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Original Article

Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes

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Pages 724-731 | Received 06 Jun 2008, Accepted 29 Apr 2009, Published online: 03 Jun 2010

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Beatriz Coutinho de Sousa, Camila Botelho Miguel, Wellington Francisco Rodrigues, Juliana Reis Machado, Marcos Vinicius da Silva, Thiago Alvares da Costa, Javier Emilio Lazo-Chica, Thatiane do Prado Degasperi, Helioswilton Sales-Campos, Elizabeth Uber Bucek & Carlo José Freire Oliveira. (2017) Effects of short-term consumption of Morinda citrifolia (Noni) fruit juice on mice intestine, liver and kidney immune modulation. Food and Agricultural Immunology 28:3, pages 528-542.
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Uday P. Pratap, Krithika Anand, Fariya Yasmine, Lalgi Hima, Hannah P. Priyanka & Srinivasan Thyagarajan. (2016) Phytochemicals in Morinda citrifolia fruit selectively modulate age-associated immunity and antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats. Journal of Receptors and Signal Transduction 36:2, pages 139-151.
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Mehri Ghafourian Boroujerdnia, Neda Khosravi, Saeed Malek-Hosseini & Zahra Amirghofran. (2014) Augmentation of lymphocytes activation and T cell modulation by the extracts from some Euphorbia species. Pharmaceutical Biology 52:11, pages 1471-1477.
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Christiana Isimi, Ifeoma Obidike, Mercy Aboh & Martins Emeje. (2011) Anti-plasmodial Activity of the Mixed Stem Bark Extracts of Anogeissus leiocarpus and Prosopis africana and in vitro Evaluation of Its Tablet Dosage Form. Journal of Herbs, Spices & Medicinal Plants 17:4, pages 419-435.
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Articles from other publishers (21)

Thị Bạch Tuyết Võ. (2023) Khả năng chống oxy hóa của cao chiết từ quả và rễ cây nhàu (Morinda citrifolia L.). TẠP CHÍ KHOA HỌC TRƯỜNG ĐẠI HỌC QUỐC TẾ HỒNG BÀNG 24, pages 125-130.
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Qingyue Zhang, Yanli Zhao, Yinhao Li, Xiaoyu Guo, Yongmei Guo, Guoqiang Ma, Xiaoshuai Liang & Sumei Yan. (2023) Dietary Polysaccharide-Rich Extract from Noni (Morinda citrifolia L.) Fruit Modified Ruminal Fermentation, Ruminal Bacterial Community and Nutrient Digestion in Cashmere Goats. Animals 13:2, pages 221.
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Qingyue Zhang, Yinhao Li, Guolin Yin, Yuan Li, Yanli Zhao, Xiaoyu Guo, Yongmei Guo & Sumei Yan. (2022) The effects of supplementation of noni ( Morinda citrifolia L.) fruit polysaccharides-rich extract on antioxidant status and immune function in cashmere goats . Journal of Animal Science 100:10.
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Haeyeop Kim, Laily Rahmawati, Yo Han Hong, Su-Young Choi & Jae Youl Cho. (2022) NK cell-mediated immunostimulatory effects of ethanol extract of Morinda citrifolia (noni) fruit. BMC Complementary Medicine and Therapies 22:1.
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Suppawit Utaiwat, Gulsiri Senawong, Kanoknan Khongsukwiwat, Khanutsanan Woranam, Jintana Sattayasai & Thanaset Senawong. (2021) Immunomodulatory Potential of the Industrialized Houttuynia cordata Fermentation Product In Vitro and in Wistar Rats. Foods 10:11, pages 2582.
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Qingfen Wang, Fei Yang, Dandan Jia & Tian Wu. (2021) Polysaccharides and polyphenol in dried Morinda citrifolia fruit tea after different processing conditions: Optimization analysis using response surface methodology . PeerJ 9, pages e11507.
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Marwa I. Ezzat, Mariam Hassan, Mai A. Abdelhalim, Ahmed M. EL-Desoky, Shanaz O. Mohamed & Shahira M. Ezzat. (2021) Immunomodulatory effect of Noni fruit and its isolates: insights into cell-mediated immune response and inhibition of LPS-induced THP-1 macrophage inflammation. Food & Function 12:7, pages 3170-3179.
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Bharat Singh & Ram A. Sharma. (2019) Indian Morinda species: A review. Phytotherapy Research 34:5, pages 924-1007.
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Madhukar Lohani, Mohammed Majrashi, Manoj Govindarajulu, Mansi Patel, Sindhu Ramesh, Dwipayan Bhattacharya, Sneha Joshi, Maali Fadan, Rishi Nadar, Benjamin Darien, Denzil V. Maurice, Barbara Kemppainen & Muralikrishnan Dhanasekaran. (2019) Immunomodulatory actions of a Polynesian herb Noni (Morinda citrifolia) and its clinical applications. Complementary Therapies in Medicine 47, pages 102206.
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Erlintan Sinaga, Syafruddin Ilyas, Salomo Hutahaean & Panal Sitorus. (2019) Immunostimulatory Activity from Pirdot Leaves Ethanolic Extract (Saurauia vulcani Korth.) in Rats (Rattus norvegicus). IOP Conference Series: Earth and Environmental Science 305:1, pages 012082.
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Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Areum Kim, Hyun-Soo Kim, Eui Jeong Han, Hak Ju Kim, Myung Sook Kim, Ginnae Ahn, You-Jin Jeon & Youngheun Jee. (2019) Differential modulation of immune response and cytokine profiles of Sargassum horneri ethanol extract in murine spleen with or without Concanavalin A stimulation. Biomedicine & Pharmacotherapy 110, pages 930-942.
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Mylena Andréa Oliveira Torres, Isadora de Fátima Braga Magalhães, Renata Mondêgo-Oliveira, Joicy Cortez de Sá, Alessandra Lima Rocha & Ana Lucia Abreu-Silva. (2017) One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia . Phytotherapy Research 31:7, pages 971-979.
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Fernando Almeida-Souza, Flávia de Oliveira Cardoso, Bruno Vinicius da Conceição Souza, Tânia Zaverucha do Valle, Joicy Cortez de Sá, Iara dos Santos da Silva Oliveira, Celeste da Silva Freitas de Souza, Carla Junqueira Moragas Tellis, Maria do Socorro dos Santos Chagas, Maria Dutra Behrens, Ana Lúcia Abreu-Silva & Kátia da Silva Calabrese. (2016) Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis. PLOS Neglected Tropical Diseases 10:8, pages e0004900.
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Jai Sunder, Tamilvannan Sujatha & Anandamoy Kundu. (2016) Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review. Journal of Experimental Biology and Agricultural Sciences 4:3S, pages 249-265.
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Pratibha Nerurkar, Phoebe Hwang & Erik Saksa. (2015) Anti-Diabetic Potential of Noni: The Yin and the Yang. Molecules 20:10, pages 17684-17719.
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Kuldeep Dhama, Mani Saminathan, Siju Susan Jacob, Mithilesh Singh, K. Karthik, Amarpal .Ruchi Tiwari, Lakshmi Tulasi Sunkara, Yashpal Singh Malik & Raj Kumar Singh. (2015) Effect of Immunomodulation and Immunomodulatory Agents on Health with some Bioactive Principles, Modes of Action and Potent Biomedical Applications. International Journal of Pharmacology 11:4, pages 253-290.
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Kazuya Murata, Yumi Abe, Megumi Futamura-Masuda, Akemi Uwaya, Fumiyuki Isami & Hideaki Matsuda. (2014) Activation of Cell-mediated Immunity by Morinda citrifolia Fruit Extract and Its Constituents . Natural Product Communications 9:4, pages 1934578X1400900.
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JINHUA LI, LENG-CHEE CHANG, MARISA WALL, D.K.W. WONG, XIANZHONG YU & YANZHANG WEI. (2013) Antitumor activity of fermented noni exudates and its fractions. Molecular and Clinical Oncology 1:1, pages 161-164.
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T. K. LimT. K. Lim. 2013. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 715 753 .
Amy C. Brown. (2012) Anticancer Activity of Morinda citrifolia (Noni) Fruit: A Review. Phytotherapy Research, pages n/a-n/a.
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William P. Clafshenkel, Tracy L. King, Mary P. Kotlarczyk, J. Mark Cline, Warren G. Foster, Vicki L. Davis & Paula A. Witt-Enderby. (2012) Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c- erb B2 Transgene . Evidence-Based Complementary and Alternative Medicine 2012, pages 1-15.
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