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Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region
Michael W. Handlogtena Cell Culture & Fermentation Sciences, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USACorrespondence[email protected]
https://orcid.org/0000-0002-6508-3228
Li Pengb Antibody Discovery and Protein Engineering, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USA
, Elizabeth A. Christianc Analytical Sciences, Bioassay, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USA
, Weichen Xud Analytical Sciences, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USA
, Shihua Linc Analytical Sciences, Bioassay, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USA
, Raghavan Venkata Cell Culture & Fermentation Sciences, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USA
, William Dall’Acquab Antibody Discovery and Protein Engineering, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USA
& Sanjeev Ahujaa Cell Culture & Fermentation Sciences, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD, USACorrespondence[email protected]
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Article: 1779974
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Received 03 Jan 2020, Accepted 28 May 2020, Published online: 07 Jul 2020
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