Drug Metabolism Reviews, Volume 44, Issue 1 (2012)

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Drug Metabolism Reviews, Volume 44, Issue 1 (2012)

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Review Article

Review Article
Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling
Dong Dong & Baojian Wu
Pages: 1-17
Published online: 30 Jan 2012
AbstractforSubstrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling | Full Text | References | PDF (2.6 MB)
  • 355 Views
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Review Article
Metabolic activation in drug-induced liver injury
Louis Leung, Amit S. Kalgutkar & R. Scott Obach
Pages: 18-33
Published online: 30 Jan 2012
AbstractforMetabolic activation in drug-induced liver injury | Full Text | References | PDF (1.1 MB)
  • 2100 Views
  • 91 CrossRef citations
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Review Article
Central role of mitochondria in drug-induced liver injury
Dominique Pessayre, Bernard Fromenty, Alain Berson, Marie-Anne Robin, Philippe Lettéron, Richard Moreau & Abdellah Mansouri
Pages: 34-87
Published online: 30 Jan 2012
AbstractforCentral role of mitochondria in drug-induced liver injury | Full Text | References | PDF (2.4 MB)
  • 2792 Views
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Review Article
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
Hartmut Jaeschke, Mitchell R. McGill & Anup Ramachandran
Pages: 88-106
Published online: 30 Jan 2012
AbstractforOxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity | Full Text | References | PDF (1.1 MB)
  • 5279 Views
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Review Article
Role of immune reactions in drug-induced liver injury (DILI)
Cynthia Ju & Timothy Reilly
Pages: 107-115
Published online: 30 Jan 2012
AbstractforRole of immune reactions in drug-induced liver injury (DILI) | Full Text | References | PDF (644.2 KB)
  • 1319 Views
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Review Article
Genetic association studies in drug-induced liver injury
Ann K. Daly & Christopher P. Day
Pages: 116-126
Published online: 30 Jan 2012
AbstractforGenetic association studies in drug-induced liver injury | Full Text | References | PDF (643.7 KB)
  • 1076 Views
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Review Article
Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development
Adrian Hill, Natalie Mesens, Margino Steemans, Jinghai James Xu & Michael D. Aleo
Pages: 127-140
Published online: 30 Jan 2012
AbstractforComparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development | Full Text | References | PDF (766 KB)
  • 1040 Views
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