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Radiation countermeasure agents: an update (2011 – 2014)

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Read on this site (16)

Vijay K. Singh, Meera Srivastava & Thomas M Seed. (2023) Protein biomarkers for radiation injury and testing of medical countermeasure efficacy: promises, pitfalls, and future directions. Expert Review of Proteomics 20:10, pages 221-246.
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Vijay K. Singh & Thomas M. Seed. (2019) The efficacy and safety of amifostine for the acute radiation syndrome. Expert Opinion on Drug Safety 18:11, pages 1077-1090.
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Vladimir N. Bykov, Igor S. Drachev, Sergey Yu. Kraev, Mikhail A. Maydin, Ekaterina A. Gubareva, Sergey E. Pigarev, Vladimir N. Anisimov, Irina A. Baldueva, Elena I. Fedoros & Andrey V. Panchenko. (2018) Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation. International Journal of Radiation Biology 94:2, pages 114-123.
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Vijay K. Singh & Ayodele O. Olabisi. (2017) Nonhuman primates as models for the discovery and development of radiation countermeasures. Expert Opinion on Drug Discovery 12:7, pages 695-709.
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Vijay K. Singh, Melissa Garcia, Stephen Y. Wise & Thomas M. Seed. (2016) Medical countermeasures for unwanted CBRN exposures: Part I chemical and biological threats with review of recent countermeasure patents. Expert Opinion on Therapeutic Patents 26:12, pages 1431-1447.
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Vijay K. Singh, Patricia L.P. Romaine, Victoria L. Newman & Thomas M. Seed. (2016) Medical countermeasures for unwanted CBRN exposures: part II radiological and nuclear threats with review of recent countermeasure patents. Expert Opinion on Therapeutic Patents 26:12, pages 1399-1408.
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Vijay K Singh, Victoria L Newman, Patricia LP Romaine, Martin Hauer-Jensen & Harvey B Pollard. (2016) Use of biomarkers for assessing radiation injury and efficacy of countermeasures. Expert Review of Molecular Diagnostics 16:1, pages 65-81.
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Vijay K Singh & Harvey B Pollard. (2015) Patents for Toll-like receptor ligands as radiation countermeasures for acute radiation syndrome. Expert Opinion on Therapeutic Patents 25:10, pages 1085-1092.
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Thomas B. Elliott, David L. Bolduc, G. David Ledney, Juliann G. Kiang, Oluseyi O. Fatanmi, Stephen Y. Wise, Patricia L. P. Romaine, Victoria L. Newman & Vijay K. Singh. (2015) Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice. International Journal of Radiation Biology 91:9, pages 690-702.
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Vijay K Singh, Victoria L Newman, Allison N Berg & Thomas J MacVittie. (2015) Animal models for acute radiation syndrome drug discovery. Expert Opinion on Drug Discovery 10:5, pages 497-517.
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Vijay K Singh, Patricia LP Romaine & Victoria L Newman. (2015) Biologics as countermeasures for acute radiation syndrome: where are we now?. Expert Opinion on Biological Therapy 15:4, pages 465-471.
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Articles from other publishers (61)

Stephen A. Shrum, Ujwani Nukala, Shivangi Shrimali, Edith Nathalie Pineda, Kimberly J. Krager, Shraddha Thakkar, Darin E. Jones, Rupak Pathak, Philip J. Breen, Nukhet Aykin-Burns & Cesar M. Compadre. (2023) Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants 12:11, pages 1987.
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Qiu Chen, Lei Yao, Quanbin Liu, Jun Hou, Xinyu Qiu, Mengyuan Chen, Zhuojun Wu, Duanmin Hu, Fengmei Cui & Tao Yan. (2023) Exosome-coated polydatin nanoparticles in the treatment of radiation-induced intestinal damage. Aging 15:14, pages 6905-6920.
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Tarun K. Garg, Sarita Garg, Isabelle R. Miousse, Stephen Y. Wise, Alana D. Carpenter, Oluseyi O. Fatanmi, Frits van Rhee, Vijay K. Singh & Martin Hauer-Jensen. (2022) Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model. International Journal of Molecular Sciences 23:24, pages 16170.
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Sushil K. Shakyawar, Nitish K. Mishra, Neetha N. Vellichirammal, Lynnette Cary, Tomáš Helikar, Robert Powers, Rebecca E. Oberley-Deegan, David B. Berkowitz, Kenneth W. Bayles, Vijay K. Singh & Chittibabu Guda. (2022) A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures. Radiation Research 199:1.
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William E. Fahl, Michela Cadarso & Torsten R. Goesch. (2022) Significant Reduction of Total-Body Irradiation-Induced Death in Mice Treated with PrC-210 24 Hours Postirradiation. Radiation Research 198:3.
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Shang Cai, Yongqiang Yang, Yuehong Kong, Qi Guo, Yingying Xu, Pengfei Xing, Yanze Sun, Jianjun Qian, Ruizhe Xu, Liwei Xie, Yijia Hu, Min Wang, Ming Li, Ye Tian & Weidong Mao. (2022) Gut Bacteria Erysipelatoclostridium and Its Related Metabolite Ptilosteroid A Could Predict Radiation-Induced Intestinal Injury. Frontiers in Public Health 10.
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Elliot Rosen, Oluseyi O. Fatanmi, Stephen Y. Wise, V. Ashutosh Rao & Vijay K. Singh. (2022) Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice. Scientific Reports 12:1.
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Ling Rui Li, Gautam Sethi, Xing Zhang, Cui Liu Liu, Yan Huang, Qun Liu, Bo Xu Ren & Feng Ru Tang. (2022) The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure. Aging 14:3, pages 1562-1588.
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Wei Hu, Jia-Wu Liang, Song Liao, Zhi-Dong Zhao, Yu-Xing Wang, Xiao-Fei Mao, Si-Wei Hao, Yi-Fan Wang, Heng Zhu & Bin Guo. (2021) Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model. Military Medical Research 8:1.
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Eunsol Yang, Hyejung Choi, Jin‐Sol Park, Young‐Woock Noh, Chi‐Min Choi, Woo‐Jong Lee, Jae‐Wook Ko & Jungryul Kim. (2021) A first‐in‐human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics. Clinical and Translational Science 14:6, pages 2161-2170.
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Xinxin Rao, Peiyuan Tang, Yuanchuang Li, Guoxiang Fu, Shengzhi Chen, Xiaoya Xu, Yi Zhou, Xiaomeng Li, Long Zhang, Shaobo Mo, Sanjun Cai, Junjie Peng, Zhen Zhang, Jianjun Gao & Guoqiang Hua. (2021) CBP/P300 Inhibitors Mitigate Radiation-Induced GI Syndrome by Promoting Intestinal Stem Cell-Mediated Crypt Regeneration. International Journal of Radiation Oncology*Biology*Physics 110:4, pages 1210-1221.
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Yaoxiang Li, Michael Girgis, Stephen Y. Wise, Oluseyi O. Fatanmi, Thomas M. Seed, Manoj Maniar, Amrita K. Cheema & Vijay K. Singh. (2021) Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure. Scientific Reports 11:1.
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Balazs J. Bene, William F. Blakely, David M. Burmeister, Lynnette Cary, Suyog J. Chhetri, Catherine M. Davis, Sanchita P. Ghosh, Gregory P. Holmes-Hampton, Sergey Iordanskiy, John F. Kalinich, Juliann G. Kiang, Vidya P. Kumar, R. Joel Lowy, Alexandra Miller, Mohammad Naeem, David A. Schauer, Lien Senchak, Vijay K. Singh, Aure J. Stewart, Elih M. Velazquez & Mang Xiao. (2021) Celebrating 60 Years of Accomplishments of the Armed Forces Radiobiology Research Institute1. Radiation Research 196:2.
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M. V. Filimonova, A. S. Saburova, L. I. Shevchenko, V. M. Makarchuk, A. A. Lychagin & A. S. Filimonov. (2021) Influence of the type of salt-forming acids on the antiradiation activity of T1023 analogs – salts of N-isobutanoyl-S-isopropylisothiourea. Radiatsionnaya Gygiena = Radiation Hygiene 14:1, pages 68-74.
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Aneta Cheda, Ewa M. Nowosielska, Jerzy Gebicki, Andrzej Marcinek, Stefan Chlopicki & Marek K. Janiak. (2021) A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice. Scientific Reports 11:1.
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Zahra Shaghaghi, Maryam Alvandi, Sahar Nosrati & Seyed Kamaledin Hadei. (2021) Potential utility of peptides against damage induced by ionizing radiation. Future Oncology 17:10, pages 1219-1235.
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Yahong Liu, Longfei Miao, Yuying Guo & Hongqi Tian. (2021) Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003. Oxidative Medicine and Cellular Longevity 2021, pages 1-11.
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Vijay K. Singh & Thomas M. Seed. (2021) Entolimod as a radiation countermeasure for acute radiation syndrome. Drug Discovery Today 26:1, pages 17-30.
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I. V. Lagoda, E. A. Yakunchikova, I. S. Drachyov, A. N. Grebenyuk, A. A. Martynenkov, L. Yu. Kuleshova, M. A. Kopanitsa & A. Yu. Ershov. (2021) Investigation of the Radioprotective Efficiency of Condensation Products of Thiol-Containing Hydrazides with Mono- and Disaccharides. Biology Bulletin 47:12, pages 1680-1685.
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Changhui Ge, Fei Su, Hanjiang Fu, Yuan Wang, Baolei Tian, Bin Liu, Jie Zhu, Yong Ding & Xiaofei Zheng. (2020) RNA Profiling Reveals a Common Mechanism of Histone Gene Downregulation and Complementary Effects for Radioprotectants in Response to Ionizing Radiation. Dose-Response 18:4, pages 155932582096843.
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Ahmed Eleojo Musa, Dheyauldeen Shabeeb, Nnamdi O. E. Okoro & Alaba Tolulope Agbele. (2020) Radiation protection by Ex-RAD: a systematic review. Environmental Science and Pollution Research 27:27, pages 33592-33600.
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Amit Alok & Paban K. Agrawala. (2020) Repurposing sodium diclofenac as a radiation countermeasure agent: A cytogenetic study in human peripheral blood lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 856-857, pages 503220.
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Elliot Rosen, Oluseyi O. Fatanmi, Stephen Y. Wise, V. Ashutosh Rao & Vijay K. Singh. (2020) Tocol Prophylaxis for Total-body Irradiation: A Proteomic Analysis in Murine Model. Health Physics 119:1, pages 12-20.
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Hossein Sadeghi, Hamed Bagheri, Babak Shekarchi, Abdolreza Javadi & Masoud Najafi. (2020) Mitigation of Radiation-Induced Gastrointestinal System Injury by Melatonin: A Histopathological Study. Current Drug Research Reviews 12:1, pages 72-79.
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Kavya Venkateswaran, Anju Shrivastava, Ashok K. Prasad, Virinder S. Parmar & Bilikere S. Dwarakanath. (2020) Developing polyphenolic acetates as radiation countermeasure agents: current status and future perspectives. Drug Discovery Today 25:4, pages 781-786.
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Jian Cao, Xuejiao Li, Xinxin Wang, Kui Li, Yahong Liu & Hongqi Tian. (2020) Surface PEGylation of MIL-101(Fe) nanoparticles for co-delivery of radioprotective agents. Chemical Engineering Journal 384, pages 123363.
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Mansi Patel, Shikha Tewari, Dhara Bhayani, Sonal Bakshi, Snehal Patel & Priti Mehta. (2020) IN VITRO EVALUATION FOR PROTECTIVE EFFECT OF BAMBOO LEAVES AGAINST GAMMA RADIATION INDUCED GENETIC DAMAGE AND THEIR POLYPHENOLS QUANTIFICATION USING RP-HPLC. INDIAN DRUGS 57:01, pages 27-36.
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A. N. Grebenyuk & V. D. Gladkikh. (2020) Modern Condition and Prospects for the Development of Medicines towards Prevention and Early Treatment of Radiation Damage. Biology Bulletin 46:11, pages 1540-1555.
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Sunirmal Paul, Norman J. Kleiman & Sally A. Amundson. (2019) Transcriptomic responses in mouse blood during the first week after in vivo gamma irradiation. Scientific Reports 9:1.
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Yu Rong Guo, Zi Wei Liu, Shuang Peng, Meng Yun Duan, Jing Wei Feng, Wei Feng Wang, Yan Hua Xu, Xi Tang, Xiang Zhi Zhang, Bo Xu Ren & Feng Ru Tang. (2019) The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis. Dose-Response 17:4, pages 155932581989591.
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Si Wei Wang, Bo Xu Ren, Feng Qian, Xue Zhi Luo, Xi Tang, Xiao Chun Peng, Jiang Rong Huang & Feng Ru Tang. (2019) Radioprotective effect of epimedium on neurogenesis and cognition after acute radiation exposure. Neuroscience Research 145, pages 46-53.
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Lirong Yi, Mei Tian, Chunnan Piao, Gang Gao, Lina Wu, Yan Pan & Jianxiang Liu. (2019) The protective effects of 1,2-propanediol against radiation-induced hematopoietic injury in mice. Biomedicine & Pharmacotherapy 114, pages 108806.
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Mindy M. Kim, Lauren Schlussel, Liman Zhao & Heather A. Himburg. (2019) Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells. Radiation Research 192:1, pages 53.
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Eric D. Miller, Feifei Song, Jason D. Smith, Ahmet S. Ayan, Xiaokui Mo, Michael Weldon, Lanchun Lu, Phil G. Campbell, Aashish D. Bhatt, Arnab Chakravarti & Naduparambil K. Jacob. (2019) Plasma-based biomaterials for the treatment of cutaneous radiation injury. Wound Repair and Regeneration 27:2, pages 139-149.
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Fan Bai, Limei Wang, Zhongtang Li, Lirong Yi, Zongchao Zuo, Cheng Zhang, Yajun Shan, Chao Yang, Renjun Peng, Rifang Yang, Zuyin Yu & Yuwen Cong. (2019) 17α-Ethinyl-androst-5-ene-3β, 17β-diol, a Novel Potent Oral Radioprotective Agent, Confers Radioprotection of Hematopoietic Stem and Progenitor Cells in a Granulocyte Colony-Stimulating Factor–Independent Manner. International Journal of Radiation Oncology*Biology*Physics 103:1, pages 217-228.
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Wan Seok Song, Jee-Hyeon Kim, Chi-Min Choi, Woo-Jong Lee & Sung-il Yoon. (2019) TLR5 binding and activation by KMRC011, a flagellin-derived radiation countermeasure. Biochemical and Biophysical Research Communications 508:2, pages 570-575.
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Vidya P. KumarShukla BiswasNeel K. SharmaSasha StoneChristine M. FamGeorge N. CoxSanchita P. Ghosh. (2018) PEGylated IL‐11 (BBT‐059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. Health Physics 115:1, pages 65-76.
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Evan L. PannkukEvagelia C. LaiakisAlbert J. Fornace, Oluseyi O. FatanmiVijay K. Singh. (2018) A Metabolomic Serum Signature from Nonhuman Primates Treated with a Radiation Countermeasure, Gamma-tocotrienol, and Exposed to Ionizing Radiation. Health Physics 115:1, pages 3-11.
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Ujwani Nukala, Shraddha Thakkar, Kimberly Krager, Philip Breen, Cesar Compadre & Nukhet Aykin-Burns. (2018) Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants 7:2, pages 33.
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Shanaz A. Ghandhi, Helen C. Turner, Igor Shuryak, Gregory O. Dugan, J. Daniel Bourland, John D. Olson, Janet A. Tooze, Shad R. Morton, Ines Batinic-Haberle, J. Mark Cline & Sally A. Amundson. (2018) Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. PLOS ONE 13:1, pages e0191402.
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Lin Tang, Tao Peng, Gang Wang, Xiaoxue Wen, Yunbo Sun, Shouguo Zhang, Shuchen Liu & Lin Wang. (2018) Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD. MedChemComm 9:4, pages 625-631.
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Igor Shuryak, Vera Y. Matrosova, Elena K. Gaidamakova, Rok Tkavc, Olga Grichenko, Polina Klimenkova, Robert P. Volpe & Michael J. Daly. (2017) Microbial cells can cooperate to resist high-level chronic ionizing radiation. PLOS ONE 12:12, pages e0189261.
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Subhajit Ghosh, Namita Indracanti, Jayadev Joshi, Jharna Ray & Prem Kumar Indraganti. (2017) Pharmacologically induced reversible hypometabolic state mitigates radiation induced lethality in mice. Scientific Reports 7:1.
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Andrea L. DiCarlo, Radia Tamarat, Carmen I. Rios, Marc Benderitter, Christine W. Czarniecki, Theresa C. Allio, Francesca Macchiarini, Bert W. Maidment & Jean-Rene Jourdain. (2017) Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop. Radiation Research 188:2, pages e54-e75.
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Michal Hofer, Zuzana Hoferová & Martin Falk. (2017) Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?. International Journal of Molecular Sciences 18:7, pages 1385.
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Yiwei Zhang, Jian Li, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Ying Zheng, Jinbin Wei & Guifang Dou. (2017) A sharp, robust, and quantitative method by liquid chromatography tandem mass spectrometry for the measurement of EAD for acute radiation syndrome and its application. Journal of Chromatography B 1055-1056, pages 45-50.
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Scott D. McVicar, Kempaiah Rayavara & Darrell H. Carney. (2017) Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation. The AAPS Journal 19:3, pages 743-753.
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Zhong-Tang Li, Li-Mei Wang, Li-Rong Yi, Chao Jia, Fan Bai, Ren-Jun Peng, Zu-Yin Yu, Guo-Lin Xiong, Shuang Xing, Ya-Jun Shan, Ri-Fang Yang, Jun-Xing Dong & Yu-Wen Cong. (2017) Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice. Scientific Reports 7:1.
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Shahanshah Khan, Jawahar Singh Adhikari, Moshahid Alam Rizvi & Nabo Kumar Chaudhury. (2017) Melatonin attenuates 60 Co γ-ray-induced hematopoietic, immunological and gastrointestinal injuries in C57BL/6 male mice . Environmental Toxicology 32:2, pages 501-518.
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Vijay K. Singh, Oluseyi O. Fatanmi, Stephen Y. Wise, Victoria L. Newman, Patricia L.P. Romaine & Thomas M. Seed. (2016) THE POTENTIATION OF THE RADIOPROTECTIVE EFFICACY OF TWO MEDICAL COUNTERMEASURES, GAMMA-TOCOTRIENOL AND AMIFOSTINE, BY A COMBINATION PROPHYLACTIC MODALITY. Radiation Protection Dosimetry 172:1-3, pages 302-310.
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Paridhi Gupta, Manoshi Gayen, Joan T. Smith, Elena K. Gaidamakova, Vera Y. Matrosova, Olga Grichenko, Barbara Knollmann-Ritschel, Michael J. Daly, Juliann G. Kiang & Radha K. Maheshwari. (2016) MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation. PLOS ONE 11:8, pages e0160575.
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Barbara Olszewska-Pazdrak, Scott D. McVicar, Kempaiah Rayavara, Stephanie M. Moya, Carla Kantara, Chris Gammarano, Paulina Olszewska, Gerald M. Fuller, Laurie E. Sower  & Darrell H. Carney . (2016) Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair. Radiation Research 186:2, pages 162-174.
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Vijay K. Singh, Oluseyi O. Fatanmi, Amit Verma, Victoria L. Newman, Stephen Y. Wise, Patricia L.P. Romaine & Allison N. Berg. (2016) Progenitor Cell Mobilization by Gamma-tocotrienol. Health Physics 111:2, pages 85-92.
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Susan Hall, Santosh Rudrawar, Matthew Zunk, Nijole Bernaitis, Devinder Arora, Catherine McDermott & Shailendra Anoopkumar-Dukie. (2016) Protection against Radiotherapy-Induced Toxicity. Antioxidants 5:3, pages 22.
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Vijay Singh & Martin Hauer-Jensen. (2016) γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. International Journal of Molecular Sciences 17:5, pages 663.
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Yu-suke TorisawaTadanori MammotoElisabeth JiangAmanda JiangAkiko MammotoAlexander L. WattersAnthony BahinskiDonald E. Ingber. (2016) Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip. Tissue Engineering Part C: Methods 22:5, pages 509-515.
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Vijay K. SinghShilpa KulkarniOluseyi O. FatanmiStephen Y. WiseVictoria L. NewmanPatricia L. P. RomaineHoward Hendrickson, Jatinder Gulani, Sanchita P. GhoshK. Sree KumarMartin Hauer-Jensen. (2016) Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates. Radiation Research 185:3, pages 285.
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Amit Alok & N.K. Chaudhury. (2016) Tetracycline hydrochloride: A potential clinical drug for radioprotection. Chemico-Biological Interactions 245, pages 90-99.
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Vadim I. Krivokrysenko, Ilia A. Toshkov, Anatoli S. Gleiberman, Peter Krasnov, Inna Shyshynova, Ivan Bespalov, Ratan K. Maitra, Natalya V. Narizhneva, Vijay K. Singh, Mark H. Whitnall, Andrei A. Purmal, Alexander N. Shakhov, Andrei V. Gudkov & Elena Feinstein. (2015) The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. PLOS ONE 10:9, pages e0135388.
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Eliot M. Rosen, Regina Day & Vijay K. Singh. (2015) New Approaches to Radiation Protection. Frontiers in Oncology 4.
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Vijay K. Singh, Stephen Y. Wise, Oluseyi O. Fatanmi, Jessica Scott, Patricia L. P. Romaine, Victoria L. Newman, Amit Verma, Thomas B. Elliott & Thomas M. Seed. (2014) Progenitors Mobilized by Gamma-Tocotrienol as an Effective Radiation Countermeasure. PLoS ONE 9:11, pages e114078.
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