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An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
Source:
Informa UK Limited
In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus.
Source:
Informa UK Limited
High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy
Source:
Informa UK Limited
An engineered human IgG1 antibody with longer serum half-life.
Source:
The American Association of Immunologists
Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Screening antibody-antigen interactions in parallel using Biacore A100
Source:
Elsevier BV
Pharmacokinetics of Monoclonal Antibodies
Source:
Wiley
The Predictive Sample Reuse Method with Applications
Source:
Informa UK Limited
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.
Source:
Nature Portfolio
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring.
Source:
eScholarship, University of California
Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus
Source:
Informa UK Limited
Determination of the net charge (valence) of a protein: a fundamental but elusive parameter
Source:
Elsevier BV
Neonatal Fc receptor and IgG-based therapeutics.
Source:
Informa UK Limited
An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies.
Source:
Informa UK Limited
A High Through-put Platform for Recombinant Antibodies to Folded Proteins
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies.
Source:
Informa UK Limited
High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice
Source:
Landes Bioscience
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
Source:
Informa UK Limited
Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design
Source:
Springer Science and Business Media LLC
Enhanced antibody half-life improves in vivo activity
Source:
Springer Science and Business Media LLC
Biophysical properties of the clinical-stage antibody landscape
Source:
Proceedings of the National Academy of Sciences
Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates.
Source:
The American Association of Immunologists
Efficient production of antibodies against a mammalian integral membrane protein by phage display
Source:
Oxford University Press (OUP)
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
Source:
Springer Science and Business Media LLC
Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis.
Source:
Informa UK Limited
Use of generic LC-MS/MS assays to characterize atypical PK profile of a biotherapeutic monoclonal antibody.
Source:
Future Science Ltd
Characterization and screening of IgG binding to the neonatal Fc receptor
Source:
Informa UK Limited
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