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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 45, 2017 - Issue 3
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Original Articles

Preparation and characterization of PLGA-β-CD polymeric nanoparticles containing methotrexate and evaluation of their effects on T47D cell line

Fatemeh GorjikhahDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran;
,
Farid Azizi JalalianDepartment of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran;
,
Roya SalehiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran;
,
Yunes PanahiChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;
,
Arash HasanzadehLaboratory of Biochemistry, Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran;
,
Effat AlizadehDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
,
Abolfazl AkbarzadehDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected]
&
Soodabeh DavaranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected]
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Pages 432-440 | Received 15 Dec 2015, Accepted 27 Feb 2016, Published online: 22 Mar 2016

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Dilip Patil, Sopan Nangare, Gaurav Patil, Kalpesh Nerkar & Ganesh Patil. (2023) Development of thiolated polyethylene glycol-poly (lactic-co-glycolic acid) co-polymeric nanoparticles for intranasal delivery of quetiapine: in vitro–ex vivo characterization. International Journal of Polymeric Materials and Polymeric Biomaterials 72:9, pages 714-724.
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Hossein Danafar, Hoda Jaberizadeh & Sina Andalib. (2018) In vitro and in vivo delivery of gliclazide loaded mPEG-PCL micelles and its kinetic release and solubility study. Artificial Cells, Nanomedicine, and Biotechnology 46:8, pages 1625-1636.
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Rabia Cakir-Koc, Yasemin Budama-Kilinc, Yagmur Kokcu & Serda Kecel-Gunduz. (2018) Molecular docking of immunogenic peptide of Toxoplasma gondii and encapsulation with polymer as vaccine candidate. Artificial Cells, Nanomedicine, and Biotechnology 46:sup2, pages 744-754.
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Sivaraj Ramasamy, Rex Jeya Rajkumar Sam David & Israel V. M. V. Enoch. (2018) Folate-molecular encapsulator-tethered biocompatible polymer grafted with magnetic nanoparticles for augmented drug delivery. Artificial Cells, Nanomedicine, and Biotechnology 46:sup2, pages 675-682.
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S. Rajalakshmi, Niraj Vyawahare, Atmaram Pawar, Paresh Mahaparale & Bothiraja Chellampillai. (2018) Current development in novel drug delivery systems of bioactive molecule plumbagin. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 209-218.
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Farzaneh Salimi, Karim Akbari Dilmaghani, Effat Alizadeh, Abolfazl Akbarzadeh & Soodabeh Davaran. (2018) Enhancing cisplatin delivery to hepatocellular carcinoma HepG2 cells using dual sensitive smart nanocomposite. Artificial Cells, Nanomedicine, and Biotechnology 46:5, pages 949-958.
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Azizeh Rahmani Del Bakhshayesh, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Mohammad Samiei, Effat Alizadeh, Mohammadreza Alizadeh-Ghodsi, Soodabeh Davaran & Azadeh Montaseri. (2018) Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering. Artificial Cells, Nanomedicine, and Biotechnology 46:4, pages 691-705.
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Saeideh Abdolahpour, Tayebeh Toliyat, Kobra Omidfar, Helmout Modjtahedi, Albert J. Wong, Mohammad Javad Rasaee, Susan Kashanian & Maliheh Paknejad. (2018) Targeted delivery of doxorubicin into tumor cells by nanostructured lipid carriers conjugated to anti-EGFRvIII monoclonal antibody. Artificial Cells, Nanomedicine, and Biotechnology 46:1, pages 89-94.
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Li Zhu, Hongjiao Li, Jiyu Li, Yuan Zhong, Shuai Wu, Meng Yan, Sheng Ni, Kun Zhang, Guixue Wang, Kai Qu, Deqin Yang, Xian Qin & Wei Wu. (2023) Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis. Journal of Nanobiotechnology 21:1.
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Mahwash Mukhtar, Amanda-Lee Ezra Manicum, Masoumeh Shojaei Barjouei, Rahime Eshaghi Malekshah, Razieh Behzadmehr, Abbas Rahdar, Suresh Ghotekar & Francesco Baino. (2023) Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review. Frontiers in Biomaterials Science 2.
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Zahra Taran, Sepideh Yektaniroumand Digehsaraei, Mojtaba Salouti, Bahram Amini, Sanaz Mahmazi & Mohsen Kalantari. (2023) Methotrexate loaded in alginate beads for controlled drug release against breast cancer. Gene 851, pages 146941.
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Miaomiao Yan, Jing Li, Xiulian Gu, Xinyi Hou, Yue Ma, Haoyu Cui, Chuanxing Feng, Liying Ma & Guangcheng Wei. (2022) Development of Drug Carriers with Biocompatibility Based On Human Serum Albumin and β-Cyclodextrin Molecules and Study of Anticancer Activity. Langmuir 38:45, pages 13686-13696.
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Anandakrishnan Karthic, Arpita Roy, Jaya Lakkakula, Saad Alghamdi, Afnan Shakoori, Ahmad O. Babalghith, Talha Bin Emran, Rohit Sharma, Clara Mariana Gonçalves Lima, Bonglee Kim, Moon Nyeo Park, Sher Zaman Safi, Ray Silva de Almeida & Henrique Douglas Melo Coutinho. (2022) Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review. Frontiers in Cell and Developmental Biology 10.
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Ali Sartaj, Zufika Qamar, Farheen Fatima Qizilbash, Annu, Shadab Md, Nabil A. Alhakamy, Sanjula Baboota & Javed Ali. (2021) Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations. Polymers 13:24, pages 4400.
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Abhishek Pandey. (2021) Cyclodextrin-based nanoparticles for pharmaceutical applications: a review. Environmental Chemistry Letters 19:6, pages 4297-4310.
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Akram Rahmani, Fariborz Rahimi, Mehrdad Iranshahi, Houman Kahroba, Amir Zarebkohan, Mehdi Talebi, Roya Salehi & Hassan Zavvar Mousavi. (2021) Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells. Scientific Reports 11:1.
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Dhananjay Jadhav & Pradeep Vavia. (2021) Dexamethasone Sodium Phosphate Loaded Modified Cyclodextrin Based Nanoparticles: An Efficient Treatment for Rheumatoid Arthritis. Journal of Pharmaceutical Sciences 110:3, pages 1206-1218.
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Sanyog Jain, Kaisar Raza, Ashish Kumar Agrawal & Ankur Vaidya. 2021. Nanotechnology Applications for Cancer Chemotherapy. Nanotechnology Applications for Cancer Chemotherapy 341 350 .
Abhishek Pandey. 2020. The History of Cyclodextrins. The History of Cyclodextrins 305 343 .
Ji-Hun Jang, Seung-Hyun Jeong & Yong-Bok Lee. (2019) Preparation and In Vitro/In Vivo Characterization of Polymeric Nanoparticles Containing Methotrexate to Improve Lymphatic Delivery. International Journal of Molecular Sciences 20:13, pages 3312.
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Leniher Castan Chibas, Priscila Pavini Cintra, Monique Rodrigues Moreira, Mirian Oliveira Goulart, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos & Raquel Alves dos Santos. (2019) Polyalthic Acid in Polymeric Nanoparticles Causes Selective Growth Inhibition and Genotoxicity in MCF-7 Cells. Natural Product Communications 14:4, pages 1934578X1984270.
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Paula dos Passos Menezes, Tatianny de Araújo Andrade, Luiza Abrahão Frank, Eloísa Portugal Barros Silva Soares de Souza, Gabriela das Graças Gomes Trindade, Igor Araújo Santos Trindade, Mairim Russo Serafini, Sílvia Stanisçuaski Guterres & Adriano Antunes de Souza Araújo. (2019) Advances of nanosystems containing cyclodextrins and their applications in pharmaceuticals. International Journal of Pharmaceutics 559, pages 312-328.
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Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi & Hossein Danafar. (2018) Amphiphilic Y shaped miktoarm star copolymer for anticancer hydrophobic and hydrophilic drugs codelivery: Synthesis, characterization, in vitro , and in vivo biocompatibility study . Journal of Biomedical Materials Research Part A 106:11, pages 2817-2826.
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Sara Gholizadeh-Ghaleh Aziz & Hadi Almasi. (2018) Physical Characteristics, Release Properties, and Antioxidant and Antimicrobial Activities of Whey Protein Isolate Films Incorporated with Thyme (Thymus vulgaris L.) Extract-Loaded Nanoliposomes. Food and Bioprocess Technology 11:8, pages 1552-1565.
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Alice R. de Oliveira, Philippe C. Mesquita, Paula R.L. Machado, Kleber J.S. Farias, Yêda M.B. de Almeida, Matheus F. Fernandes-Pedrosa, Alianda M. Cornélio, Eryvaldo Sócrates T. do Egito & Arnóbio A. da Silva-Júnior. (2017) Monitoring structural features, biocompatibility and biological efficacy of gamma-irradiated methotrexate-loaded spray-dried microparticles. Materials Science and Engineering: C 80, pages 438-448.
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Anupama Singh, Nagarani Thotakura, Rajendra Kumar, Bhupinder Singh, Gajanand Sharma, Om Prakash Katare & Kaisar Raza. (2017) PLGA-soya lecithin based micelles for enhanced delivery of methotrexate: Cellular uptake, cytotoxic and pharmacokinetic evidences. International Journal of Biological Macromolecules 95, pages 750-756.
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