Xenobiotica, Volume 44, Issue 1 (2014)

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Xenobiotica, Volume 44, Issue 1 (2014)

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General Xenobiochemistry

Article
Metabolic detoxification pathways for 5-methoxy-sterigmatocystin in primary tracheal epithelial cells
Odile Cabaret, Olivier Puel, Françoise Botterel, Marcel Delaforge & Stéphane Bretagne
Pages: 1-9
Published online: 11 Jun 2013
AbstractforMetabolic detoxification pathways for 5-methoxy-sterigmatocystin in primary tracheal epithelial cells | Full Text | References | PDF (809.9 KB)
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Research Article

Article
Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation
Katsuhiro Ohyama, Norie Murayama, Makiko Shimizu & Hiroshi Yamazaki
Pages: 10-16
Published online: 18 Jun 2013
AbstractforDrug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation | Full Text | References | PDF (503.4 KB)
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Article
Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors
C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell
Pages: 17-27
Published online: 24 Jul 2013
AbstractforPrediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors | Full Text | References | PDF (467.7 KB)
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Article
Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics
Kyle S. Saitta, Carmen Zhang, Kang Kwang Lee, Kazunori Fujimoto, Matthew R. Redinbo & Urs A. Boelsterli
Pages: 28-35
Published online: 05 Jul 2013
AbstractforBacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics | Full Text | References | PDF (597.9 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism and disposition of [14C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application
James M. Mathews, Scott L. Watson, Purvi R. Patel, Sherry R. Black, Yan Hong, Keith E. Levine, Glenn Ross, Dori R. Germolec, Sheetal A. Thakur & Suramya Waidyanatha
Pages: 36-47
Published online: 20 Jun 2013
AbstractforMetabolism and disposition of [14C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application | Full Text | References | PDF (620.2 KB)
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Research Article

Article
Non-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist
Kazutaka Sekiguchi, Takushi Kanazu, Masaharu Takeuchi, Hiroshi Hasegawa & Yoshitaka Yamaguchi
Pages: 48-58
Published online: 13 Jun 2013
AbstractforNon-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor
Ning Li, Zhixia Qiu, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Yang Lu, Di Zhao & Xijing Chen
Pages: 59-69
Published online: 17 Jun 2013
AbstractforPharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor | Full Text | References | PDF (780.1 KB)
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Molecular Toxicology

Article
A new approach on methamphetamine-induced hepatotoxicity: involvement of mitochondrial dysfunction
Mohammad Reza Eskandari, Mokhtar Rahmati, Ali Reza Khajeamiri, Farzad Kobarfard, Maryam Noubarani & Himan Heidari
Pages: 70-76
Published online: 20 Jun 2013
AbstractforA new approach on methamphetamine-induced hepatotoxicity: involvement of mitochondrial dysfunction | Full Text | References | PDF (201.3 KB)
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Topics in Xenobochemistry

Review Article
Pharmacokinetics of drugs in spontaneously or secondary hypertensive rats
Sihyung Yang, Young Sun Lee & Euichaul Oh
Pages: 77-88
Published online: 28 Jun 2013
AbstractforPharmacokinetics of drugs in spontaneously or secondary hypertensive rats | Full Text | References | PDF (190.7 KB)
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Commentary

Article Commentary
Drug peptide conjugates in human urine?
Stephen Mitchell, Glyn Steventon & Rosemary Waring
Pages: 89-93
Published online: 18 Jun 2013
AbstractforDrug peptide conjugates in human urine? | Full Text | References | PDF (229.9 KB)
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Errata

Correction
Erratum
Page: 94
Published online: 12 Dec 2013
CitationforErratum | Full Text | PDF (77.3 KB)
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