mAbs, Volume 7, Issue 4 (2015)

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mAbs, Volume 7, Issue 4 (2015)

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Review

Regulatory considerations in oncologic biosimilar drug development
Judith C Macdonald, Helen Hartman & Ira A Jacobs
Pages: 653-661
Published online: 29 Jun 2015
AbstractforRegulatory considerations in oncologic biosimilar drug development | Full Text | References | PDF (171 KB)
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Cross-reactive and pre-existing antibodies to therapeutic antibodies—Effects on treatment and immunogenicity
Karin A van Schie, Gerrit-Jan Wolbink & Theo Rispens
Pages: 662-671
Published online: 29 Jun 2015
AbstractforCross-reactive and pre-existing antibodies to therapeutic antibodies—Effects on treatment and immunogenicity | Full Text | References | PDF (214.1 KB)
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Report

Article
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Ewald TJ van den Bremer, Frank J Beurskens, Marleen Voorhorst, Patrick J Engelberts, Rob N de Jong, Burt G van der Boom, Erika M Cook, Margaret A Lindorfer, Ronald P Taylor, Patrick HC van Berkel & Paul WHI Parren
Pages: 672-680
Published online: 29 Jun 2015
AbstractforHuman IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation | Full Text | References | PDF (713 KB) | Supplemental
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Open Access
Article
Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1
Gang Chen, Leonid Gorelik, Kenneth J Simon, Alevtina Pavlenco, Anne Cheung, Margot Brickelmaier, Ling Ling Chen, Ping Jin, Paul H Weinreb & Sachdev S Sidhu
Pages: 681-692
Published online: 04 Jun 2015
AbstractforSynthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1 | Full Text | References | PDF (788 KB) | Supplemental
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Free Access
Article
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform
Alex Klarenbeek, Khalil El Mazouari, Aline Desmyter, Christophe Blanchetot, Anna Hultberg, Natalie de Jonge, Rob C Roovers, Christian Cambillau, Sylvia Spinelli, Jurgen Del-Favero, Theo Verrips, Hans J de Haard & Ikbel Achour
Pages: 693-706
Published online: 29 Jun 2015
AbstractforCamelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform | Full Text | References | PDF (933.6 KB) | Supplemental
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Article
Efficient generation of monoclonal antibodies from single rhesus macaque antibody secreting cells
Weixu Meng, Leike Li, Wei Xiong, Xuejun Fan, Hui Deng, Andrew J Bett, Zhifeng Chen, Aimin Tang, Kara S Cox, Joseph G Joyce, Daniel C Freed, Elizabeth Thoryk, Tong-Ming Fu, Danilo R Casimiro, Ningyan Zhang, Kalpit A Vora & Zhiqiang An
Pages: 707-718
Published online: 29 Jun 2015
AbstractforEfficient generation of monoclonal antibodies from single rhesus macaque antibody secreting cells | Full Text | References | PDF (855 KB) | Supplemental
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Article
A chemical and computational approach to comprehensive glycation characterization on antibodies
Ramsey A Saleem, Brittany R Affholter, Sihong Deng, Phil C Campbell, Kelli Matthies, Catherine M Eakin & Alison Wallace
Pages: 1-13
Published online: 29 Jun 2015
AbstractforA chemical and computational approach to comprehensive glycation characterization on antibodies | Full Text | References | PDF (946.9 KB)
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Article
Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods
Dietmar Reusch, Markus Haberger, David Falck, Britta Peter, Bernd Maier, Jana Gassner, Michaela Hook, Katharina Wagner, Lea Bonnington, Patrick Bulau & Manfred Wuhrer
Pages: 732-742
Published online: 29 Jun 2015
AbstractforComparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods | Full Text | References | PDF (879.2 KB) | Supplemental
  • 5298 Views
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Open Access
Article
Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding
M Jack Borrok, Nadia M Luheshi, Nurten Beyaz, Gareth C Davies, James W Legg, Herren Wu, William F Dall'Acqua & Ping Tsui
Pages: 743-751
Published online: 29 Jun 2015
AbstractforEnhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding | Full Text | References | PDF (759.5 KB) | Supplemental
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Article
A novel screening method to assess developability of antibody-like molecules
Neeraj Kohli, Nidhi Jain, Melissa L Geddie, Maja Razlog, Lihui Xu & Alexey A Lugovskoy
Pages: 752-758
Published online: 29 Jun 2015
AbstractforA novel screening method to assess developability of antibody-like molecules | Full Text | References | PDF (178.5 KB) | Supplemental
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Article
A fluorescent imaging method for analyzing the biodistribution of therapeutic monoclonal antibodies that can distinguish intact antibodies from their breakdown products
Takuo Suzuki, Chihiro Miyazaki, Akiko Ishii-Watabe, Minoru Tada, Kumiko Sakai-Kato, Toru Kawanishi & Nana Kawasaki
Pages: 759-769
Published online: 04 Jun 2015
AbstractforA fluorescent imaging method for analyzing the biodistribution of therapeutic monoclonal antibodies that can distinguish intact antibodies from their breakdown products | Full Text | References | PDF (919.4 KB) | Supplemental
  • 1954 Views
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Article
High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice
Ryan L Kelly, Tingwan Sun, Tushar Jain, Isabelle Caffry, Yao Yu, Yuan Cao, Heather Lynaugh, Michael Brown, Maximiliano Vásquez, K Dane Wittrup & Yingda Xu
Pages: 770-777
Published online: 29 Jun 2015
AbstractforHigh throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice | Full Text | References | PDF (447.6 KB) | Supplemental
  • 5335 Views
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Article
Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody
Sanjaya Singh, Rachel R Kroe-Barrett, Keith A Canada, Xiang Zhu, Eliud Sepulveda, Helen Wu, Yaqin He, Ernest L Raymond, Jennifer Ahlberg, Lee E Frego, Laura M Amodeo, Katrina M Catron, David H Presky & Jeffrey H Hanke
Pages: 778-791
Published online: 03 Jun 2015
AbstractforSelective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody | Full Text | References | PDF (829.5 KB) | Supplemental
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Article
Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration
Sorina Morar-Mitrica, Manasi Puri, Alexandra Beumer Sassi, Joshua Fuller, Ping Hu, George Crotts & Douglas Nesta
Pages: 792-803
Published online: 29 Jun 2015
AbstractforDevelopment of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration | Full Text | References | PDF (507.2 KB)
  • 2984 Views
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