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Review

Current progress of DNA vaccine studies in humans

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Pages 175-191 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Xiangchuan He, Longfei Ding, Kangli Cao, Haoran Peng, Chenjian Gu, Yutang Li, Duoduo Li, Lanlan Dong, Xiujing Hong, Xiangwei Wang, Meilan Fu, Chenli Qiu, Cuisong Zhu, Ziling Zhang, Shu Song, Chenguang Wang, Zhengfan Jiang, Youhua Xie, Zhongtian Qi, Chen Zhao, Ping Zhao, Xiaoyan Zhang & Jianqing Xu. (2021) A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge. Emerging Microbes & Infections 10:1, pages 1555-1573.
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Kimia Kardani, Azam Bolhassani & Ali Namvar. (2020) An overview of in silico vaccine design against different pathogens and cancer. Expert Review of Vaccines 19:8, pages 699-726.
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Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams & Anders Fomsgaard. (2017) Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant. Human Vaccines & Immunotherapeutics 13:8, pages 1823-1830.
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Julie L. Dutton, Wai-Ping Woo, Janin Chandra, Yan Xu, Bo Li, Neil Finlayson, Paul Griffin & Ian H. Frazer. (2016) An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1. Human Vaccines & Immunotherapeutics 12:12, pages 3079-3088.
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Chad E. Mire, Thomas W. Geisbert, Heinz Feldmann & Andrea Marzi. (2016) Ebola virus vaccines – reality or fiction?. Expert Review of Vaccines 15:11, pages 1421-1430.
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Nora C Hogan, Andrew J Taberner, Lynette A Jones & Ian W Hunter. (2015) Needle-free delivery of macromolecules through the skin using controllable jet injectors. Expert Opinion on Drug Delivery 12:10, pages 1637-1648.
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Kenneth Bagley, Rong Xu, Ayuko Ota-Setlik, Michael Egan, Jennifer Schwartz & Timothy Fouts. (2015) The catalytic A1 domains of cholera toxin and heat-labile enterotoxin are potent DNA adjuvants that evoke mixed Th1/Th17 cellular immune responses. Human Vaccines & Immunotherapeutics 11:9, pages 2228-2240.
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Jonathan Pol, Norma Bloy, Florine Obrist, Alexander Eggermont, Jérôme Galon, Wolf Hervé Fridman, Isabelle Cremer, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Trial Watch. OncoImmunology 3:4.
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Andrea Marzi & Heinz Feldmann. (2014) Ebola virus vaccines: an overview of current approaches. Expert Review of Vaccines 13:4, pages 521-531.
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Anna Gil, Siyuan Shen, Scott Coley, Laura Gibson, Don J Diamond, Shixia Wang & Shan Lu. (2013) DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus. Human Vaccines & Immunotherapeutics 9:10, pages 2120-2132.
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Andrés A. Herrada, Nicole Rojas-Colonelli, Paula González-Figueroa, Jonathan Roco, César Oyarce, Maarten A Ligtenberg & Alvaro Lladser. (2012) Harnessing DNA-induced immune responses for improving cancer vaccines. Human Vaccines & Immunotherapeutics 8:11, pages 1682-1693.
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Ching-Liang Chu, Dz-Chi Chen & Chi-Chen Lin. (2011) A novel adjuvant Ling Zhi-8 for cancer DNA vaccines. Human Vaccines 7:11, pages 1161-1164.
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Mark C. Johnson, Bo Wang & Roland Tisch. (2011) Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Human Vaccines 7:1, pages 27-36.
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Darryl Falzarano, Thomas W Geisbert & Heinz Feldmann. (2011) Progress in filovirus vaccine development: evaluating the potential for clinical use. Expert Review of Vaccines 10:1, pages 63-77.
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Rogier Bodewes, Guus F Rimmelzwaan & Albert DME Osterhaus. (2010) Animal models for the preclinical evaluation of candidate influenza vaccines. Expert Review of Vaccines 9:1, pages 59-72.
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Yun-Zhou Yu, Na Li, Shuang Wang, Wei-Yuan Yu & Zhi-Wei Sun. (2009) Improved immunogenicity and protective efficacy of a replicon DNA vaccine encoding the Hc domain of botulinum neurotoxin serotype A by electric pulses and protein boosting. Immunopharmacology and Immunotoxicology 31:3, pages 397-404.
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De-chu C Tang, Jianfeng Zhang, Haroldo Toro, Zhongkai Shi & Kent R Van Kampen. (2009) Adenovirus as a carrier for the development of influenza virus-free avian influenza vaccines. Expert Review of Vaccines 8:4, pages 469-481.
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Celio L Silva, Vânia LD Bonato, Rubens R dos Santos-Júnior, Carlos R Zárate-Bladés & Alexandrina Sartori. (2009) Recent advances in DNA vaccines for autoimmune diseases. Expert Review of Vaccines 8:2, pages 239-252.
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Luiz Rodrigues & Cristina Bonorino. (2009) Role of IL-15 and IL-21 in viral immunity: applications for vaccines and therapies. Expert Review of Vaccines 8:2, pages 167-177.
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Kathryn Sykes. (2008) Progress in the development of genetic immunization. Expert Review of Vaccines 7:9, pages 1395-1404.
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Jean-François Nicolas & Bruno Guy. (2008) Intradermal, epidermal and transcutaneous vaccination: from immunology to clinical practice. Expert Review of Vaccines 7:8, pages 1201-1214.
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Hideki Garren. (2008) A DNA vaccine for multiple sclerosis. Expert Opinion on Biological Therapy 8:10, pages 1539-1550.
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Patrícia RM Souza, Carlos R Zárate-Bladés, Juliana I Hori, Simone G Ramos, Deison S Lima, Tatiana Schneider, Rogério S Rosada, Lucimara GL Torre, Maria Helena A Santana, Izaíra T Brandão, Ana P Masson, Arlete AM Coelho-Castelo, Vânia L Bonato, Fabio CS Galetti, Eduardo D Gonçalves, Domingos A Botte, Jeanne BM Machado & Celio L Silva. (2008) Protective efficacy of different strategies employing Mycobacterium leprae heat-shock protein 65 against tuberculosis. Expert Opinion on Biological Therapy 8:9, pages 1255-1264.
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Lei Li, Fadi Saade & Nikolai Petrovsky. (2012) The future of human DNA vaccines. Journal of Biotechnology 162:2-3, pages 171-182.
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Fang Fu, Xuesong Li, Yuekun Lang, Yuju Yang, Guangzhi Tong, Guoxin Li, Yanjun Zhou & Xi Li. (2011) Co-expression of Ubiquitin gene and capsid protein gene enhances the potency of DNA immunization of PCV2 in mice. Virology Journal 8:1.
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Hong Chen, Bo Wen, Yao Deng, Wen Wang, Xiao Yin, Jie Guan, Li Ruan & Wenjie Tan. (2011) Enhanced Effect of DNA Immunization plus In Vivo Electroporation with a Combination of Hepatitis B Virus Core-PreS1 and S-PreS1 Plasmids . Clinical and Vaccine Immunology 18:11, pages 1789-1795.
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Zhiyong Qiu, David C. Diamond, Kent A. Smith, Dar Rosario, Sabrina Miles, Mihail Obrocea, Thomas M. Kundig & Adrian Bot. 2011. Cancer Vaccines: From Research to Clinical Practice. Cancer Vaccines: From Research to Clinical Practice 103 125 .
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Kenneth C. Bagley, George K. Lewis & Timothy R. Fouts. (2011) Adjuvant Activity of the Catalytic A1 Domain of Cholera Toxin for Retroviral Antigens Delivered by GeneGun. Clinical and Vaccine Immunology 18:6, pages 922-930.
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Yuhong Zeng, Joshua D. Ramsey, Robert King, Michael Leviten, Ruth Mcguire, David B. Volkin, Sangeeta B. Joshi & C. Russell Middaugh. (2011) Identifying Stabilizers of Plasmid DNA for Pharmaceutical Use. Journal of Pharmaceutical Sciences 100:3, pages 904-914.
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Karoline Bragstad, Cyril J. Martel, Joakim S. Thomsen, Kim L. Jensen, Lars P. Nielsen, Bent Aasted & Anders Fomsgaard. (2011) Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades. Influenza and Other Respiratory Viruses 5:1, pages 13-23.
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Pier Adelchi Ruffini, Gunnveig Grødeland, Agnete B. Fredriksen & Bjarne Bogen. (2010) Human chemokine MIP1α increases efficiency of targeted DNA fusion vaccines. Vaccine 29:2, pages 191-199.
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Angela Shaulov Kask, Xianfeng Chen, Joshua O. Marshak, Lichun Dong, Misty Saracino, Dexiang Chen, Courtney Jarrahian, Mark A. Kendall & David M. Koelle. (2010) DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge. Vaccine 28:47, pages 7483-7491.
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Yun-Zhou Yu, Na Li, Wen-Bin Wang, Shuang Wang, Yao Ma, Wei-Yuan Yu & Zhi-Wei Sun. (2010) Distinct immune responses of recombinant plasmid DNA replicon vaccines expressing two types of antigens with or without signal sequences. Vaccine 28:47, pages 7529-7535.
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Yun-Zhou Yu, Wen-Bin Wang, Na Li, Shuang Wang, Wei-Yuan Yu & Zhi-Wei Sun. (2010) Enhanced potency of individual and bivalent DNA replicon vaccines or conventional DNA vaccines by formulation with aluminum phosphate. Biologicals 38:6, pages 658-663.
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Prerona Chakravarty, Wei Qian, Mostafa A. El-Sayed & Mark R. Prausnitz. (2010) Delivery of molecules into cells using carbon nanoparticles activated by femtosecond laser pulses. Nature Nanotechnology 5:8, pages 607-611.
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Sue D. Xiang, Cordelia Selomulya, Jenny Ho, Vasso Apostolopoulos & Magdalena Plebanski. (2010) Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetic nanoparticles. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2:3, pages 205-218.
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Jenny Ho, Yi Huang, Michael K. Danquah, Huanting Wang & Gareth M. Forde. (2010) Synthesis of biodegradable polymer–mesoporous silica composite microspheres for DNA prime-protein boost vaccination. European Journal of Pharmaceutical Sciences 39:5, pages 412-420.
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Shixia Wang, Innocent Mboudjeka, Jon D. Goguen & Shan Lu. (2010) Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines. Vaccine 28:8, pages 2011-2019.
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