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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 1
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Short Communication

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

Ahmed ElkamhawyChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon, South Korea,
,
Jung-eun ParkChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea,
,
Nam-Chul ChoCenter of Neuromedicine, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biotechnology, Yonsei University, Seoul, South Korea, and
,
Taebo SimChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon, South Korea, ;KU-KIST Graduate School of Converging Science and Technology, Seoul, South Korea
,
Ae Nim PaeCenter of Neuromedicine, Korea Institute of Science and Technology (KIST), Seoul, South Korea,
&
Eun Joo RohChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon, South Korea, Correspondence[email protected]
Pages 158-166 | Received 15 Sep 2014, Accepted 24 Dec 2014, Published online: 25 Mar 2015

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Ahmed Elkamhawy, Eslam M. H. Ali & Kyeong Lee. (2021) New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insights. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1572-1600.
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Sofia Sagredou, Panagiotis Dalezis, Nikolaos Nikoleousakos, Michail Nikolaou, Maria Voura, Konstantinos Almpanakis, Mihalis I Panayiotidis, Vasiliki Sarli & Dimitrios T Trafalis. (2020) 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha. OncoTargets and Therapy 13, pages 7369-7386.
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Elodie Henriet, Margaux Sala, Aya Abou Hammoud, Adjanie Tuariihionoa, Julie Di Martino, Manon Ros & Frédéric Saltel. (2018) Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer. Cell Adhesion & Migration 12:4, pages 363-377.
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Articles from other publishers (19)

Zukela Ruzi, Khurshed Bozorov, Lifei Nie, Jiangyu Zhao & Haji Akber Aisa. (2023) Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties. Bioorganic Chemistry 135, pages 106506.
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Ganesh Prasad Shenoy, Rohit Pal, Gurubasavaraja Swamy Purwarga Matada, Ekta Singh, Nulgumnalli Manjunathaiah Raghavendra & Prasad Sanjay Dhiwar. (2023) Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship. Bioorganic Chemistry 130, pages 106215.
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Xiaoli Li, Huiling Chen & Dekui Zhang. (2022) Discoidin domain receptor 1 may be involved in biological barrier homeostasis. Journal of Clinical Pharmacy and Therapeutics 47:12, pages 2397-2407.
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Hossam Nada, Kyeong Lee, Lizaveta Gotina, Ae Nim Pae & Ahmed Elkamhawy. (2022) Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches. Computers in Biology and Medicine 142, pages 105217.
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William A. Denny & Jack U. Flanagan. (2021) Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation. Biomolecules 11:11, pages 1671.
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Ahmed Elkamhawy, Usama M. Ammar, Sora Paik, Magda H. Abdellattif, Mohamed H. Elsherbeny, Kyeong Lee & Eun Joo Roh. (2021) Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening. Molecules 26:17, pages 5324.
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Mohamed H. Elsherbeny, Ahmed Elkamhawy, Hossam Nada, Magda H. Abdellattif, Kyeong Lee & Eun Joo Roh. (2021) Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity. Biomedicines 9:9, pages 1131.
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Ahmed Elkamhawy, Qili Lu, Hossam Nada, Jiyu Woo, Guofeng Quan & Kyeong Lee. (2021) The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer. International Journal of Molecular Sciences 22:12, pages 6535.
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Sofia Sagredou, Panagiotis Dalezis, Eirini Papadopoulou, Maria Voura, Maria V. Deligiorgi, Michail Nikolaou, Mihalis I. Panayiotidis, George Nasioulas, Vasiliki Sarli & Dimitrios T. Trafalis. (2021) Effects of a Novel Thiadiazole Derivative with High Anticancer Activity on Cancer Cell Immunogenic Markers: Mismatch Repair System, PD-L1 Expression, and Tumor Mutation Burden. Pharmaceutics 13:6, pages 885.
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Pushkar Saralkar, Alexander Mdzinarishvili, Tasneem A Arsiwala, Yoon-Kwang Lee, Patrick G. Sullivan, Mark V. Pinti, John M. Hollander, Eric E. Kelley, Xuefang Ren, Heng Hu, James Simpkins, Candice Brown, Lori E. Hazlehurst, Jason D. Huber & Werner J. Geldenhuys. (2021) The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke. Pharmaceutical Research 38:5, pages 803-817.
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Sandra Majo & Patrick Auguste. (2021) The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development. Cancers 13:7, pages 1725.
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Dimitrios T. Trafalis, Sofia Sagredou, Panayiotis Dalezis, Maria Voura, Stella Fountoulaki, Nikolaos Nikoleousakos, Konstantinos Almpanakis, Maria V. Deligiorgi & Vasiliki Sarli. (2021) Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation. Pharmaceutics 13:4, pages 493.
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Yuan Gao, Jiuli Zhou & Jin Li. (2021) Discoidin domain receptors orchestrate cancer progression: A focus on cancer therapies. Cancer Science 112:3, pages 962-969.
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Hossam Nada, Ahmed Elkamhawy & Kyeong Lee. (2021) Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer. Molecules 26:3, pages 553.
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Yaling Zhang, Qiaoli Hou, Xiabing Li, Jiuling Zhu, Wei Wang, Baolin Li, Lijun Zhao & Haibin Xia. (2019) Enrichment of novel quinazoline derivatives with high antitumor activity in mitochondria tracked by its self-fluorescence. European Journal of Medicinal Chemistry 178, pages 417-432.
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Coralie Reger de Moura, Maxime Battistella, Anjum Sohail, Anne Caudron, Jean Paul Feugeas, Marie‐Pierre Podgorniak, Cecile Pages, Sarra Mazouz Dorval, Oren Marco, Suzanne Menashi, Rafael Fridman, Celeste Lebbé, Samia Mourah & Fanélie Jouenne. (2019) Discoidin domain receptors: A promising target in melanoma. Pigment Cell & Melanoma Research.
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Runjhun Tandon, Iqubal Singh, Vijay Luxami, Nitin Tandon & Kamaldeep Paul. (2018) Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines . The Chemical Record 19:2-3, pages 362-393.
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Zhen Wang, Yali Zhang, Sergio G. BartualJinfeng Luo, Tingting Xu, Wenting Du, Qiuju Xun, Zhengchao Tu, Rolf A. Brekken, Xiaomei Ren, Alex N. BullockGuang Liang, Xiaoyun Lu & Ke Ding. (2017) Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Medicinal Chemistry Letters 8:3, pages 327-332.
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Zhen Wang, Huan Bian, Sergio G. BartualWenting Du, Jinfeng Luo, Hu Zhao, Shasha Zhang, Cheng Mo, Yang Zhou, Yong Xu, Zhengchao Tu, Xiaomei Ren, Xiaoyun Lu, Rolf A. Brekken, Libo Yao, Alex N. BullockJin Su & Ke Ding. (2016) Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. Journal of Medicinal Chemistry 59:12, pages 5911-5916.
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