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Original Article

Shrunken Pore Syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting

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Pages 74-81 | Received 26 Jul 2015, Accepted 21 Sep 2015, Published online: 09 Dec 2015

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Esmee C. M. Kooijmans, Helena J. H. van der Pal, Maxime C. F. Pilon, Saskia M. F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Hanneke M. van Santen, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Margreet A. Veening & Arend Bökenkamp. (2022) Shrunken pore syndrome in childhood cancer survivors treated with potentially nephrotoxic therapy. Scandinavian Journal of Clinical and Laboratory Investigation 82:7-8, pages 541-548.
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Anne Cecilie K. Larstorp, Cathrin Lytomt Salvador, Bjørn Andreas Svensvik, Olav Klingenberg & Sonia Distante. (2022) Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cystatin C are early biomarkers of acute kidney injury associated with cardiac surgery. Scandinavian Journal of Clinical and Laboratory Investigation 82:5, pages 410-418.
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Elisabet Söderström, Ravna Blind, Patrik Wennberg, Jonas Andersson, Stefan Söderberg, Torbjörn K. Nilsson & Johan Hultdin. (2021) Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women. Scandinavian Journal of Clinical and Laboratory Investigation 81:6, pages 438-445.
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Magnus H. Jonsson, Anna Åkesson, Ami Hommel, Anders Grubb & Peter Bentzer. (2021) Markers of renal function at admission and mortality in hip fracture patients - a single center prospective observational study. Scandinavian Journal of Clinical and Laboratory Investigation 81:3, pages 201-207.
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Ichiro Yoshii & Susumu Nishiyama. (2021) The impact of shrunken pore syndrome in patient with rheumatic diseases on bone mineral metabolism. Scandinavian Journal of Clinical and Laboratory Investigation 81:1, pages 72-81.
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Song Jin, Jian Xu, Gan Shen & Pengying Gu. (2021) Predictive value of circulating cystatin C level in patients with acute coronary syndrome: a meta-analysis. Scandinavian Journal of Clinical and Laboratory Investigation 81:1, pages 1-7.
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Anna Åkesson, Veronica Lindström, Ulf Nyman, Magnus Jonsson, Magnus Abrahamson, Anders Christensson, Jonas Björk & Anders Grubb. (2020) Shrunken pore syndrome and mortality: a cohort study of patients with measured GFR and known comorbidities. Scandinavian Journal of Clinical and Laboratory Investigation 80:5, pages 412-422.
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Emil den Bakker, Reinoud Jbj Gemke, Joanna Ae van Wijk, Isabelle Hubeek, Birgit Stoffel-Wagner & Arend Bökenkamp. (2020) Evidence for shrunken pore syndrome in children. Scandinavian Journal of Clinical and Laboratory Investigation 80:1, pages 32-38.
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Johan Ljungberg, Bengt Johansson, Ingvar A. Bergdahl, Anders Holmgren, Ulf Näslund, Johan Hultdin & Stefan Söderberg. (2019) Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk for future surgery for aortic stenosis. Scandinavian Journal of Clinical and Laboratory Investigation 79:7, pages 524-530.
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Erik Herou, Alain Dardashti, Shahab Nozohoor, Igor Zindovic, Per Ederoth, Anders Grubb & Henrik Bjursten. (2019) The mortality increase in cardiac surgery patients associated with shrunken pore syndrome correlates with the eGFRcystatin C/eGFRcreatinine-ratio. Scandinavian Journal of Clinical and Laboratory Investigation 79:3, pages 167-173.
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Araceli Jarquin Campos, Lorenz Risch, Marc Baumann, Mette-Triin Purde, Sebastian Neuber, Harald Renz, Beatrice Mosimann, Luigi Raio, Markus Mohaupt, Daniel Surbek & Martin Risch. (2019) Shrunken pore syndrome, preeclampsia, and markers of NO metabolism in pregnant women during the first trimester. Scandinavian Journal of Clinical and Laboratory Investigation 79:1-2, pages 91-98.
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Emil den Bakker, Reinoud J. B. J. Gemke & Arend Bökenkamp. (2018) Endogenous markers for kidney function in children: a review. Critical Reviews in Clinical Laboratory Sciences 55:3, pages 163-183.
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Felicia Leion, Josefine Hegbrant, Emil den Bakker, Magnus Jonsson, Magnus Abrahamson, Ulf Nyman, Jonas Björk, Veronica Lindström, Anders Larsson, Arend Bökenkamp & Anders Grubb. (2017) Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables diagnosing Shrunken Pore Syndrome. Scandinavian Journal of Clinical and Laboratory Investigation 77:5, pages 338-344.
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Anders Christensson, Anders Grubb, John Molvin, Hannes Holm, Klas Gransbo, Gordana Tasevska-Dinevska, Erasmus Bachus, Amra Jujic & Martin Magnusson. (2016) The shrunken pore syndrome is associated with declined right ventricular systolic function in a heart failure population – the HARVEST study. Scandinavian Journal of Clinical and Laboratory Investigation 76:7, pages 568-574.
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Martin Risch, Lorenz Risch, Mette-Triin Purde, Harald Renz, Patrice Ambühl, Thomas Szucs & Yuki Tomonaga. (2016) Association of the cystatin C/creatinine ratio with the renally cleared hormones parathyroid hormone (PTH) and brain natriuretic peptide (BNP) in primary care patients: a cross-sectional study. Scandinavian Journal of Clinical and Laboratory Investigation 76:5, pages 379-385.
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Mette-Triin Purde, Stefan Nock, Lorenz Risch, Pedro Medina Escobar, Chris Grebhardt, Urs E. Nydegger, Zeno Stanga & Martin Risch. (2016) Ratio of cystatin C and creatinine-based estimates of the glomerular filtration rate predicts mortality in healthy seniors independent of kidney function. Scandinavian Journal of Clinical and Laboratory Investigation 76:4, pages 341-343.
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Anders O. Grubb, Martin Magnusson & Anders Christensson. (2023) Etiologic and Diagnostic Implications of Morbidity and Mortality Associations When Cystatin C–Based Estimated GFR Is Lower Than Creatinine-Based Estimated GFR. American Journal of Kidney Diseases 82:5, pages 509-511.
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Juan-Jesús Carrero, Edouard L. Fu, Yingying Sang, Shoshana Ballew, Marie Evans, Carl-Gustaf Elinder, Peter Barany, Lesley A. Inker, Andrew S. Levey, Josef Coresh & Morgan E. Grams. (2023) Discordances Between Creatinine- and Cystatin C–Based Estimated GFR and Adverse Clinical Outcomes in Routine Clinical Practice. American Journal of Kidney Diseases 82:5, pages 534-542.
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Anders O. Larsson, Michael Hultström, Robert Frithiof, Miklos Lipcsey & Mats B. Eriksson. (2022) Shrunken Pore Syndrome Is Frequently Occurring in Severe COVID-19. International Journal of Molecular Sciences 23:24, pages 15687.
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Erik Linné, Alma Elfström, Anna Åkesson, Jane Fisher, Anders Grubb, Ville Pettilä, Suvi T. Vaara, Adam Linder & Peter Bentzer. (2022) Cystatin C and derived measures of renal function as risk factors for mortality and acute kidney injury in sepsis – A post-hoc analysis of the FINNAKI cohort. Journal of Critical Care 72, pages 154148.
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Erik Herou, Anders Grubb, Alain Dardashti, Shahab Nozohoor, Igor Zindovic, Per Ederoth & Henrik Bjursten. (2022) Reduced renal elimination of larger molecules is a strong predictor for mortality. Scientific Reports 12:1.
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Zhongcai Wu, Le Wang, Yueqiang Li, Ying Yao & Rui Zeng. (2022) Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases. BioMed Research International 2022, pages 1-11.
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Agnė Laučytė-Cibulskienė, Ali-Reza Biglarnia, Carin Wallquist & Anders Christensson. (2022) Updated Pathways in Cardiorenal Continuum after Kidney Transplantation. Transplantology 3:2, pages 156-168.
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Gustavo Laham, Juan Pablo Ponti & Gervasio Soler Pujol. (2022) Assessing Renal Function for Kidney Donation. How Low Is Too Low?. Frontiers in Medicine 8.
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Linnea Malmgren, Fiona E. McGuigan, Anders Christensson & Kristina E. Akesson. (2022) Impaired selective renal filtration captured by eGFRcysC/eGFRcrea ratio is associated with mortality in a population based cohort of older women. Scientific Reports 12:1.
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Matthias Thielmann, David Corteville, Gabor SzaboMadhav SwaminathanAndre LamyLukas J. Lehner, Craig D. Brown, Nicolas NoiseuxMohamed G. AttaElizabeth C. Squiers, Shai Erlich, Daniel RothensteinBruce MolitorisC. David Mazer. (2021) Teprasiran, a Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study. Circulation 144:14, pages 1133-1144.
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Liana Xhakollari, Anders Grubb, Amra Jujic, Erasmus Bachus, Peter M. Nilsson, Margret Leosdottir, Anders Christensson & Martin Magnusson. (2021) The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study. ESC Heart Failure 8:5, pages 3577-3586.
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Anders Grubb. (2021) Glomerular filtration and shrunken pore syndrome in children and adults. Acta Paediatrica 110:9, pages 2503-2508.
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Carl M. Öberg, Martin Lindström, Anders Grubb & Anders Christensson. (2021) Potential relationship between eGFR cystatin C /eGFR creatinine ‐ratio and glomerular basement membrane thickness in diabetic kidney disease . Physiological Reports 9:13.
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Anders Grubb. (2020) Shrunken pore syndrome - a common kidney disorder with high mortality. Diagnosis, prevalence, pathophysiology and treatment options. Clinical Biochemistry 83, pages 12-20.
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Lingling Tan, Ruicen Li, Xiaoyi Hu, Yuan Zhu, Ting Bao, Yun Zuo & Ming Yang. (2020) Serum creatinine/cystatin C ratio as a case-finding tool for low handgrip strength in Chinese middle-aged and older adults. Scientific Reports 10:1.
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Hua Zhou, Min Yang, Xiaozhou He & Ning Xu. (2019) eGFR, cystatin C and creatinine in shrunken pore syndrome. Clinica Chimica Acta 498, pages 1-5.
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Jonas Björk, Anders Grubb, Vilmundur Gudnason, Olafur S Indridason, Andrew S Levey, Runolfur Palsson & Ulf Nyman. (2018) Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort. Nephrology Dialysis Transplantation 33:8, pages 1380-1388.
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