Xenobiotica, Volume 43, Issue 11 (2013)

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Xenobiotica, Volume 43, Issue 11 (2013)

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General Xenobiochemistry

Article
Metabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent
Xianai Wu, Izabela Kania-Korwel, Hao Chen, Marianna Stamou, Karigowda J. Dammanahalli, Michael Duffel, Pamela J. Lein & Hans-Joachim Lehmler
Pages: 933-947
Published online: 12 Apr 2013
AbstractforMetabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent | Full Text | References | PDF (1.1 MB)
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Research Article

Article
Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs
Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura & Masashi Yabuki
Pages: 948-955
Published online: 17 Apr 2013
AbstractforSpecies differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs | Full Text | References | PDF (358.2 KB)
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Article
Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes
Chiaki Tanoue, Kazumi Sugihara, Naoto Uramaru, Yoshitaka Tayama, Yoko Watanabe, Toru Horie, Shigeru Ohta & Shigeyuki Kitamura
Pages: 956-962
Published online: 08 May 2013
AbstractforPrediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes | Full Text | References | PDF (430.5 KB)
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Article
Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha
Amit S. Kalgutkar, Danny Chen, Manthena V. Varma, Bo Feng, Steven G. Terra, Renato J. Scialis, Charles J. Rotter, Kosea S. Frederick, Mark A. West, Theunis C. Goosen, James R. Gosset, Robert L. Walsky & Omar L. Francone
Pages: 963-972
Published online: 30 Apr 2013
AbstractforElucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha | Full Text | References | PDF (417.4 KB)
  • 348 Views
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Article
Potential role of CYP2D6 in the central nervous system
Jie Cheng, Yueying Zhen, Sharon Miksys, Diren Beyoğlu, Kristopher W. Krausz, Rachel F. Tyndale, Aiming Yu, Jeffrey R. Idle & Frank J. Gonzalez
Pages: 973-984
Published online: 25 Apr 2013
AbstractforPotential role of CYP2D6 in the central nervous system | Full Text | References | PDF (1.1 MB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats
Ju Myung Kim, Ji Na Yoon, Ji Won Jung, Hye Duck Choi, Young June Shin, Chang Kyun Han, Hye Suk Lee & Hee Eun Kang
Pages: 985-992
Published online: 22 Apr 2013
AbstractforPharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats | Full Text | References | PDF (300.9 KB)
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Research Article

Article
Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats
Juhyun Kim, Ronghua Wang, Karen A. Veverka & James T. Dalton
Pages: 993-1009
Published online: 22 Apr 2013
AbstractforAbsorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats | Full Text | References | PDF (1.4 MB)
  • 470 Views
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Article
Toxicokinetics of Isoeugenol in F344 rats and B6C3F1 mice
S. Peter Hong, Alfred F. Fuciarelli, Jerry D. Johnson, Steven W. Graves, Derrick J. Bates, Cynthia S. Smith & Suramya Waidyanatha
Pages: 1010-1017
Published online: 29 Apr 2013
AbstractforToxicokinetics of Isoeugenol in F344 rats and B6C3F1 mice | Full Text | References | PDF (432.2 KB)
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Topics in Xenobiochemistry

Review Article
Structure-activity relationships and in silico models of P-glycoprotein (ABCB1) inhibitors
Hongming Liu, Zhiguo Ma & Baojian Wu
Pages: 1018-1026
Published online: 25 Apr 2013
AbstractforStructure-activity relationships and in silico models of P-glycoprotein (ABCB1) inhibitors | Full Text | References | PDF (1.2 MB)
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