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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 10
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Clinical Pharmacokinetics and Metabolism

Human mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor

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Pages 887-902 | Received 20 Jan 2015, Accepted 04 Mar 2015, Published online: 19 May 2015

References

  • Aksoy IA, Sochorová V, Weinshilboum RM. (1993). Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variation. Clin Pharmacol Ther 54:498–506
  • Chen NC, Yang F, Capecci LM, et al. (2010). Regulation of homocysteine metabolism and methylation in human and mouse tissues. FASEB J 24:2804–17
  • Chiba K, Saitoh A, Koyama E, et al. (1994). The role of S-mephenytoin 4′-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation. Br J Clin Pharmacol 37:237–42
  • Cubitt HE, Houston JB, Galetin A. (2011). Prediction of human drug clearance by multiple metabolic pathways: integration of hepatic and intestinal microsomal and cytosolic data. Drug Metab Dispos 39:864–73
  • Emanuelli M, Cecati M, Sartini D, Pozzi V. (2010). NNMT (nicotinamide N-methyltransferase). Atlas Genet Cytogenet Oncol Haematol 14:570–7
  • Hanano M, Umemura K, Iga T. (1985). Applied pharmacokinetics – theory and experiments. Tokyo, Japan: Soft Science, Inc
  • Higashi Y, Inami M, Ito M, et al. (2012). ASP015K: a novel JAK inhibitor demonstrated potent efficacy in a chronic oxazolone-induced dermatitis model in rats. Abstracts (P093) of the 3rd World Psoriasis & Psoriatic Arthritis Conference: “Psoriasis-a global health challenge”
  • Honma W, Shimada M, Sasano H, et al. (2002). Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver. Drug Metab Dispos 30:944–9
  • Hop CE, Wang Z, Chen Q, Kwei G. (1998). Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening J Pharm Sci 87:901–3
  • Hoshino J, Schlüter U, Kröger H. (1984). Nicotinamide methylation and its relation to NAD synthesis in rat liver tissue culture. Biochemical basis for the physiological activities of 1-methylnicotinamide. Biochim Biophys Acta 801:250–8
  • Imada K, Leonard WJ. (2000). The Jak-STAT pathway. Mol Immunol 37:1–11
  • Kitagawa H, Masuzawa T, Nakamura T, Matsumoto E. (1993). A batch preparation method for graphite targets with low background for AMS 14C measurements. Radiocarbon 35:295–300
  • Leonard WJ, Lin JX. (2000). Cytokine receptor signaling pathways. J Allergy Clin Immunol 105:877–88
  • Nagata K, Shimada M, Yamazoe Y. (2005). Species differences in cytosolic sulfotransferases. In: Pacifici GM, Coughtrie MHW, eds. Human cytosolic sulfotransferases. Boca Raton (FL): Taylor & Francis, 253–78
  • Oda K, Mera K, Nagasaka Y, Tokoro K. (2014). Simultaneous determination of novel oral Janus Kinase inhibitor ASP015K and sulfuric metabolite M2 concentrations in rat plasma using high-performance liquid chromatography with tandem mass spectrometric detection. Biomed Chromatogr in press
  • Jenks BH, McKee RW, Swendseid ME, et al. (1987). Methylated niacin derivatives in plasma and urine after an oral dose of nicotinamide given to subjects fed a low-methionine diet. Am J Clin Nutr 46:496–502
  • Pumpo R, Sarnelli G, Spinella A, et al. (2001). The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production. Am J Gastroenterol 96:1183–7
  • Ring BJ, Binkley SN, Roskos L, Wrighton SA. (1995). Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1′-hydroxy midazolam formation in vitro. J Pharmacol Exp Ther 275:1131–5
  • Saito S, Iida A, Sekine A, et al. (2001). Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population. J Hum Genet 46:529–37
  • Sakuma S, Nishigaki F, Magari K, et al. (2001). FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis. Inflamm Res 50:509–14
  • Takeuchi T, Tanaka Y, Iwasaki M, et al. (2014). A phase 2b study of an oral JAK inhibitor ASP015K monotherapy in Japanese patients with moderate to severe rheumatoid arthritis. EULAR; 2014 Jun 11–14; Paris, France
  • Teubner W, Meinl W, Florian S, et al. (2007). Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. Biochem J 404:207–15
  • Thomae BA, Eckloff BW, Freimuth RR, et al. (2002). Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies. Pharmacogen J 2:48–56
  • Yamazoe Y, Kato R. (1995). Structure and function of sulphotransferases. In: Pacifici GM, Fracchia GN, eds. Advances in drug metabolism in man. Luxembourg: European Commission, 659–78
  • Zhu T. (2012). Pharmacodynamics of ASP015K, a novel Janus kinase inhibitor, in healthy volunteers. San Diego, CA: American College of Clinical Pharmacology

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