
Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments
Elena Krayukhina, Masanori Noda, Kentaro Ishii, Takahiro Maruno, Hirotsugu Wakabayashi, Minoru Tada, Takuo Suzuki, Akiko Ishii-Watabe, Masahiko Kato & Susumu Uchiyama
Pages: 664-679
Published online: 07 Apr 2017
AbstractforAnalytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments | Full Text | References | PDF (1.5 MB) | Supplemental
  • 3042 Views
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Report
Transmembrane TNF-dependent uptake of anti-TNF antibodies
Arun Deora, Subramanya Hegde, Jacqueline Lee, Chee-Ho Choi, Qing Chang, Cheryl Lee, Lucia Eaton, Hua Tang, Dongdong Wang, David Lee, Mark Michalak, Medha Tomlinson, Qingfeng Tao, Nidhi Gaur, Bohdan Harvey, Shaun McLoughlin, Boris Labkovsky & Tariq Ghayur
Pages: 680-695
Published online: 17 Apr 2017
AbstractforTransmembrane TNF-dependent uptake of anti-TNF antibodies | Full Text | References | PDF (1.3 MB)
  • 6215 Views
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Report
Generation and characterization of protective antibodies to Marburg virus
Jeffrey W. Froude, Thibaut Pelat, Sebastian Miethe, Samantha E. Zak, Anna Z. Wec, Kartik Chandran, Jennifer Mary Brannan, Russell R. Bakken, Michael Hust, Philippe Thullier & John M. Dye
Pages: 696-703
Published online: 05 Apr 2017
AbstractforGeneration and characterization of protective antibodies to Marburg virus | Full Text | References | PDF (675.1 KB) | Supplemental
  • 1601 Views
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Report
Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar
Seokkyun Kim, Jinsu Song, Seungkyu Park, Sunyoung Ham, Kyungyeol Paek, Minjung Kang, Yunjung Chae, Heewon Seo, Hyung-Chan Kim & Michael Flores
Pages: 704-714
Published online: 12 Apr 2017
AbstractforDrifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar | Full Text | References | PDF (1.6 MB) | Supplemental
  • 9734 Views
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Report
Arabinosylation of recombinant human immunoglobulin-based protein therapeutics
Patrick Hossler, Christopher Chumsae, Christopher Racicot, David Ouellette, Alexander Ibraghimov, Daniel Serna, Alessandro Mora, Sean McDermott, Boris Labkovsky, Susanne Scesney, Christine Grinnell, Gregory Preston, Sahana Bose & Ralf Carrillo
Pages: 715-734
Published online: 05 Apr 2017
AbstractforArabinosylation of recombinant human immunoglobulin-based protein therapeutics | Full Text | References | PDF (1.9 MB)
  • 2586 Views
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