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Volume 25, Issue 12

Expert Opinion on Investigational Drugs

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Expert Opinion on Investigational Drugs, Volume 25, Issue 12 (2016)

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Expert Opinion on Investigational Drugs, Volume 25, Issue 12 (2016)

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Editorial

Developments with investigational Janus kinase inhibitors for rheumatoid arthritis

Luca Semerano, Patrice Decker, Gaëlle Clavel & Marie-Christophe Boissier

Pages: 1355-1359

Published online: 31 Oct 2016

First Page PreviewforDevelopments with investigational Janus kinase inhibitors for rheumatoid arthritis | Full Text | References | PDF (849.7 KB)

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Free Access

Original Research

Article

Bioequivalence, safety and immunogenicity of BI 695501, an adalimumab biosimilar candidate, compared with the reference biologic in a randomized, double-blind, active comparator phase I clinical study (VOLTAIRE®-PK) in healthy subjects

Christopher Wynne, Mario Altendorfer, Ivo Sonderegger, Lien Gheyle, Rod Ellis-Pegler, Susanne Buschke, Benjamin Lang, Deepak Assudani, Sandeep Athalye & Niklas Czeloth

Pages: 1361-1370

Published online: 18 Nov 2016

AbstractforBioequivalence, safety and immunogenicity of BI 695501, an adalimumab biosimilar candidate, compared with the reference biologic in a randomized, double-blind, active comparator phase I clinical study (VOLTAIRE®-PK) in healthy subjects | Full Text | References | PDF (895 KB)

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Review

Experimental drugs for bipolar psychosis

Michele Fornaro, António E. Nardi, Domenico De Berardis & Mauro Giovanni Carta

Pages: 1371-1375

Published online: 18 Nov 2016

AbstractforExperimental drugs for bipolar psychosis | Full Text | References | PDF (391 KB)

191 Views
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Review

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV

Michelle B. Kim, Kyle E. Giesler, Yesim A. Tahirovic, Valarie M. Truax, Dennis C. Liotta & Lawrence J. Wilson

Pages: 1377-1392

Published online: 18 Nov 2016

AbstractforCCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV | Full Text | References | PDF (1.5 MB)

527 Views
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Review

Investigational histone deacetylase inhibitors (HDACi) in myeloproliferative neoplasms

Prithviraj Bose & Srdan Verstovsek

Pages: 1393-1403

Published online: 31 Oct 2016

AbstractforInvestigational histone deacetylase inhibitors (HDACi) in myeloproliferative neoplasms | Full Text | References | PDF (958.2 KB)

294 Views
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Review

Folate receptor alpha antagonists in preclinical and early stage clinical development for the treatment of epithelial ovarian cancer

Alice Bergamini, Simone Ferrero, Umberto Leone Roberti Maggiore, Carolina Scala, Francesca Pella, Valerio Gaetano Vellone, Micaela Petrone, Emanuela Rabaiotti, Raffaella Cioffi, Massimo Candiani & Giorgia Mangili

Pages: 1405-1412

Published online: 18 Nov 2016

AbstractforFolate receptor alpha antagonists in preclinical and early stage clinical development for the treatment of epithelial ovarian cancer | Full Text | References | PDF (873 KB)

535 Views
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Review

Experimental and early investigational drugs for angina pectoris

Islam Y. Elgendy, David E. Winchester & Carl J. Pepine

Pages: 1413-1421

Published online: 14 Nov 2016

AbstractforExperimental and early investigational drugs for angina pectoris | Full Text | References | PDF (787.2 KB)

263 Views
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Review

Novel investigational therapies for treating biliary tract carcinoma

M. Tampellini, A. La Salvia & G. V. Scagliotti

Pages: 1423-1436

Published online: 03 Nov 2016

AbstractforNovel investigational therapies for treating biliary tract carcinoma | Full Text | References | PDF (1.2 MB)

328 Views
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Review

Investigational drugs in dry eye disease

Marcella Nebbioso, Valeria Fameli, Magda Gharbiya, Marta Sacchetti, Anna Maria Zicari & Alessandro Lambiase

Pages: 1437-1446

Published online: 28 Oct 2016

AbstractforInvestigational drugs in dry eye disease | Full Text | References | PDF (1.1 MB)

591 Views
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Drug Evaluation

Article

Vinflunine for the treatment of non-small cell lung cancer

C. Genova, A. Alama, S. Coco, E. Rijavec, MG. Dal Bello, I. Vanni, F. Biello, G. Barletta, G. Rossi & F. Grossi

Pages: 1447-1455

Published online: 01 Nov 2016

AbstractforVinflunine for the treatment of non-small cell lung cancer | Full Text | References | PDF (721.4 KB)

162 Views
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Article

Lomitapide for the treatment of hypertriglyceridemia

Amanda J. Brahm & Robert A. Hegele

Pages: 1457-1463

Published online: 09 Nov 2016

AbstractforLomitapide for the treatment of hypertriglyceridemia | Full Text | References | PDF (686.9 KB)

327 Views
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