Expert Opinion on Drug Discovery, Volume 12, Issue 6 (2017)

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Expert Opinion on Drug Discovery, Volume 12, Issue 6 (2017)

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Editorial

Editorial
Academia–pharma partnerships for novel drug discovery: essential or nice to have?
Michelle Palmer & Rathnam Chaguturu
Pages: 537-540
Published online: 17 Apr 2017
First Page PreviewforAcademia–pharma partnerships for novel drug discovery: essential or nice to have? | Full Text | References | PDF (335.2 KB)
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Free Access

Review

Review
Applications of CRISPR genome editing technology in drug target identification and validation
Quinn Lu, George P. Livi, Sundip Modha, Kosuke Yusa, Ricardo Macarrón & David J. Dow
Pages: 541-552
Published online: 23 Apr 2017
AbstractforApplications of CRISPR genome editing technology in drug target identification and validation | Full Text | References | PDF (1.1 MB)
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Review
Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design
Amanda T.S. Albanaz, Carlos H.M. Rodrigues, Douglas E.V. Pires & David B. Ascher
Pages: 553-563
Published online: 11 May 2017
AbstractforCombating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design | Full Text | References | PDF (1.4 MB)
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Review
Therapeutic targeting and patient selection for cancers with homologous recombination defects
Francien Talens, Mathilde Jalving, Jourik A. Gietema & Marcel A. Van Vugt
Pages: 565-581
Published online: 02 May 2017
AbstractforTherapeutic targeting and patient selection for cancers with homologous recombination defects | Full Text | References | PDF (1.8 MB)
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Open Access
Review
An overview of quinoline as a privileged scaffold in cancer drug discovery
Robert Musiol
Pages: 583-597
Published online: 20 Apr 2017
AbstractforAn overview of quinoline as a privileged scaffold in cancer drug discovery | Full Text | References | PDF (1.3 MB)
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Review
‘Big data’ approaches for novel anti-cancer drug discovery
Graeme Benstead-Hume, Sarah K. Wooller & Frances M. G. Pearl
Pages: 599-609
Published online: 02 May 2017
Abstractfor‘Big data’ approaches for novel anti-cancer drug discovery | Full Text | References | PDF (1 MB)
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Review
Enhancing the therapeutic potential of peptide toxins
Raymond S. Norton
Pages: 611-623
Published online: 20 Apr 2017
AbstractforEnhancing the therapeutic potential of peptide toxins | Full Text | References | PDF (1.4 MB)
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Review
An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs
Wooseong Kim, Gabriel Lambert Hendricks, Kiho Lee & Eleftherios Mylonakis
Pages: 625-633
Published online: 21 Apr 2017
AbstractforAn update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs | Full Text | References | PDF (1.4 MB)
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Drug Discovery Case History

Article
Discovery and preclinical development of dasabuvir for the treatment of hepatitis C infection
Mohamed El Kassas, Tamer Elbaz, Enas Hafez, Mohamed Naguib Wifi & Gamal Esmat
Pages: 635-642
Published online: 05 May 2017
AbstractforDiscovery and preclinical development of dasabuvir for the treatment of hepatitis C infection | Full Text | References | PDF (824.3 KB)
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