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Volume 8, Issue 5

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 5 (2012)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 5 (2012)

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Research Article

Article

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Page: 1

Published online: 19 Apr 2012

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Editorial

Predicting and detecting adverse drug reactions in old age: challenges and opportunities

Arduino A Mangoni (Professor of Medicine of Old Age) PhD FRACP FRCP

Pages: 527-530

Published online: 19 Apr 2012

AbstractforPredicting and detecting adverse drug reactions in old age: challenges and opportunities | Full Text | References | PDF (167.7 KB)

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Free Access

Reviews

Review Article

Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling

Travis T Wager, Jennifer L Liras, Scot Mente & Patrick Trapa

Pages: 531-542

Published online: 29 Mar 2012

AbstractforStrategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling | Full Text | References | PDF (532.3 KB)

691 Views
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Review Article

Metabolic, toxicological, and safety considerations for drugs used to treat ADHD

Sophie Duong BA, Kara Chung BA & Sharon B Wigal PhD

Pages: 543-552

Published online: 13 Mar 2012

AbstractforMetabolic, toxicological, and safety considerations for drugs used to treat ADHD | Full Text | References | PDF (217.5 KB)

1525 Views
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Review Article

Fluoroquinolone disposition: identification of the contribution of renal secretory and reabsorptive drug transporters

Aditi Mulgaonkar B Pharmacy, Jurgen Venitz (Associate Professor and Vice Chairman) MD PhD & Douglas H Sweet (Associate Professor) PhD

Pages: 553-569

Published online: 22 Mar 2012

AbstractforFluoroquinolone disposition: identification of the contribution of renal secretory and reabsorptive drug transporters | Full Text | References | PDF (391.6 KB)

528 Views
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Review Article

Xenobiotic-induced liver injury and fibrosis

Christoph H Österreicher & Michael Trauner (Professor and Chair of Gastroenterology and Hepatology) MD

Pages: 571-580

Published online: 28 Mar 2012

AbstractforXenobiotic-induced liver injury and fibrosis | Full Text | References | PDF (213.7 KB)

488 Views
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Review Article

Pharmacokinetics of recombinant bifunctional fusion proteins

Xiaoying Chen, Jennica L Zaro & Wei-Chiang Shen

Pages: 581-595

Published online: 20 Mar 2012

AbstractforPharmacokinetics of recombinant bifunctional fusion proteins | Full Text | References | PDF (421.7 KB)

507 Views
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Review Article

Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants

Igor Koturbash MD PhD, Frederick A Beland & Igor P Pogribny

Pages: 597-606

Published online: 21 Mar 2012

AbstractforRole of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants | Full Text | References | PDF (217.8 KB)

391 Views
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Review Article

Cell-based in vitro models for predicting drug permeability

Bruno Sarmento, Fernanda Andrade, Sara Baptista da Silva, Francisca Rodrigues, José das Neves & Domingos Ferreira

Pages: 607-621

Published online: 18 Mar 2012

AbstractforCell-based in vitro models for predicting drug permeability | Full Text | References | PDF (592.5 KB)

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Drug Evaluations

Article

Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity

Paul G Richardson MD, Cathy Eng (Associate Professor, Associate Director of the Colorectal Center) MD FACP, Jill Kolesar PharmD, Teru Hideshima MD & Kenneth C Anderson MD

Pages: 623-633

Published online: 19 Apr 2012

Abstractfor Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity | Full Text | References | PDF (321 KB)

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Expert Opinion on Drug Metabolism & Toxicology (Vol.8, Iss.5, 2012)

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