843
Views
24
CrossRef citations to date
0
Altmetric
Research Article

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring

, , , &
Pages 773-777 | Received 08 Sep 2014, Accepted 24 Sep 2014, Published online: 12 Feb 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
Read now
Claudiu T. Supuran. (2020) Coumarin carbonic anhydrase inhibitors from natural sources. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1462-1470.
Read now
Hasan Küçükbay, Zeynep Gönül, F. Zehra Küçükbay, Andrea Angeli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1021-1026.
Read now
Alessio Nocentini & Claudiu T. Supuran. (2019) Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery. Expert Opinion on Drug Discovery 14:11, pages 1175-1197.
Read now
Claudiu T. Supuran. (2017) Advances in structure-based drug discovery of carbonic anhydrase inhibitors. Expert Opinion on Drug Discovery 12:1, pages 61-88.
Read now
Murat Bozdag, Silvia Bua, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Carbonic anhydrase I, II, IV and IX inhibition with a series of 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 885-892.
Read now
Elif Unluer, Halise Inci Gul, Alkan Demirtas, Hiroshi Sakagami, Naoki Umemura, Muhammet Tanc, Cavit Kazaz & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 105-109.
Read now
Burhanettin Turan, Kivilcim Şendil, Emin Şengül, Mehmet Serdar Gültekin, Parham Taslimi, İlhami Gulçin & Claudiu T. Supuran. (2016) The synthesis of some β-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup1, pages 79-88.
Read now
F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1476-1483.
Read now
F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1198-1202.
Read now
Afsun Sujayev, Leyla Polat Kose, Emin Garibov, İlhami Gülçin, Vagif Farzaliev, Saleh H. Alwasel & Claudiu T. Supuran. (2016) Synthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1192-1197.
Read now
Claudiu T. Supuran. (2016) How many carbonic anhydrase inhibition mechanisms exist?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:3, pages 345-360.
Read now

Articles from other publishers (12)

Shivangi Jaiswal, Nikhilesh Arya, Neetu Yaduvanshi, Meenu Devi, Sonika Jain, Smita Jain, Jaya Dwivedi & Swapnil Sharma. (2023) Current updates on green synthesis and biological properties of 4-quinolone derivatives. Journal of Molecular Structure 1294, pages 136565.
Crossref
Satyajit Khatua & Srabani Taraphder. (2023) Dynamics of an inhibitor at and away from an out-of-active site binding location in human carbonic anhydrase II. Chemical Physics Impact 7, pages 100329.
Crossref
Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 298 329 .
Simone Giovannuzzi, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2022) Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII. Molecules 27:13, pages 4076.
Crossref
Hasan Küçükbay, Zeynep Gönül, Fatümetüzzehra Zehra Küçükbay, Zehra Tekin, Andrea Angeli, Gianluca Bartolucci, Claudiu T. Supuran, Eray Tatlıcı, Elif Apohan & Özfer Yeşilada. (2021) Synthesis of new 7‐amino‐3,4‐dihydroquinolin‐2(1 H )‐one‐peptide derivatives and their carbonic anhydrase enzyme inhibition, antioxidant, and cytotoxic activities . Archiv der Pharmazie 354:11.
Crossref
Claudiu T. Supuran. 2021. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications 115 131 .
Chandra B. Mishra, Manisha Tiwari & Claudiu T. Supuran. (2020) Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?. Medicinal Research Reviews 40:6, pages 2485-2565.
Crossref
Prashant Dhiman, Nidhi Arora, Punniyakoti Veeraveedu Thanikachalam & Vikramdeep Monga. (2019) Recent advances in the synthetic and medicinal perspective of quinolones: A review. Bioorganic Chemistry 92, pages 103291.
Crossref
Claudiu T. Supuran & Andrea Scozzafava. 2019. Carbonic Anhydrases. Carbonic Anhydrases 245 255 .
Alessio Nocentini & Claudiu T. Supuran. 2019. Carbonic Anhydrases. Carbonic Anhydrases 3 16 .
Claudiu T. Supuran, Vincenzo Alterio, Anna Di Fiore, Katia D’ Ambrosio, Fabrizio Carta, Simona Maria Monti & Giuseppina De Simone. (2018) Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one. Medicinal Research Reviews 38:6, pages 1799-1836.
Crossref
Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M. Osman, Zeid AlOthman, William A. Donald, Claudiu T. Supuran & Clemente Capasso. (2017) Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. Bioorganic & Medicinal Chemistry Letters 27:3, pages 490-495.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.