Xenobiotica, Volume 49, Issue 6 (2019)

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Xenobiotica, Volume 49, Issue 6 (2019)

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General Xenobiochemistry

Article
Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats
Yuka Ono, Souta Sugiyama, Mayu Matsushita, Takio Kitazawa, Tomoko Amano, Yasuhiro Uno, Shinichi Ikushiro & Hiroki Teraoka
Pages: 627-635
Published online: 13 Jul 2018
AbstractforLimited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate
Haruka Nishimuta, Kimihiko Sato, Takao Watanabe & Masashi Yabuki
Pages: 636-645
Published online: 23 Jul 2018
AbstractforTime-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Effect of pretreatment regimens of 1-aminobenzotriazole on metabolism and gastric emptying of probe compounds in rat
Shweta Padmanabhan, Harbeer Kaur, Abhijith Rao, Ajay Saxena, Yogesh Kumar Gupta, T. Thanga Mariappan & Vinay K. Holenarsipur
Pages: 646-654
Published online: 07 Sep 2018
AbstractforEffect of pretreatment regimens of 1-aminobenzotriazole on metabolism and gastric emptying of probe compounds in rat | Full Text | References | PDF (811.7 KB) | EPUB
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Article
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice
Yi-Kun Wang, Xiao-Nan Yang, Wei-Qing Liang, Yao Xiao, Qi Zhao, Xue-Rong Xiao, Frank J. Gonzalez & Fei Li
Pages: 655-670
Published online: 23 Jul 2018
AbstractforA metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
In vitro characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases
Yang-Liu Xia, Tong-Yi Dou, Xia Lv & Guang-Bo Ge
Pages: 671-677
Published online: 21 Sep 2018
AbstractforIn vitro characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases | Full Text | References | PDF (1,011 KB) | EPUB
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Article
Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu
Pages: 678-687
Published online: 04 Oct 2018
AbstractforExpression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers | Full Text | References | PDF (1.5 MB) | EPUB
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Disposition and metabolism of [14C]lemborexant, a novel dual orexin receptor antagonist, in rats and monkeys
Takashi Ueno, Tomomi Ishida & Kazutomi Kusano
Pages: 688-697
Published online: 05 Jul 2018
AbstractforDisposition and metabolism of [14C]lemborexant, a novel dual orexin receptor antagonist, in rats and monkeys | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Impact of collagen-induced arthritis on the pharmacokinetic disposition of voriconazole, a widely used antifungal agent: in vitro and in vivo investigations in DBA/1J mice
Poonam Giri, Prashant Delvadia, Lakshmikant Gupta, Priyal Trivedi, Nirmal Patel, Manoranjan Sharma, Jaideep Singh, Abhijit Chatterjee, Shekhar Kadam & Nuggehally R. Srinivas
Pages: 698-707
Published online: 30 Jul 2018
AbstractforImpact of collagen-induced arthritis on the pharmacokinetic disposition of voriconazole, a widely used antifungal agent: in vitro and in vivo investigations in DBA/1J mice | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si–Ni–San decoction to functional dyspepsia patients
Xi Huang, Jianjun Xu, Juan He, Shaoqi Shi, Hongbin Yan, Jian Wang & Ping Ren
Pages: 708-717
Published online: 05 Oct 2018
AbstractforPharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si–Ni–San decoction to functional dyspepsia patients | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Animal pharmacokinetics and metabolism

Article
In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin
Mark P. Grillo, John C. L. Erve, Ryan Dick, James P. Driscoll, Nicole Haste, Svetlana Markova, Priscilla Brun, Timothy J. Carlson & Marc Evanchik
Pages: 718-733
Published online: 01 Oct 2018
AbstractforIn vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat
In-Hwan Baek
Pages: 734-739
Published online: 12 Sep 2018
AbstractforDose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat | Full Text | References | PDF (779 KB) | EPUB
  • 196 Views
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Molecular Toxicology

Article
Liver-specific knockout of histone methyltransferase G9a impairs liver maturation and dysregulates inflammatory, cytoprotective, and drug-processing genes
Hong Lu, Xiaohong Lei & Qinghao Zhang
Pages: 740-752
Published online: 23 Jul 2018
AbstractforLiver-specific knockout of histone methyltransferase G9a impairs liver maturation and dysregulates inflammatory, cytoprotective, and drug-processing genes | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 363 Views
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