Supplemental material
Open access
6,302
Views
10
CrossRef citations to date
0
Altmetric
Report
Influence of the bispecific antibody IgG subclass on T cell redirection
Stephanie KapelskiBiologics Discovery, Janssen BioTherapeutics, Janssen Research and Development, Beerse, Belgium;Oncology Biology & Discovery, Janssen Research and Development, Beerse, BelgiumCorrespondence[email protected]
View further author information
, View further author information
Erna CleirenFormer Discovery Sciences, LD-Screening BE, Janssen Research and Development, Beerse, Belgium;Charles River Laboratories, Beerse, BelgiumView further author information
, Ricardo M. AttarOncology Biology & Discovery, Janssen Research and Development, Spring House, PA,USAhttps://orcid.org/0000-0002-6942-8019View further author information
, Ulrike PhilipparOncology Biology & Discovery, Janssen Research and Development, Beerse, BelgiumView further author information
, Julien HäslerBiologics Discovery, Janssen BioTherapeutics, Janssen Research and Development, Beerse, BelgiumView further author information
& Mark L. ChiuBioTherapeutics Analytical Development, Discovery, Product Development & Supply, Janssen Research and Development, Malvern, PA, USACorrespondence[email protected]
View further author information
View further author information
Pages 1012-1024
|
Received 15 Mar 2019, Accepted 23 May 2019, Published online: 26 Jun 2019
Related Research Data
Novel immunotherapies in lymphoid malignancies.
Source:
Springer Science and Business Media LLC
Structural variations, chemical modifications and possible impacts to stability and biological function
Source:
Informa UK Limited
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
Source:
Springer Science and Business Media LLC
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
Source:
Proceedings of the National Academy of Sciences
Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Radius of gyration as an indicator of protein structure compactness
Source:
Pleiades Publishing Ltd
In-depth analysis of subclass-specific conformational preferences of IgG antibodies
Source:
International Union of Crystallography
The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.
Source:
American Society of Hematology
Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3
Source:
Proceedings of the National Academy of Sciences
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys
Source:
Nature Publishing Group
Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcγ receptors
Source:
Impact Journals, LLC
Constant domains influence binding of mouse-human chimeric antibodies to the capsular polypeptide of Bacillus anthracis.
Source:
Informa UK Limited
PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma
Source:
American Society of Hematology
Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.
Source:
Proceedings of the National Academy of Sciences
Biophysical mechanism of T-cell receptor triggering in a reconstituted system
Source:
Springer Science and Business Media LLC
A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.
Source:
American Society of Hematology
IgG Fc engineering to modulate antibody effector functions
Source:
SpringerOpen
Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells
Source:
Informa UK Limited
Generation of single-chain bispecific green fluorescent protein fusion antibodies for imaging of antibody-induced T cell synapses
Source:
Elsevier BV
Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclasses
Source:
Wiley
Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy
Source:
Springer Science and Business Media LLC
Bispecific abs for Treatment of PCa
Source:
Wiley
Bispezifische Antikörper
Source:
Elsevier BV
Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen
Source:
Springer Science and Business Media LLC
GD2-BsAb redirects T cells to target tumors
Source:
Wiley
Mechanisms for T cell receptor triggering
Source:
Springer Science and Business Media LLC
An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia.
Source:
American Society of Hematology
The making of bispecific antibodies
Source:
Taylor & Francis
“NextGen” Biologics: Bispecific Antibodies and Emerging Clinical Results
Source:
Informa Healthcare
FDA Approval: Blinatumomab.
Source:
American Association for Cancer Research (AACR)
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.