Leukemia & Lymphoma, Volume 61, Issue 13 (2020)

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Leukemia & Lymphoma, Volume 61, Issue 13 (2020)

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Commentaries

Article Commentary
Improving patient access to modern myeloma therapy in Latin America: first step, know what your problem really is
Nelson Hamerschlak & Marcos de Lima
Pages: 3033-3034
Published online: 24 Sep 2020
CitationforImproving patient access to modern myeloma therapy in Latin America: first step, know what your problem really is | Full Text | References | PDF (246.1 KB) | EPUB
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Article Commentary
Long-term outcomes in patients with AML achieving first complete remission: confronting the double-hit of survivorship
Strachan Mackenzie & Saar Gill
Pages: 3035-3037
Published online: 25 Oct 2020
First Page PreviewforLong-term outcomes in patients with AML achieving first complete remission: confronting the double-hit of survivorship | Full Text | References | PDF (310.1 KB) | EPUB
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Review

Therapeutic vaccines for aggressive B-cell lymphoma
Zijun Y. Xu-Monette & Ken H. Young
Pages: 3038-3051
Published online: 25 Aug 2020
AbstractforTherapeutic vaccines for aggressive B-cell lymphoma | Full Text | References | PDF (1.9 MB) | EPUB
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Original Articles

Article
A proteomic study of myeloproliferative neoplasms using reverse-phase protein arrays
Raquel Tognon, Danillo C. Almeida-e-Silva, Rita Andraos-Rey, Mitko Ristov, Luciana Ambrósio, Felipe Campos de Almeida, Natália de Souza Nunes, Elizabeth Xisto Souto, Leila de Lourdes Perobelli, Belinda Pinto Simões, Daniel Alexander Guthy, Thomas Radimerski & Fabíola Attié de Castro
Pages: 3052-3065
Published online: 15 Aug 2020
AbstractforA proteomic study of myeloproliferative neoplasms using reverse-phase protein arrays | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 226 Views
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Article
RNA-sequencing of acute promyelocytic leukemia primary blasts reveals novel molecular biomarkers of early death events
Johann-Christoph Jann, Alexander Streuer, Anna Hecht, Florian Nolte, Verena Nowak, Justine Danner, Julia Obländer, Iris Palme, Eva Lengfelder, Uwe Platzbecker, Wolf-Karsten Hofmann, Johanna Flach & Daniel Nowak
Pages: 3066-3077
Published online: 29 Jul 2020
AbstractforRNA-sequencing of acute promyelocytic leukemia primary blasts reveals novel molecular biomarkers of early death events | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 383 Views
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Article
Modeling pediatric AML FLT3 mutations using CRISPR/Cas12a- mediated gene editing
Natalia Rivera-Torres, Kelly Banas & Eric B. Kmiec
Pages: 3078-3088
Published online: 20 Aug 2020
AbstractforModeling pediatric AML FLT3 mutations using CRISPR/Cas12a- mediated gene editing | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1723 Views
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Open Access
Article
SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome
Saara Laukkanen, Laura Oksa, Atte Nikkilä, Mari Lahnalampi, Mataleena Parikka, Masafumi Seki, Junko Takita, Sofie Degerman, Charles E. de Bock, Merja Heinäniemi & Olli Lohi
Pages: 3089-3100
Published online: 24 Aug 2020
AbstractforSIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Impact of autologous stem cell transplantation on long term renal function and associated progression-free and overall survival in multiple myeloma
Ala Abudayyeh, Heather Lin, Omar Mamlouk, Maen Abdelrahim, Rima Saliba, Gabriela Rondon, Charles S. Martinez, Ruby Delgado, Valda Page, Arun Rajasekaran, Paul W. Sanders & Muzaffar Qazilbash
Pages: 3101-3111
Published online: 29 Jul 2020
AbstractforImpact of autologous stem cell transplantation on long term renal function and associated progression-free and overall survival in multiple myeloma | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 258 Views
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Article
Different outcomes for transplant-eligible newly diagnosed multiple myeloma patients in Latin America according to the public versus private management: a GELAMM study
Camila Peña, Eloisa Riva, Natalia Schutz, Luz Tarín-Arzaga, Humberto Martínez-Cordero, Virginia Bove, Rocío Osorio, Mauricio Chandía, Cecilia Beltrán, Javier Schulz, Daniela Cardemil, Carolina Contreras, Carmen Gloria Vergara, Javiera Donoso, Marcela Espinoza, Gabriel La Rocca, Hernán López-Vidal, Pilar León, Christine Rojas Hopkins, Pablo Soto, Sandra Aranda, Vivianne Torres, Macarena Roa, Paola Ochoa, Patricio Jose Duarte, Guillermina Remaggi, Sebastián Yantorno, Ariel Corzo, Soledad Zabaljauregui, Claudia Shanley, Sergio Lopresti, Sergio Orlando, Verónica Verri, Luis Quiroga, Carlos García, Vanesa Fernández, Jhoanna Ramirez, Alicia Molina, María Pacheco, Alex Mite, Inés Reyes, Brenner Sabando, Francisca Ramírez, Claudia Sossa, Virginia Abello, Henry Idrobo, Kenny Mauricio Galvez Cardenas, Domingo Saavedra, Guillermo Quintero, Raimundo Gazitúa, Lina Gaviria, Rigoberto Gomez, Mónica Osuna, Alicia Henao-Uribe, Omar Cantú-Martínez, David Gómez-Almaguer, Yarely Itzayana García-Navarrete, Antonio Cruz-Mora, Yahveth Cantero-Fortiz, Guillermo J Ruiz-Argüelles & Dorotea Fantl
Pages: 3112-3119
Published online: 26 Aug 2020
AbstractforDifferent outcomes for transplant-eligible newly diagnosed multiple myeloma patients in Latin America according to the public versus private management: a GELAMM study | Full Text | References | PDF (1.3 MB) | EPUB
  • 219 Views
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Article
Survivorship in AML – a landmark analysis on the outcomes of acute myelogenous leukemia patients after maintaining complete remission for at least 3 years
Catherine Kendall Major, Hagop Kantarjian, Koji Sasaki, Gautam Borthakur, Tapan Kadia, Naveen Pemmaraju, Courtney DiNardo, Nicholas J. Short, Naval Daver, Elias Jabbour, Richard Champlin, Guillermo Garcia-Manero, Marina Konopleva, Michael Andreeff, Steven Kornblau, William Wierda, Sherry Pierce, Farhad Ravandi & Jorge Cortes
Pages: 3120-3127
Published online: 05 Aug 2020
AbstractforSurvivorship in AML – a landmark analysis on the outcomes of acute myelogenous leukemia patients after maintaining complete remission for at least 3 years | Full Text | References | PDF (999.8 KB) | EPUB
  • 513 Views
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Article
High-dose cytarabine chemotherapy (≥4 g/m2/day) before allogeneic hematopoietic stem cell transplantation for non-core-binding-factor AML in the first complete remission
Yosuke Nagahata, Tadakazu Kondo, Yuichiro Ono, Nobuhiro Hiramoto, Toshiyuki Kitano, Masakatsu Hishizawa, Kouhei Yamashita, Hisako Hashimoto, Takayuki Ishikawa & Akifumi Takaori-Kondo
Pages: 3128-3136
Published online: 17 Aug 2020
AbstractforHigh-dose cytarabine chemotherapy (≥4 g/m2/day) before allogeneic hematopoietic stem cell transplantation for non-core-binding-factor AML in the first complete remission | Full Text | References | PDF (1.3 MB) | EPUB
  • 91 Views
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Article
Absolute lymphocyte count on the first day of thymoglobulin predicts relapse-free survival in matched unrelated peripheral blood stem cell transplantation
Dipenkumar Modi, Seongho Kim, Malini Surapaneni, Lois Ayash, Voravit Ratanatharathorn, Joseph P. Uberti & Abhinav Deol
Pages: 3137-3145
Published online: 11 Aug 2020
AbstractforAbsolute lymphocyte count on the first day of thymoglobulin predicts relapse-free survival in matched unrelated peripheral blood stem cell transplantation | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 172 Views
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Article
Updated safety of midostaurin plus chemotherapy in newly diagnosed FLT3 mutation–positive acute myeloid leukemia: the RADIUS-X expanded access program
Gail J. Roboz, Stephen A. Strickland, Mark R. Litzow, Andrew Dalovisio, Alexander E. Perl, Gaetano Bonifacio, Kelly Haines, Alysha Barbera, Das Purkayastha & Kendra Sweet
Pages: 3146-3153
Published online: 19 Aug 2020
AbstractforUpdated safety of midostaurin plus chemotherapy in newly diagnosed FLT3 mutation–positive acute myeloid leukemia: the RADIUS-X expanded access program | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3017 Views
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Open Access
Article
Machine learning derived genomics driven prognostication for acute myeloid leukemia with RUNX1-RUNX1T1
Anam Fatima Shaikh, Chinmayee Kakirde, Chetan Dhamne, Prasanna Bhanshe, Swapnali Joshi, Shruti Chaudhary, Gaurav Chatterjee, Prashant Tembhare, Maya Prasad, Nirmalya Roy Moulik, Anant Gokarn, Avinash Bonda, Lingaraj Nayak, Sachin Punatkar, Hasmukh Jain, Bhausaheb Bagal, Dhanalaxmi Shetty, Manju Sengar, Gaurav Narula, Navin Khattry, Shripad Banavali, Sumeet Gujral, Subramanian P. G.Nikhil Patkar
Pages: 3154-3160
Published online: 05 Aug 2020
AbstractforMachine learning derived genomics driven prognostication for acute myeloid leukemia with RUNX1-RUNX1T1 | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2761 Views
  • 7 CrossRef citations
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Open Access
Article
Levocarnitine for pegasparaginase-induced hepatotoxicity in acute lymphoblastic leukemia
Elena Trang, Dat Ngo, Jason Chen, Ibrahim Aldoss, Amandeep Salhotra & Vinod Pullarkat
Pages: 3161-3164
Published online: 13 Aug 2020
AbstractforLevocarnitine for pegasparaginase-induced hepatotoxicity in acute lymphoblastic leukemia | Full Text | References | PDF (473.9 KB) | EPUB
  • 564 Views
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Article
Combination of the dual PIM/PI3-kinase inhibitor IBL-202 and venetoclax is effective in diffuse large B-cell lymphoma
Grace Gifford, William Stevenson & Giles Best
Pages: 3165-3176
Published online: 29 Jul 2020
AbstractforCombination of the dual PIM/PI3-kinase inhibitor IBL-202 and venetoclax is effective in diffuse large B-cell lymphoma | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 281 Views
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Article
Concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and hairy cell leukemia: clinical, pathologic and molecular features
Ifeyinwa Emmanuela Obiorah, Ivo M.B. Francischetti, Hao-Wei Wang, Inhye E. Ahn, Weixin Wang, Mark Raffeld, Robert J. Kreitman, Adrian Wiestner & Katherine R. Calvo
Pages: 3177-3187
Published online: 05 Aug 2020
AbstractforConcurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and hairy cell leukemia: clinical, pathologic and molecular features | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 324 Views
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Article
Final 5-year findings from the phase 3 HELIOS study of ibrutinib plus bendamustine and rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma
Graeme A.M. Fraser, Asher Chanan-Khan, Fatih Demirkan, Rodrigo Santucci Silva, Sebastian Grosicki, Ann Janssens, Jiri Mayer, Nancy L. Bartlett, Marie-Sarah Dilhuydy, Javier Loscertales, Abraham Avigdor, Simon Rule, Olga Samoilova, Miguel A. Pavlovsky, Andre Goy, Anthony Mato, Michael Hallek, Mariya Salman, Monelle Tamegnon, Steven Sun, Anne Connor, Kerri Nottage, Natasha Schuier, Sriram Balasubramanian, Angela Howes & Paula Cramer
Pages: 3188-3197
Published online: 06 Aug 2020
AbstractforFinal 5-year findings from the phase 3 HELIOS study of ibrutinib plus bendamustine and rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma | Full Text | References | PDF (1.1 MB) | EPUB
  • 5329 Views
  • 25 CrossRef citations
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Open Access
Article
High incidence but low mortality of EBV-reactivation and PTLD after alloHCT using ATG and PTCy for GVHD prophylaxis
Maria Queralt Salas, Shruti Prem, Mats Remberger, Wilson Lam, Dennis Dong Hwan Kim, Fotios Vasilios Michelis, Zeyad Al-Shaibani, Armin Gerbitz, Jeffrey Howard Lipton, Auro Viswabandya, Rajat Kumar, Deepali Kumar, Jonas Mattsson & Arjun Datt Law
Pages: 3198-3208
Published online: 25 Jul 2020
AbstractforHigh incidence but low mortality of EBV-reactivation and PTLD after alloHCT using ATG and PTCy for GVHD prophylaxis | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 352 Views
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Article
Clinical and prognostic role of interim 18F-FDG PET/CT in elderly Hodgkin lymphoma: a dual-center experience
Domenico Albano, Angelica Mazzoletti, Vittorio Ruggero Zilioli, Cristina Muzi, Lara Crucitti, Alessandra Tucci, Chiara Pagani, Alessandro Re, Claudio Rossetti, Raffaele Giubbini & Francesco Bertagna
Pages: 3209-3216
Published online: 24 Jul 2020
AbstractforClinical and prognostic role of interim 18F-FDG PET/CT in elderly Hodgkin lymphoma: a dual-center experience | Full Text | References | PDF (1.2 MB) | EPUB
  • 108 Views
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Article
Assessment of tumor Epstein-Barr Virus status and its impact on outcomes in intermediate and high-risk childhood classic Hodgkin Lymphoma treated at a tertiary cancer center in India
Badira Cheriyalinkal Parambil, Gaurav Narula, Chetan Dhamne, Nirmalya Roy Moulik, Tanuja Shet, Epari Shridhar, Sumeet Gujral, Sneha Shah, Siddhartha Laskar, Nehal Khanna & Shripad Banavali
Pages: 3217-3225
Published online: 30 Jul 2020
AbstractforAssessment of tumor Epstein-Barr Virus status and its impact on outcomes in intermediate and high-risk childhood classic Hodgkin Lymphoma treated at a tertiary cancer center in India | Full Text | References | PDF (1.8 MB) | EPUB
  • 232 Views
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Article
Utility of bone marrow aspirate and biopsy in staging of patients with T-cell lymphoma in the PET-Era – tissue remains the issue
Suchitra Sundaram, Mazen Jizzini, Dominick Lamonica, Kristopher Attwood, Matthew Gravina, Francisco Hernandez-Ilizaliturri & Pallawi Torka
Pages: 3226-3233
Published online: 04 Aug 2020
AbstractforUtility of bone marrow aspirate and biopsy in staging of patients with T-cell lymphoma in the PET-Era – tissue remains the issue | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 222 Views
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Letters to the Editor

Letter
Long-term outcomes of frontline 90Y-ibritumomab tiuxetan in marginal zone lymphoma
Izidore S. Lossos, Isildinha M. Reis, Joseph D. Rosenblatt & Juan Pablo Alderuccio
Pages: 3234-3238
Published online: 05 Aug 2020
First Page PreviewforLong-term outcomes of frontline 90Y-ibritumomab tiuxetan in marginal zone lymphoma | Full Text | References | PDF (884 KB) | EPUB | Supplemental
  • 147 Views
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Letter
Vinblastine for elderly and frail patients with Hodgkin lymphoma
Lucie Meynard, Jean Galtier, Simon Favre, Lucile Debus, Axelle Lascaux, Marie-Sarah Dilhuydy, François-Xavier Gros, Mathieu Sauvezie, Noel Milpied, Krimo Bouabdallah & Sophie Dimicoli
Pages: 3239-3242
Published online: 27 Jul 2020
First Page PreviewforVinblastine for elderly and frail patients with Hodgkin lymphoma | Full Text | References | PDF (445.7 KB) | EPUB
  • 236 Views
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Letter
Clonal evolution with acquisition of BCR-ABL1 in refractory acute myeloid leukemia post therapy with FLT3-inhibitor
Beenu Thakral, Naval Daver, Zhenya Tang, Keyur P. Patel, Chi Young Ok, Sanam Loghavi, Joseph D. Khoury, Ahmad S. Alotaibi, Marina Konopleva, Musa Yilmaz & L. Jeffrey Medeiros
Pages: 3243-3246
Published online: 22 Jul 2020
First Page PreviewforClonal evolution with acquisition of BCR-ABL1 in refractory acute myeloid leukemia post therapy with FLT3-inhibitor | Full Text | References | PDF (830.2 KB) | EPUB
  • 280 Views
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Letter
Renal pathology in patients with monoclonal gammopathy or multiple myeloma: monoclonal immunoglobulins are not always the cause
Efstathios Kastritis, Nikolaos Kanellias, Foteini Theodorakakou, Erasmia Psimenou, Charikleia Gakiopoulou, Smaragdi Marinaki, Maria Roussou, Maria Gavriatopoulou, Magdalini Migkou, Despina Fotiou, Evangelos Eleutherakis-Papaiakovou, Panagiotis Malandrakis, Evangelos Terpos & Meletios A. Dimopoulos
Pages: 3247-3250
Published online: 27 Jul 2020
First Page PreviewforRenal pathology in patients with monoclonal gammopathy or multiple myeloma: monoclonal immunoglobulins are not always the cause | Full Text | References | PDF (891.4 KB) | EPUB
  • 112 Views
  • 3 CrossRef citations
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Letter
Germline JAK2 V617F mutation as a susceptibility gene causing myeloproliferative neoplasm in first-degree relatives
Hee Sue Park, Bo Ra Son, Kyeong Seob Shin, Hee Kyung Kim, Yaewon Yang, Yusook Jeong, Hye Sook Han, Ki Hyeong Lee & Jihyun Kwon
Pages: 3251-3254
Published online: 07 Aug 2020
First Page PreviewforGermline JAK2 V617F mutation as a susceptibility gene causing myeloproliferative neoplasm in first-degree relatives | Full Text | References | PDF (701.3 KB) | EPUB
  • 591 Views
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Letter
Daratumumab, lenalidomide, and dexamethasone combination in relapsed/refractory myeloma patients: a real-life single-center experience
Elisabetta Antonioli, Michela Staderini, Sofia Pilerci, Federico Perfetto, Francesco Cappelli, Marco Allinovi, Chiara Nozzoli, Irene Attucci, Alessandra Buzzichelli, Maria Messeri & Alberto Bosi
Pages: 3255-3258
Published online: 10 Aug 2020
First Page PreviewforDaratumumab, lenalidomide, and dexamethasone combination in relapsed/refractory myeloma patients: a real-life single-center experience | Full Text | References | PDF (646.9 KB) | EPUB | Supplemental
  • 422 Views
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Letter
Improvement of therapy-induced myelodysplastic syndrome by infusion of autologous CD34-positive hematopoietic progenitor cells without chemotherapy
Anne-Sophie Alary, Marguerite Vignon, Raphael Carapito, Najeeb Halabi, Lise Willems, Alexa Green, Nicolas Chapuis, Farhad Heshmati, Wendy Cuccuini, Sophie Kaltenbach, Isabelle Radford-Weiss, Olivier Kosmider, Didier Bouscary, Seiamak Bahram, Arash Rafii & Jerome Tamburini
Pages: 3259-3262
Published online: 28 Aug 2020
First Page PreviewforImprovement of therapy-induced myelodysplastic syndrome by infusion of autologous CD34-positive hematopoietic progenitor cells without chemotherapy | Full Text | References | PDF (752.7 KB) | EPUB | Supplemental
  • 250 Views
  • 1 CrossRef citations
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Letter
Lutetium 177 dotatate induced acute myeloid leukemia
Dilip Harindran Vallathol, Abubacker Zakir Ali, Neeharika Alapati, Navya Manasa, Prasad Vasanth & Raghunadharao Digumarti
Pages: 3263-3265
Published online: 25 Jul 2020
First Page PreviewforLutetium 177 dotatate induced acute myeloid leukemia | Full Text | References | PDF (495.7 KB) | EPUB
  • 210 Views
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Letter
Clinical characteristics and outcomes of duodenal-type follicular lymphoma
Ryohei Abe, Takehiko Mori, Tomohiko Tanigawa, Yuya Koda, Naoki Hosoe, Masatoshi Sakurai, Taku Kikuchi, Jun Kato, Takayuki Shimizu, Haruhiko Ogata, Takanori Kanai, Aya Sasaki, Kaori Kameyama & Shinichiro Okamoto
Pages: 3266-3268
Published online: 22 Jul 2020
First Page PreviewforClinical characteristics and outcomes of duodenal-type follicular lymphoma | Full Text | References | PDF (332.3 KB) | EPUB
  • 522 Views
  • 3 CrossRef citations
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Letter
Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival
Wade L. Schulz, Henry M. Rinder, Thomas J. S. Durant, Christopher A. Tormey, Richard Torres, Brian R. Smith, Karl M. Hager, John Greg Howe & Alexa J. Siddon
Pages: 3269-3271
Published online: 26 Jul 2020
First Page PreviewforImpact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival | Full Text | References | PDF (461 KB) | EPUB | Supplemental
  • 114 Views
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Letter
Central nervous system involvement at diagnosis in extranodal natural killer/T-cell lymphoma: a single-center study
Chong Wei, Wei Zhang & Daobin Zhou
Pages: 3272-3274
Published online: 12 Aug 2020
First Page PreviewforCentral nervous system involvement at diagnosis in extranodal natural killer/T-cell lymphoma: a single-center study | Full Text | References | PDF (540.2 KB) | EPUB | Supplemental
  • 170 Views
  • 2 CrossRef citations
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Letter
The successful use of FLT3 inhibitors in FLT3-positive mixed phenotype acute leukemia
Claire Andrews, Wilson Lam & Hassan Sibai
Pages: 3275-3277
Published online: 06 Aug 2020
First Page PreviewforThe successful use of FLT3 inhibitors in FLT3-positive mixed phenotype acute leukemia | Full Text | References | PDF (319.1 KB) | EPUB
  • 280 Views
  • 5 CrossRef citations
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Letter
The management of chronic lymphoproliferative disorders at the time of SARS-Covid2 pandemic: weathering the storm
Anna Maria Frustaci, Giulia Zamprogna, Marina Deodato, Roberto Cairoli, Marco Montillo & Alessandra Tedeschi
Pages: 3278-3279
Published online: 23 Jul 2020
CitationforThe management of chronic lymphoproliferative disorders at the time of SARS-Covid2 pandemic: weathering the storm | Full Text | References | PDF (244 KB) | EPUB
  • 62 Views
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Letter
Refractory acquired angioedema in chronic lymphocytic leukemia
Avani Singh, Vijeyaluxmy Motilal Nehru & David Peace
Pages: 3280-3281
Published online: 25 Aug 2020
CitationforRefractory acquired angioedema in chronic lymphocytic leukemia | Full Text | References | PDF (287.8 KB) | EPUB | Supplemental
  • 101 Views
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