Xenobiotica, Volume 49, Issue 3 (2019)

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Xenobiotica, Volume 49, Issue 3 (2019)

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General Xenobiochemistry

Article
Porcine interleukin-6 enhances the expression of CYP2C33 through a constitutive androstane receptor/retinoid X receptor-mediated pathway
Lixia Xie, Yucheng He, Xiaoqiao Zhou, Xiaowen Li, Xiue Jin, Xiliang Wang & Deshi Shi
Pages: 257-264
Published online: 27 Feb 2018
AbstractforPorcine interleukin-6 enhances the expression of CYP2C33 through a constitutive androstane receptor/retinoid X receptor-mediated pathway | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver
Toru Oshio, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 265-269
Published online: 21 Feb 2018
AbstractforMarmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver | Full Text | References | PDF (652.5 KB) | EPUB
  • 120 Views
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Article
Expression and activities of sulfotransferase in rat brain
Yuki Asai, Yukiko Sakakibara, Miyabi Kondo, Masayuki Nadai & Miki Katoh
Pages: 270-275
Published online: 26 Feb 2018
AbstractforExpression and activities of sulfotransferase in rat brain | Full Text | References | PDF (746.1 KB) | EPUB
  • 152 Views
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Article
Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin
Chunli Qi, Jiangnan Fu, Huinan Zhao, Huijie Xing, Dong Dong & Baojian Wu
Pages: 276-283
Published online: 27 Feb 2018
AbstractforIdentification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin | Full Text | References | PDF (892.7 KB) | EPUB
  • 221 Views
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Article
Cross-species comparison of the metabolism and excretion of selexipag
Tomohiko Ichikawa, Tetsuhiro Yamada, Alexander Treiber, Carmela Gnerre, Jérôme Segrestaa, Swen Seeland & Kiyoko Nonaka
Pages: 284-301
Published online: 21 Mar 2018
AbstractforCross-species comparison of the metabolism and excretion of selexipag | Full Text | References | PDF (2.4 MB) | EPUB
  • 357 Views
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Article
Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate
Austin C. Li, Donghui Cui, Erya Yu, Kyle Dobson, Edward T. Hellriegel & Philmore Robertson Jr
Pages: 302-312
Published online: 14 Mar 2018
AbstractforIdentification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate | Full Text | References | PDF (1.4 MB) | EPUB
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Clinical Pharmacokinetis and Metabolism

Article
Pharmacokinetics and tolerability of cinitapride in healthy Chinese volunteers: a randomized, open-label, single- and multiple-dose study
Xiong Zhang, Ying Wang, Junlin Cheng, Yunfang Hu, Jianghui Liu, Jing Chen, Xingye Yang & Hongwei Fan
Pages: 313-321
Published online: 28 Mar 2018
AbstractforPharmacokinetics and tolerability of cinitapride in healthy Chinese volunteers: a randomized, open-label, single- and multiple-dose study | Full Text | References | PDF (1.7 MB) | EPUB
  • 144 Views
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics and distribution of schisandrol A and its major metabolites in rats
Xu Liu, Lixin Cong, Chunmei Wang, He Li, Chengyi Zhang, Xingang Guan, Peng Liu, Yu Xie, Jianguang Chen & Jinghui Sun
Pages: 322-331
Published online: 16 Jan 2019
AbstractforPharmacokinetics and distribution of schisandrol A and its major metabolites in rats | Full Text | References | PDF (746.3 KB) | EPUB
  • 175 Views
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Article
Metabolic disposition of WTX101 (bis-choline tetrathiomolybdate) in a rat model of Wilson disease
Thomas Plitz & Lee Boyling
Pages: 332-338
Published online: 27 Feb 2018
AbstractforMetabolic disposition of WTX101 (bis-choline tetrathiomolybdate) in a rat model of Wilson disease | Full Text | References | PDF (1.3 MB) | EPUB
  • 311 Views
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Article
Pharmacokinetics and brain penetration study of chlorogenic acid in rats
Gaurav Kumar, Pankaj Paliwal, Sumedha Mukherjee, Nishant Patnaik, Sairam Krishnamurthy & Ranjana Patnaik
Pages: 339-345
Published online: 21 Mar 2018
AbstractforPharmacokinetics and brain penetration study of chlorogenic acid in rats | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Distribution and metabolism of 14C-sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice
Tatsushi Ruike, Yoshihiro Kanai, Kazuki Iwabata, Yuki Matsumoto, Hiroshi Murata, Masahiro Ishima, Keisuke Ohta, Masahiko Oshige, Shinji Katsura, Koji Kuramochi, Shinji Kamisuki, Hiroeki Sahara, Masahiko Miura, Fumio Sugawara & Kengo Sakaguchi
Pages: 346-362
Published online: 24 Apr 2018
AbstractforDistribution and metabolism of 14C-sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Xenobiotic Transporters

Article
Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters
Lisa Chedik, Arnaud Bruyere & Olivier Fardel
Pages: 363-374
Published online: 06 Mar 2018
AbstractforInteractions of organophosphorus pesticides with solute carrier (SLC) drug transporters | Full Text | References | PDF (1.8 MB) | EPUB
  • 497 Views
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Pharmacogenetics

Article
Effects of CYP3A4*1G and CYP3A5*3 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjects
Sufeng Zhou, Mingxue Tao, Yuanyuan Wang, Lu Wang, Lijun Xie, Juan Chen, Yuqing Zhao, Yun Liu, Hongwen Zhang, Ning Ou, Guangji Wang, Feng Shao & Jiye Aa
Pages: 375-380
Published online: 28 Mar 2018
AbstractforEffects of CYP3A4*1G and CYP3A5*3 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjects | Full Text | References | PDF (737.4 KB) | EPUB | Supplemental
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