Drug Design, Development and Therapy, Volume 7, Issue (2013)

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Drug Design, Development and Therapy, Volume 7, Issue (2013)

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Original Research

Article
Single early instillation of mitomycin C and urinary alkalinization in low-risk non-muscle-invasive bladder cancer: a preliminary study
Hamit Ersoy, Muhammet Yaytokgil, Ahmet Nihat Karakoyunlu, Hikmet Topaloglu, Levent Sagnak & Hakki Ugur Ozok
Pages: 1-6
Published online: 28 Dec 2012
AbstractforSingle early instillation of mitomycin C and urinary alkalinization in low-risk non-muscle-invasive bladder cancer: a preliminary study | Full Text | References | PDF (205.8 KB)
  • 81 Views
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Open Access
Article
Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain
Beniamino Palmieri, Valentina Rottigni & Tommaso Iannitti
Pages: 7-12
Published online: 03 Oct 2022
AbstractforPreliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain | Full Text | References | PDF (254.7 KB)
  • 199 Views
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Open Access

Review

Review Article
New treatments for myasthenia: a focus on antisense oligonucleotides
Corrado Angelini, Sara Martignago & Michela Bisciglia
Pages: 13-17
Published online: 10 Jan 2013
AbstractforNew treatments for myasthenia: a focus on antisense oligonucleotides | Full Text | References | PDF (200.8 KB)
  • 73 Views
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Open Access

Original Research

Article
Impact of ghrelin on vitreous cytokine levels in an experimental uveitis model
Burak Turgut, Fatih Cem Gül, Ferda Dağli, Nevin Ilhan & Metin Özgen
Pages: 19-24
Published online: 09 Jan 2013
AbstractforImpact of ghrelin on vitreous cytokine levels in an experimental uveitis model | Full Text | References | PDF (189.8 KB)
  • 73 Views
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Open Access
Article
Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines
Samer Hasan Hussein Al Ali, Mothanna Al-Qubaisi, Mohd Zobir Hussein, Maznah Ismail & Saifullah Bullo
Pages: 25-31
Published online: 14 Jan 2013
AbstractforHippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines | Full Text | References | PDF (328.5 KB)
  • 89 Views
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Open Access

Case Report

Case Report
Acetazolamide-induced cilio-choroidal effusion after cataract surgery: unusual posterior involvement
Romualdo Malagola, Loredana Arrico, Rossella Giannotti & Luigi Pattavina
Pages: 33-36
Published online: 23 Jan 2013
AbstractforAcetazolamide-induced cilio-choroidal effusion after cataract surgery: unusual posterior involvement | Full Text | References | PDF (1.9 MB)
  • 104 Views
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Open Access

Review

Review Article
Emerging treatment options for nasopharyngeal carcinoma
Lu Zhang, Qiu-Yan Chen, Huai Liu, Lin-Quan Tang & Hai-Qiang Mai
Pages: 37-52
Published online: 01 Feb 2013
AbstractforEmerging treatment options for nasopharyngeal carcinoma | Full Text | References | PDF (304.2 KB)
  • 273 Views
  • 33 CrossRef citations
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Open Access

Original Research

Article
Risk factors in patients with AFB smear-positive sputum who receive inappropriate antituberculous treatment
Cheng-Yu Chang, Jen-Yee Hong, Mei-Kang Yuan, Shu-Ju Chang, Yuan-Ming Lee, Shih-Chieh Chang, Li-Cho Hsu & Shin-Lung Cheng
Pages: 53-58
Published online: 31 Jan 2013
AbstractforRisk factors in patients with AFB smear-positive sputum who receive inappropriate antituberculous treatment | Full Text | References | PDF (207.5 KB)
  • 103 Views
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Open Access
Article
Design and physicochemical characterization of advanced spray-dried tacrolimus multifunctional particles for inhalation
Xiao Wu, Don Hayes Jr, Joseph B Zwischenberger, Robert J Kuhn & Heidi M Mansour
Pages: 59-72
Published online: 04 Feb 2013
AbstractforDesign and physicochemical characterization of advanced spray-dried tacrolimus multifunctional particles for inhalation | Full Text | References | PDF (2.9 MB)
  • 147 Views
  • 7 CrossRef citations
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Open Access
Article
Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs
Wael M El-Sayed & Warda A Hussin
Pages: 73-81
Published online: 03 Oct 2022
AbstractforAntimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs | Full Text | References | PDF (261.5 KB)
  • 62 Views
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Open Access
Article
Formulation and in vitro and in vivo evaluation of film-coated montelukast sodium tablets using Opadry® yellow 20A82938 on an industrial scale
Abdel Naser Zaid, Salam Natour, Aiman Qaddomi & Abeer Abu Ghoush
Pages: 83-91
Published online: 03 Oct 2022
AbstractforFormulation and in vitro and in vivo evaluation of film-coated montelukast sodium tablets using Opadry® yellow 20A82938 on an industrial scale | Full Text | References | PDF (277 KB)
  • 388 Views
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Open Access

Review

Review Article
An early indicator of drug success: Top Journal Selectivity Index
Igor Kissin
Pages: 93-98
Published online: 03 Oct 2022
AbstractforAn early indicator of drug success: Top Journal Selectivity Index | Full Text | References | PDF (243.4 KB)
  • 178 Views
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Open Access

Original Research

Article
Sitagliptin as add-on therapy in insulin deficiency: biomarkers of therapeutic efficacy respond differently in type 1 and type 2 diabetes
Ottavio Giampietro, Chiara Giampietro, Luca Della Bartola, Maria Chiara Masoni & Elena Matteucci
Pages: 99-104
Published online: 14 Feb 2013
AbstractforSitagliptin as add-on therapy in insulin deficiency: biomarkers of therapeutic efficacy respond differently in type 1 and type 2 diabetes | Full Text | References | PDF (361.8 KB)
  • 84 Views
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Open Access

Review

Review Article
Profile of alisporivir and its potential in the treatment of hepatitis C
Philippe A Gallay & Kai Lin
Pages: 105-115
Published online: 15 Feb 2013
AbstractforProfile of alisporivir and its potential in the treatment of hepatitis C | Full Text | References | PDF (1.1 MB)
  • 96 Views
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Open Access
Review Article
Advances with RNA interference in Alzheimer’s disease research
Shun Chen, Xuemei Ge, Yinghui Chen, Nan Lv, Zhenguo Liu & Weien Yuan
Pages: 117-125
Published online: 22 Feb 2013
AbstractforAdvances with RNA interference in Alzheimer’s disease research | Full Text | References | PDF (1.6 MB)
  • 248 Views
  • 11 CrossRef citations
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Open Access

Original Research

Article
The therapeutic efficacy of propranolol in children with recurrent primary epistaxis
Bojko Bjelakovic, Mila Bojanovic, Stevo Lukic, Ljiljana Saranac, Vladislav Vukomanovic, Sergej Prijic, Nikola Zivkovic & Dusica Randjelovic
Pages: 127-129
Published online: 01 Mar 2013
AbstractforThe therapeutic efficacy of propranolol in children with recurrent primary epistaxis | Full Text | References | PDF (135.5 KB)
  • 91 Views
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Open Access

Review

Review Article
Alemtuzumab: evidence for its potential in relapsing—remitting multiple sclerosis
JWL Brown & Alasdair J Coles
Pages: 131-138
Published online: 06 Mar 2013
AbstractforAlemtuzumab: evidence for its potential in relapsing—remitting multiple sclerosis | Full Text | References | PDF (211.8 KB)
  • 75 Views
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Open Access

Original Research

Article
The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion
Johann M van Zyl, Johan Smith & Arthur Hawtrey
Pages: 139-148
Published online: 11 Mar 2013
AbstractforThe effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion | Full Text | References | PDF (501.9 KB)
  • 68 Views
  • 8 CrossRef citations
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Open Access
Article
Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
Zhi-Jun Dai, Jie Gao, Hua-Feng Kang, Yu-Guang Ma, Xiao-Bin Ma, Wang-Feng Lu, Shuai Lin, Hong-Bing Ma, Xi-Jing Wang & Wen-Ying Wu
Pages: 149-159
Published online: 19 Mar 2013
AbstractforTargeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells | Full Text | References | PDF (853.8 KB)
  • 92 Views
  • 19 CrossRef citations
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Open Access

Case Report

Case Report
Successful management of an inadvertent excessive treprostinil overdose
Wolfgang Hohenforst-Schmidt, Juergen Hornig, Norbert Friedel, Paul Zarogoulidis, Konstantinos Zarogoulidis & Johannes Brachmann
Pages: 161-165
Published online: 03 Oct 2022
AbstractforSuccessful management of an inadvertent excessive treprostinil overdose | Full Text | References | PDF (1.7 MB)
  • 77 Views
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Open Access

Review

Review Article
A review of tasquinimod in the treatment of advanced prostate cancer
Stuart Charles Williamson, Alice Elizabeth Hartley & Rakesh Heer
Pages: 167-174
Published online: 21 Mar 2013
AbstractforA review of tasquinimod in the treatment of advanced prostate cancer | Full Text | References | PDF (257.6 KB)
  • 75 Views
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Open Access

Original Research

Article
Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial
Takeshi Takami & Yoshihiko Saito
Pages: 175-183
Published online: 22 Mar 2013
AbstractforAzelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial | Full Text | References | PDF (313.2 KB)
  • 163 Views
  • 12 CrossRef citations
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Open Access
Article
Novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship
Warda A Hussin, Mohamed A Ismail & Wael M El-Sayed
Pages: 185-193
Published online: 03 Oct 2022
AbstractforNovel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship | Full Text | References | PDF (1.8 MB)
  • 82 Views
  • 4 CrossRef citations
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Open Access

Case Report

Case Report
Development of primary malignant melanoma during treatment with a TNF-α antagonist for severe Crohn’s disease: a case report and review of the hypothetical association between TNF-α blockers and cancer
George Kouklakis, Eleni I Efremidou, Michael Pitiakoudis, Nikolaos Liratzopoulos & Alexandros Ch Polychronidis
Pages: 195-199
Published online: 03 Oct 2022
AbstractforDevelopment of primary malignant melanoma during treatment with a TNF-α antagonist for severe Crohn’s disease: a case report and review of the hypothetical association between TNF-α blockers and cancer | Full Text | References | PDF (133.3 KB)
  • 81 Views
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Open Access

Review

Review Article
New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast
Andrew C Palfreeman, Kay E McNamee & Fiona E McCann
Pages: 201-210
Published online: 27 Mar 2013
AbstractforNew developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast | Full Text | References | PDF (418.8 KB)
  • 276 Views
  • 68 CrossRef citations
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Open Access

Original Research

Article
Hepatocyte-targeting gene transfer mediated by galactosylated poly(ethylene glycol)-graft-polyethylenimine derivative
Yuqiang Wang, Jing Su, Wenwei Cai, Ping Lu, Lifen Yuan, Tuo Jin, Shuyan Chen & Jing Sheng
Pages: 211-221
Published online: 26 Mar 2013
AbstractforHepatocyte-targeting gene transfer mediated by galactosylated poly(ethylene glycol)-graft-polyethylenimine derivative | Full Text | References | PDF (1.8 MB)
  • 74 Views
  • 18 CrossRef citations
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Open Access
Article
Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks
Aleksander Mendyk, Paweł K Tuszyński, Sebastian Polak & Renata Jachowicz
Pages: 223-232
Published online: 03 Oct 2022
AbstractforGeneralized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks | Full Text | References | PDF (444.2 KB)
  • 133 Views
  • 14 CrossRef citations
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Open Access
Article
Effect of 7-Difluoromethyl-5, 4′-dimethoxygenistein on aorta atherosclerosis in hyperlipidemia ApoE−/− mice induced by a cholesterol-rich diet
Yong Zhang, Lesai Li, Jiliang You, Jianguo Cao & Xiaohua Fu
Pages: 233-242
Published online: 03 Apr 2013
AbstractforEffect of 7-Difluoromethyl-5, 4′-dimethoxygenistein on aorta atherosclerosis in hyperlipidemia ApoE−/− mice induced by a cholesterol-rich diet | Full Text | References | PDF (1.2 MB)
  • 59 Views
  • 11 CrossRef citations
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Open Access

Review

Review Article
Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections
Olatz Urbina, Olivia Ferrández, Mercè Espona, Esther Salas, Irene Ferrández & Santiago Grau
Pages: 243-265
Published online: 03 Apr 2013
AbstractforPotential role of tedizolid phosphate in the treatment of acute bacterial skin infections | Full Text | References | PDF (918.8 KB)
  • 110 Views
  • 7 CrossRef citations
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Open Access
Review Article
Phentermine and topiramate for the management of obesity: a review
Gina Cosentino, Ariane O Conrad & Gabriel I Uwaifo
Pages: 267-278
Published online: 05 Apr 2013
AbstractforPhentermine and topiramate for the management of obesity: a review | Full Text | References | PDF (285 KB)
  • 1323 Views
  • 10 CrossRef citations
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Open Access

Original Research

Article
Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics
Lei Liu, Ying Ma, Run-Ling Wang, Wei-Ren Xu, Shu-Qing Wang & Kuo-Chen Chou
Pages: 279-288
Published online: 08 Apr 2013
AbstractforFind novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics | Full Text | References | PDF (1.3 MB)
  • 100 Views
  • 9 CrossRef citations
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Open Access

Review

Review Article
Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab
Alessandro Armuzzi, Daniela Pugliese, Olga Maria Nardone & Luisa Guidi
Pages: 289-296
Published online: 08 Apr 2013
AbstractforManagement of difficult-to-treat patients with ulcerative colitis: focus on adalimumab | Full Text | References | PDF (191.2 KB)
  • 72 Views
  • 7 CrossRef citations
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Open Access

Original Research

Article
Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation
Ibrahim Gueler, Susanne Mueller, Matthias Helmschrott, Christian U Oeing, Christian Erbel, Lutz Frankenstein, Christian Gleißner, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus & Andreas O Doesch
Pages: 297-303
Published online: 08 Apr 2013
AbstractforEffects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation | Full Text | References | PDF (233.2 KB)
  • 69 Views
  • 5 CrossRef citations
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Open Access
Article
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis
Seigo Miyoshi, Hironobu Hamada, Ryoji Ito, Hitoshi Katayama, Kazunori Irifune, Toshimitsu Suwaki, Norihiko Nakanishi, Takanori Kanematsu, Kentaro Dote, Mayuki Aibiki, Takafumi Okura & Jitsuo Higaki
Pages: 305-316
Published online: 10 Apr 2013
AbstractforUsefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis | Full Text | References | PDF (423 KB)
  • 100 Views
  • 26 CrossRef citations
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Open Access
Article
In vitro and in vivo evaluation of a sublingual fentanyl wafer formulation
Stephen CB Lim, Michael J Paech, Bruce Sunderland & Yandi Liu
Pages: 317-324
Published online: 12 Apr 2013
AbstractforIn vitro and in vivo evaluation of a sublingual fentanyl wafer formulation | Full Text | References | PDF (925.6 KB)
  • 174 Views
  • 2 CrossRef citations
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Open Access

Review

Review Article
Current and emerging pharmacological treatments for sarcoidosis: a review
Scott H Beegle, Kerry Barba, Romel Gobunsuy & Marc A Judson
Pages: 325-338
Published online: 12 Apr 2013
AbstractforCurrent and emerging pharmacological treatments for sarcoidosis: a review | Full Text | References | PDF (1.4 MB)
  • 171 Views
  • 17 CrossRef citations
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Open Access
Review Article
Profile of certolizumab and its potential in the treatment of psoriatic arthritis
Maria Sole Chimenti, Rosita Saraceno, Andrea Chiricozzi, Alessandro Giunta, Sergio Chimenti & Roberto Perricone
Pages: 339-348
Published online: 15 Apr 2013
AbstractforProfile of certolizumab and its potential in the treatment of psoriatic arthritis | Full Text | References | PDF (824.5 KB)
  • 101 Views
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Open Access

Corrigendum

Correction
Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial [Corrigendum]
Page: 349
Published online: 17 Apr 2013
CitationforAzelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial [Corrigendum] | Full Text | PDF (112.7 KB)
  • 67 Views
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Open Access

Review

Review Article
Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis
Giovanni M Pitari
Pages: 351-360
Published online: 19 Apr 2013
AbstractforPharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis | Full Text | References | PDF (862 KB)
  • 88 Views
  • 18 CrossRef citations
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Open Access

Original Research

Article
Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis – a multicenter, randomized, investigator-masked, parallel group study in Chinese patients
Tong Lin, Lan Gong, Xing-huai Sun, Nai-qing Zhao, Wei Chen, Hui-ping Yuan, Yan Shao, Ming-hong Gao & Hai Tang
Pages: 361-368
Published online: 29 Apr 2013
AbstractforEffectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis – a multicenter, randomized, investigator-masked, parallel group study in Chinese patients | Full Text | References | PDF (287.6 KB)
  • 84 Views
  • 9 CrossRef citations
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Open Access
Article
Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study
Yasushi Kono, Shota Fukuda, Kenei Shimada, Koki Nakanishi, Kenichiro Otsuka, Tomoichiro Kubo, Satoshi Jissho, Haruyuki Taguchi, Junichi Yoshikawa & Minoru Yoshiyama
Pages: 369-374
Published online: 03 May 2013
AbstractforVery rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study | Full Text | References | PDF (258.7 KB)
  • 85 Views
  • 1 CrossRef citations
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Open Access

Review

Review Article
Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
Stuart Ibsen, Carolyn E Schutt & Sadik Esener
Pages: 375-388
Published online: 03 May 2013
AbstractforMicrobubble-mediated ultrasound therapy: a review of its potential in cancer treatment | Full Text | References | PDF (4.6 MB)
  • 584 Views
  • 130 CrossRef citations
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Open Access

Original Research

Article
Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin
Niharika Nath, Xiaoping Liu, Lloydine Jacobs & Khosrow Kashfi
Pages: 389-396
Published online: 06 May 2013
AbstractforFlurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin | Full Text | References | PDF (622 KB)
  • 70 Views
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Open Access

Review

Review Article
Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults
Marco Mula
Pages: 397-402
Published online: 14 May 2013
AbstractforProfile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults | Full Text | References | PDF (282.1 KB)
  • 104 Views
  • 8 CrossRef citations
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Open Access

Original Research

Article
Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization
Courtney Zych, Alexander Domling & Velpandi Ayyavoo
Pages: 403-412
Published online: 24 May 2013
AbstractforDevelopment of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization | Full Text | References | PDF (859 KB)
  • 65 Views
  • 1 CrossRef citations
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Open Access
Article
Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study
Farouk M Sakr, Ali MI Gado, Haseebur R Mohammed & Abdel Nasser Ismail Adam
Pages: 413-423
Published online: 30 May 2013
AbstractforPreparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study | Full Text | References | PDF (1,012.8 KB)
  • 342 Views
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Open Access

Review

Review Article
Fluocinolone acetonide intravitreal implant for the treatment of diabetic macular edema
Wyatt B Messenger, Robert M Beardsley & Christina J Flaxel
Pages: 425-434
Published online: 24 May 2013
AbstractforFluocinolone acetonide intravitreal implant for the treatment of diabetic macular edema | Full Text | References | PDF (329.3 KB)
  • 77 Views
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Open Access
Review Article
Osteoporosis – a current view of pharmacological prevention and treatment
Subhajit Das & Julie C Crockett
Pages: 435-448
Published online: 31 May 2013
AbstractforOsteoporosis – a current view of pharmacological prevention and treatment | Full Text | References | PDF (1 MB)
  • 599 Views
  • 41 CrossRef citations
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Open Access

Original Research

Article
Novel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR
Premkumar Jayaraman, Kishore R Sakharkar, ChuSing Lim, Mohammad Imran Siddiqi, Sarinder K Dhillon & Meena K Sakharkar
Pages: 449-475
Published online: 17 Jun 2013
AbstractforNovel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR | Full Text | References | PDF (10.7 MB)
  • 176 Views
  • 3 CrossRef citations
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Open Access
Article
Early achievement and maintenance of stable asthma control using initially higher-dose inhaled corticosteroids as part of combination therapy: an open-label pilot study
Shih-Lung Cheng, Hao-Chien Wang & Sow-Hsong Kuo
Pages: 477-484
Published online: 17 Jun 2013
AbstractforEarly achievement and maintenance of stable asthma control using initially higher-dose inhaled corticosteroids as part of combination therapy: an open-label pilot study | Full Text | References | PDF (1.3 MB)
  • 50 Views
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Open Access

Review

Review Article
Resistance to antivascular endothelial growth factor treatment in age-related macular degeneration
Paris Tranos, Athanasios Vacalis, Solon Asteriadis, Stavrenia Koukoula, Athanasios Vachtsevanos, Georgia Perganta & Ilias Georgalas
Pages: 485-490
Published online: 03 Oct 2022
AbstractforResistance to antivascular endothelial growth factor treatment in age-related macular degeneration | Full Text | References | PDF (152.6 KB)
  • 87 Views
  • 13 CrossRef citations
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Open Access

Original Research

Article
Drug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells
Hsin-chung Lee, Qing-Dong Ling, Wan-Chun Yu, Chunh-Ming Hung, Ta-Chun Kao, Yi-Wei Huang & Akon Higuchi
Pages: 491-502
Published online: 17 Jun 2013
AbstractforDrug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells | Full Text | References | PDF (4.4 MB)
  • 73 Views
  • 3 CrossRef citations
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Open Access

Review

Review Article
Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib
Hannah V Woodcock, Philip L Molyneaux & Toby M Maher
Pages: 503-510
Published online: 19 Jun 2013
AbstractforReducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib | Full Text | References | PDF (177.7 KB)
  • 133 Views
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Open Access

Original Research

Article
The drug efficacy and adverse reactions in a mouse model of oral squamous cell carcinoma treated with oxaliplatin at different time points during a day
Kai Yang, Ningbo Zhao, Dan Zhao, Dan Chen & Yadong Li
Pages: 511-517
Published online: 20 Jun 2013
AbstractforThe drug efficacy and adverse reactions in a mouse model of oral squamous cell carcinoma treated with oxaliplatin at different time points during a day | Full Text | References | PDF (598.9 KB)
  • 74 Views
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Open Access

Review

Review Article
Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma
C Lance Cowey
Pages: 519-527
Published online: 21 Jun 2013
AbstractforProfile of tivozanib and its potential for the treatment of advanced renal cell carcinoma | Full Text | References | PDF (279 KB)
  • 89 Views
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Open Access

Original Research

Article
A comparative study of the effects of vitamin C, sirolimus, and paclitaxel on the growth of endothelial and smooth muscle cells for cardiovascular medical device applications
Sandeep Kakade & Gopinath Mani
Pages: 529-544
Published online: 24 Jun 2013
AbstractforA comparative study of the effects of vitamin C, sirolimus, and paclitaxel on the growth of endothelial and smooth muscle cells for cardiovascular medical device applications | Full Text | References | PDF (13.6 MB)
  • 91 Views
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Open Access
Article
Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice
Tian-yu Chen, Zhong-min Zhang, Xiao-chen Zheng, Liang Wang, Min-jun Huang, Si Qin, Jian Chen, Ping-lin Lai, Cheng-liang Yang, Jia Liu, Yi-fan Dai, Da-di Jin & Xiao-chun Bai
Pages: 545-552
Published online: 03 Oct 2022
AbstractforEndogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice | Full Text | References | PDF (2.8 MB)
  • 75 Views
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Open Access
Article
S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis
Daniel FC Mazo, Marcelo G de Oliveira, Isabel VA Pereira, Bruno Cogliati, José T Stefano, Gabriela FP de Souza, Fabíola Rabelo, Fabiana R Lima, Venâncio A Ferreira Alves, Flair J Carrilho & Claudia PMS de Oliveira
Pages: 553-563
Published online: 28 Jun 2013
AbstractforS-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis | Full Text | References | PDF (3.7 MB)
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Short Report

Brief Report
Effect of ranibizumab on serous and vascular pigment epithelial detachments associated with exudative age-related macular degeneration
Georgios D Panos, Zisis Gatzioufas, Ioannis K Petropoulos, Doukas Dardabounis, Gabriele Thumann & Farhad Hafezi
Pages: 565-569
Published online: 10 Jul 2013
AbstractforEffect of ranibizumab on serous and vascular pigment epithelial detachments associated with exudative age-related macular degeneration | Full Text | References | PDF (983.5 KB)
  • 76 Views
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Original Research

Article
Intratumoral chemotherapy for lung cancer: re-challenge current targeted therapies
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Kaid Darwiche, Thomas Vogl, Eugene P Goldberg, Haidong Huang, Michael Simoff, Qiang Li, Robert Browning, Francis J Turner, Patrick Le Pivert, Dionysios Spyratos, Konstantinos Zarogoulidis, Seyhan I Celikoglu, Firuz Celikoglu & Johannes Brachmann
Pages: 571-583
Published online: 18 Jul 2013
AbstractforIntratumoral chemotherapy for lung cancer: re-challenge current targeted therapies | Full Text | References | PDF (1.4 MB)
  • 238 Views
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Review

Review Article
Organelle targeting: third level of drug targeting
Niraj M Sakhrani & Harish Padh
Pages: 585-599
Published online: 17 Jul 2013
AbstractforOrganelle targeting: third level of drug targeting | Full Text | References | PDF (1.4 MB)
  • 601 Views
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Review Article
Profile of bazedoxifene/conjugated estrogens for the treatment of estrogen deficiency symptoms and osteoporosis in women at risk of fracture
Maurizio Rossini, Stefano Lello, Ignazio Sblendorio, Ombretta Viapiana, Elena Fracassi, Silvano Adami & Davide Gatti
Pages: 601-610
Published online: 22 Jul 2013
AbstractforProfile of bazedoxifene/conjugated estrogens for the treatment of estrogen deficiency symptoms and osteoporosis in women at risk of fracture | Full Text | References | PDF (266.5 KB)
  • 81 Views
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Original Research

Article
Immunomodifiers in combination with conventional chemotherapy in small cell lung cancer: a Phase II, randomized study
Konstantinos Zarogoulidis, Eftimios Ziogas, Efimia Boutsikou, Paul Zarogoulidis, Kaid Darwiche, Theodoros Kontakiotis, Kosmas Tsakiridis, Konstantinos Porpodis, Dimitrios Latsios, Olga Chatzizisi, Ilias Karapantzos, Qiang Li & Georgios Kyriazis
Pages: 611-617
Published online: 23 Jul 2013
AbstractforImmunomodifiers in combination with conventional chemotherapy in small cell lung cancer: a Phase II, randomized study | Full Text | References | PDF (1 MB)
  • 70 Views
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Article
Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine
Robert J Noveck, Pamela S Douglas, Shein-Chung Chow, Barry Mangum, Shashidhar Kori & Donald J Kellerman
Pages: 619-625
Published online: 24 Jul 2013
AbstractforAssessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine | Full Text | References | PDF (227.7 KB)
  • 64 Views
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Expert Opinion

Successful application of extracorporeal membrane oxygenation due to pulmonary hemorrhage secondary to granulomatosis with polyangiitis
Wolfgang Hohenforst-Schmidt, Arndt Petermann, Aikaterini Visouli, Paul Zarogoulidis, Kaid Darwiche, Ioanna Kougioumtzi, Kosmas Tsakiridis, Nikolaos Machairiotis, Markus Ketteler, Konstantinos Zarogoulidis & Johannes Brachmann
Pages: 627-633
Published online: 24 Jul 2013
AbstractforSuccessful application of extracorporeal membrane oxygenation due to pulmonary hemorrhage secondary to granulomatosis with polyangiitis | Full Text | References | PDF (3 MB)
  • 107 Views
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Original Research

Article
Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis
Qingli Li, Mark J Lambrechts, Qiuyang Zhang, Sen Liu, Dongxia Ge, Rutie Yin, Mingrong Xi & Zongbing You
Pages: 635-643
Published online: 24 Jul 2013
AbstractforGlyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis | Full Text | References | PDF (505.3 KB)
  • 201 Views
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Review

Review Article
RETRACTED ARTICLE: Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome
Giovanni Mantovani, Clelia Madeddu & Antonio Macciò
Pages: 645-656
Published online: 12 Aug 2013
AbstractforRETRACTED ARTICLE: Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome | PDF (943.2 KB)
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Original Research

Article
Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial
Benchalak Maneeton, Narong Maneeton, Manit Srisurapanont & Kaweesak Chittawatanarat
Pages: 657-667
Published online: 24 Jul 2013
AbstractforQuetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial | Full Text | References | PDF (387.4 KB)
  • 439 Views
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Article
Mycobacterium marinum: a potential immunotherapy for Mycobacterium tuberculosis infection
Wei-wei Tian, Qian-qiu Wang, Wei-da Liu, Jian-ping Shen & Hong-sheng Wang
Pages: 669-680
Published online: 03 Oct 2022
AbstractforMycobacterium marinum: a potential immunotherapy for Mycobacterium tuberculosis infection | Full Text | References | PDF (900.5 KB)
  • 79 Views
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Review

Review Article
Amrubicin: potential in combination with cisplatin or carboplatin to treat small-cell lung cancer
Qian Ding & Jinbiao Zhan
Pages: 681-689
Published online: 01 Aug 2013
AbstractforAmrubicin: potential in combination with cisplatin or carboplatin to treat small-cell lung cancer | Full Text | References | PDF (201.8 KB)
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Original Research

Article
Synthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis
Jamal A Jilani, Maha Shomaf & Karem H Alzoubi
Pages: 691-698
Published online: 31 Jul 2013
AbstractforSynthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis | Full Text | References | PDF (1.2 MB)
  • 134 Views
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Methodology

Article
Quantification of imatinib in human serum: validation of a high-performance liquid chromatography-mass spectrometry method for therapeutic drug monitoring and pharmacokinetic assays
Vinicius Marcondes Rezende, Ariane Rivellis, Mafalda Megumi Yoshinaga Novaes, Dalton de Alencar Fisher Chamone & Israel Bendit
Pages: 699-710
Published online: 05 Aug 2013
AbstractforQuantification of imatinib in human serum: validation of a high-performance liquid chromatography-mass spectrometry method for therapeutic drug monitoring and pharmacokinetic assays | Full Text | References | PDF (358.1 KB)
  • 129 Views
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Review

Review Article
Aflibercept in wet AMD: specific role and optimal use
F Semeraro, F Morescalchi, S Duse, F Parmeggiani, E Gambicorti & C Costagliola
Pages: 711-722
Published online: 05 Aug 2013
AbstractforAflibercept in wet AMD: specific role and optimal use | Full Text | References | PDF (340.3 KB)
  • 482 Views
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Case Report

Case Report
Renal thrombotic microangiopathy caused by interferon beta-1a treatment for multiple sclerosis
Julien Mahe, Aurélie Meurette, Anne Moreau, Caroline Vercel & Pascale Jolliet
Pages: 723-728
Published online: 03 Oct 2022
AbstractforRenal thrombotic microangiopathy caused by interferon beta-1a treatment for multiple sclerosis | Full Text | References | PDF (1.2 MB)
  • 103 Views
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Review

Review Article
Developing therapeutic approaches for metachromatic leukodystrophy
Shilpa A Patil & Gustavo HB Maegawa
Pages: 729-745
Published online: 08 Aug 2013
AbstractforDeveloping therapeutic approaches for metachromatic leukodystrophy | Full Text | References | PDF (1.9 MB)
  • 247 Views
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Original Research

Article
N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids
Stephanie L Grillo, Jantana Keereetaweep, Michael A Grillo, Kent D Chapman & Peter Koulen
Pages: 747-752
Published online: 12 Aug 2013
AbstractforN-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids | Full Text | References | PDF (235.2 KB)
  • 76 Views
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Review

Review Article
Open-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases
Minna Allarakhia
Pages: 753-766
Published online: 08 Aug 2013
AbstractforOpen-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases | Full Text | References | PDF (304.5 KB)
  • 343 Views
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Review Article
Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review
Hai-Fei Chen, Li-Ping Xu, Zhi-Yong Luo, Zi-Qiang Yu, Zheng-Yang Li, Qing-Ya Cui, Long-Mei Qin, Yong-Ya Ren, Hong-Shi Shen, Jie-Qing Tang, Ling-Juan Jin, Jing-Jing Zhu, Jing Wang, Ke-Yuan Wang, Tian-Qin Wu & Zhao-Yue Wang
Pages: 767-770
Published online: 13 Aug 2013
AbstractforValproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review | Full Text | References | PDF (502.2 KB)
  • 69 Views
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Rapid Communication

Article
Clinical study of etomidate emulsion combined with remifentanil in general anesthesia
Digui Weng, Menghua Huang, Runnian Jiang, Rufu Zhan & Chunni Yang
Pages: 771-776
Published online: 20 Aug 2013
AbstractforClinical study of etomidate emulsion combined with remifentanil in general anesthesia | Full Text | References | PDF (239.4 KB)
  • 74 Views
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Review

Review Article
Update on rescue therapies in patients with lamivudine-resistant chronic hepatitis B
Daniel C Chao & Ke-Qin Hu
Pages: 777-788
Published online: 20 Aug 2013
AbstractforUpdate on rescue therapies in patients with lamivudine-resistant chronic hepatitis B | Full Text | References | PDF (243.5 KB)
  • 84 Views
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Original Research

Article
In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features
Mingli Xiang, Kai Lei, Wenjie Fan, Yuchun Lin, Gu He, Mingli Yang, Lijuan Chen & Yirong Mo
Pages: 789-839
Published online: 14 Aug 2013
AbstractforIn silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features | Full Text | References | PDF (5.6 MB)
  • 96 Views
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Article
Bioequivalence study of two formulations of candesartan cilexetil tablet in healthy subjects under fasting conditions
Raymond R Tjandrawinata, Effi Setiawati, Danang Agung Yunaidi, Ronal Simanjuntak, Iwan Dwi Santoso & Liana W Susanto
Pages: 841-847
Published online: 20 Aug 2013
AbstractforBioequivalence study of two formulations of candesartan cilexetil tablet in healthy subjects under fasting conditions | Full Text | References | PDF (547.8 KB)
  • 303 Views
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Review

Review Article
Causes, consequences, and treatment of osteoporosis in men
Jameela Banu
Pages: 849-860
Published online: 22 Aug 2013
AbstractforCauses, consequences, and treatment of osteoporosis in men | Full Text | References | PDF (686.6 KB)
  • 267 Views
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Original Research

Article
Preparation and in vivo absorption evaluation of spray dried powders containing salmon calcitonin loaded chitosan nanoparticles for pulmonary delivery
Chutima Sinsuebpol, Jittima Chatchawalsaisin & Poj Kulvanich
Pages: 861-873
Published online: 28 Aug 2013
AbstractforPreparation and in vivo absorption evaluation of spray dried powders containing salmon calcitonin loaded chitosan nanoparticles for pulmonary delivery | Full Text | References | PDF (1.9 MB)
  • 179 Views
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Review

Review Article
Enzalutamide as a second generation antiandrogen for treatment of advanced prostate cancer
Julius Semenas, Nishtman Dizeyi & Jenny Liao Persson
Pages: 875-881
Published online: 27 Aug 2013
AbstractforEnzalutamide as a second generation antiandrogen for treatment of advanced prostate cancer | Full Text | References | PDF (416.8 KB)
  • 140 Views
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Original Research

Article
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties
Carmen Limban, Alexandru Vasile Missir, Khairi Mustafa Salem Fahelelbom, Moawia Mohammad Al-Tabakha, Miron Teodor Caproiu & Bassem Sadek
Pages: 883-892
Published online: 28 Aug 2013
AbstractforNovel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties | Full Text | References | PDF (503.2 KB)
  • 65 Views
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Review

Review Article
A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment
Vinay S Eligar & Stephen C Bain
Pages: 893-903
Published online: 30 Aug 2013
AbstractforA review of sitagliptin with special emphasis on its use in moderate to severe renal impairment | Full Text | References | PDF (305.6 KB)
  • 304 Views
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Original Research

Article
Surfactant treatment before first breath for respiratory distress syndrome in preterm lambs: comparison of a peptide-containing synthetic lung surfactant with porcine-derived surfactant
Johann M van Zyl & Johan Smith
Pages: 905-916
Published online: 29 Aug 2013
AbstractforSurfactant treatment before first breath for respiratory distress syndrome in preterm lambs: comparison of a peptide-containing synthetic lung surfactant with porcine-derived surfactant | Full Text | References | PDF (1.7 MB)
  • 66 Views
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Article
Identification of PPARγ ligands with One-dimensional Drug Profile Matching
Diána Kovács, Zoltán Simon, Péter Hári, András Málnási-Csizmadia, Csaba Hegedűs, László Drimba, József Németh, Réka Sári, Zoltán Szilvássy & Barna Peitl
Pages: 917-928
Published online: 02 Sep 2013
AbstractforIdentification of PPARγ ligands with One-dimensional Drug Profile Matching | Full Text | References | PDF (971.4 KB)
  • 64 Views
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Review

Review Article
Development, clinical utility, and place of ivacaftor in the treatment of cystic fibrosis
Ruth O’Reilly & Heather E Elphick
Pages: 929-937
Published online: 30 Aug 2013
AbstractforDevelopment, clinical utility, and place of ivacaftor in the treatment of cystic fibrosis | Full Text | References | PDF (282.7 KB)
  • 117 Views
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Original Research

Article
Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study
Hikmat Abdel-Razeq, Salah Abbasi, Iyad Saadi, Rana Jaber & Hazem Abdelelah
Pages: 939-944
Published online: 30 Aug 2013
AbstractforIntravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study | Full Text | References | PDF (187.7 KB)
  • 100 Views
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Review

Review Article
Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
Xiaoyun Hong, Liangming Wei, Fei Wu, Zaozhan Wu, Lizhu Chen, Zhenguo Liu & Weien Yuan
Pages: 945-952
Published online: 04 Sep 2013
AbstractforDissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine | Full Text | References | PDF (1.8 MB)
  • 604 Views
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Original Research

Article
Hologram quantitative structure–activity relationship and comparative molecular field analysis studies within a series of tricyclic phthalimide HIV-1 integrase inhibitors
Uiaran de Oliveira Magalhães, Alessandra Mendonça Teles de Souza, Magaly Girão Albuquerque, Monique Araújo de Brito, Murilo Lamim Bello, Lucio Mendes Cabral & Carlos Rangel Rodrigues
Pages: 953-961
Published online: 03 Oct 2022
AbstractforHologram quantitative structure–activity relationship and comparative molecular field analysis studies within a series of tricyclic phthalimide HIV-1 integrase inhibitors | Full Text | References | PDF (1.3 MB)
  • 65 Views
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Review

Review Article
Long-acting preparations of exenatide
Yunpeng Cai, Liangming Wei, Liuqing Ma, Xiwen Huang, Anqi Tao, Zhenguo Liu & Weien Yuan
Pages: 963-970
Published online: 05 Sep 2013
AbstractforLong-acting preparations of exenatide | Full Text | References | PDF (498 KB)
  • 258 Views
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Corrigendum

Correction
S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis [Corrigendum]
Pages: 971-972
Published online: 13 Sep 2013
CitationforS-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis [Corrigendum] | Full Text | PDF (1.3 MB)
  • 54 Views
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Review

Review Article
Prevention of venous thromboembolism in hospitalized acutely ill medical patients: focus on the clinical utility of (low-dose) fondaparinux
Marcello Di Nisio & Ettore Porreca
Pages: 973-980
Published online: 03 Oct 2022
AbstractforPrevention of venous thromboembolism in hospitalized acutely ill medical patients: focus on the clinical utility of (low-dose) fondaparinux | Full Text | References | PDF (203.6 KB)
  • 73 Views
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Original Research

Article
Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
Gáspár Oláh, Judit Herédi, Ákos Menyhárt, Zsolt Czinege, Dávid Nagy, János Fuzik, Kitti Kocsis, Levente Knapp, Erika Krucsó, Levente Gellért, Zsolt Kis, Tamás Farkas, Ferenc Fülöp, Árpád Párdutz, János Tajti, László Vécsei & József Toldi
Pages: 981-987
Published online: 16 Sep 2013
AbstractforUnexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability | Full Text | References | PDF (922.2 KB)
  • 110 Views
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Review

Review Article
Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin
Annalisa Capuano, Liberata Sportiello, Maria Ida Maiorino, Francesco Rossi, Dario Giugliano & Katherine Esposito
Pages: 989-1001
Published online: 17 Sep 2013
AbstractforDipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin | Full Text | References | PDF (288.6 KB)
  • 219 Views
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Review Article
Vitamin D in asthma and future perspectives
Haidong Huang, Konstantinos Porpodis, Paul Zarogoulidis, Kalliopi Domvri, Paschalina Giouleka, Antonis Papaiwannou, Stella Primikyri, Efi Mylonaki, Dionysis Spyratos, Wolfgang Hohenforst-Schmidt, Ioannis Kioumis & Konstantinos Zarogoulidis
Pages: 1003-1013
Published online: 23 Sep 2013
AbstractforVitamin D in asthma and future perspectives | Full Text | References | PDF (997.9 KB)
  • 185 Views
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Original Research

Article
Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system
Dena Dorniani, Mohd Zobir bin Hussein, Aminu Umar Kura, Sharida Fakurazi, Abdul Halim Shaari & Zalinah Ahmad
Pages: 1015-1026
Published online: 25 Sep 2013
AbstractforPreparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system | Full Text | References | PDF (1.5 MB)
  • 209 Views
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Article
Pharmaceutical suspension containing both immediate/sustained-release amoxicillin-loaded gelatin nanoparticles: preparation and in vitro characterization
Sree Harsha
Pages: 1027-1033
Published online: 26 Sep 2013
AbstractforPharmaceutical suspension containing both immediate/sustained-release amoxicillin-loaded gelatin nanoparticles: preparation and in vitro characterization | Full Text | References | PDF (1.1 MB)
  • 357 Views
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Article
Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures
T Iannitti, V Rottigni & B Palmieri
Pages: 1035-1041
Published online: 26 Sep 2013
AbstractforCorticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures | Full Text | References | PDF (901 KB)
  • 134 Views
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Article
New structure–activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity
Luciana Pereira Rangel, Evelyn Winter, Charlotte Gauthier, Raphaël Terreux, Louise D Chiaradia-Delatorre, Alessandra Mascarello, Ricardo J Nunes, Rosendo A Yunes, Tania B Creczynski-Pasa, Sira Macalou, Doriane Lorendeau, Hélène Baubichon-Cortay, Antonio Ferreira-Pereira & Attilio Di Pietro
Pages: 1043-1052
Published online: 30 Sep 2013
AbstractforNew structure–activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity | Full Text | References | PDF (1.2 MB)
  • 116 Views
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Review

Review Article
Efficacy, tolerability, and acceptability of bupropion for major depressive disorder: a meta-analysis of randomized–controlled trials comparison with venlafaxine
Narong Maneeton, Benchalak Maneeton, Kanokkwan Eurviriyanukul & Manit Srisurapanont
Pages: 1053-1062
Published online: 03 Oct 2022
AbstractforEfficacy, tolerability, and acceptability of bupropion for major depressive disorder: a meta-analysis of randomized–controlled trials comparison with venlafaxine | Full Text | References | PDF (348.2 KB)
  • 210 Views
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Original Research

Article
Amniotic fluid stem cells morph into a cardiovascular lineage: analysis of a chemically induced cardiac and vascular commitment
Margherita Maioli, Giovanni Contini, Sara Santaniello, Pasquale Bandiera, Gianfranco Pigliaru, Raimonda Sanna, Salvatore Rinaldi, Alessandro P Delitala, Andrea Montella, Luigi Bagella & Carlo Ventura
Pages: 1063-1073
Published online: 27 Sep 2013
AbstractforAmniotic fluid stem cells morph into a cardiovascular lineage: analysis of a chemically induced cardiac and vascular commitment | Full Text | References | PDF (2.2 MB)
  • 69 Views
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Article
A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing
Tian-Jiao Xu, Qi Wang, Xiao-Wen Ma, Zhen Zhang, Wei Zhang, Xiao-Chang Xue, Cun Zhang, Qiang Hao, Wei-Na Li, Ying-Qi Zhang & Meng Li
Pages: 1075-1088
Published online: 01 Oct 2013
AbstractforA novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing | Full Text | References | PDF (3.6 MB)
  • 114 Views
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Article
Anti-insulin-like growth factor-IIP3 DNAzymes inhibit cell proliferation and induce caspase-dependent apoptosis in human hepatocarcinoma cell lines
Min Zhang, Gregor PC Drummen & Su Luo
Pages: 1089-1102
Published online: 03 Oct 2022
AbstractforAnti-insulin-like growth factor-IIP3 DNAzymes inhibit cell proliferation and induce caspase-dependent apoptosis in human hepatocarcinoma cell lines | Full Text | References | PDF (4.6 MB)
  • 78 Views
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Review

Review Article
Advances with microRNAs in Parkinson’s disease research
Liuqing Ma, Liangming Wei, Fei Wu, Zhenhua Hu, Zhenguo Liu & Weien Yuan
Pages: 1103-1113
Published online: 01 Oct 2013
AbstractforAdvances with microRNAs in Parkinson’s disease research | Full Text | References | PDF (988.5 KB)
  • 151 Views
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Review Article
Clinical experimentation with aerosol antibiotics: current and future methods of administration
Paul Zarogoulidis, Ioannis Kioumis, Konstantinos Porpodis, Dionysios Spyratos, Kosmas Tsakiridis, Haidong Huang, Qiang Li, J Francis Turner, Robert Browning, Wolfgang Hohenforst-Schmidt & Konstantinos Zarogoulidis
Pages: 1115-1134
Published online: 02 Oct 2013
AbstractforClinical experimentation with aerosol antibiotics: current and future methods of administration | Full Text | References | PDF (969.5 KB)
  • 180 Views
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Review Article
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
Steve Poirier & Gaétan Mayer
Pages: 1135-1148
Published online: 04 Oct 2013
AbstractforThe biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol | Full Text | References | PDF (1.7 MB)
  • 139 Views
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Original Research

Article
The effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes
Panagiotis Tsikripis, Dimitrios Papaconstantinou, Chryssanthi Koutsandrea, Michalis Apostolopoulos & Ilias Georgalas
Pages: 1149-1156
Published online: 04 Oct 2013
AbstractforThe effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes | Full Text | References | PDF (306.6 KB)
  • 106 Views
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Review

Review Article
8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat & Virapong Prachayasittikul
Pages: 1157-1178
Published online: 04 Oct 2013
Abstractfor8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications | Full Text | References | PDF (828.9 KB)
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Article
Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma
Hongqing Zhuang, Zhiyong Yuan, Jun Wang, Lujun Zhao, Qingsong Pang & Ping Wang
Pages: 1179-1186
Published online: 08 Oct 2013
AbstractforPhase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma | Full Text | References | PDF (705.8 KB)
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Review

Review Article
Review of daclizumab and its therapeutic potential in the treatment of relapsing–remitting multiple sclerosis
Jennifer Reardon & Jai S Perumal
Pages: 1187-1193
Published online: 03 Oct 2022
AbstractforReview of daclizumab and its therapeutic potential in the treatment of relapsing–remitting multiple sclerosis | Full Text | References | PDF (199.7 KB)
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Article
A comparative study of internal laser-assisted and conventional liposuction: a look at the influence of drugs and major surgery on laboratory postoperative values
Andrzej Feliks Przylipiak, Elżbieta Galicka, Magdalena Donejko, Marek Niczyporuk & Jerzy Przylipiak
Pages: 1195-1200
Published online: 11 Oct 2013
AbstractforA comparative study of internal laser-assisted and conventional liposuction: a look at the influence of drugs and major surgery on laboratory postoperative values | Full Text | References | PDF (197.1 KB)
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Review

Review Article
New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol
Mario Cazzola, Andrea Segreti & Maria Gabriella Matera
Pages: 1201-1208
Published online: 10 Oct 2013
AbstractforNew developments in the combination treatment of COPD: focus on umeclidinium/vilanterol | Full Text | References | PDF (189 KB)
  • 144 Views
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Review Article
Current and future G protein-coupled receptor signaling targets for heart failure therapy
Ashley Siryk-Bathgate, Samalia Dabul & Anastasios Lymperopoulos
Pages: 1209-1222
Published online: 11 Oct 2013
AbstractforCurrent and future G protein-coupled receptor signaling targets for heart failure therapy | Full Text | References | PDF (1.1 MB)
  • 115 Views
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Review Article
Daclatasvir: potential role in hepatitis C
Choongho Lee
Pages: 1223-1233
Published online: 16 Oct 2013
AbstractforDaclatasvir: potential role in hepatitis C | Full Text | References | PDF (277.6 KB)
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Original Research

Article
Intestinal absorption and biliary elimination of glycyrrhizic acid diethyl ester in rats
Kenjiro Koga, Mayuri Kawamura, Hiroshi Iwase & Nobuji Yoshikawa
Pages: 1235-1243
Published online: 21 Oct 2013
AbstractforIntestinal absorption and biliary elimination of glycyrrhizic acid diethyl ester in rats | Full Text | References | PDF (806.3 KB)
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Article
Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity
Ali M Gado & Badr A Aldahmash
Pages: 1245-1252
Published online: 21 Oct 2013
AbstractforAntioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity | Full Text | References | PDF (1.4 MB)
  • 170 Views
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Article
Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
Andreas O Doesch, Susanne Mueller, Ceylan Akyol, Christian Erbel, Lutz Frankenstein, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler & Hugo A Katus
Pages: 1253-1258
Published online: 21 Oct 2013
AbstractforIncreased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation | Full Text | References | PDF (278.1 KB)
  • 79 Views
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Review

Review Article
Advances in the proteomic discovery of novel therapeutic targets in cancer
Shanchun Guo, Jin Zou & Guangdi Wang
Pages: 1259-1271
Published online: 24 Oct 2013
AbstractforAdvances in the proteomic discovery of novel therapeutic targets in cancer | Full Text | References | PDF (598.5 KB)
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Original Research

Article
Biodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid/N-isopropylacrylamide molar ratio
Jui-Yang Lai
Pages: 1273-1285
Published online: 24 Oct 2013
AbstractforBiodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid/N-isopropylacrylamide molar ratio | Full Text | References | PDF (1.4 MB)
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Article
RETRACTED ARTICLE: Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells
Mingrong Cheng, Hongzhi Xu, Yong Wang, Houxiang Chen, Bing He, Xiaoyan Gao, Yingchun Li, Jiang Han & Zhiping Zhang
Pages: 1287-1299
Published online: 25 Oct 2013
AbstractforRETRACTED ARTICLE: Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells | PDF (2.4 MB)
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Article
Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence
Juan Antonio Marchal, Esther Carrasco, Alberto Ramirez, Gema Jiménez, Carmen Olmedo, Macarena Peran, Ahmad Agil, Ana Conejo-García, Olga Cruz-López, Joaquin María Campos & María Ángel García
Pages: 1301-1313
Published online: 29 Oct 2013
AbstractforBozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence | Full Text | References | PDF (1.7 MB)
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Review

Review Article
Molecularly targeted drugs for metastatic colorectal cancer
Ying-dong Cheng, Hua Yang, Guo-qing Chen & Zhi-cao Zhang
Pages: 1315-1322
Published online: 01 Nov 2013
AbstractforMolecularly targeted drugs for metastatic colorectal cancer | Full Text | References | PDF (1.2 MB)
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Original Research

Article
Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study
Andreas O Doesch, Susanne Mueller, Christian Erbel, Christian A Gleissner, Lutz Frankenstein, Stefan Hardt, Arjang Ruhparwar, Philipp Ehlermann, Thomas Dengler & Hugo A Katus
Pages: 1323-1328
Published online: 05 Nov 2013
AbstractforHeart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study | Full Text | References | PDF (222.7 KB)
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Review

Review Article
New and emerging treatments for symptomatic tardive dyskinesia
Abdul Qayyum Rana, Zishan M Chaudry & Pierre J Blanchet
Pages: 1329-1340
Published online: 06 Nov 2013
AbstractforNew and emerging treatments for symptomatic tardive dyskinesia | Full Text | References | PDF (281.8 KB)
  • 198 Views
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Review Article
Animal models of ulcerative colitis and their application in drug research
Daren Low, Deanna D Nguyen & Emiko Mizoguchi
Pages: 1341-1357
Published online: 12 Nov 2013
AbstractforAnimal models of ulcerative colitis and their application in drug research | Full Text | References | PDF (2.4 MB)
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Review Article
Profile of gantenerumab and its potential in the treatment of Alzheimer’s disease
Dijana Novakovic, Marco Feligioni, Sergio Scaccianoce, Alessandra Caruso, Sonia Piccinin, Chiara Schepisi, Francesco Errico, Nicola B Mercuri, Ferdinando Nicoletti & Robert Nisticò
Pages: 1359-1364
Published online: 13 Nov 2013
AbstractforProfile of gantenerumab and its potential in the treatment of Alzheimer’s disease | Full Text | References | PDF (191 KB)
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Original Research

Article
Antituberculosis nanodelivery system with controlled-release properties based on para-amino salicylate–zinc aluminum-layered double-hydroxide nanocomposites
Bullo Saifullah, Mohd Zobir Hussein, Samer Hasan Hussein-Al-Ali, Palanisamy Arulselvan & Sharida Fakurazi
Pages: 1365-1375
Published online: 13 Nov 2013
AbstractforAntituberculosis nanodelivery system with controlled-release properties based on para-amino salicylate–zinc aluminum-layered double-hydroxide nanocomposites | Full Text | References | PDF (1.4 MB)
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Article
In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models
Sarah Schleiferböck, Christian Scheurer, Masataka Ihara, Isamu Itoh, Ian Bathurst, Jeremy N Burrows, Pascal Fantauzzi, Julie Lotharius, Susan A Charman, Julia Morizzi, David M Shackleford, Karen L White, Reto Brun & Sergio Wittlin
Pages: 1377-1384
Published online: 15 Nov 2013
AbstractforIn vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models | Full Text | References | PDF (325.8 KB)
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Retraction

Retraction
Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome [Retraction]
Page: 1385
Published online: 21 Nov 2013
CitationforDrugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome [Retraction] | Full Text | PDF (92.1 KB)
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Review

Review Article
Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?
Annette J Theron, Helen C Steel, Gregory R Tintinger, Charles Feldman & Ronald Anderson
Pages: 1387-1398
Published online: 22 Nov 2013
AbstractforCan the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting? | Full Text | References | PDF (320.3 KB)
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Review Article
Canagliflozin: a novel treatment option for type 2 diabetes
Eric Dietrich, Jason Powell & James R Taylor
Pages: 1399-1408
Published online: 22 Nov 2013
AbstractforCanagliflozin: a novel treatment option for type 2 diabetes | Full Text | References | PDF (265.6 KB)
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Original Research

Article
Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes
Sani Ismaila Muhammad, Ismail Maznah, Rozi Bint Mahmud, Mohammed Ibrahim Saeed, Mustapha Umar Imam & Aminu Ishaka
Pages: 1409-1420
Published online: 02 Dec 2013
AbstractforEstrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes | Full Text | References | PDF (1.1 MB)
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Article
Conversion to generic cyclosporine A in stable chronic patients after heart transplantation
Maximilian Kraeuter, Matthias Helmschrott, Christian Erbel, Christian A Gleissner, Lutz Frankenstein, Bastian Schmack, Arjang Ruhparwar, Philipp Ehlermann, Hugo A Katus & Andreas O Doesch
Pages: 1421-1426
Published online: 28 Nov 2013
AbstractforConversion to generic cyclosporine A in stable chronic patients after heart transplantation | Full Text | References | PDF (244.9 KB)
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Article
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome
Masomeh Hajishafiha, Meisam Dehghan, Nazila Kiarang, Nahideh Sadegh-Asadi, Seyed Navid Shayegh & Mohammad Ghasemi-Rad
Pages: 1427-1431
Published online: 03 Dec 2013
AbstractforCombined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome | Full Text | References | PDF (460.9 KB)
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Article
Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain – an in vivo study
Patrick T Udvardi, Karl J Föhr, Carolin Henes, Stefan Liebau, Jens Dreyhaupt, Tobias M Boeckers & Andrea G Ludolph
Pages: 1433-1446
Published online: 04 Dec 2013
AbstractforAtomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain – an in vivo study | Full Text | References | PDF (1.8 MB)
  • 239 Views
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Article
P-glycoprotein alters blood–brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy
Aimei Ma, Cuicui Wang, Yinghui Chen & Weien Yuan
Pages: 1447-1454
Published online: 03 Dec 2013
AbstractforP-glycoprotein alters blood–brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy | Full Text | References | PDF (354.5 KB)
  • 100 Views
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Article
Development and characterization of gastroretentive sustained-release formulation by combination of swelling and mucoadhesive approach: a mechanistic study
R Sankar & Subheet Kumar Jain
Pages: 1455-1469
Published online: 05 Dec 2013
AbstractforDevelopment and characterization of gastroretentive sustained-release formulation by combination of swelling and mucoadhesive approach: a mechanistic study | Full Text | References | PDF (838.5 KB)
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Review

Review Article
Disease-modifying drugs in Alzheimer’s disease
Laura Ghezzi, Elio Scarpini & Daniela Galimberti
Pages: 1471-1479
Published online: 06 Dec 2013
AbstractforDisease-modifying drugs in Alzheimer’s disease | Full Text | References | PDF (202.5 KB)
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Original Research

Article
Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and β-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson’s disease
Na Wu, Xinxin Yang, Lu Song, Jianglei Wei & Zhenguo Liu
Pages: 1481-1489
Published online: 10 Dec 2013
AbstractforEffect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and β-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson’s disease | Full Text | References | PDF (2.9 MB)
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