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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 15, 1998 - Issue 1
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Original Article

The Human Phase Response Curve (Prc) to Melatonin is About 12 Hours out of Phase with the Prc to Light

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Pages 71-83 | Received 24 Jul 1997, Accepted 14 Oct 1997, Published online: 07 Jul 2009

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Naoko Kudo, Hitomi Shinohara, Satoko Kagabu & Hideya Kodama. (2021) Evaluation of salivary melatonin concentrations as a circadian phase maker of morning awakening and their association with depressive mood in postpartum mothers. Chronobiology International 38:10, pages 1409-1420.
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Emma van Andel, Denise Bijlenga, Suzan W. N. Vogel, Aartjan T. F. Beekman & J. J. Sandra Kooij. (2021) Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: a randomized clinical trial. Chronobiology International 38:2, pages 260-269.
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Nyambura Shawa, Dale E Rae & Laura C Roden. (2018) Impact of seasons on an individual’s chronotype: current perspectives. Nature and Science of Sleep 10, pages 345-354.
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Takafumi Fukuda, Atsushi Haraguchi, Masaki Takahashi, Takashi Nakaoka, Mayuko Fukazawa, Jin Okubo, Mamiho Ozaki, Ayana Kanatome, Rena Ohya, Yutaka Miura, Kuniaki Obara & Shigenobu Shibata. (2018) A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. Chronobiology International 35:10, pages 1445-1455.
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Nicole Lovato, Gorica Micic, Michael Gradisar, Sally A. Ferguson, Helen J. Burgess, David J. Kennaway & Leon Lack. (2016) Can the circadian phase be estimated from self-reported sleep timing in patients with Delayed Sleep Wake Phase Disorder to guide timing of chronobiologic treatment?. Chronobiology International 33:10, pages 1376-1390.
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Thomas Roth, Tali Nir & Nava Zisapel. (2015) Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial. Nature and Science of Sleep 7, pages 13-23.
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Ingvild West Saxvig, Ane Wilhelmsen-Langeland, Ståle Pallesen, Øystein Vedaa, Inger Hilde Nordhus & Bjørn Bjorvatn. (2014) A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: Effects on subjective and objective sleep. Chronobiology International 31:1, pages 72-86.
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JJ Sandra Kooij & Denise Bijlenga. (2013) The circadian rhythm in adult attention-deficit/hyperactivity disorder: current state of affairs. Expert Review of Neurotherapeutics 13:10, pages 1107-1116.
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Berndt Eckerberg, Arne Lowden, Roberta Nagai & Torbjörn Åkerstedt. (2012) Melatonin Treatment Effects on Adolescent Students' Sleep Timing and Sleepiness in a Placebo-Controlled Crossover Study. Chronobiology International 29:9, pages 1239-1248.
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Beatriz Baño Otalora, Natalija Popovic, Juan Gambini, Miroljub Popovic, José Viña, Vicent Bonet-Costa, Russel J. Reiter, Pedro Javier Camello, Maria Ángeles Rol & Juan Antonio Madrid. (2012) Circadian System Functionality, Hippocampal Oxidative Stress, and Spatial Memory in the APPswe/PS1dE9 Transgenic Model of Alzheimer Disease: Effects of Melatonin or Ramelteon. Chronobiology International 29:7, pages 822-834.
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Oliver Rawashdeh, Randall L. Hudson, Iwona Stepien & Margarita L. Dubocovich. (2011) Circadian Periods of Sensitivity for Ramelteon on the onset of Running-wheel Activity and the Peak of Suprachiasmatic Nucleus Neuronal Firing Rhythms in C3H/HeN Mice. Chronobiology International 28:1, pages 31-38.
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Sally A Ferguson, Shantha MW Rajaratnam & Drew Dawson. (2010) Melatonin agonists and insomnia. Expert Review of Neurotherapeutics 10:2, pages 305-318.
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Jim Waterhouse. (2009) Melatonin: some introductory comments. Biological Rhythm Research 40:1, pages 3-6.
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Daniel P Cardinali, Seithikurippu R Pandi-Perumal, Venkataramanujan Srinivasan, D Warren Spence & Ilya Trakht. (2008) Therapeutic potential of melatonin agonists. Expert Review of Endocrinology & Metabolism 3:2, pages 269-279.
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Alfred J. Lewy, Jennifer N. Rough, Jeannine B. Songer, Neelam Mishra, Krista Yuhas & Jonathan S. Emens. (2007) The phase shift hypothesis for the circadian component of winter depression. Dialogues in Clinical Neuroscience 9:3, pages 291-300.
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Alfred J. Lewy, Jonathan Emens, Angela Jackman & Krista Yuhas. (2006) Circadian Uses of Melatonin in Humans. Chronobiology International 23:1-2, pages 403-412.
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P. Pévet, L. Agez, B. Bothorel, M. Saboureau, F. Gauer, V. Laurent & M. Masson‐Pévet. (2006) Melatonin in the multi‐oscillatory mammalian circadian world. Chronobiology International 23:1-2, pages 39-51.
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Josephine Arendt. (2006) Melatonin and Human Rhythms. Chronobiology International 23:1-2, pages 21-37.
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Yaron Dagan & Katy Borodkin. (2005) Behavioral and psychiatric consequences of sleep-wake schedule disorders. Dialogues in Clinical Neuroscience 7:4, pages 357-365.
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Mark R. Smith, Clara Lee, Stephanie J. Crowley, Louis F. Fogg & Charmane I. Eastman. (2005) Morning Melatonin Has Limited Benefit as a Soporific For Daytime Sleep After Night Work. Chronobiology International 22:5, pages 873-888.
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Alfred J. Lewy$suffix/text()$suffix/text(), Jonathan S. Emens, Bryan J. Lefler, Krista Yuhas & Angela R. Jackman. (2005) Melatonin Entrains Free‐running Blind People According to a Physiological Dose‐response Curve. Chronobiology International 22:6, pages 1093-1106.
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Alfred J. Lewy. (2003) Clinical applications of melatonin in circadian disorders. Dialogues in Clinical Neuroscience 5:4, pages 399-413.
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Helen J. Burgess, Natasha Savic, Tracey Sletten, Gregory Roach, Saul S. Gilbert & Drew Dawson. (2003) The Relationship Between the Dim Light Melatonin Onset and Sleep on a Regular Schedule in Young Healthy Adults. Behavioral Sleep Medicine 1:2, pages 102-114.
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. (2003) Abstracts. Chronobiology International 20:6, pages 1149-1221.
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Alfred J. Lewy, Jonathan Emens, Robert L. Sack, Brant P. Hasler & Rebecca A. Bernert. (2003) Zeitgeber Hierarchy in Humans: Resetting the Circadian Phase Positions of Blind People Using Melatonin. Chronobiology International 20:5, pages 837-852.
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Andres Magnusson & Diane Boivin. (2003) Seasonal Affective Disorder: An Overview. Chronobiology International 20:2, pages 189-207.
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James Waterhouse, Benjamin Edwards, Sandra Carvalho-bos, Paul Buckley & Thomas Reilly. (2002) Circadian rhythms, jet lag, and shift work, with particular reference to athletes. European Journal of Sport Science 2:6, pages 1-10.
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In-Young Yoon & Byoung-Gun Song. (2002) ROLE OF MORNING MELATONIN ADMINISTRATION AND ATTENUATION OF SUNLIGHT EXPOSURE IN IMPROVING ADAPTATION OF NIGHT-SHIFT WORKERS. Chronobiology International 19:5, pages 903-913.
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Ludger Rensing & Peter Ruoff. (2002) TEMPERATURE EFFECT ON ENTRAINMENT, PHASE SHIFTING, AND AMPLITUDE OF CIRCADIAN CLOCKS AND ITS MOLECULAR BASES. Chronobiology International 19:5, pages 807-864.
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Stacia K. Martin & Charmane I. Eastman. (2002) SLEEP LOGS OF YOUNG ADULTS WITH SELF-SELECTED SLEEP TIMES PREDICT THE DIM LIGHT MELATONIN ONSET. Chronobiology International 19:4, pages 695-707.
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Alfred J. Lewy, Jonathan S. Emens, Robert L. Sack, Brant P. Hasler & Rebecca A. Bernert. (2002) Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period. Chronobiology International 19:3, pages 649-658.
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Harusuke Aoki, Yuji Ozeki & Naoto Yamada. (2001) HYPERSENSITIVITY OF MELATONIN SUPPRESSION IN RESPONSE TO LIGHT IN PATIENTS WITH DELAYED SLEEP PHASE SYNDROME*. Chronobiology International 18:2, pages 263-271.
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J. Waterhouse, B. Edwards, A. Nevill, G. Atkinson, T. Reilly, P. Davies & R. Godfrey. (2000) Do subjective symptoms predict our perception of jet-lag?. Ergonomics 43:10, pages 1514-1527.
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B. J. Edwards, G. Atkinson, J. Waterhouse, T. Reilly, R. Godfrey & R. Budgett. (2000) Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 43:10, pages 1501-1513.
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Charmane I. Eastman, Stacia K. Martin & Marc Hebert. (2000) FAILURE OF EXTRAOCULAR LIGHT TO FACILITATE CIRCADIAN RHYTHM REENTRAINMENT IN HUMANS. Chronobiology International 17:6, pages 807-826.
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Vijay Kumar Sharma, Muniyandi Singaravel, Ramanujam Subbaraj & Maroli K. Chandrashekaran. (1999) Timely Administration of Melatonin Accelerates Reentrainment to Phase-Shifted Light-Dark Cycles in the Field Mouse Mus Booduga. Chronobiology International 16:2, pages 163-170.
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