Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics

Bingchuan Weia Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA;b Small Molecule Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USACorrespondence[email protected]

https://orcid.org/0000-0003-1025-5579

Nicholas Woona Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Lu Daia Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Raphael Fisha Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Michelle Taia Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Winode Handagamaa Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Ashley Yina Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Jia Sunc Pharmaceutical Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Andrew Maierd Purification Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Dana McDaniela Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Elvira Kadauba Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Jessica Yangc Pharmaceutical Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Miguel Sagguc Pharmaceutical Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Ann Woysc Pharmaceutical Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Oxana Pestere Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, Germany

https://orcid.org/0000-0001-5137-4262

Danny Lambertf Pharma Technical Development, F. Hoffmann-La Roche, Basel, Switzerland

Alex Pella Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Zhiqi Haog Protein Analytical Chemistry Quality Control, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Gordon Magillh Cell Culture Development and Bioprocess, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Jack Yimg Protein Analytical Chemistry Quality Control, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Jefferson Chang Protein Analytical Chemistry Quality Control, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Lindsay Yangg Protein Analytical Chemistry Quality Control, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Frank Macchia Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Christian Bellf Pharma Technical Development, F. Hoffmann-La Roche, Basel, Switzerland

Galahad Deperaltaa Protein Analytical Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

Yan Cheni Pharma Technical Development, Genentech Inc, 1 DNA Way, South San Francisco, California, USA

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Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics

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Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics

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