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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
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Volume 5, Issue sup1

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 5, Issue sup1 (2004)

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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, Volume 5, Issue sup1 (2004)

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Foreword

Article

Foreword

Gerald D. Fischbach

Page: 5

Published online: 10 Jul 2009

CitationforForeword | PDF (135.6 KB)

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Introduction

Article

Preface

Hiroshi Mitsumoto & Serge Przedborski

Pages: 6-7

Published online: 10 Jul 2009

CitationforPreface | PDF (136 KB)

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Article

Randomized control trials in ALS: lessons learned

Hiroshi Mitsumoto, Paul Gordon, Petra Kaufmann, Clifton Gooch, Serge Przedborski & Lewis P Rowland

Pages: 8-13

Published online: 10 Jul 2009

First Page PreviewforRandomized control trials in ALS: lessons learned | References | PDF (204.8 KB)

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Bench to clinic

Article

Molecular targets for neuroprotection

Serge Przedborski

Pages: 14-18

Published online: 10 Jul 2009

AbstractforMolecular targets for neuroprotection | References | PDF (186 KB)

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Article

High throughput drug screening

Jill Heemskerk

Pages: 19-21

Published online: 10 Jul 2009

First Page PreviewforHigh throughput drug screening | References | PDF (153 KB)

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Article

Preclinical studies: how much can we rely on?

Jeffrey D Rothstein

Pages: 22-25

Published online: 10 Jul 2009

First Page PreviewforPreclinical studies: how much can we rely on? | References | PDF (176.1 KB)

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Lessons learned from other neurological diseases

Article

Parkinson's disease

Stanley Fahn

Pages: 26-30

Published online: 10 Jul 2009

First Page PreviewforParkinson's disease | References | PDF (181.4 KB)

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Article

Stroke

Jay P Mohr

Pages: 31-33

Published online: 10 Jul 2009

First Page PreviewforStroke | PDF (141.4 KB)

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Article

Neuro‐Oncology

S Clifford Schold Jr

Pages: 34-35

Published online: 10 Jul 2009

CitationforNeuro‐Oncology | References | PDF (142.7 KB)

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Issues in Clinical Trials

Article

Regulatory issues in ALS clinical trials

Wilson W Bryan

Pages: 36-41

Published online: 10 Jul 2009

First Page PreviewforRegulatory issues in ALS clinical trials | References | PDF (207.2 KB)

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Article

Randomized controlled trials

John Marler

Page: 42

Published online: 10 Jul 2009

CitationforRandomized controlled trials | PDF (127.1 KB)

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Article

Statistical issues

Bruce Levin

Pages: 43-45

Published online: 10 Jul 2009

First Page PreviewforStatistical issues | References | PDF (142.1 KB)

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Article

Data Safety Monitoring Board (DSMB)

KMA Welch

Pages: 46-47

Published online: 10 Jul 2009

CitationforData Safety Monitoring Board (DSMB) | PDF (148.3 KB)

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Article

Missing data

John LP Thompson & Gilberto Levy

Pages: 48-51

Published online: 10 Jul 2009

First Page PreviewforMissing data | References | PDF (204.5 KB)

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Study design

Article

ALS trial design: expectation and reality

Robert G Miller & Dan H Moore

Pages: 52-54

Published online: 10 Jul 2009

First Page PreviewforALS trial design: expectation and reality | References | PDF (142.3 KB)

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Article

An efficient multi‐stage, single‐arm Phase II futility design for ALS

Yuko Y Palesch & Barbara C Tilley

Pages: 55-56

Published online: 10 Jul 2009

CitationforAn efficient multi‐stage, single‐arm Phase II futility design for ALS | References | PDF (131.2 KB)

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Article

Improving efficiency of ALS clinical trials using lead‐in designs

Dan H Moore II & Robert G Miller

Pages: 57-60

Published online: 10 Jul 2009

AbstractforImproving efficiency of ALS clinical trials using lead‐in designs | References | PDF (253.2 KB)

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Article

Design using historical controls

Albert Yen, Ericka Simpson, Lanny Haverkamp & Stanley Appel

Pages: 61-63

Published online: 10 Jul 2009

First Page PreviewforDesign using historical controls | References | PDF (177 KB)

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Natural history is a moving target

Article

Baseline disease characteristics

P N Leigh

Pages: 64-67

Published online: 10 Jul 2009

First Page PreviewforBaseline disease characteristics | References | PDF (291.8 KB)

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Article

Disease‐modifying drug therapies

Benjamin R Brooks & Mohammed Sanjak

Pages: 68-75

Published online: 10 Jul 2009

First Page PreviewforDisease‐modifying drug therapies | References | PDF (436.3 KB)

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Article

Disease‐modifying interventions

Edward Kasarskis

Pages: 76-78

Published online: 10 Jul 2009

First Page PreviewforDisease‐modifying interventions | References | PDF (140.4 KB)

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Endpoints

Article

Survival

J Cedarbaum

Pages: 79-83

Published online: 10 Jul 2009

First Page PreviewforSurvival | References | PDF (237.8 KB)

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Article

Maximum voluntary isometric contraction (MVIC)

Merit Cudkowicz, Hui Zhang, Muhammad Qureshi & David Schoenfeld

Pages: 84-85

Published online: 10 Jul 2009

CitationforMaximum voluntary isometric contraction (MVIC) | References | PDF (176.4 KB)

302 Views
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Article

Assessment of strength measurements

Eric J Sorensen

Pages: 86-89

Published online: 10 Jul 2009

First Page PreviewforAssessment of strength measurements | References | PDF (201.3 KB)

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Article

ALSFRS‐R

Paul H Gordon, Robert G Miller & Dan H Moore

Pages: 90-93

Published online: 10 Jul 2009

AbstractforALSFRS‐R | References | PDF (197.8 KB)

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Article

AALSS

Albert Yen, Ericka Simpson, Lanny Haverkamp & Stanley Appel

Pages: 94-98

Published online: 10 Jul 2009

First Page PreviewforAALSS | References | PDF (308.1 KB)

21 Views
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Article

Measuring pseudobulbar affect in ALS

Richard A Smith, James E Berg, Laura E Pope & Ronald A Thisted

Pages: 99-102

Published online: 10 Jul 2009

First Page PreviewforMeasuring pseudobulbar affect in ALS | References | PDF (273.7 KB)

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Surrogate markers

Article

Use of surrogate markers

Marc K Walton

Page: 103

Published online: 10 Jul 2009

CitationforUse of surrogate markers | PDF (115.5 KB)

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Article

MUNE

CL Gooch & JM Shefner

Pages: 104-107

Published online: 10 Jul 2009

AbstractforMUNE | References | PDF (209.1 KB)

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Article

The Neurophysiological Index in ALS

Michael Swash & Mamede de Carvalho

Pages: 108-110

Published online: 10 Jul 2009

AbstractforThe Neurophysiological Index in ALS | References | PDF (243.9 KB)

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Article

MRS

S Kalra & DL Arnold

Pages: 111-114

Published online: 10 Jul 2009

AbstractforMRS | References | PDF (199 KB)

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Combination treatment

Article

Drug cocktails

Jeffrey Rosenfeld

Pages: 115-117

Published online: 10 Jul 2009

First Page PreviewforDrug cocktails | PDF (209.8 KB)

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Collaborative research groups

Article

Sociology of collaborative research groups

Ira Shoulson

Pages: 118-120

Published online: 10 Jul 2009

First Page PreviewforSociology of collaborative research groups | References | PDF (152.5 KB)

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Article

Western ALS Study Group

R G Miller, D H Moore, C E Jackson & the WALS Study Group

Pages: 121-124

Published online: 10 Jul 2009

First Page PreviewforWestern ALS Study Group | References | PDF (182.8 KB)

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Article

North East ALS Study Group

Merit Cudkowicz & Jeremy Shefner

Pages: 125-127

Published online: 10 Jul 2009

First Page PreviewforNorth East ALS Study Group | PDF (180.3 KB)

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Article

Great Lakes ALS Study Group

Eric Sorenson

Page: 128

Published online: 10 Jul 2009

CitationforGreat Lakes ALS Study Group | References | PDF (128 KB)

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Article

The National Registry of Veterans with Amyotrophic Lateral Sclerosis: Department of Veterans Affairs Cooperative Studies Program (CSP) #500a

Edward J Kasarkis, Kelli Dominic & Eugene Z Oddone

Pages: 129-132

Published online: 10 Jul 2009

AbstractforThe National Registry of Veterans with Amyotrophic Lateral Sclerosis: Department of Veterans Affairs Cooperative Studies Program (CSP) #500a | References | PDF (203.6 KB)

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Article

European ALS Consortium

Vincent Meininger

Pages: 133-134

Published online: 10 Jul 2009

CitationforEuropean ALS Consortium | PDF (135.8 KB)

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Article

Future national study group in ALS

Steven P Ringel

Pages: 135-136

Published online: 10 Jul 2009

CitationforFuture national study group in ALS | PDF (152.2 KB)

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Article

Patient orientated research and clinical trials

Walter G. Bradley

Pages: 137-140

Published online: 10 Jul 2009

AbstractforPatient orientated research and clinical trials | PDF (168.7 KB)

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Conference conclusions

Article

Summing up: an action plan for ALS research

Lewis P Rowland

Pages: 141-143

Published online: 10 Jul 2009

First Page PreviewforSumming up: an action plan for ALS research | References | PDF (140.1 KB)

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