Xenobiotica, Volume 46, Issue 1 (2016)

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Xenobiotica, Volume 46, Issue 1 (2016)

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General Xenobiochemistry

Article
Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1
Danyi Lu, Zhiguo Ma, Tianpeng Zhang, Xingwang Zhang & Baojian Wu
Pages: 1-13
Published online: 11 Jun 2015
AbstractforMetabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1 | Full Text | References | PDF (1.7 MB) | Supplemental
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Article
Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
Risto O. Juvonen, Mira Kuusisto, Carolin Fohrgrup, Mari H. Pitkänen, Tapio J. Nevalainen, Seppo Auriola, Hannu Raunio, Markku Pasanen & Olli T. Pentikäinen
Pages: 14-24
Published online: 11 Jun 2015
AbstractforInhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes | Full Text | References | PDF (1 MB)
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Article
Interplay of metabolizing enzymes and transporter of xenobiotics
Hwee Ying Lim, Qin Shi Ho & Kim Ping Wong
Pages: 25-33
Published online: 30 Jul 2015
AbstractforInterplay of metabolizing enzymes and transporter of xenobiotics | Full Text | References | PDF (628.1 KB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
The effect of food on the pharmacokinetic properties and bioequivalence of two formulations of pitavastatin calcium in healthy Chinese male subjects
Dewei Shang, Shuhua Deng, Zhenhong Yao, Zhanzhang Wang, Xiaojia Ni, Ming Zhang, Jinqing Hu, Haoyang Lu, Xiuqing Zhu, Wencan Huang, Chang Qiu & Yuguan Wen
Pages: 34-39
Published online: 17 Jul 2015
AbstractforThe effect of food on the pharmacokinetic properties and bioequivalence of two formulations of pitavastatin calcium in healthy Chinese male subjects | Full Text | References | PDF (272 KB)
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Article
Characterization of fimasartan metabolites in human liver microsomes and human plasma
Ji-Yoon Lee, Young Jae Choi, Soo Jin Oh, Yong Ha Chi, Soo Heui Paik, Ki Ho Lee, Jae-Kyung Jung, Chang Seon Ryu, Kwon-Bok Kim, Dong-Hyun Kim, Young-Ran Yoon & Sang Kyum Kim
Pages: 40-51
Published online: 11 Jun 2015
AbstractforCharacterization of fimasartan metabolites in human liver microsomes and human plasma | Full Text | References | PDF (1.2 MB)
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Article
Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans
Jiachang Gong, Timothy Eley, Bing He, Vinod Arora, Thomas Philip, Hao Jiang, John Easter, W. Griffith Humphreys, Ramaswamy A. Iyer & Wenying Li
Pages: 52-64
Published online: 07 Jul 2015
AbstractforCharacterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans | Full Text | References | PDF (709.5 KB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Metabolic fate analysis of Huang–Lian–Jie–Du Decoction in rat urine and feces by LC–IT-MS combining with LC–FT-ICR-MS: a feasible strategy for the metabolism study of Chinese medical formula
Ran Zuo, Wei Ren, Bao-Lin Bian, Hong-Jie Wang, Yao-Nan Wang, Hao Hu, Hai-Yu Zhao & Nan Si
Pages: 65-81
Published online: 18 Jun 2015
AbstractforMetabolic fate analysis of Huang–Lian–Jie–Du Decoction in rat urine and feces by LC–IT-MS combining with LC–FT-ICR-MS: a feasible strategy for the metabolism study of Chinese medical formula | Full Text | References | PDF (413.7 KB)
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Molecular Toxicology

Article
Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect
Ahmad Salimi, Sadaf Eybagi, Enayatollah Seydi, Parvaneh Naserzadeh, Negar Panahi Kazerouni & Jalal Pourahmad
Pages: 82-93
Published online: 11 Jun 2015
AbstractforToxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect | Full Text | References | PDF (904.7 KB)
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List of Reviewers

Thanks to reviewers
Pages: 94-97
Published online: 11 Jan 2016
First Page PreviewforThanks to reviewers | Full Text | PDF (105 KB)
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