Xenobiotica, Volume 48, Issue 3 (2018)

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Xenobiotica, Volume 48, Issue 3 (2018)

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General Xenobiochemistry

Article
A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry
Rachel D. Crouch, J. Matthew Hutzler & J. Scott Daniels
Pages: 219-231
Published online: 10 Mar 2017
AbstractforA novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry | Full Text | References | PDF (828.6 KB) | Supplemental
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Article
Co-treatment with indole-3-carbinol and resveratrol modify porcine CYP1A and CYP3A activities and expression
Galia Zamaratskaia, Rebekka Thøgersen, Marjeta Čandek-Potokar & Martin Krøyer Rasmussen
Pages: 232-240
Published online: 19 Mar 2017
AbstractforCo-treatment with indole-3-carbinol and resveratrol modify porcine CYP1A and CYP3A activities and expression | Full Text | References | PDF (350 KB) | Supplemental
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Article
Potential biomarkers for monitoring the toxicity of long-term exposure to atrazine in rat by metabonomic analysis
Xiao-Feng Zhang, Chong-Hua Zhang, Jing Zheng, Long-Xue Li, Tian-Qi Geng & Yang Zhang
Pages: 241-249
Published online: 21 Mar 2017
AbstractforPotential biomarkers for monitoring the toxicity of long-term exposure to atrazine in rat by metabonomic analysis | Full Text | References | PDF (870.3 KB)
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Article
The inhibition of UDP-glucuronosyltransferases (UGTs) by tetraiodothyronine (T4) and triiodothyronine (T3)
Da-Wei Chen, Zuo Du, Chun-Ze Zhang, Wei-Hua Zhang, Yun-Feng Cao, Hong-Zhi Sun, Zhi-Tu Zhu, Kun Yang, Yong-Zhe Liu, Ze-Wei Zhao, Zhi-Wei Fu, Wen-Qing Gu, Yang Yu & Zhong-Ze Fang
Pages: 250-257
Published online: 30 Jun 2017
AbstractforThe inhibition of UDP-glucuronosyltransferases (UGTs) by tetraiodothyronine (T4) and triiodothyronine (T3) | Full Text | References | PDF (991.2 KB)
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Free Access
Article
Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans
Shin-Ichi Inaba, Maki Yamaguchi-Goto, Kaoru Tanaka-Takanaka, Kiyoaki Yonesu, Hidetaka Sakurai, Kazuishi Kubota & Takashi Izumi
Pages: 258-268
Published online: 03 Apr 2017
AbstractforEnzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans | Full Text | References | PDF (493.4 KB)
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Animal Pharmacokinetics and Metabolism

Article
Characterization of metabolites of larotaxel in rat by liquid chromatography coupled with Q exactive high-resolution benchtop quadrupole orbitrap mass spectrometer
Zhenzhen Liu, Pengyi Hou, Lian Liu & Feng Qian
Pages: 269-278
Published online: 10 Mar 2017
AbstractforCharacterization of metabolites of larotaxel in rat by liquid chromatography coupled with Q exactive high-resolution benchtop quadrupole orbitrap mass spectrometer | Full Text | References | PDF (1.3 MB)
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Article
Comparative pharmacokinetics study of anastrozole after single administration and combination with celecoxib
Xiaoyang Sun, Mingming Lv, Binjie Wang, Simin Zhao, Ping Guo, Shixiao Wang, Liqiang Gu & Xiaohui Chen
Pages: 279-284
Published online: 14 Sep 2017
AbstractforComparative pharmacokinetics study of anastrozole after single administration and combination with celecoxib | Full Text | References | PDF (347.2 KB)
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Article
Metabolic map of osthole and its effect on lipids
Qi Zhao, Xin-Mei Li, Hong-Ning Liu, Frank J. Gonzalez & Fei Li
Pages: 285-299
Published online: 03 Apr 2017
AbstractforMetabolic map of osthole and its effect on lipids | Full Text | References | PDF (1.5 MB) | Supplemental
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Xenobiotic Transporters

Article
Transport properties of valsartan, sacubitril and its active metabolite (LBQ657) as determinants of disposition
Imad Hanna, Natalya Alexander, Matthew H. Crouthamel, John Davis, Adrienne Natrillo, Phi Tran, Arpine Vapurcuyan & Bing Zhu
Pages: 300-313
Published online: 10 Mar 2017
AbstractforTransport properties of valsartan, sacubitril and its active metabolite (LBQ657) as determinants of disposition | Full Text | References | PDF (608.4 KB) | Supplemental
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Article
The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine
Ling Xiao, Yaru Xue, Cuifeng Zhang, Le Wang, Yunfei Lin & Guoyu Pan
Pages: 314-323
Published online: 16 Mar 2017
AbstractforThe involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine | Full Text | References | PDF (933.9 KB)
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