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mAbs Volume 14, 2022 - Issue 1
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Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

Zephania Kwong Glovera Pharmaceutical Development, Genentech Inc, South San Francisco, CA, USAView further author information
,
Aaron Weckslerb Analytical Development, Genentech Inc, South San Francisco, CA, USAView further author information
,
Baikuntha Aryalc Laboratory of Applied Biochemistry, Division of Biotechnology Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USAView further author information
,
Shrenik Mehtaa Pharmaceutical Development, Genentech Inc, South San Francisco, CA, USAView further author information
,
Melissa Peguesc Laboratory of Applied Biochemistry, Division of Biotechnology Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USAView further author information
,
Wayman Chana Pharmaceutical Development, Genentech Inc, South San Francisco, CA, USAView further author information
,
Mari Lehtimakic Laboratory of Applied Biochemistry, Division of Biotechnology Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USAView further author information
,
Allen Luod Biological Technologies, Genentech Inc, South San Francisco, CA, USAView further author information
,
Alavattam Sreedharaa Pharmaceutical Development, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
View further author information
&
V. Ashutosh Raoc Laboratory of Applied Biochemistry, Division of Biotechnology Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6817-8049View further author information
ORCID Icon show all
Article: 2122957 | Received 09 Jun 2022, Accepted 02 Sep 2022, Published online: 24 Sep 2022

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