5,296
Views
632
CrossRef citations to date
0
Altmetric
Review Article

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

, &
Pages 88-106 | Received 22 Apr 2011, Accepted 23 Jun 2011, Published online: 30 Jan 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (36)

Wanvisa Udomsinprasert. (2023) Interleukin-1 family cytokines in liver cell death: a new therapeutic target for liver diseases. Expert Opinion on Therapeutic Targets 27:11, pages 1125-1143.
Read now
Tuba Tüylü Küçükkılınç & Ayşe Ercan. (2023) Phenelzine protects against acetaminophen induced apoptosis in HepG2 cells. Drug and Chemical Toxicology 0:0, pages 1-9.
Read now
Caiqin Yan, Ting Peng, Tingting Zhang, Yuan Wang, Na Li, Kai Wang & Xijuan Jiang. (2023) Molecular mechanisms of hepatotoxicity induced by compounds occurring in Evodiae Fructus. Drug Metabolism Reviews 55:1-2, pages 75-93.
Read now
Rasha M. Hussein, Mohamed A. Kandeil, Norhan A. Mohammed & Rasha A. Khallaf. (2022) Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity: Role of inducible nitric oxide synthase. Journal of Liposome Research 32:4, pages 365-375.
Read now
Pedro Ayuso, Yolanda Macías, Javier Gómez-Tabales, Elena García-Martín & José A. G. Agúndez. (2022) Molecular monitoring of patient response to painkiller drugs. Expert Review of Molecular Diagnostics 22:5, pages 545-558.
Read now
Maryam Mirahmad, Reyhaneh Sabourian, Mohammad Mahdavi, Bagher Larijani & Maliheh Safavi. (2022) In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation. Drug Metabolism Reviews 54:2, pages 161-193.
Read now
Shambhoo Sharan Tripathi, Sandeep Singh, Geetika Garg, Raushan Kumar, Avnish Kumar Verma, Abhishek Kumar Singh, Akalabya Bissoyi & Syed Ibrahim Rizvi. (2022) Metformin ameliorates acetaminophen-induced sub-acute toxicity via antioxidant property. Drug and Chemical Toxicology 45:1, pages 52-60.
Read now
Min Tian, Shenzhi Zhou, Wei Li, Jiaru Li, Lan Yang, Ying Peng & Jiang Zheng. (2021) Metabolic activation of aegeline mediated by CYP2C19. Xenobiotica 51:11, pages 1217-1228.
Read now
Nalan Kaya Tektemur, Elif Erdem Güzel, Mehmet Gül, Ahmet Tektemur, Sena Özcan Yıldırım, Merve Kavak Balgetir, Gonca Ozan Kocamüftüoğlu, Tuba Yalçın & İbrahim Enver Ozan. (2021) The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice. Ultrastructural Pathology 45:1, pages 19-27.
Read now
Hui Chen, Yao Wang, Fang-Zhou Jiao, Fan Yang, Xun Li & Lu-Wen Wang. (2020) Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo. Drug Design, Development and Therapy 14, pages 2393-2403.
Read now
Jephte Y. Akakpo, Anup Ramachandran & Hartmut Jaeschke. (2020) Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 16:11, pages 1039-1050.
Read now
Mohammad Mehdi Ommati, Reza Heidari, Vahid Ghanbarinejad, Ahmadreza Aminian, Narges Abdoli & Hossein Niknahad. (2020) The neuroprotective properties of carnosine in a mouse model of manganism is mediated via mitochondria regulating and antioxidative mechanisms. Nutritional Neuroscience 23:9, pages 731-743.
Read now
Jingheng Wang, Monicah Bwayi, Rebecca R. Florke Gee & Taosheng Chen. (2020) PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches. Expert Opinion on Drug Metabolism & Toxicology 16:8, pages 711-722.
Read now
Zixiong Zhou, Jing Qi, Jong-Won Kim, Myung-jo You, Chae Woong Lim & Bumseok Kim. (2020) AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity in vivo and in vitro. Toxicology Mechanisms and Methods 30:5, pages 324-335.
Read now
Ghada Elsayed Elgarawany, Asmaa Gaber Abdou, Doha Maher Taie & Shaimaa Mohammed Motawea. (2020) Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity in mice. Journal of Immunoassay and Immunochemistry 41:1, pages 84-96.
Read now
Vennila Krishnan, Chitra Loganathan & Palvannan Thayumanavan. (2019) Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 56-63.
Read now
Soung Hoon Moon, Chang Min Lee, See-Hyoung Park & Myeong Jin Nam. (2019) Effects of hepatocyte growth factor gene-transfected mesenchymal stem cells on dimethylnitrosamine-induced liver fibrosis in rats. Growth Factors 37:3-4, pages 105-119.
Read now
Xu Wang, Qinghua Wu, Aimei Liu, Arturo Anadón, José-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Zonghui Yuan & María-Aránzazu Martínez. (2017) Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug Metabolism Reviews 49:4, pages 395-437.
Read now
Otto Kučera, René Endlicher, David Rychtrmoc, Halka Lotková, Ondřej Sobotka & Zuzana Červinková. (2017) Acetaminophen toxicity in rat and mouse hepatocytes in vitro. Drug and Chemical Toxicology 40:4, pages 448-456.
Read now
Rui Li, Fangping Liu, Yicong Chang, Xin Ma, Minmin Li, Changwen Li, Chenxi Shi, Jingshan He, Ying Li, Zhi Li, Yuexia Lin, Qing Han, Yulin Zhao & Dening Wang. (2017) Glutathione S-transferase A1 (GSTA1) as a marker of acetaminophen-induced hepatocyte injury in vitro. Toxicology Mechanisms and Methods 27:6, pages 401-407.
Read now
Mohammad Adil, Amit D. Kandhare, Pinaki Ghosh, Shivakumar Venkata, Kiran S. Raygude & Subhash L. Bodhankar. (2016) Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1. Renal Failure 38:6, pages 1007-1020.
Read now
Aziz Eftekhari, Yadollah Azarmi, Alireza Parvizpur & Mohammad Ali Eghbal. (2016) Involvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes. Xenobiotica 46:4, pages 369-378.
Read now
Charalampos Katselis, Konstantinos Apostolou, Themistoklis Feretis, Ioannis G. Papanikolaou, George C. Zografos, Konstantinos Toutouzas & Apostolos Papalois. (2016) Role of Stem Cells Transplantation in Tissue Regeneration After Acute or Chronic Acetaminophen Induced Liver Injury. Journal of Investigative Surgery 29:2, pages 112-120.
Read now
Mitchell R. McGill, Stefanie Kennon-McGill, Dianne Durham & Hartmut Jaeschke. (2016) Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study. Toxicology Mechanisms and Methods 26:2, pages 104-111.
Read now
YI Mahmoud, AA Mahmoud & G Nassar. (2015) Alpha-lipoic acid treatment of acetaminophen-induced rat liver damage. Biotechnic & Histochemistry 90:8, pages 594-600.
Read now
Kuo Du, Yuchao Xie, Mitchell R McGill & Hartmut Jaeschke. (2015) Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 11:11, pages 1769-1779.
Read now
Benjamin L Woolbright & Hartmut Jaeschke. (2015) Sterile inflammation in acute liver injury: myth or mystery?. Expert Review of Gastroenterology & Hepatology 9:8, pages 1027-1029.
Read now
Hassan Farghali, Nikolina Kutinová Canová & Samir Zakhari. (2015) Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms. Pharmaceutical Biology 53:6, pages 781-791.
Read now
Mitchell R. McGill, Kuo Du, Yuchao Xie, Mary Lynn Bajt, Wen-Xing Ding & Hartmut Jaeschke. (2015) The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury. Xenobiotica 45:5, pages 442-449.
Read now
Mitchell R McGill & Hartmut Jaeschke. (2014) Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opinion on Drug Metabolism & Toxicology 10:7, pages 1005-1017.
Read now
Mitchell R. McGill, Mengde Cao, Archie Svetlov, Matthew R. Sharpe, C. David Williams, Steven C. Curry, Anwar Farhood, Hartmut Jaeschke & Stanislav I. Svetlov. (2014) Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers 19:3, pages 222-230.
Read now
Mehboob Ali, Sagheer Ahmed Khan, Peter S. Chang, Rizwanul Haque, Kanchan Bhatia & Saif Ahmad. (2014) Habb-e-Asgand, polyherbal Unani formulation, protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity. Pharmaceutical Biology 52:4, pages 506-515.
Read now
Yong Zhou, Shizhen Qin & Kai Wang. (2013) Biomarkers of drug-induced liver injury. Current Biomarker Findings 3, pages 1-9.
Read now
Amal S Abdel-Azeem, Amany M Hegazy, Khadiga S Ibrahim, Abdel-Razik H. Farrag & Eman M. El-Sayed. (2013) Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats. Journal of Dietary Supplements 10:3, pages 195-209.
Read now
Alison E. M. Vickers & Robyn L. Fisher. (2013) Evaluation of drug-induced injury and human response in precision-cut tissue slices. Xenobiotica 43:1, pages 29-40.
Read now

Articles from other publishers (596)

Stephen A. Hoption Cann. (2023) Paediatric acute hepatitis and therapeutic doses of paracetamol. Acta Paediatrica 113:1, pages 19-21.
Crossref
Nanami Namba, Takehiro Kuwahara, Yuki Kondo, Kumiko Fukusaki, Keishi Miyata, Yuichi Oike, Tetsumi Irie & Yoichi Ishitsuka. (2023) Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice. Biochemical and Biophysical Research Communications 686, pages 149166.
Crossref
Hongjing Zhao, Yue Zhang, Lulu Hou, Hongmin Lu, Yingxue Zhang & Mingwei Xing. (2023) Effects of environmentally relevant cypermethrin and sulfamethoxazole on intestinal health, microbiome, and liver metabolism in grass carp. Aquatic Toxicology 265, pages 106760.
Crossref
Maimonah Fuad Koshak, Mahmoud Zaki El-Readi, Mohamed Elzubier Elzubier, Bassem Refaat, Riyad Adnan Almaimani, Shakir Idris, Mohammad Althubiti, Hiba Saeed Al-Amodi & Safaa Yehia Eid. (2023) Antioxidative and Anti-Inflammatory Protective Effects of Fucoxanthin against Paracetamol-Induced Hepatotoxicity in Rats. Marine Drugs 21:11, pages 592.
Crossref
Jiangting Hu, Anna-Liisa Nieminen, James L. Weemhoff, Hartmut Jaeschke, Laura G. Murphy, Judith A. Dent & John J. Lemasters. (2023) The mitochondrial calcium uniporter mediates mitochondrial Fe2+ uptake and hepatotoxicity after acetaminophen. Toxicology and Applied Pharmacology 479, pages 116722.
Crossref
S. S. Postnikov, N. V. Teplova, G. P. Brusov, T. N. Komarova, A. G. Rumyantsev, I. N. Tatarova, E. K. Donush, E. A. Tsimbalova, M. N. Kostyleva, A. N. Gratsianskaya & R. V. Libcis. (2023) Case of severe liver damage in 12‑year‑old child with intentional overdose of paracetamol. Medical alphabet:18, pages 28-33.
Crossref
Devaraj Ezhilarasan, Karthik Shree Harini, Munusamy Karthick & Chandrabose Selvaraj. (2023) Ethyl gallate concurrent administration protects against acetaminophen‐induced acute liver injury in mice: An in vivo and in silico approach. Chemical Biology & Drug Design.
Crossref
Benyu Liu, Shiming Fang, Kun Zhou, Lulu Ma, Yaling Shi, Yuefei Wang & Xiumei Gao. (2023) Unveiling hepatotoxicity distinction of coumarin-related compounds from glycosides to aglycones in Fructus Psoraleae by integrating UPLC-Q-TOF-MS and high content analysis. Journal of Ethnopharmacology 315, pages 116664.
Crossref
Xiaojuan Chao, Mengwei Niu, Shaogui Wang, Xiaowen Ma, Xiao Yang, Hua Sun, Xujia Hu, Hua Wang, Li Zhang, Ruili Huang, Menghang Xia, Andrea Ballabio, Hartmut Jaeschke, Hong-Min Ni & Wen-Xing Ding. (2023) High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice. Acta Pharmaceutica Sinica B.
Crossref
Chih-Min Yang, Mei-Yin Chien, Li-Yu Wang, Cheng-Hung Chuang & Chao-Hsiang Chen. (2022) Goji Ferment Ameliorated Acetaminophen-Induced Liver Injury in vitro and in vivo. Probiotics and Antimicrobial Proteins 15:5, pages 1102-1112.
Crossref
Masykur ., Nurdin ., Lukman Hakim, Rosnizar .Widya Sari, Munira Ulfa, Novi Yana Sari & Ria Ceriana. (2023) Effect of Ethanol Extract of Soursop (Annona muricata L.) Stem Bark on Rat Liver Function. Pakistan Journal of Biological Sciences 26:10, pages 516-528.
Crossref
Mylanayakanahosahalli Chandrashekar Indumathi, Kamatam Swetha, Kandahalli Venkataranganayaka Abhilasha, Shiva Siddappa, Shivamadhaiah Manjula Kumar, Govinda Keerthi Prasad, Chu-Huang Chen & Gopal Kedihithlu Marathe. (2023) Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice. Biological Trace Element Research.
Crossref
Aya S. Shalaby, Hanaa H. Eid, Riham A. El‐Shiekh, Fadia S. Youssef, Ahmed A. Al‐Karmalawy, Nahla A. Farag, Amany A. Sleem, Fatma Adly Morsy, Khaled M. Ibrahim & Soad H. Tadros. (2023) A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb‐Drug Interactions in Preventing Paracetamol‐Induced Hepatotoxicity. Chemistry & Biodiversity.
Crossref
Laiyu Zhu, Xiaoye Fan, Chunyuan Cao, Kailiang Li, Wenli Hou & Xinxin Ci. (2023) Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway. Biomedicine & Pharmacotherapy 165, pages 115097.
Crossref
Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu & Jingyuan Wan. (2023) Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice. Journal of Immunology Research 2023, pages 1-15.
Crossref
Lei Gu, Xin He, Yanqiu Zhang, Shenglan Li, Jie Tang, Ruixue Ma, Xinyi Yang, Hao Huang, Yu Peng, Yanyun Xie, Zhangzhe Peng, Jie Meng, Gaoyun Hu, Lijian Tao, Xiaowei Liu & Huixiang Yang. (2023) Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway. Biomedicine & Pharmacotherapy 164, pages 114844.
Crossref
Dalia A. Mandour, Manal M. Morsy, Amal Fawzy, Noura Mostafa Mohamed & Marwa M. Ahmad. (2023) Structural and molecular changes in the rat myocardium following perfluoroctane sulfonate (PFOS) exposure are mitigated by quercetin via modulating HSP 70 and SERCA 2. Journal of Molecular Histology 54:4, pages 283-296.
Crossref
Jihoon Tak & Sang Geon Kim. (2023) Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination. Toxicological Research.
Crossref
Wei Xie, Rongrong Jiang, Jiashu Xie, Robert Vince & Swati S. More. (2023) Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity. Chemical Research in Toxicology 36:7, pages 1071-1080.
Crossref
Yang Zhou, Jiao Wang, Ting Liu, Man Wu, Yuwei Lan, Chunping Jia & Jianlong Zhao. (2023) An adaptive three-dimensional hydrodynamic focusing microfluidic impedance flow cytometer. The Analyst 148:14, pages 3239-3246.
Crossref
Yoo-Sub Shin, Da-Bin Hwang, Dong-Hoon Won, Shin-Young Kim, Changuk Kim, Jun Won Park, Young Jeon & Jun-Won Yun. (2023) The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression. Toxicological Research 39:3, pages 443-453.
Crossref
Hanghang Wu, Xiyuan Bao, Alejandro H. Gutierrez, Yulia A. Nevzorova & Francisco Javier Cubero. (2023) Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury. Exploration of Digestive Diseases, pages 83-99.
Crossref
Peng Gao, Kun Chang, Shuo Yuan, Yanhang Wang, Kewu Zeng, Yong Jiang, Pengfei Tu, Yingyuan Lu & Xiaoyu Guo. (2023) Exploring the Mechanism of Hepatotoxicity Induced by Dictamnus dasycarpus Based on Network Pharmacology, Molecular Docking and Experimental Pharmacology. Molecules 28:13, pages 5045.
Crossref
Jéssica Moraes Cruvinel, Priscila Michelin Groff Urayama, Cássio Yutto Oura, Fernanda Kaiser de Lima Krenchinski, Tatiane Souza dos Santos, Beatriz Alves de Souza, Samir Moura Kadri, Camila Renata Correa, José Roberto Sartori & Antonio Celso Pezzato. (2023) Pequi Oil (Caryocar brasiliense Camb.) Attenuates the Adverse Effects of Cyclical Heat Stress and Modulates the Oxidative Stress-Related Genes in Broiler Chickens. Animals 13:12, pages 1896.
Crossref
Chuanxia Yao, Yiwen Wang, DanDan Gong, Tian Feng, Yaqiong Zhang, Chunhui Wang, Maorong Wang & Jin Zhu. (2023) Anti-TLR4 IgG2 Prevents Acetaminophen-induced Acute Liver Injury through the Toll-like Receptor 4/MAPKs Signaling Pathway in Mice. Current Molecular Medicine 23:5, pages 453-469.
Crossref
Jaewon Lee, Jihoon Ha, Jun-Hyeong Kim, Dongyeob Seo, Minbeom Kim, Yerin Lee, Seong Shil Park, Dahee Choi, Jin Seok Park, Young Jae Lee, Siyoung Yang, Kyung-Min Yang, Su Myung Jung, Suntaek Hong, Seung-Hoi Koo, Yong-Soo Bae, Seong-Jin Kim & Seok Hee Park. (2023) Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation. Experimental & Molecular Medicine 55:6, pages 1218-1231.
Crossref
Qiang Feng, Hongting Xu, Xiaoyu Pan, Siqi Geng, Huifeng Qian, Chujie Wang, Ying Li, Jiaying Qin, Yiting Wu, Bangyi Zhou, Xiaoyu Liu, Zhiqiu Ye, Yingchun Xu & Zhangsen Yu. (2023) Antioxidation and Anti-Inflammatory Activity of Prussian Blue Nanozymes to Alleviate Acetaminophen-Induced Acute Liver Injury. ACS Applied Nano Materials 6:10, pages 8468-8481.
Crossref
Sydney Stern, Hongbing Wang & Nakissa Sadrieh. (2023) Microphysiological Models for Mechanistic-Based Prediction of Idiosyncratic DILI. Cells 12:11, pages 1476.
Crossref
Supachaya Sriphoosanaphan, Pakkapon Rattanachaisit, Kanjana Somanawat, Natcha Wanpiyarat, Piyawat Komolmit & Duangporn Werawatganon. (2023) Calcitriol Protects against Acetaminophen-Induced Hepatotoxicity in Mice. Biomedicines 11:6, pages 1534.
Crossref
Svetlana Rodimova, Artem Mozherov, Vadim Elagin, Maria Karabut, Ilya Shchechkin, Dmitry Kozlov, Dmitry Krylov, Alena Gavrina, Nikolai Bobrov, Vladimir Zagainov, Elena Zagaynova & Daria Kuznetsova. (2023) Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS. International Journal of Molecular Sciences 24:11, pages 9195.
Crossref
Geyan Duan, Pan Huang, Changbing Zheng, Jie Zheng, Jiayi Yu, Peiwen Zhang, Mengliao Wan, Fengna Li, Qiuping Guo, Yulong Yin & Yehui Duan. (2023) Development and Recovery of Liver Injury in Piglets by Incremental Injection of LPS. Antioxidants 12:6, pages 1143.
Crossref
Mitsue Hibino, Masatoshi Maeki, Manabu Tokeshi, Yoichi Ishitsuka, Hideyoshi Harashima & Yuma Yamada. (2023) A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury. Scientific Reports 13:1.
Crossref
Guangwen Luo, Lili Huang & Zhaowei Zhang. (2023) The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. Experimental Biology and Medicine 248:5, pages 412-424.
Crossref
Meltem Macit, Gulengul Duman, Alev Cumbul, Engin Sumer & Caglar Macit. (2023) Formulation development of Silybum marianum seed extracts and silymarin nanoparticles, and evaluation of hepatoprotective effect. Journal of Drug Delivery Science and Technology 83, pages 104378.
Crossref
Yanni Xue, Daoxu Zhang, Yanyan Wei, Chunyu Guo, Bingdong Song, Yingying Cui, Cheng Zhang, Dexiang Xu, Shichen Zhang & Jun Fang. (2023) Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway. European Journal of Pharmaceutical Sciences 184, pages 106413.
Crossref
Jingyu Xiao, Jing Wang, Yong Luo, Tailin Xu & Xueji Zhang. (2023) Wearable Plasmonic Sweat Biosensor for Acetaminophen Drug Monitoring. ACS Sensors 8:4, pages 1766-1773.
Crossref
Zahra Mokhtari, Mahdieh Raeeszadeh & Loghman Akradi. (2023) Comparative Effect of the Active Substance of Thyme with N-Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity. Analytical Cellular Pathology 2023, pages 1-10.
Crossref
Sisi Pu, Yangyang Pan, Qian Zhang, Ting You, Tao Yue, Yuxing Zhang & Meng Wang. (2023) Endoplasmic Reticulum Stress and Mitochondrial Stress in Drug-Induced Liver Injury. Molecules 28:7, pages 3160.
Crossref
Malak A. Jaber, Bayan Y. Ghanim, Mohammad Al-Natour, Duaa Abu Arqoub, Qasem Abdallah, Salah Abdelrazig, Jamal Alyousse Alkrad, Dong-Hyun Kim & Nidal A. Qinna. (2023) Potential biomarkers and metabolomics of acetaminophen-induced liver injury during alcohol consumption: A preclinical investigation on C57/BL6 mice. Toxicology and Applied Pharmacology 465, pages 116451.
Crossref
Jiayi Li, He Qian & Fuwei Pi. (2023) Effects of torularhodin against acetaminophen induced liver injury base on antioxidation, anti-inflammation and anti-apoptosis. Food Bioscience 52, pages 102388.
Crossref
Yiwei Zhu, Lin Lei, Xinghui Wang, Linfang Chen, Wei Li, Jinxia Li, Chenchen Zhao, Xiliang Du, Yuxiang Song, Wenwen Gao, Guowen Liu & Xinwei Li. (2023) The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation. Acta Pharmaceutica Sinica B 13:4, pages 1616-1630.
Crossref
Wenhui Qian, Guangming Gong, Hua Su, Yang Zhao, Wenjuan Fu, Yuting Wang, Wenwen Ji, Xuetong Sun, Bei Zhang, Lijuan Ma, Jianting Li, Xiangying Zhang, Su Li, Enze Sheng, Yin Lu & Dong Zhu. (2023) Hepar-on-a-sensor-platform with hybridization chain reaction amplification strategy to intuitively monitor the hepatoxicity of natural compounds. Acta Biomaterialia 160, pages 73-86.
Crossref
Xueyan Huang, Fei Chen, Yeshuo Ma, Fan Zheng, Yanpeng Fang, Bin Feng, Shuai Huang, Hongliang Zeng & Wenbin Zeng. (2023) De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulation. Biomaterials Research 27:1.
Crossref
Afsaneh Mozaffarinia, Ali Gol & Aghileh Mohammadzadeh. (2023) Hepatoprotective Properties of Cuminum cyminum Seeds Powder as Post-Treatment for Acetaminophen-Induced Injury. Journal of Advances in Medical and Biomedical Research 31:145, pages 170-176.
Crossref
Si Zou, Yetao Gong, Xiujie Li, Yanbin Wu, Jinzhong Wu, Jianguo Wu & Ka-Hing Wong. (2023) Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1. Food Science and Human Wellness, pages 1-23.
Crossref
Long Xu & Hua Wang. (2023) A dual role of inflammation in acetaminophen-induced liver injury. Liver Research 7:1, pages 9-15.
Crossref
Naomi Kamimura, Alexander M. Wolf, Takashi Yokota, Chikako Nito, Hiroshi Takahashi & Shigeo Ohta. (2023) Transgenic type2 diabetes mouse models for in vivo redox measurement of hepatic mitochondrial oxidative stress. Biochimica et Biophysica Acta (BBA) - General Subjects 1867:3, pages 130302.
Crossref
Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, An-Hsun Chou & Huang-Ping Yu. (2023) Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice. Biology 12:2, pages 334.
Crossref
Kehong Dong, Mei Zhang, Ying Liu, Xintao Gao, Xiaochen Wu, Dayong Shi, Chuanlong Guo & Jing Wang. (2023) Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against Acetaminophen-Induced Acute Liver Injury. Molecular Pharmaceutics 20:2, pages 1189-1201.
Crossref
Chaoqun Yu, Peng Chen, Longyu Miao & Guohu Di. (2023) The Role of the NLRP3 Inflammasome and Programmed Cell Death in Acute Liver Injury. International Journal of Molecular Sciences 24:4, pages 3067.
Crossref
Vincent Di Martino, Delphine Weil Verhoeven, Frank Verhoeven, François Aubin, Jérome Avouac, Lucine Vuitton, Frédéric Lioté, Thierry Thévenot & Daniel Wendling. (2022) Busting the myth of methotrexate chronic hepatotoxicity. Nature Reviews Rheumatology 19:2, pages 96-110.
Crossref
Fares EM Ali, Mostafa K Abd El-Aziz, Elham I Sharab & Adel G Bakr. (2023) Therapeutic interventions of acute and chronic liver disorders: A comprehensive review. World Journal of Hepatology 15:1, pages 19-40.
Crossref
Yelei Cen, Guohua Lou, Jinjin Qi, Minwei Li, Min Zheng & Yanning Liu. (2023) Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury. Antioxidants 12:1, pages 158.
Crossref
He Wang, Yu Qian, Jing-Wen Wang, Yu Fang, Yu-Chen Fan, Hui-Hui Liu & Kai Wang. (2023) Hypomethylation of thymosin β4 promoter is associated with glucocorticoid therapy in patients with acute-on-chronic hepatitis B-induced liver failure. International Health 15:1, pages 19-29.
Crossref
Takamitsu Tsukahara, Yuko Makioka-Itaya, Hiroaki Takimoto & Tetsuo Ijichi. (2023) Oral supplementation of a cell preparation of <i>Enterococcus faecalis</i> strain EC-12 stimulates superoxide dismutase production in the livers of healthy and arthritis-induced mice. Journal of Clinical Biochemistry and Nutrition 72:1, pages 39-45.
Crossref
H. K. Ruben Thanacoody. (2022) Large paracetamol overdose – Higher dose NAC is NOT required. British Journal of Clinical Pharmacology 89:1, pages 39-42.
Crossref
Manasi Kotulkar, Diego Paine-Cabrera, Sarah Abernathy, Dakota R. Robarts, Wendena S. Parkes, Kristi Lin- Rahardja, September Numata, Margitta Lebofsky, Hartmut Jaeschke & Udayan Apte. (2023) Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury. Hepatology Publish Ahead of Print.
Crossref
Romeo Joel Guemmogne Temdie, Edwige Ymele Chiogo Vouffo, Borris Rosnay Tietcheu Galani, Bertrand Dabole Ladane, Josee Bianzoumbe, Marc Germain Kuum Minoue, Fidèle Ntchapda & Theophile Dimo. (2023) Potential Curative Effects of Aqueous Extracts of Cissus quadrangularis (Vitaceae) and Jatropha gossypiifolia (Euphorbiaceae) on Acetaminophen-Induced Liver Injury in Mice. Current Therapeutic Research 99, pages 100716.
Crossref
Aruna Qian, Lu Zhou, Dongxu Shi, Zongran Pang & Binan Lu. (2023) Portulaca oleracea alleviates CCl4-induced acute liver injury by regulating hepatic S100A8 and S100A9. Chinese Herbal Medicines 15:1, pages 110-116.
Crossref
Jan-Luca Stampf, Cosmin I. Ciotu, Stefan Heber, Stefan Boehm, Michael J. M. Fischer & Isabella Salzer. (2022) Analgesic Action of Acetaminophen via Kv7 Channels. International Journal of Molecular Sciences 24:1, pages 650.
Crossref
Congcong Zhou, Aijing Liu, Gengsong Liu, Cheng Yang, Qiaoyan Zhou, Haizhu Li, Hongchun Yang, Mengmeng Yang, Gonghe Li, Hongbin Si & Changbo Ou. (2022) Protective Effects of Sophorae Tonkinensis Gagnep. (Fabaceae) Radix et Rhizoma Water Extract on Carbon Tetrachloride-Induced Acute Liver Injury. Molecules 27:24, pages 8650.
Crossref
Jiaxin Li, Jingrui Cao, Wen Wu, Lanlan Xu, Siqi Zhang, Pinyi Ma, Qiong Wu & Daqian Song. (2022) A molecular imaging tool for monitoring carboxylesterase 2 during early diagnosis of liver-related diseases. Sensors and Actuators B: Chemical, pages 133122.
Crossref
Yuqi Wang, Xiaojing Liu, Hongyuan Jing, Haoran Ren, Shiwen Xu & Mengyao Guo. (2022) Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation. Ecotoxicology and Environmental Safety 248, pages 114327.
Crossref
Jooyoung Lee, Jiye Kim, Ryunjin Lee, Eunkyeong Lee, Tae Gyu Choi, Amy Sinyoung Lee, Young-In Yoon, Gil-Chun Park, Jung-Man Namgoong, Sung-Gyu Lee & Eunyoung Tak. (2022) Therapeutic strategies for liver diseases based on redox control systems. Biomedicine & Pharmacotherapy 156, pages 113764.
Crossref
Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz & Edda Tschernko. (2022) Unilateral acute lung injury in pig: a promising animal model. Journal of Translational Medicine 20:1.
Crossref
Lin Bai, Keisuke Tachibana, Michika Murata, Tetsunori Inoue, Hiroyuki Mizuguchi, Shinichiro Maeda, Kenji Ikemura, Masahiro Okuda, Tetsuya Kusakabe & Masuo Kondoh. (2022) A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of aflatoxin B1 in the human intestine. Toxicology Letters 370, pages 1-6.
Crossref
Lin Ye, Deborah K. Ngan, Tuan Xu, Zhichao Liu, Jinghua Zhao, Srilatha Sakamuru, Li Zhang, Tongan Zhao, Menghang Xia, Anton Simeonov & Ruili Huang. (2022) Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data. Toxicology and Applied Pharmacology 454, pages 116250.
Crossref
Bill J. Gurley, Mitchell R. McGill & Igor Koturbash. (2022) Hepatotoxicity due to herbal dietary supplements: Past, present and the future. Food and Chemical Toxicology 169, pages 113445.
Crossref
Li Chen, Jun Dong, Siyang Liao, Siyou Wang, Zhida Wu, Meiling Zuo, Bing Liu, Chaojun Yan, Yong Chen, He He, Qingtao Meng & Zhiyin Song. (2022) Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury. Hepatology 76:5, pages 1389-1408.
Crossref
Jiao Cai, Deqin Kong, Zi Long, Jiangzheng Liu, Rui Liu & Chunxu Hai. (2022) Targeting PARK7 Improves Acetaminophen-Induced Acute Liver Injury by Orchestrating Mitochondrial Quality Control and Metabolic Reprogramming. Antioxidants 11:11, pages 2128.
Crossref
Li-Man Qiao, Hui Zhang, Wei Liu & Dan Lou. (2022) Therapeutic effect and metabolomics mechanism of Patrinia Villosa (Thunb.) juss on liver injury in rats. Frontiers in Pharmacology 13.
Crossref
Abbasali Abbasnezhad, Fatemeh Salami & Reza Mohebbati. (2022) A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals. Animal Models and Experimental Medicine 5:5, pages 436-444.
Crossref
Xiaopeng Cai, Shiyuan Hua, Jingwen Deng, Zhen Du, Dongxiao Zhang, Zhenfeng Liu, Nazif Ullah Khan, Min Zhou & Zhi Chen. (2022) Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury. ACS Applied Materials & Interfaces 14:38, pages 42887-42903.
Crossref
Abdullah M. Alnuqaydan, Abdulmajeed G. Almutary, Mohammed A. Alsahli, Sulaiman Alnasser & Bilal Rah. (2022) Tamarix articulata Induced Prevention of Hepatotoxicity Effects of In Vivo Carbon Tetrachloride by Modulating Pro-Inflammatory Serum and Antioxidant Enzymes to Reverse the Liver Fibrosis. Antioxidants 11:9, pages 1824.
Crossref
Xiating Mao, Danning Wu, Na Xu, Jingjing Wang, Jinhua Zeng, Zhiqiang Jiang, Yingfang Liu & Huanhuan Liang. (2022) The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury. Biochemical and Biophysical Research Communications 621, pages 25-31.
Crossref
Jing Li, Xuewen Tang, Xing Wen, Xiaoyuan Ren, Huihui Zhang, Yatao Du & Jun Lu. (2022) Mitochondrial Glrx2 Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice. Antioxidants 11:9, pages 1643.
Crossref
Chao-Ling Tang, Ning Ma, Wan-Ying Sun, Wei Wang, Li-Peng Zhu, Rui-Qi Wang, Jie-Yan Liu & Xiao-Po Zhang. (2022) Hepatoprotection of Paederia scandens (Lour.) Merr. on Acetaminophen-Related Hepatic Injury Rats by 1H-NMR-Based Metabonomics Coupled with Network Pharmacology. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-14.
Crossref
Benjamin L. Woolbright, Nga T. Nguyen, Mitchell R. McGill, Matthew R. Sharpe, Steven C. Curry & Hartmut Jaeschke. (2022) Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients. Toxicology Letters 367, pages 59-66.
Crossref
Jinke Zhang, Mengcheng Li, Tianrui Zhao, Jianxin Cao, Yaping Liu, Yongpeng Wang, Yifen Wang & Guiguang Cheng. (2022) E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway. Food & Function 13:13, pages 7240-7250.
Crossref
Marja Driessen, Suzanne van der Plas - Duivesteijn, Anne S. Kienhuis, Evert-Jan van den Brandhof, Marianne Roodbergen, Bob van de Water, Herman P. Spaink, Magnus Palmblad, Leo T.M. van der Ven & Jeroen L.A. Pennings. (2022) Identification of proteome markers for drug-induced liver injury in zebrafish embryos. Toxicology 477, pages 153262.
Crossref
Ya‐Wen Xu, Bi‐Xin Xu, Jiankun Wang, Hao‐Wen Jin, Si‐Tao Xu, Guangji Wang & Le Zhen. (2022) Peroxynitrite‐Promoted Persulfide Prodrugs with Protective Potential against Paracetamol Poisoning. Chemistry – A European Journal 28:36.
Crossref
Saikat Dewanjee, Tarun K. Dua, Paramita Paul, Abhijit Dey, Jayalakshmi Vallamkondu, Sonalinandini Samanta, Ramesh Kandimalla & Vincenzo De Feo. (2022) Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity. Biomedicines 10:7, pages 1498.
Crossref
Hui-Hsuan Lin, Jen-Ying Hsu, Chiao-Yun Tseng, Xiao-Yin Huang, Hsien-Chun Tseng & Jing-Hsien Chen. (2022) Hepatoprotective Activity of Nelumbo nucifera Gaertn. Seedpod Extract Attenuated Acetaminophen-Induced Hepatotoxicity. Molecules 27:13, pages 4030.
Crossref
Jia-Yi Feng, Yan-Qing Xie, Peng Zhang, Qian Zhou, Afsar Khan, Zhi-Hong Zhou, Xian-Song Xia & Lu Liu. (2022) Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism. Molecules 27:11, pages 3602.
Crossref
Nidhi VermaDharmshila KumariDr.Dr.. (2022) MITIGATION OF PARACETAMOL INDUCED GENOTOXICITY BY CURRY LEAVES ( MURRAYA KOENIGII) EXTRACT IN BONE BARROW CELLS OF SWISS ALBINO MICE MUS MUSCULUS. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, pages 49-50.
Crossref
Ege Arzuk, Mehmet Tokdemir & Hilmi Orhan. (2022) Mitochondrial versus microsomal bioactivation of paracetamol by human liver and kidney tissues. Toxicology Letters 363, pages 36-44.
Crossref
Olamide B. Adelusi, Anup Ramachandran, John J. Lemasters & Hartmut Jaeschke. (2022) The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice. Toxicology and Applied Pharmacology 445, pages 116043.
Crossref
Shumin Feng, Zhoupeng Zheng, Shengyi Gong & Guoqiang Feng. (2022) A unique probe enables labeling cell membrane and Golgi apparatus and tracking peroxynitrite in Golgi oxidative stress and drug-induced liver injury. Sensors and Actuators B: Chemical 361, pages 131751.
Crossref
Amir Rostami, Tourandokht Baluchnejadmojarad & Mehrdad Roghani. (2022) Sinapic acid ameliorates paracetamol-induced acute liver injury through targeting oxidative stress and inflammation. Molecular Biology Reports 49:6, pages 4179-4191.
Crossref
Sabine Weber & Alexander L. Gerbes. (2022) Challenges and Future of Drug-Induced Liver Injury Research—Laboratory Tests. International Journal of Molecular Sciences 23:11, pages 6049.
Crossref
Babatunde Oluwafemi Adetuyi, Oluwaseun Abraham Adebisi, Oluwatosin Adefunke Adetuyi, Olubanke Olujoke Ogunlana, Pere-Ebi Toloyai, Chukwuebuka Egbuna, Chukwuemelie Zedech Uche, Johra Khan, Obinna Chukwuemeka Uchenna Adumanya & Kingsley C. Patrick-Iwuanyanwu. (2022) Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model. BioMed Research International 2022, pages 1-10.
Crossref
Zuojia Qin, Tian‐Bing Ren, Huijie Zhou, Xingxing Zhang, Long He, Zhe Li, Xiao‐Bing Zhang & Lin Yuan. (2022) NIRII‐HDs: A Versatile Platform for Developing Activatable NIR‐II Fluorogenic Probes for Reliable In Vivo Analyte Sensing. Angewandte Chemie International Edition 61:19.
Crossref
Zuojia Qin, Tian‐Bing Ren, Huijie Zhou, Xingxing Zhang, Long He, Zhe Li, Xiao‐Bing Zhang & Lin Yuan. (2022) NIRII‐HDs: A Versatile Platform for Developing Activatable NIR‐II Fluorogenic Probes for Reliable In Vivo Analyte Sensing. Angewandte Chemie 134:19.
Crossref
Ruizhi Gu, Alina Liang, Grace Liao, Isabelle To, Amina Shehu & Xiaochao Ma. (2022) Roles of Cofactors in Drug-Induced Liver Injury: Drug Metabolism and Beyond. Drug Metabolism and Disposition 50:5, pages 646-654.
Crossref
Chunliang Liu, Zerong Wang, Wei Wang, Lei Zheng & Ming Li. (2022) Positive effects of selenium supplementation on selenoprotein S expression and cytokine status in a murine model of acute liver injury. Journal of Trace Elements in Medicine and Biology 71, pages 126927.
Crossref
Qingfei Xiao, Ying Zhao, Lei Ma & Rongli Piao. (2022) Orientin reverses acetaminophen-induced acute liver failure by inhibiting oxidative stress and mitochondrial dysfunction. Journal of Pharmacological Sciences 149:1, pages 11-19.
Crossref
Luqi Duan, Giselle Sanchez-Guerrero, Hartmut Jaeschke & Anup Ramachandran. (2022) Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose. Food and Chemical Toxicology 163, pages 112911.
Crossref
Gustavo Axel Elizalde-Velázquez, Jonathan Ricardo Rosas-Ramírez, Demetrio Raldua, Sandra García-Medina, José Manuel Orozco-Hernández, Karina Rosales- Pérez, Hariz Islas-Flores, Marcela Galar-Martínez, Xochitl Guzmán-García & Leobardo Manuel Gómez-Oliván. (2022) Low concentrations of ciprofloxacin alone and in combination with paracetamol induce oxidative stress, upregulation of apoptotic-related genes, histological alterations in the liver, and genotoxicity in Danio rerio. Chemosphere 294, pages 133667.
Crossref
Mengyang Wang, Jinfeng Sun, Tianxiang Yu, Minxiu Wang, Leiming Jin, Shiqi Liang, Wu Luo, Yi Wang, Gao Li & Guang Liang. (2022) Diacerein protects liver against APAP-induced injury via targeting JNK and inhibiting JNK-mediated oxidative stress and apoptosis. Biomedicine & Pharmacotherapy 149, pages 112917.
Crossref
Xin Xie, Sushila Maharjan, Chastity Kelly, Tian Liu, Robert J. Lang, Roger Alperin, Shikha Sebastian, Diana Bonilla, Sakura Gandolfo, Yasmine Boukataya, Seyed Mohammad Siadat, Yu Shrike Zhang & Carol Livermore. (2021) Customizable Microfluidic Origami Liver‐on‐a‐Chip (oLOC). Advanced Materials Technologies 7:5.
Crossref
Xiyue Shen, Saddam Muhammad Ishaq, Qiao’e Wang, Juntao Yuan, Junling Gao & Zhongbing Lu. (2022) DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice. Antioxidants 11:5, pages 880.
Crossref
Huiqun Dong, Jia You, Yu Zhao, Danhua Zheng, Yi Zhong, Gaozheng Li, Zuquan Weng, Heng Luo & Shan Jiang. (2022) Study on the Characteristics of Small-Molecule Kinase Inhibitors-Related Drug-Induced Liver Injury. Frontiers in Pharmacology 13.
Crossref
Muhammad Tahir, Sakhawat Ali, Wenting Zhang, Boqiang Lv, Wenge Qiu & Juan Wang. (2022) Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases. Biomedicines 10:4, pages 905.
Crossref
Xiaopeng Cai, Huiqiang Cai, Jing Wang, Qin Yang, Jun Guan, Jingwen Deng & Zhi Chen. (2022) Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options对乙酰氨基酚诱导的肝损伤的分子发病机制及治疗策略. Journal of Zhejiang University-SCIENCE B 23:4, pages 265-285.
Crossref
Congcong Zhang, Jiacheng Lin, Chao Zhen, Fang Wang, Xuehua Sun, Xiaoni Kong & Yueqiu Gao. (2022) Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death. Biochemical and Biophysical Research Communications 602, pages 105-112.
Crossref
Zongyu Cai, Bin Wang, Zongtao Zhou, Xin Zhao, Lijun Hu, Qiang Ren, Liming Deng, Zheng Li & Guangji Wang. (2021) Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen‐induced hepatotoxicity. Chemical Biology & Drug Design 99:3, pages 483-495.
Crossref
Kirsten Eckstrum, Anneliese Striz, Martine Ferguson, Yang Zhao & Robert Sprando. (2022) Evaluation of the utility of the Beta Human Liver Emulation System (BHLES) for CFSAN's regulatory toxicology program. Food and Chemical Toxicology 161, pages 112828.
Crossref
Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
Crossref
Ahlam Alhusain, Laila Fadda, Wedad Sarawi, Hatun Alomar, Hanaa Ali, Raeesa Mahamad, Iman Hasan & Amira Badr. (2022) The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression. Dose-Response 20:1, pages 155932582210783.
Crossref
Kwazikwakhe B. Gabuza, Ntandoyenkosi Buthelezi, Abidemi Paul Kappo, Thendo I. Mabuda, Rebamang Mosa, Johan Louw & Christo J.F. Muller. (2022) In vitro and in vivo hepatotoxicity study of Afriplex™ GRT through an inflammatory response. Toxicology Reports 9, pages 1920-1928.
Crossref
Milon Mondal, Chandan Sarkar, Sushmita Saha, Md Naim Hossain, Roghayeh Norouzi, Mohammad S. Mubarak, Abolghasem Siyadatpanah, Polrat Wilairatana, Rajib Hossain, Muhammad Torequl Islam & Henrique Douglas Melo Coutinho. (2022) Hepatoprotective activity of andrographolide possibly through antioxidative defense mechanism in Sprague-Dawley rats. Toxicology Reports 9, pages 1013-1022.
Crossref
Yixue Huang, Yunhao Xie, Dong Yang, Mingrui Xiong, Xingrui Chen, Di Wu, Qing Wang, Hong Chen, Ling Zheng & Kun Huang. (2022) Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms. Pharmacological Research 175, pages 106021.
Crossref
Zhongyue Ren, Yalan Huo, Qimeng Zhang, Shufang Chen, Huihui Lv, Lingling Peng, Hua Wei & Cuixiang Wan. (2021) Protective Effect of Lactiplantibacillus plantarum 1201 Combined with Galactooligosaccharide on Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Nutrients 13:12, pages 4441.
Crossref
Riccardo Tassinari, Claudia Cavallini, Elena Olivi, Valentina Taglioli, Chiara Zannini, Orlando Ferroni & Carlo Ventura. (2021) Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells. BMC Complementary Medicine and Therapies 21:1.
Crossref
Hui Qian, Xiaojuan Chao, Jessica Williams, Sam Fulte, Tiangang Li, Ling Yang & Wen-Xing Ding. (2021) Autophagy in liver diseases: A review. Molecular Aspects of Medicine 82, pages 100973.
Crossref
Yilin Sun, Nan Ma, Xiaojing Liu, Junjie Yi & Shengbao Cai. (2021) Preventive effects of Chinese sumac fruits against acetaminophen-induced liver injury in mice via regulating oxidative stress, inflammation and apoptosis. Journal of Functional Foods 87, pages 104830.
Crossref
Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding & Anup Ramachandran. (2021) Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls. Acta Pharmaceutica Sinica B 11:12, pages 3740-3755.
Crossref
Ivan Rusyn, Xabier Arzuaga, Russell C. Cattley, J. Christopher Corton, Stephen S. Ferguson, Patricio Godoy, Kathryn Z. Guyton, Neil Kaplowitz, Salman R. Khetani, Ruth A. Roberts, Robert A. Roth & Martyn T. Smith. (2021) Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity. Hepatology 74:6, pages 3486-3496.
Crossref
Evgenia Dobrinskikh, Saif I. Al-Juboori, Miguel A. Zarate, Lijun Zheng, Robyn De Dios, Durga Balasubramaniyan, Laura G. Sherlock, David J. Orlicky & Clyde J. Wright. (2021) Pulmonary implications of acetaminophen exposures independent of hepatic toxicity. American Journal of Physiology-Lung Cellular and Molecular Physiology 321:5, pages L941-L953.
Crossref
Shaojun Shi, Ling Wang, Luc J.W. van der Laan, Qiuwei Pan & Monique M. A. Verstegen. (2021) Mitochondrial Dysfunction and Oxidative Stress in Liver Transplantation and Underlying Diseases: New Insights and Therapeutics. Transplantation 105:11, pages 2362-2373.
Crossref
Lisa Delahaye, Luc De Baerdemaeker & Christophe P. Stove. (2021) Determination of paracetamol and its metabolites via LC-MS/MS in dried blood volumetric absorptive microsamples: A tool for pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 206, pages 114361.
Crossref
Ajmal Khan, Rehmat Gul, Najeeb Ur Rehman, Haroon Khan, Nasiara Karim, Sobia Ahsan Halim, Sagheer Ahmed & Ahmed Al-Harrasi. (2021) Myrrhanone B and Myrrhanol B from resin of Commipohora mukul exhibit hepatoprotective effects in-vivo. Biomedicine & Pharmacotherapy 143, pages 112131.
Crossref
Meiyu Zhang, Yizhu Wang, Yongxi Wu, Fangtong Li, Mingxin Han, Yulin Dai, Fei Zheng & Hao Yue. (2021) In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-10.
Crossref
Shengyu Cui, Xinhui Zhu, Dawei Xu, Wei Liu, Hong Yi & Jun Yan. (2021) Novel design and combination strategy of minocycline and OECs-loaded CeO 2 nanoparticles with SF for the treatment of spinal cord injury: In vitro and in vivo evaluations . Green Processing and Synthesis 10:1, pages 614-627.
Crossref
Jie Zhao, Xiaotong Lv, Yan Huo, Xiaodi Hu, Xiaochen Li, Shizhuo Sun, Xin Zhao, Xuewei Kong & Jialin Xu. (2021) Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice. International Journal of Molecular Sciences 22:19, pages 10788.
Crossref
EA Ahmed, AM Abd-Eldayem & E Ahmed. (2021) Can granulocyte colony stimulating factor (G-CSF) ameliorate acetaminophen-induced hepatotoxicity?. Human & Experimental Toxicology 40:10, pages 1755-1766.
Crossref
Lihong Gong, Li Liao, Xuyang Dai, Xinyan Xue, Cheng Peng & Yunxia Li. (2021) The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets. Toxicology Letters 351, pages 37-52.
Crossref
Baolin Song, Min Fu, Fang He, Huan Zhao, Yu Wang, Qihang Nie & Bangyuan Wu. (2021) Methionine Deficiency Affects Liver and Kidney Health, Oxidative Stress, and Ileum Mucosal Immunity in Broilers. Frontiers in Veterinary Science 8.
Crossref
Ao Li, Lingxuan Li, Xing Liu, Dongxia Chen, Yifan Fan, Hongyu Lin & Jinhao Gao. (2021) Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19 F MRI nanoprobes . Chemical Communications 57:75, pages 9622-9625.
Crossref
Yanfeng Sun, Yanjian Wan, Ying Jiang & Huaiji Wang. (2021) Urinary concentrations of acetaminophen in young children in central and south China: Repeated measurements and associations with 8-hydroxy-guanosine and 8-hydroxy-2′-deoxyguanosine. Science of The Total Environment 787, pages 147614.
Crossref
Han-You Wu, Xiang-Cheng Zhang, Bing-Bing Jia, Ye Cao, Kai Yan, Jing-Yuan Li, Li Tao, Zhi-Gang Jie & Quan-Wen Liu. (2021) Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway. Journal of Pharmacological Sciences 147:1, pages 143-155.
Crossref
Yoon Seok Jung, Yong-Hoon Kim, Kamalakannan Radhakrishnan, Jina Kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Steven Dooley, Chul-Ho Lee & Hueng-Sik Choi. (2021) Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl4-induced acute liver injury. Archives of Toxicology 95:9, pages 3071-3084.
Crossref
Guo-Chen Liao, Jia-Hua Jhuang & Hsien-Tsung Yao. (2021) Artichoke leaf extract supplementation lowers hepatic oxidative stress and inflammation and increases multidrug resistance-associated protein 2 in mice fed a high-fat and high-cholesterol diet. Food & Function 12:16, pages 7239-7249.
Crossref
Oner Ulger, Gokhan Burcin Kubat, Zehra Cicek, Ertugrul Celik, Ozbeyen Atalay, Serpil Suvay & Mehmet Ozler. (2021) The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats. Life Sciences 279, pages 119669.
Crossref
Md Harunur Rashid, Dinesh Babu & Arno G. Siraki. (2021) Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants. Chemico-Biological Interactions 345, pages 109574.
Crossref
Muhammad Torequl Islam, Cristina Quispe, Md. Amirul Islam, Eunus S. Ali, Sushmita Saha, Umma Hafsa Asha, Milon Mondal, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Manoj Kumar & Javad Sharifi-Rad. (2021) Effects of nerol on paracetamol-induced liver damage in Wistar albino rats. Biomedicine & Pharmacotherapy 140, pages 111732.
Crossref
Bingrui Wang, Jichang Li, Junzhe Jiao, Min Xu, Yichun Luo, Fang Wang, Qiang Xia, Yueqiu Gao, Yu Feng, Xiaoni Kong & Xuehua Sun. (2021) Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response. Aging 13:14, pages 18879-18893.
Crossref
Bret BernerAndrew K. Smith, Ryan C. Kennedy, Brenden K. Petersen, Glen E.P. Ropella & Carver Anthony Hunt. 2021. Drug Delivery Approaches. Drug Delivery Approaches 375 405 .
Agostino Di Ciaula, Giuseppe Calamita, Harshitha Shanmugam, Mohamad Khalil, Leonilde Bonfrate, David Q.-H. Wang, Gyorgy Baffy & Piero Portincasa. (2021) Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests. International Journal of Molecular Sciences 22:14, pages 7702.
Crossref
Yue Zhuo, Yida Zhang, Meng Li, Haiying Wu, Shilin Gong, Xiaolan Hu, Yu Fu, Xinzi Shen, Baoqing Sun, Jian-Lin Wu & Na Li. (2021) Hepatotoxic evaluation of toosendanin via biomarker quantification and pathway mapping of large-scale chemical proteomics. Food and Chemical Toxicology 153, pages 112257.
Crossref
Mohammad Mehdi Ommati, Ali Mobasheri & Reza Heidari. (2021) Drug‐induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies. Journal of Biochemical and Molecular Toxicology 35:7.
Crossref
Hartmut Jaeschke, Olamide B. Adelusi & Anup Ramachandran. (2021) Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?. Gene Expression 20:3, pages 169-178.
Crossref
Jingwen Qu, Haoyuan Niu, Jian Wang, Qiang Wang & Yongjun Li. (2021) Potential mechanism of lead poisoning to the growth and development of ovarian follicle. Toxicology 457, pages 152810.
Crossref
Nirmala Sehrawat, Sushil Kumar Upadhyay, Anil Kumar Sharma, Sunil Kumar & Mukesh Yadav. (2021) Emerging Renoprotective Role of Citrus Flavonoid Naringin: Current Pharmaceutical Status and Future Perspectives. Current Pharmacology Reports 7:3, pages 96-101.
Crossref
Tao Chen, Rui Li & Peng Chen. (2021) Gut Microbiota and Chemical-Induced Acute Liver Injury. Frontiers in Physiology 12.
Crossref
Evgenia Dobrinskikh, Laura G. Sherlock, David J. Orlicky, Lijun Zheng, Robyn De Dios, Durga Balasubramaniyan, Thom Sizemore, Brittany Butler & Clyde J. Wright. (2021) The developing murine lung is susceptible to acetaminophen toxicity. American Journal of Physiology-Lung Cellular and Molecular Physiology 320:5, pages L969-L978.
Crossref
Bo Wang, Ling Liu, Yuejiao Li, Jiaying Zou, Dayong Li, Dan Zhao, Wei Li & Wenxian Sun. (2021) Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Toxicology 456, pages 152786.
Crossref
Verónica Margarita Gutiérrez-Noya, Leobardo Manuel Gómez-Oliván, María del Carmen Ramírez-Montero, Hariz Islas-Flores, Marcela Galar-Martínez & Sandra García-Medina. (2021) Survival and malformations rates, oxidative status in early life stages of Cyprinus carpio due to exposure to environmentally realistic concentrations of paracetamol. Science of The Total Environment 768, pages 144585.
Crossref
Alexandre Louvet, Line Carolle Ntandja Wandji, Elise Lemaître, Marion Khaldi, Claire Lafforgue, Florent Artru, Benoît Quesnel, Guillaume Lassailly, Sébastien Dharancy & Philippe Mathurin. (2021) Acute Liver Injury With Therapeutic Doses of Acetaminophen: A Prospective Study. Hepatology 73:5, pages 1945-1955.
Crossref
Ashaq Hussain RatherRekha Rao. (2021) Evaluation of Antioxidant and Hepatoprotective Activity of Biomass and Crude Astaxanthin extract of Green Alga Haematococcus pluvialis. Research Journal of Pharmacy and Technology, pages 1933-1937.
Crossref
Warunyoo Phannasorn, Arpamas Chariyakornkul, Phumon Sookwong & Rawiwan Wongpoomchai. (2021) Comparative Studies on the Hepatoprotective Effect of White and Coloured Rice Bran Oil against Acetaminophen-Induced Oxidative Stress in Mice through Antioxidant- and Xenobiotic-Metabolizing Systems. Oxidative Medicine and Cellular Longevity 2021, pages 1-13.
Crossref
Dae Won Park, Hyelin Jeon, Jeong Eun Kwon, Young Geun Lee, Rina So, Tae Hwan Choe, Yong Joon Jeong & Se Chan Kang. (2020) Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice. Toxicological Research 37:2, pages 261-275.
Crossref
Luling Wu, Jihong Liu, Xue Tian, Robin R. Groleau, Steven D. Bull, Ping Li, Bo Tang & Tony D. James. (2021) Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury. Chemical Science 12:11, pages 3921-3928.
Crossref
Byoung Ok Cho, Jang Hoon Kim, Denis Nchang Che, Hyun Ju Kang, Jae Young Shin, Suping Hao, Ji Hyeon Park, Feng Wang, Yun Ji Lee & Seon Il Jang. (2021) Kushenol C Prevents Tert-Butyl Hydroperoxide and Acetaminophen-Induced Liver Injury. Molecules 26:6, pages 1635.
Crossref
Marina Villanueva-Paz, Laura Morán, Nuria López-Alcántara, Cristiana Freixo, Raúl J. Andrade, M Isabel Lucena & Francisco Javier Cubero. (2021) Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice. Antioxidants 10:3, pages 390.
Crossref
Brendan Le Daré, Pierre-Jean Ferron & Thomas Gicquel. (2021) Il était une fois l’hépatotoxicité…. médecine/sciences 37:3, pages 235-241.
Crossref
David S Umbaugh, Nga T Nguyen, Hartmut Jaeschke & Anup Ramachandran. (2021) Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure. Toxicological Sciences 180:1, pages 186-195.
Crossref
Boris Khalfin, Alexandra Lichtenstein, Amnon Albeck & Ilana Nathan. (2021) Targeting Necrosis: Elastase-like Protease Inhibitors Curtail Necrotic Cell Death Both In Vitro and in Three In Vivo Disease Models . Journal of Medicinal Chemistry 64:3, pages 1510-1523.
Crossref
Zhao Wang, Fan Zhang, Jianhua Xiong, Zhiqiang Mao & Zhihong Liu. (2021) Investigations of drug-induced liver injury by a peroxynitrite activatable two-photon fluorescence probe. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 246, pages 118960.
Crossref
Lijun Hu, Qiang Ren, Liming Deng, Zongtao Zhou, Zongyu Cai, Bin Wang & Zheng Li. (2021) Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist. European Journal of Medicinal Chemistry 211, pages 113106.
Crossref
Claudio N. Cavasotto & Juan I. Di Filippo. (2021) Artificial intelligence in the early stages of drug discovery. Archives of Biochemistry and Biophysics 698, pages 108730.
Crossref
Lamiaa A. Ahmed, Rana H. Abd El-Rhman, Amany M. Gad, Sherifa K. Hassaneen & Mohamad F. El-Yamany. (2020) Dibenzazepine combats acute liver injury in rats via amendments of Notch signaling and activation of autophagy. Naunyn-Schmiedeberg's Archives of Pharmacology 394:2, pages 337-348.
Crossref
María Teresa Donato & Laia Tolosa. (2021) High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells. Antioxidants 10:1, pages 106.
Crossref
Zhenglai Hua, Rui Liu, Youwen Chen, Guangzhi Liu, Chenxi Li, Yurong Song, Zhiwen Cao, Wen Li, Weifeng Li, Cheng Lu & Yuanyan Liu. (2021) Contamination of Aflatoxins Induces Severe Hepatotoxicity Through Multiple Mechanisms. Frontiers in Pharmacology 11.
Crossref

Displaying 200 of 632 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.