Cancer Biology & Therapy, Volume 8, Issue 20 (2009)

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Cancer Biology & Therapy, Volume 8, Issue 20 (2009)

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Editor's Corner

Editorial
Cover caption
Page: i
Published online: 15 Oct 2009
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News

News
Blackburn, Greider, and Szostak win Nobel prize in physiology or medicine
Pages: 1877-1880
Published online: 15 Oct 2009
AbstractforBlackburn, Greider, and Szostak win Nobel prize in physiology or medicine | PDF (403 KB)
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News
NEDD9 protein supports growth of aggressive breast cancer
Pages: 1877-1880
Published online: 15 Oct 2009
AbstractforNEDD9 protein supports growth of aggressive breast cancer | PDF (403 KB)
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News
Loss of tumor suppressor gene essential for transformation of benign nerve tumors into deadly type of sarcoma
Pages: 1877-1880
Published online: 15 Oct 2009
AbstractforLoss of tumor suppressor gene essential for transformation of benign nerve tumors into deadly type of sarcoma | PDF (403 KB)
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Review

Review Article
Noninvasive assessment of pediatric brain tumors
Katherine E. Warren
Pages: 1881-1888
Published online: 15 Oct 2009
AbstractforNoninvasive assessment of pediatric brain tumors | PDF (766.3 KB)
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Journal Club

Early growth response 1 (EGR1): A gene with as many names as biological functions
J. Thomas DeLigio & Diego A. R. Zorio
Pages: 1889-1892
Published online: 15 Oct 2009
AbstractforEarly growth response 1 (EGR1): A gene with as many names as biological functions | PDF (216.9 KB)
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Research Paper

Article
Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models
Qing Chang, Eric Chen & David Hedley
Pages: 1893-1901
Published online: 15 Oct 2009
AbstractforEffects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models | PDF (2.2 MB)
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Commentary

A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: Promise or deja vu?
Andrew D Rhim
Pages: 1902-1903
Published online: 15 Oct 2009
AbstractforA combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: Promise or deja vu? | PDF (169.6 KB)
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Research Paper

Article
Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant hep G2 cells through a mitochondria-dependent oxidative stress mechanism
Jeng-Fong Chiou, Cheng-Jeng Tai, Yu-Huei Wang, Tsan-Zon Liu, Yee-Min Jen & Chia-Yang Shiau
Pages: 1904-1913
Published online: 15 Oct 2009
AbstractforSorafenib induces preferential apoptotic killing of a drug- and radio-resistant hep G2 cells through a mitochondria-dependent oxidative stress mechanism | PDF (1.4 MB)
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Article
The overexpression of ERCC-1 is involved in the resistance of lung cancer cells to cetuximab combined with DDP
Jing-Jing Li, Ya Ding, Dan-Dan Li, Rui-Qing Peng, Gong-Kan Feng, Yi-Xin Zeng, Xiao-Feng Zhu & Xiao-Shi Zhang
Pages: 1914-1921
Published online: 15 Oct 2009
AbstractforThe overexpression of ERCC-1 is involved in the resistance of lung cancer cells to cetuximab combined with DDP | PDF (1.2 MB)
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Commentary

A new step ahead for the consideration of ERCC1 as a candidate biomarker to select NSCLC patients for the treatment of cetuximab in combination with cisplatin
Ken André Olaussen
Pages: 1922-1923
Published online: 15 Oct 2009
AbstractforA new step ahead for the consideration of ERCC1 as a candidate biomarker to select NSCLC patients for the treatment of cetuximab in combination with cisplatin | PDF (76.9 KB)
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Research Paper

Article
Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model
Nagendra S. Ningaraj, Umesh T. Sankpal, Divya Khaitan, Edward A. Meister & Tribhawan S. Vats
Pages: 1924-1933
Published online: 15 Oct 2009
AbstractforModulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model | PDF (1.6 MB)
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Article
Green tea (-)-Epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells
Hoang Thanh Chi, Hoang Anh Vu, Reo Iwasaki, Le Ba Thao, Yukihiko Hara, Takahiro Taguchi, Toshiki Watanabe & Yuko Sato
Pages: 1934-1939
Published online: 15 Oct 2009
AbstractforGreen tea (-)-Epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells | PDF (2.3 MB)
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Article
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model
Kwang Mo Yang, James Russell, Mihaela E. Lupu, HyungJoon Cho, Xiao-Feng Li, Jason A. Koutcher & C.Clifton Ling
Pages: 1940-1946
Published online: 15 Oct 2009
AbstractforAtrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model | PDF (631 KB)
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Article
Signaling pathways in adenoid cystic cancers: Implications for treatment
Anjali K. Gupta, Werner W. Wilke, Erin N. Taylor, Kellie L. Bodeker, Henry T. Hoffman, Mohammed M. Milhem, John M. Buatti & Robert A. Robinson
Pages: 1947-1951
Published online: 15 Oct 2009
AbstractforSignaling pathways in adenoid cystic cancers: Implications for treatment | PDF (676.4 KB)
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Article
Elevated expression of nuclear Hsp90 in invasive breast tumors
Malissa C. Diehl, Michael O. Idowu, Katherine Kimmelshue, Timothy P. York, Lynne W. Elmore & Shawn E. Holt
Pages: 1952-1961
Published online: 15 Oct 2009
AbstractforElevated expression of nuclear Hsp90 in invasive breast tumors | PDF (1.5 MB)
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Article
Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts
Changbin Du, Zhen Gao, Venkatasubbaiah A. Venkatesha, Amanda L. Kalen, Leena Chaudhuri, Douglas R. Spitz, Joseph J. Cullen, Larry W. Oberley & Prabhat C Goswami
Pages: 1962-1971
Published online: 15 Oct 2009
AbstractforMitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts | PDF (1.2 MB)
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Commentary

Preventing Dr. Jekyll from becoming Mr. Hyde: Is manganese superoxide dismutase the key to prevent radiation-induced neoplastic transformation?
Aaron K. Holley & Daret K. St. Clair
Pages: 1972-1973
Published online: 15 Oct 2009
AbstractforPreventing Dr. Jekyll from becoming Mr. Hyde: Is manganese superoxide dismutase the key to prevent radiation-induced neoplastic transformation? | PDF (309.8 KB)
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