Xenobiotica, Volume 50, Issue 11 (2020)

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Xenobiotica, Volume 50, Issue 11 (2020)

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General Xenobiochemistry

Article
Inhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a, 27b, 148a, 298 and 451a levels
Weiyao Ding, Change Cao, Yangyang Gao, Xuan Zhou & Yong Lai
Pages: 1267-1274
Published online: 12 Aug 2020
AbstractforInhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a, 27b, 148a, 298 and 451a levels | Full Text | References | PDF (1.3 MB) | EPUB
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Article
First dose in neonates: pharmacokinetic bridging study from juvenile mice to neonates for drugs metabolized by CYP3A
Pan-Pan Ye, Yi Zheng, Bin Du, Xi-Ting Liu, Bo-Hao Tang, Min Kan, Yue Zhou, Guo-Xiang Hao, Xin Huang, Le-Qun Su, Wen-Qi Wang, Feng Yu & Wei Zhao
Pages: 1275-1284
Published online: 25 May 2020
AbstractforFirst dose in neonates: pharmacokinetic bridging study from juvenile mice to neonates for drugs metabolized by CYP3A | Full Text | References | PDF (1.3 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Metabolism and in vitro drug–drug interaction assessment of viloxazine
Chungping Yu
Pages: 1285-1300
Published online: 10 Jun 2020
AbstractforMetabolism and in vitro drug–drug interaction assessment of viloxazine | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting
Chuong Pham, Swati Nagar & Ken Korzekwa
Pages: 1301-1310
Published online: 24 Aug 2020
AbstractforNumerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 245 Views
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Article
Metabolism study of hesperetin and hesperidin in rats by UHPLC-LTQ-Orbitrap MSn
Qishu Jiao, Lulu Xu, Lijuan Jiang, Yanyan Jiang, Jiayu Zhang & Bin Liu
Pages: 1311-1322
Published online: 12 Aug 2020
AbstractforMetabolism study of hesperetin and hesperidin in rats by UHPLC-LTQ-Orbitrap MSn | Full Text | References | PDF (2 MB) | EPUB
  • 263 Views
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Article
In vivo pharmacokinetics, distribution, and excretion of an anticancer agent isolated from red ginseng, in rat
Qian Zheng, Ruili Wang, Nanqi Zhang, Cuizhu Wang & Pingya Li
Pages: 1323-1331
Published online: 14 May 2020
AbstractforIn vivo pharmacokinetics, distribution, and excretion of an anticancer agent isolated from red ginseng, in rat | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Effect of rutin on pharmacokinetic modulation of diclofenac in rats
Ashish Dogra, Abhishek Gour, Shipra Bhatt, Priyanka Sharma, Anjna Sharma, Pankul Kotwal, Priya Wazir, Prashant Mishra, Gurdarshan Singh & Utpal Nandi
Pages: 1332-1340
Published online: 02 Jun 2020
AbstractforEffect of rutin on pharmacokinetic modulation of diclofenac in rats | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 235 Views
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Article
Disposition and metabolism of 2,2′-dimorpholinodiethyl ether in sprague dawley rats and B6C3F1/N mice after oral, intravenous administration, and dermal application
Suramya Waidyanatha, Jacob D. McDonald, J. Michael Sanders, Melanie Doyle-Eisele, Benjamin C. Moeller & C. Edwin Garner
Pages: 1341-1351
Published online: 22 Jun 2020
AbstractforDisposition and metabolism of 2,2′-dimorpholinodiethyl ether in sprague dawley rats and B6C3F1/N mice after oral, intravenous administration, and dermal application | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Molecular Toxicology

Article
Bidirectional regulation of genistein on the proliferation and differentiation of C2C12 myoblasts
Mailin Gan, Dongli Yang, Yuan Fan, Jingjing Du, Linyuan Shen, Qiang Li, Yanzhi Jiang, Guoqing Tang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang & Li Zhu
Pages: 1352-1358
Published online: 24 Aug 2020
AbstractforBidirectional regulation of genistein on the proliferation and differentiation of C2C12 myoblasts | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Identification of gene expression markers and development of evaluation method using cell-based and RT-PCR-based assay for skin sensitising potential of chemicals
Maho Ukaji Nishikawa, Megumi Iwaki, Kosuke Tashiro & Kouichi Kurose
Pages: 1359-1369
Published online: 21 May 2020
AbstractforIdentification of gene expression markers and development of evaluation method using cell-based and RT-PCR-based assay for skin sensitising potential of chemicals | Full Text | References | PDF (1.2 MB) | EPUB
  • 142 Views
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Xenobiotic Transporters

Article
Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism
Seigo Sanoh, Yoichi Naritomi, Satoshi Kitamura, Akihiko Shinagawa, Masakazu Kakuni, Chise Tateno & Shigeru Ohta
Pages: 1370-1379
Published online: 05 Jun 2020
AbstractforPredictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 493 Views
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Article
Differential interactions of carbamate pesticides with drug transporters
Nelly Guéniche, Arnaud Bruyere, Mélanie Ringeval, Elodie Jouan, Antoine Huguet, Ludovic Le Hégarat & Olivier Fardel
Pages: 1380-1392
Published online: 04 Jun 2020
AbstractforDifferential interactions of carbamate pesticides with drug transporters | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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