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Preclinical models for pulmonary drug delivery

, PharmD & , PharmD PhD
Pages 1231-1245 | Published online: 26 Oct 2009

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Thomas Sécher & Nathalie Heuzé-Vourc’h. (2023) Barriers for orally inhaled therapeutic antibodies. Expert Opinion on Drug Delivery 20:8, pages 1071-1084.
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Priya Patel, Mihir Raval, Vishal Airao, Vaibhav Bhatt & Pranav Shah. (2022) Silibinin loaded inhalable solid lipid nanoparticles for lung targeting. Journal of Microencapsulation 39:1, pages 1-24.
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Luigino Calzetta, Angelo Coppola, Beatrice Ludovica Ritondo, Matteo Matino, Alfredo Chetta & Paola Rogliani. (2021) The Impact of Muscarinic Receptor Antagonists on Airway Inflammation: A Systematic Review. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 257-279.
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Nashwa Osman, Kan Kaneko, Valeria Carini & Imran Saleem. (2018) Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies. Expert Opinion on Drug Delivery 15:8, pages 821-834.
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Sabrina Nickel, Caoimhe G. Clerkin, Mohammed Ali Selo & Carsten Ehrhardt. (2016) Transport mechanisms at the pulmonary mucosa: implications for drug delivery. Expert Opinion on Drug Delivery 13:5, pages 667-690.
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Shari Sellers, Walter Horodnik, Aileen House, Jennifer Wylie, Peter Mauser, Natalie Garber, Yu (Elaine) Pu, Julianne Berry & Brent Donovan. (2015) The in vitro and in vivo investigation of inhaled migraine therapies using a novel aerosol delivery system consisting of an air pressurized capsule device (APCD) in combination with a pMDI spacer for endotracheal dosing into beagle dogs. Drug Development and Industrial Pharmacy 41:12, pages 1989-1996.
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Shari Sellers, Walter Horodnik, Aileen House, Jennifer Wylie, Peter Mauser & Brent Donovan. (2015) The in vitro and in vivo investigation of a novel small chamber dry powder inhalation delivery system for preclinical dosing to rats. Inhalation Toxicology 27:13, pages 706-716.
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Chris MacDonald, Di Shao, Angus Oli & Remigius U. Agu. (2013) Characterization of Calu-3 cell monolayers as a model of bronchial epithelial transport: organic cation interaction studies. Journal of Drug Targeting 21:1, pages 97-106.
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Remigius U Agu & Michael I Ugwoke. (2011) In vitro and in vivo testing methods for respiratory drug delivery. Expert Opinion on Drug Delivery 8:1, pages 57-69.
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Leslie Y Yeo, James R Friend, Michelle P McIntosh, Els NT Meeusen & David AV Morton. (2010) Ultrasonic nebulization platforms for pulmonary drug delivery. Expert Opinion on Drug Delivery 7:6, pages 663-679.
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Articles from other publishers (72)

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Vuk Uskoković. (2023) Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics. Advances in Colloid and Interface Science 315, pages 102903.
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Prakash Khadka, Jack Dummer, Philip C. Hill, Rajesh Katare & Shyamal C. Das. (2022) A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation. Drug Delivery and Translational Research 13:5, pages 1246-1271.
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Elena Marcello & Valeria Chiono. (2023) Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting. International Journal of Molecular Sciences 24:4, pages 3390.
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Emma R. Sudduth, Emily L. Kolewe, Jodi Graf, Yinkui Yu, Joaquina Somma & Catherine A. Fromen. (2023) Nebulization of model hydrogel nanoparticles to macrophages at the air-liquid interface. Frontiers in Chemical Engineering 4.
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Austin J. Scholp, Jordan Jensen, Sathivel Chinnathambi, Keerthi Atluri, Alyssa Mendenhall, Timothy Fowler, Aliasger K. Salem, James A. Martin & Edward A. Sander. (2022) Force-Bioreactor for Assessing Pharmacological Therapies for Mechanobiological Targets. Frontiers in Bioengineering and Biotechnology 10.
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Aikaterini Gkoufa, Tomás Sou, Ilias Karaiskos, Christina Routsi, Yu-Wei Lin, Mina Psichogiou, Spyros Zakynthinos, Helen Giamarellou, Jian Li & Lena E. Friberg. (2022) Pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following nebulisation of CMS among patients with ventilator-associated pneumonia. International Journal of Antimicrobial Agents 59:6, pages 106588.
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Michael Y.T. Chow, Rachel Yoon Kyung Chang & Hak-Kim Chan. (2021) Inhalation delivery technology for genome-editing of respiratory diseases. Advanced Drug Delivery Reviews 168, pages 217-228.
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Abigail A. Matthews, Pui Lai Rachel Ee & Ruowen Ge. (2020) Developing inhaled protein therapeutics for lung diseases. Molecular Biomedicine 1:1.
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T. Sécher, E. Bodier-Montagutelli, A. Guillon & N. Heuzé-Vourc’h. (2020) Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals. Advanced Drug Delivery Reviews 167, pages 148-169.
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Catherine A. Fromen & Jason P. Gleghorn. (2020) Engineering Preclinical Tools and Therapeutics to Understand and Treat COVID-19. Delaware Journal of Public Health 6:2, pages 32-35.
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Tomoyuki Okuda & Hirokazu Okamoto. (2020) Present Situation and Future Progress of Inhaled Lung Cancer Therapy: Necessity of Inhaled Formulations with Drug Delivery Functions. Chemical and Pharmaceutical Bulletin 68:7, pages 589-602.
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Cristina Cigana, Serena Ranucci, Alice Rossi, Ida De Fino, Medede Melessike & Alessandra Bragonzi. (2020) Antibiotic efficacy varies based on the infection model and treatment regimen for Pseudomonas aeruginosa . European Respiratory Journal 55:3, pages 1802456.
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Masahiro Sakagami. (2020) In vitro, ex vivo and in vivo methods of lung absorption for inhaled drugs. Advanced Drug Delivery Reviews 161-162, pages 63-74.
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Dania Movia, Despina Bazou & Adriele Prina-Mello. (2019) ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance. BMC Cancer 19:1.
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Danielle Freches, Natacha Rocks, Harshad P. Patil, Fabienne Perin, Jacques Van Snick, Rita Vanbever & Didier Cataldo. (2019) Preclinical evaluation of topically-administered PEGylated Fab’ lung toxicity. International Journal of Pharmaceutics: X 1, pages 100019.
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S Artur, S Przemysław, P Andrzej, Z Katarzyna & E Kaczorek. (2019) Nebulization as complementary therapy for dogs with respiratory tract infections. Insights in Veterinary Science 3:1, pages 030-035.
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Michael CanigaHongshi YuHyun-Hee LeeMeiyao WangDavid WitterMichael SalmonPeter W. Fan. (2019) Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:5, pages 251-265.
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Dominique N. Price, Nitesh K. Kunda & Pavan Muttil. (2019) Challenges Associated with the Pulmonary Delivery of Therapeutic Dry Powders for Preclinical Testing. KONA Powder and Particle Journal 36:0, pages 129-144.
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Sariah A. Kell, Melissa A. Kachura, Alex Renn, Paula Traquina, Robert L. Coffman & John D. Campbell. (2019) Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells. International Immunopharmacology 66, pages 296-308.
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Larissa Gomes dos Reis, Maree Svolos, Lyn M Moir, Rima Jaber, Norbert Windhab, Paul M Young & Daniela Traini. (2018) Delivery of pDNA Polyplexes to Bronchial and Alveolar Epithelial Cells Using a Mesh Nebulizer. Pharmaceutical Research 36:1.
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Ting Wu, Weiping Liao, Wei Wang, Jie Zhou, Weiguo Tan, Weibing Xiang, Jinglin Zhang, Lina Guo, Tao Chen, Dong Ma, Weiye Yu & Xiang Cai. (2018) Genipin-crosslinked carboxymethyl chitosan nanogel for lung-targeted delivery of isoniazid and rifampin. Carbohydrate Polymers 197, pages 403-413.
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Dania Movia, Despina Bazou, Yuri Volkov & Adriele Prina-Mello. (2018) Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs. Scientific Reports 8:1.
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Nitesh Kunda, Dominique Price & Pavan Muttil. (2018) Respiratory Tract Deposition and Distribution Pattern of Microparticles in Mice Using Different Pulmonary Delivery Techniques. Vaccines 6:3, pages 41.
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Jennifer L Wylie, Aileen House, Peter J Mauser, Shari Sellers, Jenna Terebetski, Zhenyu Wang & Jason D Ehrick. (2018) Inhaled formulation and device selection: bridging the gap between preclinical species and first-in-human studies. Therapeutic Delivery 9:5, pages 387-404.
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Putri D. Utari, Rita Setroikromo, Barbro N. Melgert & Wim J. Quax. (2018) PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection. Frontiers in Cellular and Infection Microbiology 8.
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Sujit Kumar Debnath, Srinivasan Saisivam, Monalisha Debanth & Abdelwahab Omri. (2018) Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide. PLOS ONE 13:1, pages e0190976.
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Sujit K. Debnath, Saisivam Srinivasan & Monalisha Debnath. (2017) Development of Dry Powder Inhaler Containing Prothionamide-PLGA Nanoparticles Optimized Through Statistical Design: In-vivo Study. The Open Nanomedicine Journal 4:1, pages 30-40.
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Yu-Wei Lin, Qi Tony Zhou, Yang Hu, Nikolas J. Onufrak, Siping Sun, Jiping Wang, Alan Forrest, Hak-Kim Chan & Jian Li. (2017) Pulmonary Pharmacokinetics of Colistin following Administration of Dry Powder Aerosols in Rats. Antimicrobial Agents and Chemotherapy 61:11.
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Sujit Kumar Debnath, Srinivasan Saisivam & Abdelwahab Omri. (2017) PLGA Ethionamide Nanoparticles for Pulmonary Delivery: Development and in vivo evaluation of dry powder inhaler. Journal of Pharmaceutical and Biomedical Analysis 145, pages 854-859.
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M-J. Guichard, T. Leal & R. Vanbever. (2017) PEGylation, an approach for improving the pulmonary delivery of biopharmaceuticals. Current Opinion in Colloid & Interface Science 31, pages 43-50.
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Danielle Freches, Harshad P. Patil, Maria Machado Franco, Catherine Uyttenhove, Sam Heywood & Rita Vanbever. (2017) PEGylation prolongs the pulmonary retention of an anti-IL-17A Fab’ antibody fragment after pulmonary delivery in three different species. International Journal of Pharmaceutics 521:1-2, pages 120-129.
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Corinne Dejous, Hamida Hallil, Vincent Raimbault, Rajagopalan Rukkumani & Jatinder Vir Yakhmi. 2017. Nanostructures for Novel Therapy. Nanostructures for Novel Therapy 539 566 .
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Tae Kang & Hyun Kim. (2016) Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems. Micromachines 7:7, pages 107.
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Chantal DarquenneJohn S. FlemingIra KatzAndrew R. MartinJeffry SchroeterOmar S. UsmaniJose VenegasOtmar Schmid. (2016) Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:2, pages 107-126.
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Catherine A. Fromen, Tojan B. Rahhal, Gregory R. Robbins, Marc P. Kai, Tammy W. Shen, J. Christopher Luft & Joseph M. DeSimone. (2016) Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells. Nanomedicine: Nanotechnology, Biology and Medicine 12:3, pages 677-687.
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Moritz Beck-Broichsitter, Katharina Stoisiek, Adam Bohr, Leticia Aragão-Santiago, Tobias Gessler, Werner Seeger & Thomas Kissel. (2016) Potential of the isolated lung technique for the examination of sildenafil absorption from lung-delivered poly(lactide- co -glycolide) microparticles. Journal of Controlled Release 226, pages 15-20.
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Elena A. Shlyapnikova, Igor L. Kanev, Nadezhda N. Novikova, Elena G. Litvinova, Yuri M. Shlyapnikov & Victor N. Morozov. (2016) Exposure to bleomycin nanoaerosol does not induce fibrosis in mice. European Journal of Nanomedicine 8:4.
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Susanne R. Youngren-Ortiz, Nishant S. Gandhi, Laura España-Serrano & Mahavir B. Chougule. (2016) Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems. KONA Powder and Particle Journal 33:0, pages 63-85.
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Fernanda Andrade, João Albuquerque & Ana Vanessa Nascimento. 2016. Concepts and Models for Drug Permeability Studies. Concepts and Models for Drug Permeability Studies 101 113 .
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L Gaohua, J Wedagedera, BG Small, L Almond, K Romero, D Hermann, D Hanna, M Jamei & I Gardner. (2015) Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs. CPT: Pharmacometrics & Systems Pharmacology 4:10, pages 605-613.
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