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‘Latest articles’ are articles accepted for publication in this journal but not yet published in a volume/issue. Articles are removed from the ‘Latest articles’ list when they are published in a volume/issue. Latest articles are citable using the author(s), year of online publication, article title, journal and article DOI.

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RESEARCH ARTICLE

Article
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities
Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki & Miki Katoh
Accepted author version posted online: 06 Aug 2024
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RESEARCH ARTICLE

Article
In Vitro and In Vivo Pharmacokinetic Preclinical Characterization of Aficamten, a Small Molecule Cardiac Myosin Inhibitor
Rajaa Sukhun, Peadar Cremin, Donghong Xu, Jeanelle Zamora, Jennifer Cheung, Luke Ashcraft, Mark P. Grillo & Bradley P. Morgan
Accepted author version posted online: 05 Aug 2024
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General Xenobiochemistry

Rapid Communication
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver
Kazuaki Taguchi, Mai Hashimoto, Masahiro Tokuno, Shinji Takeoka, Toru Maruyama, Keishi Yamasaki & Masaki Otagiri
Accepted author version posted online: 01 Aug 2024
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Rapid Communication

Rapid Communication
Preface for Special Issue: “Emerging strategies, technologies and approaches for the next generation ADCs”
M Walles & K Xu
Accepted author version posted online: 29 Jul 2024
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Rapid Communication

Rapid Communication
A systematic review of allometric scaling exponents for IgG mAbs
Simon Rowland, Emma Nixon, Krithika Mohan, Qianwen Wang & James Yates
Accepted author version posted online: 27 Jul 2024
  • 21 Views
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RESEARCH ARTICLE

Article
Improved Preclinical Drug Metabolism and Pharmacokinetics of Pibothiadine (HEC121210), a Novel Hepatitis B Virus Capsid Assembly Modulator
Ming Li, Xingguo Yan, Li Zhang, Xinchang Liu, Yayi Liu, Qian Wang & Jing Li
Accepted author version posted online: 26 Jul 2024
  • 8 Views
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RESEARCH ARTICLE

Article
Pharmacokinetics, Mass Balance, Tissue Distribution, Metabolism, and Excretion of [14C]Aficamten Following Single Oral Dose Administration to Rats
Mark P. Grillo, Rajaa Sukhun, Mohammad Bashir, Luke Ashcraft & Bradley P. Morgan
Accepted author version posted online: 26 Jul 2024
  • 45 Views
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General Xenobiochemistry

Article
Prediction of human serum concentration–time profiles of therapeutic monoclonal antibodies using common marmosets (Callithrix jacchus): initial assessment with canakinumab, adalimumab, and bevacizumab
Ayaka Tajiri, Shogo Matsumoto, Satoshi Maeda, Takuma Soga, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Atsunori Miyata & Hidetaka Kamimura
Published online: 26 Jul 2024
  • 248 Views
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Open Access

Review Article

Review Article
Beyond Cytotoxic Potency: Disposition Features Required to Design ADC Payload
Hao Sun, Larry C. Wienkers & Anthony Lee
Accepted author version posted online: 17 Jul 2024
  • 75 Views
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DMDG meeting Frankfurt (2024)

Rapid Communication
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders
Caroline Rynn & Heide Marika Duevel
Published online: 12 Jul 2024
  • 153 Views
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Review Article

Review Article
Application of quantitative pharmacology analysis to support early clinical development of oncology drugs: dose selection
Ningyuan Zhang, Yu Li, Wenbin Cui, Xiangqing Yu & Ying Huang
Accepted author version posted online: 12 Jul 2024
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General Xenobiochemistry

Article
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation
Qingxia Liu, Jianxing Zhou, You Zheng, Baohua Xu, Dandan Li, Maobai Liu, Xiaohan Zhang & Xuemei Wu
Published online: 08 Jul 2024
  • 35 Views
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Research Article

Article
Study on pharmacokinetics and tissue distribution of deoxypodophyllotoxin and its metabolites in tumour-bearing mice
Fei Liu, Aibin Zheng, Min Li, Yang Chen & Xiaodong Liu
Published online: 01 Jul 2024
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Topics in Xenobiochemistry

Review Article
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research
Dennis A. Smith
Published online: 01 Jul 2024
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Editorial

Editorial
Xenobiotica Special Edition Preface
Alan GE Wilson
Accepted author version posted online: 25 Jun 2024
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Free Access

Molecular Toxicology

Article
An in silico investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products
Hai Duc Nguyen, Thuy Linh Hoang & Giang Huong Vu
Published online: 24 Jun 2024
  • 57 Views
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Xenobiotic transporters

Article
Assessment of P-glycoprotein function using canine intestinal organoid-derived epithelial interfaces
Itsuma Nagao, Meg Nakazawa, Yurika Tachibana, Minae Kawasaki & Yoko M. Ambrosini
Published online: 24 Jun 2024
  • 361 Views
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Open Access

General Xenobiochemistry

Article
In vitro safety evaluation of (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate (K-116) – the novel potential UV filter designed by means of a double chromophore strategy
Justyna Popiół, Agnieszka Gunia-Krzyżak, Karolina Słoczyńska, Kamil Piska, Natalia Kocot, Dorota Żelaszczyk, Anna Krupa, Katarzyna Wójcik-Pszczoła, Henryk Marona & Elżbieta Pękala
Published online: 24 Jun 2024
  • 25 Views
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General Xenobiochemistry

Article
Selection of a suitable animal model to evaluate secretion of drugs in the human milk: a systematic approach
Riya Nilkant, Chintha Kathiresan, Namrata Kumar, Steve Caritis, Imam H. Shaik & Raman Venkataramanan
Published online: 24 Jun 2024
  • 113 Views
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RESEARCH ARTICLE

Article
Prediction of the Liver Safety Profile of a First-in-Class Myeloperoxidase Inhibitor Using Quantitative Systems Toxicology Modeling
Jeffrey L. Woodhead, Yeshi Gebremichael, Joyce Macwan, Irfan A. Qureshi, Richard Bertz, Victoria Wirtz & Brett A. Howell
Accepted author version posted online: 14 Jun 2024
  • 36 Views
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Animal Pharmacokinetics and Metabolism

Article
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1
Anna Kerins, Phil Butler, Rob Riley, Marta Koszyczarek, Caroline Smith, Faye Cruickshank, Vamsi Madgula, Nilkanth Naik, Matthew R. Redinbo & Ian D. Wilson
Published online: 12 Jun 2024
  • 483 Views
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Open Access

RESEARCH ARTICLE

Article
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray, Karina M. Zielinski, Fanny Xu, Kayla K. Elder, Steven J. McKay, Victor T. Ojo, Samantha R. Benjamin, Aiman A. Yaseen, Tracy A. Brooks & L. Nathan Tumey
Accepted author version posted online: 13 May 2024
  • 261 Views
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Review Article

Review Article
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao, Douglas D. Leipold, Shang-Chiung Chen, Zao Li, Amrita V. Kamath & Chunze Li
Accepted author version posted online: 13 May 2024
  • 516 Views
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Review Article

Review Article
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang, Minu Ravindra Pilvankar, Rakesh Dixit & Hongbin Yu
Accepted author version posted online: 11 May 2024
  • 211 Views
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Review Article

Review Article
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu & Italo Poggesi
Accepted author version posted online: 30 Apr 2024
  • 59 Views
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General Xenobiochemistry

Article
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle
Paula Ichinose, María Victoria Miró, Paula Viviani, Juan Manuel Herrera, Adrián Lifschitz & Guillermo Virkel
Published online: 25 Apr 2024
  • 112 Views
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Commentary

Rapid Communication
Academic foreign compound metabolism – ‘quo vadis’?
S. C. Mitchell & R. H. Waring
Published online: 24 Apr 2024
  • 256 Views
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Open Access

RESEARCH ARTICLE

Article
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species
Victor Yip, Ola M. Saad, Doug Leipold, Chunze Li, Amrita Kamath & Ben-Quan Shen
Accepted author version posted online: 22 Apr 2024
  • 1112 Views
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Open Access

Research Article

Article
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophages
Chen-Chung Lin, Brandon F. Law & Justin M. Hettick
Published online: 19 Apr 2024
  • 175 Views
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Review Article

Review Article
Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins
Anthony Murphy, Ryan Hill & Michael Berna
Accepted author version posted online: 12 Apr 2024
  • 410 Views
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RESEARCH ARTICLE

Article
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury
Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu & Kouichi Yoshinari
Accepted author version posted online: 05 Feb 2024
  • 145 Views
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Review Article

Review Article
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.
Dennis A Smith, Lucy Melanie Burton & Sophie Amanda
Accepted author version posted online: 14 Dec 2023
  • 57 Views
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SPECIAL ISSUE

Review Article
The history and future of population pharmacokinetic analysis in drug development
Nathan Teuscher
Accepted author version posted online: 05 Dec 2023
  • 134 Views
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RESEARCH ARTICLE

Article
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry
Seo-jin Park, Jeong-hyeon Lim, Jiyu Lee, Jeongmin Lee, Sangsoo Hwang, Hyunjin Kim, Seunghyun Jo, Duckhyang Shin, Sang Ho MA, Myung L. Kim & Young G. Shin
Accepted author version posted online: 16 Nov 2023
  • 69 Views
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RESEARCH ARTICLE

Article
Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning
Mario Öeren, Peter A. Hunt, Charlotte E. Wharrick, Hamed Tabatabaei Ghomi & Matthew D. Segall
Accepted author version posted online: 15 Nov 2023
  • 170 Views
  • 1 CrossRef citations
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Review Article

Review Article
In silico ADME/tox comes of age: twenty years later
Sean Ekins, Thomas R. Lane, Fabio Urbina & Ana C. Puhl
Published online: 08 Aug 2023
  • 446 Views
  • 1 CrossRef citations
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