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Original papers

Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses: A randomized, double-blind radiostereometric study of 50 patients

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Pages 795-799 | Received 14 Mar 2007, Accepted 29 Jul 2007, Published online: 08 Jul 2009

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Read on this site (12)

Bart G Pijls, José W M Plevier & Rob G H H Nelissen. (2018) RSA migration of total knee replacements. Acta Orthopaedica 89:3, pages 320-328.
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Vasileios Zampelis, Ola Belfrage, Magnus Tägil, Martin Sundberg & Gunnar Flivik. (2018) Decreased migration with locally administered bisphosphonate in cemented cup revisions using impaction bone grafting technique. Acta Orthopaedica 89:1, pages 17-22.
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Torsten Johansson. (2016) PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. Acta Orthopaedica 87:1, pages 79-82.
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Per Aspenberg. (2014) Alendronate-eluting polyglucose-lignol composite (POGLICO). Acta Orthopaedica 85:6, pages 687-690.
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Rami Madanat, Tatu J Mäkinen, Hannu T Aro, Charles Bragdon & Henrik Malchau. (2014) Adherence of hip and knee arthroplasty studies to RSA standardization guidelines. Acta Orthopaedica 85:5, pages 447-455.
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Maria Luisa Brandi. (2013) Healing of the bone with anti-fracture drugs. Expert Opinion on Pharmacotherapy 14:11, pages 1441-1447.
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Bart G Pijls, Edward R Valstar, Klaas-Auke Nouta, Josepha WM Plevier, Marta Fiocco, Saskia Middeldorp & Rob GHH Nelissen. (2012) Early migration of tibial components is associated with late revision. Acta Orthopaedica 83:6, pages 614-624.
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Maria Luisa Brandi. (2012) Drugs for bone healing. Expert Opinion on Investigational Drugs 21:8, pages 1169-1176.
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Anna Fahlgren, Mathias PG Bostrom, Xu Yang, Lars Johansson, Ulf Edlund, Fredrik Agholme & Per Aspenberg. (2010) Fluid pressure and flow as a cause of bone resorption. Acta Orthopaedica 81:4, pages 508-516.
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Theis Muncholm Thillemann. (2009) Use of medications and risk of revision after primary total hip arthroplasty. Acta Orthopaedica 80:338, pages 1-36.
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Per Aspenberg. (2009) Bisphosphonates and implants. Acta Orthopaedica 80:1, pages 119-123.
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Per Aspenberg, Philippe Wagner, Kjell G Nilsson & Jonas Ranstam. (2008) Fixed or loose? Dichotomy in RSA data for cemented cups. Acta Orthopaedica 79:4, pages 467-473.
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Articles from other publishers (58)

Abigail E. Niesen & Maury L. Hull. (2023) State of the Art in Radiostereometric Analysis for Tibial Baseplate Migration and Future Research Directions. Journal of Biomechanical Engineering 145:12.
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Jiahao Zhang, Zhenni Liu, Jiezi Qiu & Jianxin Yang. (2023) Impact of locally delivered diphosphonates on dental implants: A systematic review and meta-analysis. Journal of Stomatology, Oral and Maxillofacial Surgery 124:6, pages 101521.
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Jonathan Brandt, Håkan Ledin, Jonas Ranstam, Ewa Roos, Per Aspenberg & Jörg Schilcher. (2020) Single postoperative infusion of zoledronic acid to improve patient-reported outcome after hip or knee replacement: study protocol for a randomised, controlled, double-blinded clinical trial. BMJ Open 10:9, pages e040985.
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J. Mark Wilkinson. (2020) The use of bisphosphonates to meet orthopaedic challenges. Bone 137, pages 115443.
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Sanjay Kumar Bhadada, Rimesh Pal, Ashwani Sood, Vandana Dhiman & Uttam Chand Saini. (2019) Co-administration of Systemic and Intralesional Zoledronic Acid in a Case of Fibrous Dysplasia: A Potentially Novel Therapy. Frontiers in Endocrinology 10.
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Søren Rytter, Frank Madsen, Claus Fink Jepsen & Maiken Stilling. (2019) Implant fracture of the Regenerex® modular metal tibial component: A report of three cases. The Knee 26:5, pages 1143-1151.
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Karina N. Linde, Frank Madsen, Katriina B. Puhakka, Bente L. Langdahl, Kjeld Søballe, Inger Krog-Mikkelsen & Maiken Stilling. (2019) Preoperative Systemic Bone Quality Does Not Affect Tibial Component Migration in Knee Arthroplasty: A 2-Year Radiostereometric Analysis of a Hundred Consecutive Patients. The Journal of Arthroplasty 34:10, pages 2351-2359.
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Benjamin A. McArthur, Ryan Scully, F. Patrick Ross, Mathias P. G. Bostrom & Anna Falghren. (2018) Mechanically Induced Periprosthetic Osteolysis: A Systematic Review. HSS Journal ® 15:3, pages 286-296.
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Jakob E. Schanda, Rainer Mittermayr, Christian Muschitz & Christian Fialka. (2019) Knochenqualität bei der Versorgung orthopädischer und traumatologischer SchultergelenkserkrankungenBone quality in the treatment of orthopedic and traumatic shoulder joint diseases. Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen.
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Cheng Cheng & Dolores Shoback. (2019) Mechanisms Underlying Normal Fracture Healing and Risk Factors for Delayed Healing. Current Osteoporosis Reports 17:1, pages 36-47.
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Samuel AbuMoussa, David S. Ruppert, Christopher Lindsay, Laurence Dahners & Paul Weinhold. (2018) Local delivery of a zoledronate solution improves osseointegration of titanium implants in a rat distal femur model. Journal of Orthopaedic Research® 36:12, pages 3294-3298.
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Matthew R. Cohn, Arianna L. Gianakos, Kirsten Grueter, Natalie Rosen, Guang-Ting Cong & Joseph M. Lane. (2018) Update on the Comprehensive Approach to Fragility Fractures. Journal of Orthopaedic Trauma 32:9, pages 480-490.
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Andrew H. Glassman, Nicole T. Meschbach & Joshua S. Everhart. 2018. Revision Total Knee Arthroplasty. Revision Total Knee Arthroplasty 389 399 .
Thomas Jakobsen, Søren Kold, Juan Shiguetomi-Medina, Jorgen Baas, Kjeld Soballe & Ole Rahbek. (2017) Topical zoledronic acid decreases micromotion induced bone resorption in a sheep arthroplasty model. BMC Musculoskeletal Disorders 18:1.
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M.B. Guimarães, T.H. Antes, M.B. Dolacio, D.D. Pereira & M. Marquezan. (2017) Does local delivery of bisphosphonates influence the osseointegration of titanium implants? A systematic review. International Journal of Oral and Maxillofacial Surgery 46:11, pages 1429-1436.
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Thomas Jakobsen, Joan E. Bechtold, Kjeld Søballe, Thomas Jensen, Marianne T. Vestermark & Jørgen Baas. (2017) Local delivery of zoledronate from a poly ( d , l -lactide)-coating increases fixation of hydroxy-coated implants . Journal of Orthopaedic Research 35:5, pages 974-979.
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J. SchilcherL. PalmI. IvarssonP. Aspenberg. (2017) Local bisphosphonate reduces migration and formation of radiolucent lines adjacent to cemented acetabular components. The Bone & Joint Journal 99-B:3, pages 317-324.
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Per Aspenberg, Jorge Malouf, Umberto Tarantino, Pedro A. García-Hernández, Costantino Corradini, Søren Overgaard, Jan J. Stepan, Lars Borris, Eric Lespessailles, Frede Frihagen, Kyriakos Papavasiliou, Helmut Petto, José Ramón Caeiro & Fernando Marin. (2016) Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture. Journal of Bone and Joint Surgery 98:22, pages 1868-1878.
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Nitesh Gahlot & Uttam Chand Saini. (2016) Bisphosphonates in Orthopedics: Evidence-based Review of Indications and Adverse Effects. Journal of Postgraduate Medicine, Education and Research 50:2, pages 75-85.
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Jenny Ann Pura, J. Dennis Bobyn & Michael Tanzer. (2016) Implant-delivered Alendronate Causes a Dose-dependent Response on Net Bone Formation Around Porous Titanium Implants in Canines. Clinical Orthopaedics and Related Research? 474:5, pages 1224-1233.
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Robert S. Namba, Maria C.S. Inacio, T. Craig Cheetham, Richard M. Dell, Elizabeth W. Paxton & Monti X. Khatod. (2016) Lower Total Knee Arthroplasty Revision Risk Associated With Bisphosphonate Use, Even in Patients With Normal Bone Density. The Journal of Arthroplasty 31:2, pages 537-541.
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Thomas Jakobsen, Joan E. Bechtold, Kjeld Søballe, Thomas Jensen, Stefan Greiner, Marianne T. Vestermark & Jørgen Baas. (2016) Local delivery of zoledronate from a poly (D,L-lactide)-Coating increases fixation of press-fit implants. Journal of Orthopaedic Research 34:1, pages 65-71.
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F. Barvencik. (2015) Medikamente und KnochenstoffwechselMedication and bone metabolism. Der Unfallchirurg 118:12, pages 1017-1024.
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Viktor Savel'evich Prikhod'ko, Anton Aleksandrovich Tarbushkin, Marina Yur'evna Prokhorova, Anton Pavlovich Shilin, Damir Niyamovich Usmanov & Dmitriy Sergeevich Morozov. (2015) Risks of endoprosthetic replacement of large joints in patients with obesity. Obesity and metabolism 12:4, pages 52-56.
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Thord von Schewelov, Håkan Magnusson, Maria Cöster, Caroline Karlsson & Björn E Rosengren. (2015) Osteoarthritis of the Distal Interphalangeal and First Carpometacarpal Joints is Associated with High Bone Mass in Women and Small Bone Size and Low Lean Mass in Men. The Open Orthopaedics Journal 9:1, pages 399-404.
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Magnus Bernhardsson, Olof Sandberg & Per Aspenberg. (2015) Anti-RANKL treatment improves screw fixation in cancellous bone in rats. Injury 46:6, pages 990-995.
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D Prieto-Alhambra, M K Javaid, A Judge, J Maskell, C Cooper & N K Arden. (2015) Hormone replacement therapy and mid-term implant survival following knee or hip arthroplasty for osteoarthritis: a population-based cohort study. Annals of the Rheumatic Diseases 74:3, pages 557-563.
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Magnus K Karlsson, Håkan Magnusson, Thord von Schewelov, Maria Cöster, Caroline Karlsson & Björn. E Rosengren. (2014) Patients with Osteoarthritis in all Three Knee Compartments and Patients with Medial Knee Osteoarthritis Have a Phenotype with High Bone Mass and High Fat Mass but Proportionally Low Lean Mass. The Open Orthopaedics Journal 8:1, pages 390-396.
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N. M. C. Mathijssen, P. Buma & G. Hannink. (2013) Combining bisphosphonates with allograft bone for implant fixation. Cell and Tissue Banking 15:3, pages 329-336.
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Magnus K. Karlsson, Håkan Magnusson, Maria C. Cöster, Tord vonSchewelov, Caroline Karlsson & Björn E. Rosengren. (2013) Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass. Clinical Orthopaedics and Related Research® 472:4, pages 1224-1229.
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M.C. Cöster, B.E. Rosengren, C. Karlsson, T. von Schevelow, H. Magnusson, L. Brudin & M.K. Karlsson. (2014) Bone mass and anthropometry in patients with osteoarthritis of the foot and ankle. Foot and Ankle Surgery 20:1, pages 52-56.
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J. Dennis Bobyn, Rebecca Thompson, Letitia Lim, Jenny Ann Pura, Kristian Bobyn & Michael Tanzer. (2013) Local Alendronic Acid Elution Increases Net Periimplant Bone Formation: A Micro-CT Analysis. Clinical Orthopaedics and Related Research? 472:2, pages 687-694.
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Tuuli M. Saari, Georgios Digas & Johan N. Kärrholm. (2018) Risedronate does not Enhance Fixation or BMD in Revision Cups: Randomised Study with Three Years follow-up. HIP International 24:1, pages 49-55.
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J. Abtahi, F. Agholme, O. Sandberg & P. Aspenberg. (2012) Effect of Local vs . Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw . Journal of Dental Research 92:3, pages 279-283.
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Y. F. Li, X. D. Li, C. Y. Bao, Q. M. Chen, H. Zhang & J. Hu. (2013) Promotion of peri-implant bone healing by systemically administered parathyroid hormone (1-34) and zoledronic acid adsorbed onto the implant surface. Osteoporosis International 24:3, pages 1063-1071.
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Per Aspenberg. (2013) Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials. BoneKEy Reports 2:1.
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David A Back, Stephan Pauly, Lisa Rommel, Norbert P Haas, Gerhard Schmidmaier, Britt Wildemann & Stefan H Greiner. (2012) Effect of local zoledronate on implant osseointegration in a rat model. BMC Musculoskeletal Disorders 13:1.
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Murugan Ramalingam, Pekka Vallittu, Ugo Ripamonti & Wan-Ju LiNiko Moritz, Paula Linderbäck & Timo Närhi. 2012. Tissue Engineering and Regenerative Medicine. Tissue Engineering and Regenerative Medicine 59 84 .
J. Goldhahn, J.-M. F?ron, J. Kanis, S. Papapoulos, J.-Y. Reginster, R. Rizzoli, W. Dere, B. Mitlak, Y. Tsouderos & S. Boonen. (2012) Implications for Fracture Healing of Current and New Osteoporosis Treatments: An ESCEO Consensus Paper. Calcified Tissue International 90:5, pages 343-353.
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Sheila M McRae, Jaskarndip Chahal, Jeff R Leiter, Robert G Marx & Peter B MacDonald. (2011) Survey Study of Members of the Canadian Orthopaedic Association on the Natural History and Treatment of Anterior Cruciate Ligament Injury. Clinical Journal of Sport Medicine 21:3, pages 249-258.
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Fredrik Agholme, Hanna Isaksson, Stuart Kuhstoss & Per Aspenberg. (2011) The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions. Bone 48:5, pages 988-996.
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Yi Zeng, Oujie Lai, Bin Shen, Jing Yang, Zongke Zhou, Pengde Kang & Fuxing Pei. (2011) A Systematic Review Assessing the Effectiveness of Alendronate in Reducing Periprosthetic Bone Loss After Cementless Primary THA. Orthopedics 34:4.
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Kimberly McKenzie, J. Dennis Bobyn, Jacintha Roberts, Dorota Karabasz & Michael Tanzer. (2010) Bisphosphonate Remains Highly Localized After Elution From Porous Implants. Clinical Orthopaedics and Related Research? 469:2, pages 514-522.
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Therese Andersson, Fredrik Agholme, Per Aspenberg & Pentti Tengvall. (2010) Surface immobilized zoledronate improves screw fixation in rat bone: A new method for the coating of metal implants. Journal of Materials Science: Materials in Medicine 21:11, pages 3029-3037.
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Fredrik Agholme, Xiaodong Li, Hanna Isaksson, Hua Zhu Ke & Per Aspenberg. (2010) Sclerostin antibody treatment enhances metaphyseal bone healing in rats. Journal of Bone and Mineral Research 25:11, pages 2412-2418.
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J. Abtahi, P. Tengvall & P. Aspenberg. (2010) Bisphosphonate coating might improve fixation of dental implants in the maxilla: A pilot study. International Journal of Oral and Maxillofacial Surgery 39:7, pages 673-677.
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Theis M. Thillemann, Alma B. Pedersen, Frank Mehnert, Søren P. Johnsen & Kjeld Søballe. (2010) Postoperative use of bisphosphonates and risk of revision after primary total hip arthroplasty: A nationwide population-based study. Bone 46:4, pages 946-951.
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J. Goldhahn, D. Little, P. Mitchell, N.L. Fazzalari, I.R. Reid, P. Aspenberg & D. Marsh. (2010) Evidence for anti-osteoporosis therapy in acute fracture situations?Recommendations of a multidisciplinary workshop of the International Society for Fracture Repair. Bone 46:2, pages 267-271.
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Bart L. Clarke. (2009) New and emerging treatments for osteoporosis. Clinical Endocrinology 71:3, pages 309-321.
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Reiner Bartl & Bertha FrischReiner Bartl & Bertha Frisch. 2009. Osteoporosis. Osteoporosis 247 250 .
R. Bartl, C. Bartl & R. Gradinger. (2008) Einsatz der Bisphosphonate in der Orthopädie und UnfallchirurgieUse of bisphosphonates in orthopedic surgery. Der Orthopäde 37:6, pages 595-614.
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