Xenobiotica, Volume 46, Issue 8 (2016)

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Xenobiotica, Volume 46, Issue 8 (2016)

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General Xenobiochemistry

Article
Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans
Kelli J. Glenn, Li J. Yu, Micaela B. Reddy, Adrian J. Fretland, Neil Parrott, Sazzad Hussain, Mary Palacios, Faye Vazvaei, Jianguo Zhi & Dietrich Tuerck
Pages: 667-676
Published online: 19 Nov 2015
AbstractforInvestigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans | Full Text | References | PDF (310.4 KB)
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Article
Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A
Chung-Ping Yu, Hui-Ju Lin, Shiuan-Pey Lin, Chi-Sheng Shia, Pei-Hua Chang, Yu-Chi Hou & Yo-Wen Hsieh
Pages: 677-682
Published online: 04 Dec 2015
AbstractforRhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A | Full Text | References | PDF (306.8 KB)
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Clinical Pharmacokinetics and Metabolism

Article
The metabolism and disposition of GSK2140944 in healthy human subjects
Kitaw Negash, Clara Andonian, Clive Felgate, Cathy Chen, Igor Goljer, Bianca Squillaci, Dung Nguyen, Jill Pirhalla, Mally Lev, Ernest Schubert, Courtney Tiffany, Mohammad Hossain & May Ho
Pages: 683-702
Published online: 19 Nov 2015
AbstractforThe metabolism and disposition of GSK2140944 in healthy human subjects | Full Text | References | PDF (1.8 MB)
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Article
Evaluation of drug–drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males
Liupeng Wang, Chunyong Wu, Lu Shen, Haiyan Liu, Ying Chen, Fang Liu, Youqun Wang & Jin Yang
Pages: 703-708
Published online: 26 Nov 2015
AbstractforEvaluation of drug–drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males | Full Text | References | PDF (259.5 KB)
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Pharmacogenetics

Article
Genetic polymorphisms analysis of drug-metabolizing enzyme CYP2C9 in the Uyghur population
Tianbo Jin, Xiaojie Xun, Shuli Du, Tingting Geng, Hong Wang, Tian Feng, Chen Chen, Dongya Yuan & Longli Kang
Pages: 709-714
Published online: 26 Nov 2015
AbstractforGenetic polymorphisms analysis of drug-metabolizing enzyme CYP2C9 in the Uyghur population | Full Text | References | PDF (592.1 KB)
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Molecular Toxicology

Article
Zinc-induced metallothionein overexpression prevents doxorubicin toxicity in cardiomyocytes by regulating the peroxiredoxins
Li Jing, Lizhong Li, Jing Zhao, Jun Zhao, Zhiwei Sun & Shuangqing Peng
Pages: 715-725
Published online: 24 Nov 2015
AbstractforZinc-induced metallothionein overexpression prevents doxorubicin toxicity in cardiomyocytes by regulating the peroxiredoxins | Full Text | References | PDF (1.6 MB)
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Article
In vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1
Adam V. Wisnewski, Jian Liu & Ala F. Nassar
Pages: 726-732
Published online: 18 Dec 2015
AbstractforIn vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1 | Full Text | References | PDF (619 KB) | Supplemental
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Xenobiotic Transporters

The permeability characteristics and interaction of the main components from Zhizi Bopi decoction in the MDCK cell model
Zhengyue Qian, Cheng Huang, Chenlin Shen, Xiaoming Meng, Zhaolin Chen, Tingting Hu, Yangyang Li & Jun Li
Pages: 733-742
Published online: 04 Dec 2015
AbstractforThe permeability characteristics and interaction of the main components from Zhizi Bopi decoction in the MDCK cell model | Full Text | References | PDF (790.1 KB) | Supplemental
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Topics in Xenobiochemistry

Xenobiotic conjugation with phosphate – a metabolic rarity
Stephen C. Mitchell
Pages: 743-756
Published online: 26 Nov 2015
AbstractforXenobiotic conjugation with phosphate – a metabolic rarity | Full Text | References | PDF (372.1 KB)
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Discussion
Commentary concerning the review by Mitchell et al. (2014): curiosities in drug metabolism (Xenobiotica 2014; 44:666–76)
Karlheinz Seifert & Lutz Kiep
Page: 757
Published online: 04 Dec 2015
CitationforCommentary concerning the review by Mitchell et al. (2014): curiosities in drug metabolism (Xenobiotica 2014; 44:666–76) | Full Text | References | PDF (100.1 KB)
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