https://orcid.org/0000-0003-0755-6282
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ABSTRACT
Edible cassava leaves (Manihot esculenta) were consumed as vegetables for their bioactive compounds, however the effect of harvesting time on these bioactive compounds and their antidiabetic and anti-obesity inhibitory activities were scarcely reported in the literature. Phenolics from edible leaves harvested at different times were assessed using HPLC-DAD, and their antidiabetic and anti-obesity inhibitory activities were investigated before and after in vitro gastrointestinal digestion. The results showed a significant (P < .05) effect of harvesting time on phenolic contents. Bound phenolics showed higher lipase inhibitory activity than their free fractions. However, phenolic contents decreased after in vitro digestion, while they showed high antidiabetic and anti-obesity inhibitory activities. The present study demonstrated that edible leaves harvested at different times are rich in flavonoids, stilbenes, tannins and saponins. These bioactive compounds are highly potent against α-amylase, α-glucosidase and lipase before and after in vitro gastrointestinal digestion. Therefore, we recommend edible cassava leaves for important biological active compounds for the prevention of obesity and type 2 diabetes.
Supplemental data
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Acknowledgments
The LA acknowledges CSIR-TWAS for award of fellowship to undertake this work. The author also thanks CSIR-Central Food Technological Research Institute, Mysore (India), for the instrument facilities.
Data availability
Data are available from the corresponding author on reasonable request.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Author contributions
Alphonse Laya designed, performed experiments, analyzed data, and wrote the article. Benoît B. Koubala and Singh Negi Pradeep designed the research study and both contributed to the critical revision of the article.