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Research Article

Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode

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Pages 934-940 | Received 11 Jun 2010, Accepted 13 Aug 2010, Published online: 13 Sep 2010

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Bianca A. W. Hoeben, Johan Bussink, Esther G. C. Troost, Wim J. G. Oyen & Johannes H. A. M. Kaanders. (2013) Molecular PET imaging for biology-guided adaptive radiotherapy of head and neck cancer. Acta Oncologica 52:7, pages 1257-1271.
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David Mönnich, Esther G. C. Troost, Johannes H. A. M. Kaanders, Wim J. G. Oyen, Markus Alber, Daniel Zips & Daniela Thorwarth. (2013) Correlation between tumor oxygenation and 18F-fluoromisonidazole PET data simulated based on microvessel images. Acta Oncologica 52:7, pages 1308-1313.
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Crossref
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Crossref
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Crossref
I N Fleming, R Manavaki, P J Blower, C West, K J Williams, A L Harris, J Domarkas, S Lord, C Baldry & F J Gilbert. (2014) Imaging tumour hypoxia with positron emission tomography. British Journal of Cancer 112:2, pages 238-250.
Crossref
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Crossref
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Crossref
Eline E Verwer. (2014) Positron emission tomography to assess hypoxia and perfusion in lung cancer. World Journal of Clinical Oncology 5:5, pages 824.
Crossref
Rajan Rakheja & Stephan Probst. (2013) FDG PET/CT as a marker for grading sarcomas and for the individualization of disease management. Imaging in Medicine 5:1, pages 75-81.
Crossref
Paul Okunieff, Walter O’Dell, Mei Zhang, Lurong Zhang & David Maguire. 2013. Oxygen Transport to Tissue XXXIV. Oxygen Transport to Tissue XXXIV 195 201 .
Rachel M. Bartlett, Bradley J. Beattie, Manoj Naryanan, Jens-Christoph Georgi, Qing Chen, Sean D. Carlin, Gordon Roble, Pat B. Zanzonico, Mithat Gonen, Joseph O’Donoghue, Alexander Fischer & John L. Humm. (2012) Image-Guided Po 2 Probe Measurements Correlated with Parametric Images Derived from 18 F-Fluoromisonidazole Small-Animal PET Data in Rats . Journal of Nuclear Medicine 53:10, pages 1608-1615.
Crossref
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Crossref
Eivind Smeland, Thomas K. Kilvaer, Sveinung Sorbye, Andrej Valkov, Sigve Andersen, Roy M. Bremnes, Lill-Tove Busund & Tom Donnem. (2012) Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma. Sarcoma 2012, pages 1-10.
Crossref
Kasper Toustrup, Brita Singers Sørensen, Pernille Lassen, Carsten Wiuf, Jan Alsner & Jens Overgaard. (2012) Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck. Radiotherapy and Oncology 102:1, pages 122-129.
Crossref
Kasper Toustrup, Brita Singers Sørensen, Marianne Nordsmark, Morten Busk, Carsten Wiuf, Jan Alsner & Jens Overgaard. (2011) Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer. Cancer Research 71:17, pages 5923-5931.
Crossref
Stephen R. Bowen, Albert J. van der Kogel, Marianne Nordsmark, Søren M. Bentzen & Robert Jeraj. (2011) Characterization of positron emission tomography hypoxia tracer uptake and tissue oxygenation via electrochemical modeling. Nuclear Medicine and Biology 38:6, pages 771-780.
Crossref
Jens Overgaard. (2011) Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis. Radiotherapy and Oncology 100:1, pages 22-32.
Crossref
Lise Saksø Mortensen, Morten Busk, Marianne Nordsmark, Steen Jakobsen, Jørn Theil, Jens Overgaard & Michael R. Horsman. (2011) Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: A preclinical study. Radiotherapy and Oncology 99:3, pages 418-423.
Crossref
Stefan Stangl, George Themelis, Lars Friedrich, Vasilis Ntziachristos, Athanasios Sarantopoulos, Michael Molls, Arne Skerra & Gabriele Multhoff. (2011) Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment. Radiotherapy and Oncology 99:3, pages 313-316.
Crossref
Alan W. Stitt, Christina L. O’Neill, Michelle T. O’Doherty, Desmond B. Archer, Tom A. Gardiner & Reinhold J. Medina. (2011) Vascular stem cells and ischaemic retinopathies. Progress in Retinal and Eye Research 30:3, pages 149-166.
Crossref

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