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Volume 2, Issue 7

Bioanalysis

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Bioanalysis, Volume 2, Issue 7 (2010)

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Bioanalysis, Volume 2, Issue 7 (2010)

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Special Focus: Metabolites in safety testing and bioanalysis - Foreword

Introduction

Welcome to MIST and Bioanalysis

Ajai Chaudhary

Pages: 1169-1170

Published online: 13 Jul 2010

CitationforWelcome to MIST and Bioanalysis | Full Text | References | PDF (658.1 KB)

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Editorial

Importance of Metabolite Testing in Regulated Bioanalysis

Fabio Garofolo, Natasha Savoie, Annik Bergeron, Claude Amestoy, Marc Lefebvre, Louis Caillé, Milton Furtado & Chantal Menard

Pages: 1171-1174

Published online: 13 Jul 2010

First Page PreviewforImportance of Metabolite Testing in Regulated Bioanalysis | Full Text | References | PDF (671.8 KB)

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News & Analysis

News

News & Analysis

Pages: 1175-1177

Published online: 13 Jul 2010

First Page PreviewforNews & Analysis | Full Text | PDF (517.3 KB)

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News

Book Review: Ion-Pair Chromatography and Related Techniques

Amy Webster & Nicole Pamme

Pages: 1179-1180

Published online: 13 Jul 2010

CitationforBook Review: Ion-Pair Chromatography and Related Techniques | Full Text | PDF (416.7 KB)

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News

Conference Report: Inaugural Applied Pharmaceutical Analysis: India 2010 Conference

Ragu Ramanathan & Ajai Chaudhary

Pages: 1181-1184

Published online: 13 Jul 2010

AbstractforConference Report: Inaugural Applied Pharmaceutical Analysis: India 2010 Conference | Full Text | PDF (369.7 KB)

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White Paper

Discussion

Best Practices in a Tiered Approach to Metabolite Quantification: Views and Recommendations of The European Bioanalysis Forum

Philip Timmerman, Morten Anders Kall, Ben Gordon, Sirpa Laakso, Achim Freisleben & Richard Hucker

Pages: 1185-1194

Published online: 13 Jul 2010

AbstractforBest Practices in a Tiered Approach to Metabolite Quantification: Views and Recommendations of The European Bioanalysis Forum | Full Text | References | PDF (1.6 MB)

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Research Article

Article

A Radiocalibration Method with Pseudo Internal Standard to Estimate Circulating Metabolite Concentrations

Ping Yi & Debra Luffer-Atlas

Pages: 1195-1210

Published online: 13 Jul 2010

AbstractforA Radiocalibration Method with Pseudo Internal Standard to Estimate Circulating Metabolite Concentrations | Full Text | References | PDF (1.2 MB)

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Article

Assessing Covalent Binding of Reactive Drug Metabolites by Complete Protein Digestion and LC–MS Analysis

Nicoleta Mitrea, André LeBlanc, Maude St-Onge & Lekha Sleno

Pages: 1211-1221

Published online: 13 Jul 2010

AbstractforAssessing Covalent Binding of Reactive Drug Metabolites by Complete Protein Digestion and LC–MS Analysis | Full Text | References | PDF (1.1 MB)

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Perspective

Review Article

Metabolites: Have We MIST Out the Importance of Structure and Physicochemistry?

Dennis A Smith & R Scott Obach

Pages: 1223-1233

Published online: 13 Jul 2010

AbstractforMetabolites: Have We MIST Out the Importance of Structure and Physicochemistry? | Full Text | References | PDF (812.1 KB)

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Review Article

Looking Back Through the MIST: A Perspective of Evolving Strategies and Key Focus Areas for Metabolite Safety Analysis

Angus NR Nedderman & Pat Wright

Pages: 1235-1248

Published online: 13 Jul 2010

AbstractforLooking Back Through the MIST: A Perspective of Evolving Strategies and Key Focus Areas for Metabolite Safety Analysis | Full Text | References | PDF (942.7 KB)

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Review Article

Overview of Metabolite Safety Testing from an Industry Perspective

Shelby Anderson, Mary Pat Knadler & Debra Luffer-Atlas

Pages: 1249-1261

Published online: 13 Jul 2010

AbstractforOverview of Metabolite Safety Testing from an Industry Perspective | Full Text | References | PDF (1.1 MB)

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Review

Review Article

NMR Spectroscopy as a Tool to Close The Gap on Metabolite Characterization Under MIST

Janet Caceres-Cortes & Michael D Reily

Pages: 1263-1276

Published online: 13 Jul 2010

AbstractforNMR Spectroscopy as a Tool to Close The Gap on Metabolite Characterization Under MIST | Full Text | References | PDF (1.6 MB)

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Review Article

Production of Human Phase 1 and 2 Metabolites by Whole-Cell Biotransformation with Recombinant Microbes

Andy Zöllner, Daniela Buchheit, Markus R Meyer, Hans H Maurer, Frank T Peters & Matthias Bureik

Pages: 1277-1290

Published online: 13 Jul 2010

AbstractforProduction of Human Phase 1 and 2 Metabolites by Whole-Cell Biotransformation with Recombinant Microbes | Full Text | References | PDF (933.3 KB)

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Review Article

Novel MS Solutions Inspired by MIST

Ragu Ramanathan, Jonathan L Josephs, Mohammed Jemal, Mark Arnold & W Griffith Humphreys

Pages: 1291-1313

Published online: 13 Jul 2010

AbstractforNovel MS Solutions Inspired by MIST | Full Text | References | PDF (5.8 MB)

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Review Article

Addressing Metabolite Safety During First-In-Man Studies Using ¹⁴C-Labeled Drug and Accelerator Mass Spectrometry

Graham Lappin & Mark Seymour

Pages: 1315-1324

Published online: 13 Jul 2010

AbstractforAddressing Metabolite Safety During First-In-Man Studies Using ¹⁴C-Labeled Drug and Accelerator Mass Spectrometry | Full Text | References | PDF (905.4 KB)

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General content - Regulatory Focus

Article

Regulatory Observations in Bioanalytical Determinations

CT Viswanathan

Pages: 1325-1329

Published online: 13 Jul 2010

AbstractforRegulatory Observations in Bioanalytical Determinations | Full Text | References | PDF (675.8 KB)

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