5,724
Views
85
CrossRef citations to date
0
Altmetric
Review Article

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & show all
Pages 689-721 | Received 21 Aug 2014, Accepted 15 Sep 2014, Published online: 27 Oct 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (19)

Claudiu T Supuran. (2023) Targeting carbonic anhydrases for the management of hypoxic metastatic tumors. Expert Opinion on Therapeutic Patents 0:0, pages 1-20.
Read now
Haytham O. Tawfik, Amany Belal, Mohammed A. S. Abourehab, Andrea Angeli, Alessandro Bonardi, Claudiu T. Supuran & Mervat H. El-Hamamsy. (2022) Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2765-2785.
Read now
Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
Read now
Muhammad Umair Amin, Sajid Ali, Muhammad Yasir Ali, Dominik C. Fuhrmann, Imran Tariq, Benjamin S. Seitz, Eduard Preis, Jana Brüßler, Bernhard Brüne & Udo Bakowsky. (2022) Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance. Drug Delivery 29:1, pages 2072-2085.
Read now
Liuyun Gong, Yujie Zhang, Chengcheng Liu, Mingzhen Zhang & Suxia Han. (2021) Application of Radiosensitizers in Cancer Radiotherapy. International Journal of Nanomedicine 16, pages 1083-1102.
Read now
Ilaria Dettori, Irene Fusco, Irene Bulli, Lisa Gaviano, Elisabetta Coppi, Federica Cherchi, Martina Venturini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Alessio Nocentini, Claudiu T. Supuran, Anna Maria Pugliese & Felicita Pedata. (2021) Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 964-976.
Read now
Alessio Nocentini, Andrea Angeli, Fabrizio Carta, Jean-Yves Winum, Raivis Zalubovskis, Simone Carradori, Clemente Capasso, William A. Donald & Claudiu T. Supuran. (2021) Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 561-580.
Read now
Claudiu T Supuran. (2020) Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors. Journal of Experimental Pharmacology 12, pages 603-617.
Read now
Blaise Calpe & Werner J. Kovacs. (2020) High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment. Expert Opinion on Drug Discovery 15:8, pages 955-967.
Read now
Claudiu T. Supuran. (2018) Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors. Expert Opinion on Investigational Drugs 27:12, pages 963-970.
Read now
Özlen Güzel-Akdemir, Andrea Angeli, Kübra Demir, Claudiu T. Supuran & Atilla Akdemir. (2018) Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1299-1308.
Read now
Ashok Aspatwar, Holger M. Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila & Jean-Yves Winum. (2018) Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1064-1073.
Read now
Claudiu T. Supuran. (2017) Advances in structure-based drug discovery of carbonic anhydrase inhibitors. Expert Opinion on Drug Discovery 12:1, pages 61-88.
Read now
F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1476-1483.
Read now
Lorenzo Di Cesare Mannelli, Laura Micheli, Fabrizio Carta, Andrea Cozzi, Carla Ghelardini & Claudiu T. Supuran. (2016) Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 894-899.
Read now
Claudiu T. Supuran. (2016) CA IX stratification based on cancer treatment: a patent evaluation of US2016/0002350. Expert Opinion on Therapeutic Patents 26:10, pages 1105-1109.
Read now
Claudiu T. Supuran. (2016) How many carbonic anhydrase inhibition mechanisms exist?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:3, pages 345-360.
Read now
Claudiu T. Supuran. (2016) Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 423-431.
Read now
Shuang Li, Qingzhu Wei, Qin Li, Bin Zhang & Qiang Xiao. (2015) Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer. Cancer Biology & Therapy 16:6, pages 866-875.
Read now

Articles from other publishers (66)

Xiu-wu Pan, Wen-jin Chen, Da Xu, Wen-bin Guan, Lin Li, Jia-xin Chen, Wei-jie Chen, Ke-qin Dong, Jian-qing Ye, Si-shun Gan, Wang Zhou & Xin-gang Cui. (2023) Molecular subtyping and characterization of clear cell renal cell carcinoma by tumor differentiation trajectories. iScience 26:12, pages 108370.
Crossref
Behrouz Ebadi Sharafabad, Asghar Abdoli, Lida Abdolmohammadi Khiav, Maryam Meskini, Parisa Jamur & Azita Dilmaghani. (2023) Therapeutic Potential of Clostridium novyi-NT in Cancer: Current Knowledge and Future Perspectives. Current Cancer Drug Targets 23:9, pages 682-696.
Crossref
Claudiu T. Supuran. (2023) A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation. Bioorganic & Medicinal Chemistry Letters 93, pages 129411.
Crossref
Zikuan Zhang, Bo Wu, Yuan Shao, Yongquan Chen & Dongwen Wang. (2022) A systematic review verified by bioinformatic analysis based on TCGA reveals week prognosis power of CAIX in renal cancer. PLOS ONE 17:12, pages e0278556.
Crossref
Ashok Aspatwar, Martti E. E. Tolvanen, Harlan Barker, Leo Syrjänen, Susanna Valanne, Sami Purmonen, Abdul Waheed, William S. Sly & Seppo Parkkila. (2022) Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology. Physiological Reviews 102:3, pages 1327-1383.
Crossref
Esma Dervisevic, Muamer Dervisevic, Bryan Ang, James Carthew, Kellie L. Tuck, Nicolas H. Voelcker & Victor J. Cadarso. (2022) Integrated microfluidic device to monitor unseen Escherichia coli contamination in mammalian cell culture. Sensors and Actuators B: Chemical 359, pages 131522.
Crossref
X. Joseph, V. Akhil, A. Arathi & PV. Mohanan. (2022) Comprehensive Development in Organ-On-A-Chip Technology. Journal of Pharmaceutical Sciences 111:1, pages 18-31.
Crossref
Maria R. Abbattista, Amir Ashoorzadeh, Christopher P. Guise, Alexandra M. Mowday, Rituparna Mittra, Shevan Silva, Kevin O. Hicks, Matthew R. Bull, Victoria Jackson-Patel, Xiaojing Lin, Gareth A. Prosser, Neil K. Lambie, Gabi U. Dachs, David F. Ackerley, Jeff B. Smaill & Adam V. Patterson. (2021) Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3. Pharmaceuticals 14:12, pages 1231.
Crossref
Amba Datt Pant, Kanetada Nagamine, Eiko Torikai, Ichiro Shiraki, Koichiro Shimomura, Francis L. Pratt, Hiroko Ariga-Miwa, Katsuhiko Ishida & Jerome S. Schultz. (2021) Muonium response to low oxygen levels in haemoglobin and other biological aqueous solutions and potential application towards monitoring hypoxia. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 1011, pages 165561.
Crossref
Claudiu T. Supuran. (2021) Emerging role of carbonic anhydrase inhibitors. Clinical Science 135:10, pages 1233-1249.
Crossref
Irene Bulli, Ilaria Dettori, Elisabetta Coppi, Federica Cherchi, Martina Venturini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Alessio Nocentini, Claudiu T. Supuran, Anna Maria Pugliese & Felicita Pedata. (2021) Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents. International Journal of Molecular Sciences 22:9, pages 5029.
Crossref
Christiana M. Neophytou, Myrofora Panagi, Triantafyllos Stylianopoulos & Panagiotis Papageorgis. (2021) The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities. Cancers 13:9, pages 2053.
Crossref
Tobias Ocklenburg, Fabian Neumann, Alexandra Wolf, Julia Vogel, Kirsten Göpelt, Melanie Baumann, Jennifer Baumann, Philip Kranz, Eric Metzen & Ulf Brockmeier. (2021) In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway. Scientific Reports 11:1.
Crossref
Sha Chen, Songtao Yu, Zaizhi Du, Xie Huang, Meng He, Shuang Long, Jing Liu, Yu Lan, Dong Yang, Hao Wang, Shuhui Li, An Chen, Yuhui Hao, Yongping Su, Changning Wang & Shenglin Luo. (2021) Synthesis of Mitochondria-Anchored Nitroimidazoles with a Versatile NIR Fluorophore for Hypoxic Tumor-Targeting Imaging and Chemoradiotherapy. Journal of Medicinal Chemistry 64:6, pages 3381-3391.
Crossref
Ye Liu, Zahra Mohri, Wissal Alsheikh & Umber Cheema. (2021) The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review. Cancers 13:6, pages 1334.
Crossref
Hasan Al-HabibMargaret Ashcroft. (2021) CHCHD4 (MIA40) and the mitochondrial disulfide relay system. Biochemical Society Transactions 49:1, pages 17-27.
Crossref
Nilesh Malavia, Kaushik Kuche, Rohan Ghadi & Sanyog Jain. (2021) A bird's eye view of the advanced approaches and strategies for overshadowing triple negative breast cancer. Journal of Controlled Release 330, pages 72-100.
Crossref
Alina Küper, Jennifer Baumann, Kirsten Göpelt, Melanie Baumann, Christopher Sänger, Eric Metzen, Philip Kranz & Ulf Brockmeier. (2021) Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis. Cell Death & Disease 12:1.
Crossref
Amir Tofighi Zavareh, Brian Ko, Jason Roberts, Sakib Elahi & Michael J. Mcshane. (2021) A Versatile Multichannel Instrument for Measurement of Ratiometric Fluorescence Intensity and Phosphorescence Lifetime. IEEE Access 9, pages 103835-103849.
Crossref
Seppo Parkkila. 2021. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets 13 36 .
Morten Busk, Jens Overgaard & Michael R. Horsman. (2020) Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions. Seminars in Nuclear Medicine 50:6, pages 562-583.
Crossref
Fabian Liebisch, Andreas Weltin, Julia Marzioch, Gerald A. Urban & Jochen Kieninger. (2020) Zero-consumption Clark-type microsensor for oxygen monitoring in cell culture and organ-on-chip systems. Sensors and Actuators B: Chemical 322, pages 128652.
Crossref
Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy M. Eldehna, Clemente Capasso, Giuseppina De Simone, Simona Maria Monti, Simone Carradori, William A. Donald, Shoukat Dedhar & Claudiu T. Supuran. (2020) Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment. Metabolites 10:10, pages 412.
Crossref
Liliana Silva, Pedro Coelho, Dulce Teixeira, Armanda Monteiro, Gabriela Pinto, Raquel Soares, Cristina Prudêncio & Mónica Vieira. (2020) Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives. Anti-Cancer Agents in Medicinal Chemistry 20:1, pages 111-120.
Crossref
Carol Ward, James Meehan, Mark E Gray, Alan F Murray, David J Argyle, Ian H Kunkler & Simon P Langdon. (2020) The impact of tumour pH on cancer progression: strategies for clinical intervention. Exploration of Targeted Anti-tumor Therapy 1:2, pages 71-100.
Crossref
Rodolfo Garza-Morales, Beatriz E. Rendon, Mohammad Tariq Malik, Jeannete E. Garza-Cabrales, Anne Aucouturier, Luis G. Bermúdez-Humarán, Kelly M. McMasters, Lacey R. McNally & Jorge G. Gomez-Gutierrez. (2020) Targeting Melanoma Hypoxia with the Food-Grade Lactic Acid Bacterium Lactococcus Lactis. Cancers 12:2, pages 438.
Crossref
Feiyun Cui, Zhiru Zhou & H. Susan Zhou. (2020) Review—Measurement and Analysis of Cancer Biomarkers Based on Electrochemical Biosensors. Journal of The Electrochemical Society 167:3, pages 037525.
Crossref
Kaye J. Williams & Roben G. Gieling. (2019) Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers. International Journal of Molecular Sciences 20:23, pages 6080.
Crossref
Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai & Margaret Ashcroft. (2019) CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism. Cancer & Metabolism 7:1.
Crossref
Hoang-Phuong Phan, Mostafa Kamal Masud, Raja Kumar Vadivelu, Toan Dinh, Tuan-Khoa Nguyen, Kieu Ngo, Dzung Viet Dao, Muhammad J. A. Shiddiky, Md Shahriar A. Hossain, Yusuke Yamauchi & Nam-Trung Nguyen. (2019) Transparent crystalline cubic SiC-on-glass electrodes enable simultaneous electrochemistry and optical microscopy. Chemical Communications 55:55, pages 7978-7981.
Crossref
Liliana Silva, Pedro Coelho, Raquel Soares, Cristina Prudêncio & Mónica Vieira. (2019) Quinoxaline-1,4-dioxide derivatives inhibitory action in melanoma and brain tumor cells. Future Medicinal Chemistry 11:7, pages 645-657.
Crossref
Wei Li & Yubo Zhou. (2019) LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial–mesenchymal transition. Bioscience Reports 39:1.
Crossref
Dean C. Singleton & Adrian L. Harris. 2019. The Unfolded Protein Response in Cancer. The Unfolded Protein Response in Cancer 75 108 .
Jordan Morreall, Feng Hong & Zihai Li. 2019. The Unfolded Protein Response in Cancer. The Unfolded Protein Response in Cancer 49 74 .
Carol Ward, James Meehan, Mark Gray, Ian H. Kunkler, Simon P. Langdon, Alan Murray & David Argyle. 2021. Three Dimensional Human Organotypic Models for Biomedical Research. Three Dimensional Human Organotypic Models for Biomedical Research 225 246 .
Hoon Kim, Qun Lin, Peter M. Glazer & Zhong Yun. (2018) The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Research 20:1.
Crossref
Julia Marzioch, Jochen Kieninger, Andreas Weltin, Hubert Flamm, Kuppusamy Aravindalochanan, Joe A. Sandvik, Erik O. Pettersen, Qian Peng & Gerald A. Urban. (2018) On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors. Lab on a Chip 18:22, pages 3353-3360.
Crossref
Athina Angelopoulou, Argiris Kolokithas-Ntoukas, Ligeri Papaioannou, Zacharias Kakazanis, Nikolas Khoury, Vassilis Zoumpourlis, Spyridon Papatheodorou, Dimitrios Kardamakis, Aristides Bakandritsos, Sophia Hatziantoniou & Konstantinos Avgoustakis. (2018) Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy. Nanomedicine 13:19, pages 2435-2454.
Crossref
Eloy Moreno Roig, Ala Yaromina, Ruud Houben, Arjan J. Groot, Ludwig Dubois & Marc Vooijs. (2018) Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis. Frontiers in Oncology 8.
Crossref
Justina Kazokaitė, Raymon Niemans, Virginija Dudutienė, Holger M. Becker, Jānis Leitāns, Asta Zubrienė, Lina Baranauskienė, Gabor Gondi, Reinhard Zeidler, Jurgita Matulienė, Kaspars Tārs, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois & Daumantas Matulis. (2018) Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget 9:42, pages 26800-26816.
Crossref
Sara Carvalho, Ralph T. H. Leijenaar, Esther G. C. Troost, Janna E. van Timmeren, Cary Oberije, Wouter van Elmpt, Lioe-Fee de Geus-Oei, Johan Bussink & Philippe Lambin. (2018) 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) – A prospective externally validated study. PLOS ONE 13:3, pages e0192859.
Crossref
Stine Gyland Mikalsen, Nina Jeppesen Edin, Joe Alexander Sandvik & Erik Olai Pettersen. (2017) Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia. Acta Radiologica 59:1, pages 26-33.
Crossref
Ahmed Salem, Marie-Claude Asselin, Bart Reymen, Alan Jackson, Philippe Lambin, Catharine M L West, James P B O’Connor & Corinne Faivre-Finn. (2018) Targeting Hypoxia to Improve Non–Small Cell Lung Cancer Outcome. JNCI: Journal of the National Cancer Institute 110:1, pages 14-30.
Crossref
Jochen Kieninger, Andreas Weltin, Hubert Flamm & Gerald A. Urban. (2018) Microsensor systems for cell metabolism – from 2D culture to organ-on-chip. Lab on a Chip 18:9, pages 1274-1291.
Crossref
Marta Ferraroni, Benedetta Cornelio, Janos Sapi, Claudiu T. Supuran & Andrea Scozzafava. (2018) Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms. Inorganica Chimica Acta 470, pages 128-132.
Crossref
Martin Brischwein & Joachim Wiest. 2019. Label-Free Monitoring of Cells in vitro. Label-Free Monitoring of Cells in vitro 163 188 .
Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Claudiu Supuran & Stefano Fais. (2017) Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy. Metabolites 8:1, pages 2.
Crossref
Claudiu T. Supuran. (2017) Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors. Metabolites 7:3, pages 48.
Crossref
Roh-Eul Yoo, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Sung-Hye Park, Jae-Kyung Won, Il Han Kim, Soon Tae Lee, Hye Jeong Choi, Sung-Hye You, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim & Chul-Ho Sohn. (2016) Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study. European Radiology 27:8, pages 3156-3166.
Crossref
Amarnath Challapalli, Laurence Carroll & Eric O. Aboagye. (2017) Molecular mechanisms of hypoxia in cancer. Clinical and Translational Imaging 5:3, pages 225-253.
Crossref
Fabrizio Carta, Daniela Vullo, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs. Bioorganic & Medicinal Chemistry 25:9, pages 2569-2576.
Crossref
Menshawy A. Mohamed, Alaa A.-M. Abdel-Aziz, Helmy M. Sakr, Adel S. El-Azab, Silvia Bua & Claudiu T. Supuran. (2017) Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties. Bioorganic & Medicinal Chemistry 25:8, pages 2524-2529.
Crossref
Simon J.A. van Kuijk, Nanda Kumar Parvathaneni, Raymon Niemans, Marike W. van Gisbergen, Fabrizio Carta, Daniela Vullo, Silvia Pastorekova, Ala Yaromina, Claudiu T. Supuran, Ludwig J. Dubois, Jean-Yves Winum & Philippe Lambin. (2017) New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs. European Journal of Medicinal Chemistry 127, pages 691-702.
Crossref
Seung-Hyun Jeong, You-Jin Jeon & Sun Joo Park. (2016) Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells. Molecular Medicine Reports 14:6, pages 5148-5154.
Crossref
Ruben T. H. M. Larue, Lien Van De Voorde, Maaike Berbée, Wouter J. C. van Elmpt, Ludwig J. Dubois, Kranthi M. Panth, Sarah G. J. A. Peeters, Ann Claessens, Wendy M. J. Schreurs, Marius Nap, Fabiënne A. R. M. Warmerdam, Frans L. G. Erdkamp, Meindert N. Sosef & Philippe Lambin. (2016) A phase 1 ‘window-of-opportunity’ trial testing evofosfamide (TH-302), a tumour-selective hypoxia-activated cytotoxic prodrug, with preoperative chemoradiotherapy in oesophageal adenocarcinoma patients. BMC Cancer 16:1.
Crossref
Haiwen Chen, Qi Chen & Qidong Luo. (2016) Expression of netrin-1 by hypoxia contributes to the invasion and migration of prostate carcinoma cells by regulating YAP activity. Experimental Cell Research 349:2, pages 302-309.
Crossref
Javad Garousi, Hadis Honarvar, Ken G. Andersson, Bogdan Mitran, Anna Orlova, Jos Buijs, John Löfblom, Fredrik Y. Frejd & Vladimir Tolmachev. (2016) Comparative Evaluation of Affibody Molecules for Radionuclide Imaging of in Vivo Expression of Carbonic Anhydrase IX. Molecular Pharmaceutics 13:11, pages 3676-3687.
Crossref
J Marzioch, J Kieninger, J A Sandvik, E O Pettersen, Q Peng & G Urban. (2016) Electrochemical microsensor system for cancer research on photodynamic therapy in vitro . Journal of Physics: Conference Series 757, pages 012002.
Crossref
Ninna Aggerholm-Pedersen, Brita Singers Sørensen, Jens Overgaard, Kasper Toustrup, Steen Baerentzen, Ole Steen Nielsen, Katja Maretty-Kongstad, Marianne Nordsmark, Jan Alsner & Akmal Safwat. (2016) A prognostic profile of hypoxia-induced genes for localised high-grade soft tissue sarcoma. British Journal of Cancer 115:9, pages 1096-1104.
Crossref
Sarah E. Corcoran & Luke A.J. O’Neill. (2016) HIF1α and metabolic reprogramming in inflammation. Journal of Clinical Investigation 126:10, pages 3699-3707.
Crossref
Simon J. A. van Kuijk, Roben G. Gieling, Raymon Niemans, Natasja G. Lieuwes, Rianne Biemans, Brian A. Telfer, Guido R. M. M. Haenen, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois & Kaye J. Williams. (2016) The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy. PLOS ONE 11:8, pages e0161040.
Crossref
Simon J. A. van Kuijk, Ala Yaromina, Ruud Houben, Raymon Niemans, Philippe Lambin & Ludwig J. Dubois. (2016) Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis. Frontiers in Oncology 6.
Crossref
Alessandra Cincinelli, Tania Martellini, Daniela Vullo & Claudiu T. Supuran. (2015) Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. Bioorganic & Medicinal Chemistry Letters 25:23, pages 5485-5489.
Crossref
Alfonso Maresca, Gulay Akyuz, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2015) Inhibition of mammalian carbonic anhydrase isoforms I–XIV with a series of phenolic acid esters. Bioorganic & Medicinal Chemistry 23:22, pages 7181-7188.
Crossref
Samantha Grist, Jonathan Schmok, Meng-Chi Liu, Lukas Chrostowski & Karen Cheung. (2015) Designing a Microfluidic Device with Integrated Ratiometric Oxygen Sensors for the Long-Term Control and Monitoring of Chronic and Cyclic Hypoxia. Sensors 15:8, pages 20030-20052.
Crossref
Shuang Li & Qin Li. (2015) Cancer stem cells, lymphangiogenesis, and lymphatic metastasis. Cancer Letters 357:2, pages 438-447.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.