Xenobiotica, Volume 45, Issue 4 (2015)

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Xenobiotica, Volume 45, Issue 4 (2015)

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Research Article

Article
Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions
Yan-Ying Wang, Jun Yang, Hang Liu, Feng-Qin Lin, Jing-Shan Shi & Feng Zhang
Pages: 279-285
Published online: 28 Oct 2014
AbstractforEffects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions | Full Text | References | PDF (717.8 KB)
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Article
Investigation of the prerequisites for the optimization of specific plasma protein binding as a strategy for the reduction of first-pass hepatic metabolism
Andreas Mats Svennebring
Pages: 286-301
Published online: 03 Nov 2014
AbstractforInvestigation of the prerequisites for the optimization of specific plasma protein binding as a strategy for the reduction of first-pass hepatic metabolism | Full Text | References | PDF (653.3 KB)
  • 318 Views
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Article
Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer
Yan Li, Hongjie Wang, Nan Si, Wei Ren, Lingyu Han, Shaokun Xin, Ran Zuo, Xiaolu Wei, Jian Yang, Haiyu Zhao & Baolin Bian
Pages: 302-311
Published online: 05 Nov 2014
AbstractforMetabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer | Full Text | References | PDF (1 MB)
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Article
Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro–in vivo correlation
Takashi Koyanagi, Yasuharu Nakanishi, Norie Murayama, Yoshiyuki Yamaura, Kanami Ikeda, Koji Yano, Shotaro Uehara, Masahiro Utoh, Soonih Kim, Yasuhiro Uno & Hiroshi Yamazaki
Pages: 312-321
Published online: 03 Nov 2014
AbstractforAge-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro–in vivo correlation | Full Text | References | PDF (673.1 KB)
  • 411 Views
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Article
Physicochemical characteristics and gastrointestinal absorption behaviors of S-propargyl-cysteine, a potential new drug candidate for cardiovascular protection and antitumor treatment
Guo Ma, Lin Zhang, Peng Zhang, Xingfei Bao, Ning Zhou, Qingling Shi, Yuanting Zheng, Hongrui Liu, Fengjiao Bu, Ying Zhang, Wenjie Huang, Fen Wang, Yizhun Zhu & Weimin Cai
Pages: 322-334
Published online: 06 Nov 2014
AbstractforPhysicochemical characteristics and gastrointestinal absorption behaviors of S-propargyl-cysteine, a potential new drug candidate for cardiovascular protection and antitumor treatment | Full Text | References | PDF (442.1 KB)
  • 163 Views
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Article
Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine
Qiaoli Wang, Xiaotong Han, Jian Li, Xinghui Gao, Yan Wang, Mingzhou Liu, Guicheng Dong & Jiang Yue
Pages: 335-344
Published online: 12 Nov 2014
AbstractforRegulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine | Full Text | References | PDF (1.1 MB)
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Article
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz
Yohei Kosugi & Junzo Takahashi
Pages: 345-352
Published online: 11 Nov 2014
AbstractforSpecies differences and substrate specificity of CYP3A heteroactivation by efavirenz | Full Text | References | PDF (489.6 KB)
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Article
Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies
Yoshiya Yamamura, Noriyuki Koyama & Ken Umehara
Pages: 353-360
Published online: 19 Nov 2014
AbstractforComprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies | Full Text | References | PDF (637.2 KB)
  • 313 Views
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Article
Reactive metabolite activation by CYP2C19-mediated rhein hepatotoxicity
Li-Na He, Ai-Hong Yang, Tian-Yi Cui, Yi-Ran Zhai, Fang-Liang Zhang, Jun-Xiu Chen, Chun-Huan Jin, Yao-Wen Fan, Zi-Jun Wu, Li-Li Wang & Xin He
Pages: 361-372
Published online: 19 Nov 2014
AbstractforReactive metabolite activation by CYP2C19-mediated rhein hepatotoxicity | Full Text | References | PDF (1.7 MB)
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