Expert Opinion on Drug Discovery, Volume 18, Issue 2 (2023)

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Expert Opinion on Drug Discovery, Volume 18, Issue 2 (2023)

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The discovery and development of RNA-based therapeutics

Editorial

Editorial
A meditation on accelerating the development of small molecule medicines targeting RNA
Xueyi Yang, Jessica L. Childs-Disney & Matthew D. Disney
Pages: 115-117
Published online: 05 Jun 2022
First Page PreviewforA meditation on accelerating the development of small molecule medicines targeting RNA | Full Text | References | PDF (395.4 KB) | EPUB
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Free Access

Special Report

Article
Vaccines on demand, part II: future reality
Andrew J. Geall, Zoltan Kis & Jeffrey B. Ulmer
Pages: 119-127
Published online: 23 Nov 2022
AbstractforVaccines on demand, part II: future reality | Full Text | References | PDF (639.3 KB) | EPUB
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Perspective

Article
Reality check: lipid-oligonucleotide conjugates for therapeutic applications
Robert A Goodnow
Pages: 129-134
Published online: 22 Dec 2022
AbstractforReality check: lipid-oligonucleotide conjugates for therapeutic applications | Full Text | References | PDF (529 KB) | EPUB
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Review

Review
Strategies for targeting RNA with small molecule drugs
Christopher L. Haga & Donald G. Phinney
Pages: 135-147
Published online: 17 Aug 2022
AbstractforStrategies for targeting RNA with small molecule drugs | Full Text | References | PDF (4.1 MB) | EPUB
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Review
A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applications
Ahmed Khaled Abosalha, Waqar Ahmad, Jacqueline Boyajian, Paromita Islam, Merry Ghebretatios, Sabrina Schaly, Rahul Thareja, Karan Arora & Satya Prakash
Pages: 149-161
Published online: 17 Dec 2022
AbstractforA comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applications | Full Text | References | PDF (1.6 MB) | EPUB
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Review
The discovery and development of RNA-based therapies for treatment of HIV-1 infection
Michelle J Chen, Anne Gatignol & Robert J. Scarborough
Pages: 163-179
Published online: 15 Sep 2022
AbstractforThe discovery and development of RNA-based therapies for treatment of HIV-1 infection | Full Text | References | PDF (3.7 MB) | EPUB
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Review
RNA-based drug discovery for spinal muscular atrophy: a story of small molecules and antisense oligonucleotides
Blanca Torroba, Natsuko Macabuag, Elisabeth M. Haisma, Amy O’Neill, Maria E. Herva, Roxana S. Redis, Michael V. Templin, Lauren E. Black & David F. Fischer
Pages: 181-192
Published online: 22 Nov 2022
AbstractforRNA-based drug discovery for spinal muscular atrophy: a story of small molecules and antisense oligonucleotides | Full Text | References | PDF (6.1 MB) | EPUB
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Article
The Promising Therapeutic Potential of Oligonucleotides for Pulmonary Fibrotic Diseases
Divyani Paul, Madelyn H Miller, Josh Born, Shayak Samaddar, Huanzhen Ni, Hugo Avila, Venkata R. Krishnamurthy & Kannan Thirunavukkarasu
Pages: 193-206
Published online: 26 Dec 2022
AbstractforThe Promising Therapeutic Potential of Oligonucleotides for Pulmonary Fibrotic Diseases | Full Text | References | PDF (3.7 MB) | EPUB
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Open Access
Review
Discovery of RNA-targeted small molecules through the merging of experimental and computational technologies
Ella Czarina Morishita
Pages: 207-226
Published online: 09 Nov 2022
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Open Access

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