Leukemia & Lymphoma, Volume 61, Issue 6 (2020)

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Leukemia & Lymphoma, Volume 61, Issue 6 (2020)

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Commentaries

Article Commentary
Mutational profiling of myeloid neoplasms, focusing on AML with myelodysplasia-related changes (MRC) in comparison with MDS and AML without MRC
Qing Ching Chen & Yi-Hua Chen
Pages: 1269-1271
Published online: 31 Mar 2020
First Page PreviewforMutational profiling of myeloid neoplasms, focusing on AML with myelodysplasia-related changes (MRC) in comparison with MDS and AML without MRC | Full Text | References | PDF (305 KB) | EPUB
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Article Commentary
Incidence and diagnosis of Richter transformation: transition from the era of chemoimmunotherapy to novel targeted agents
Tamar Tadmor & Sarah Greenfeld
Pages: 1272-1274
Published online: 09 Mar 2020
First Page PreviewforIncidence and diagnosis of Richter transformation: transition from the era of chemoimmunotherapy to novel targeted agents | Full Text | References | PDF (299.3 KB) | EPUB
  • 180 Views
  • 1 CrossRef citations
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Article Commentary
The challenge of unavailable IGH mutational status in CLL in resource-limited settings
Estella Matutes & Aaron Polliack
Pages: 1275-1276
Published online: 24 Feb 2020
CitationforThe challenge of unavailable IGH mutational status in CLL in resource-limited settings | Full Text | References | PDF (240.8 KB) | EPUB
  • 86 Views
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Reviews

Review
Recent developments and persisting challenges in the prevention and treatment of venous thromboembolism in patients with hematological malignancies
Marc Sorigue, Eloi Cañamero, Patricia Siguenza, Meritxell Nomdedeu & Juan J. López-Núñez
Pages: 1277-1291
Published online: 21 Jan 2020
AbstractforRecent developments and persisting challenges in the prevention and treatment of venous thromboembolism in patients with hematological malignancies | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 379 Views
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Review
Waldenstrom's macroglobulinemia in the era of immunotherapy
Iuliana Vaxman & Morie Gertz
Pages: 1292-1304
Published online: 21 Jan 2020
AbstractforWaldenstrom's macroglobulinemia in the era of immunotherapy | Full Text | References | PDF (1.1 MB) | EPUB
  • 471 Views
  • 1 CrossRef citations
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Review
Liposomal encapsulated cytarabine and daunorubicin (CPX-351) for older patients with acute myeloid leukemia
Hannah Asghari & Jeffrey Lancet
Pages: 1305-1312
Published online: 08 Feb 2020
AbstractforLiposomal encapsulated cytarabine and daunorubicin (CPX-351) for older patients with acute myeloid leukemia | Full Text | References | PDF (821.6 KB) | EPUB
  • 293 Views
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Emerging Drug Profile

Article
Venetoclax in acute myeloid leukemia – current and future directions
Curtis Lachowiez, Courtney D. DiNardo & Marina Konopleva
Pages: 1313-1322
Published online: 07 Feb 2020
AbstractforVenetoclax in acute myeloid leukemia – current and future directions | Full Text | References | PDF (863.2 KB) | EPUB
  • 1998 Views
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Original Articles

Article
Health-related quality of life results from the IFM 2009 trial: treatment with lenalidomide, bortezomib, and dexamethasone in transplant-eligible patients with newly diagnosed multiple myeloma
Murielle Roussel, Benjamin Hebraud, Cyrille Hulin, Aurore Perrot, Denis Caillot, Anne-Marie Stoppa, Margaret Macro, Martine Escoffre, Bertrand Arnulf, Karim Belhadj, Lionel Karlin, Laurent Garderet, Thierry Facon, Shien Guo, Josh Weng, Sujith Dhanasiri, Xavier Leleu, Philippe Moreau & Michel Attal
Pages: 1323-1333
Published online: 22 Feb 2020
AbstractforHealth-related quality of life results from the IFM 2009 trial: treatment with lenalidomide, bortezomib, and dexamethasone in transplant-eligible patients with newly diagnosed multiple myeloma | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3672 Views
  • 15 CrossRef citations
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Open Access
Article
Objective quantification of BCL2 protein by multiplex immunofluorescence in routine biopsy samples of diffuse large B-cell lymphoma demonstrates associations with survival and BCL2 gene alterations
Lina Chen, Kathrin Tyryshkin, Alison Moore, David W. Scott, Christian Steidl, Yi Li, Lois E. Shepherd, Michael Rauh, Lan Deng, David Good, Shakeel Virk, Bingshu E. Chen, Susan Crocker, Tara Baetz & David P. LeBrun
Pages: 1334-1344
Published online: 16 Jan 2020
AbstractforObjective quantification of BCL2 protein by multiplex immunofluorescence in routine biopsy samples of diffuse large B-cell lymphoma demonstrates associations with survival and BCL2 gene alterations | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 368 Views
  • 1 CrossRef citations
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Article
Increased risk of osteoporosis following commonly used first-line treatments for lymphoma: a Danish Nationwide Cohort Study
Joachim Baech, Steen Moeller Hansen, Lasse Hjort Jakobsen, Andreas K. Øvlisen, Marianne Tang Severinsen, Peter de Nully Brown, Peter Vestergaard, Henrik Frederiksen, Judit Jørgensen, Jørn Starklint, Pär Josefsson, Troels Hammer, Michael Roost Clausen, Christian Torp-Pedersen, Paw Jensen & Tarec Christoffer El-Galaly
Pages: 1345-1354
Published online: 11 Feb 2020
AbstractforIncreased risk of osteoporosis following commonly used first-line treatments for lymphoma: a Danish Nationwide Cohort Study | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 503 Views
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Article
A phase 1, open-label, single-dose study of the pharmacokinetics of zanubrutinib in subjects with varying degrees of hepatic impairment
Ying C. Ou, Richard A. Preston, Thomas C. Marbury, Zhiyu Tang, William Novotny, Manal Tawashi, Ta-Kai Li & Srikumar Sahasranaman
Pages: 1355-1363
Published online: 07 Feb 2020
AbstractforA phase 1, open-label, single-dose study of the pharmacokinetics of zanubrutinib in subjects with varying degrees of hepatic impairment | Full Text | References | PDF (892.4 KB) | EPUB
  • 361 Views
  • 11 CrossRef citations
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Article
Diffuse large B-cell lymphoma with low 18F-fluorodeoxyglucose avidity features silent B-cell receptor signaling
Dong Sheng, Ting Li, Wei-Ge Wang, Meng-Jiao Li, Kai-Long Jiang, An-Hui Gao, Jia Li, Xiao-Yan Zhou & Xiao-Qiu Li
Pages: 1364-1371
Published online: 22 Feb 2020
AbstractforDiffuse large B-cell lymphoma with low 18F-fluorodeoxyglucose avidity features silent B-cell receptor signaling | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 157 Views
  • 3 CrossRef citations
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Article
Metabolic tumor volume, cancer cell fraction, and prognosis – the case of T-cell/histiocyte-rich large B-cell lymphoma
Christine Schmitz, Jan Rekowski, Sarah Reinke, Stefan P. Müller, Andreas Hüttmann, Wolfram Klapper & Ulrich Dührsen
Pages: 1372-1379
Published online: 05 Feb 2020
AbstractforMetabolic tumor volume, cancer cell fraction, and prognosis – the case of T-cell/histiocyte-rich large B-cell lymphoma | Full Text | References | PDF (2.1 MB) | EPUB
  • 212 Views
  • 3 CrossRef citations
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Article
Pretreatment SUVmax may influence the clinical benefit of BR over R-CHOP in patients with previously untreated FL
Paolo Strati, Mohamed Amin Ahmed, Loretta J. Nastoupil, Lei Feng, Fredrick B. Hagemeister, Luis E. Fayad, Maria A. Rodriguez, Felipe Samaniego, Michael Wang, Jason R. Westin, Hun J. Lee, Swaminathan P. Iyer, Simrit Parmar, Sairah Ahmed, Ranjit Nair, Raphael E. Steiner, Mansoor Noorani, Christopher R. Flowers, R. Eric Davis, Nathan H. Fowler & Sattva S. Neelapu
Pages: 1380-1387
Published online: 23 Jan 2020
AbstractforPretreatment SUVmax may influence the clinical benefit of BR over R-CHOP in patients with previously untreated FL | Full Text | References | PDF (1.3 MB) | EPUB
  • 424 Views
  • 3 CrossRef citations
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Article
A matched case-control study comparing features, treatment and outcomes between patients with non-IgM lymphoplasmacytic lymphoma and Waldenström macroglobulinemia
Jorge J. Castillo, Gilad Itchaki, Joshua N. Gustine, Kirsten Meid, Catherine A. Flynn, Maria G. Demos, Maria L. Guerrera, Cristina Jimenez, Amanda Kofides, Xia Liu, Manit Munshi, Nicholas Tsakmaklis, Christopher J. Patterson, Lian Xu, Guang Yang, Zachary R. Hunter & Steven P. Treon
Pages: 1388-1394
Published online: 29 Jan 2020
AbstractforA matched case-control study comparing features, treatment and outcomes between patients with non-IgM lymphoplasmacytic lymphoma and Waldenström macroglobulinemia | Full Text | References | PDF (1.4 MB) | EPUB
  • 333 Views
  • 9 CrossRef citations
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Article
Comparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1
Lynh Nguyen, Xiaohui Zhang, Evans Roberts, Seongseok Yun, Kathy McGraw, Ivo Abraham, Jinming Song, Diana Braswell, Dahui Qin, David A. Sallman, Jeffrey E. Lancet, Alan F. List, Lynn C. Moscinski, Eric Padron & Ling Zhang
Pages: 1395-1405
Published online: 24 Feb 2020
AbstractforComparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1 | Full Text | References | PDF (1.6 MB) | EPUB
  • 306 Views
  • 3 CrossRef citations
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Article
The unique burden of rare cancer caregiving: caregivers of patients with Erdheim–Chester disease
Allison J. Applebaum, Laura C. Polacek, Leah Walsh, Anne S. Reiner, Kathleen Lynch, Stephanie Benvengo, Justin Buthorn, Thomas M. Atkinson, Jun J. Mao, Katherine S. Panageas & Eli L. Diamond
Pages: 1406-1417
Published online: 24 Feb 2020
AbstractforThe unique burden of rare cancer caregiving: caregivers of patients with Erdheim–Chester disease | Full Text | References | PDF (883.4 KB) | EPUB
  • 375 Views
  • 7 CrossRef citations
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Article
Interrogation of molecular profiles can help in differentiating between MDS and AML with MDS-related changes
Talha Badar, Aniko Szabo, David Sallman, Rami Komrojki, Jefferey Lancet, Eric Padron, Jinming Song & Mohammad Omar Hussaini
Pages: 1418-1427
Published online: 04 Feb 2020
AbstractforInterrogation of molecular profiles can help in differentiating between MDS and AML with MDS-related changes | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 388 Views
  • 14 CrossRef citations
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Article
Response to hyperfractionated accelerated radiotherapy in chemotherapy-refractory non-Hodgkin lymphoma
Daniel W. Kim, Grace Lee, Hwan Lee, Amandeep R. Mahal, Miranda B. Lam & Andrea K. Ng
Pages: 1428-1434
Published online: 26 Feb 2020
AbstractforResponse to hyperfractionated accelerated radiotherapy in chemotherapy-refractory non-Hodgkin lymphoma | Full Text | References | PDF (706.4 KB) | EPUB | Supplemental
  • 147 Views
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Article
Richter’s transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study
Yasmin Ben-Dali, Mariam H. Hleuhel, Caspar da Cunha-Bang, Christian Brieghel, Christian B. Poulsen, Erik Clasen-Linde, Hans H. N. Bentzen, Henrik Frederiksen, Ilse Christiansen, Linda H. Nielsen, Lisbeth Enggaard, Marie Helleberg, Michael Clausen, Mikael Frederiksen, Robert S. Pedersen, Carsten U. Niemann & Michael A. Andersen
Pages: 1435-1444
Published online: 07 Feb 2020
AbstractforRichter’s transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 555 Views
  • 11 CrossRef citations
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Article
Healthcare utilization in patients with higher-risk MDS/low-blast count AML treated with azacitidine in the ‘real-world’
Lee Mozessohn, Matthew C. Cheung, Nicole Mittmann, Craig C. Earle, Ning Liu & Rena Buckstein
Pages: 1445-1454
Published online: 08 Feb 2020
AbstractforHealthcare utilization in patients with higher-risk MDS/low-blast count AML treated with azacitidine in the ‘real-world’ | Full Text | References | PDF (879.9 KB) | EPUB | Supplemental
  • 346 Views
  • 5 CrossRef citations
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Article
Wide variation in use and interpretation of gene mutation profiling panels among health care providers of patients with myelodysplastic syndromes: results of a large web-based survey
Alexander B. Pine, Nora Chokr, Maximilian Stahl, David P. Steensma, Mikkael A. Sekeres, Mark R. Litzow, Selina M. Luger, Richard M. Stone, Peter L. Greenberg, Rafael Bejar, Jan P. Bewersdorf, Steven D. Gore & Amer M. Zeidan
Pages: 1455-1464
Published online: 06 Feb 2020
AbstractforWide variation in use and interpretation of gene mutation profiling panels among health care providers of patients with myelodysplastic syndromes: results of a large web-based survey | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 243 Views
  • 4 CrossRef citations
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Article
Role of a second transplantation for children with acute leukemia following posttransplantation relapse: a study by the Turkish Bone Marrow Transplantation Study Group
Volkan Hazar, Gülsün Tezcan Karasu, Vedat Uygun, Namık Özbek, Musa Karakükçü, Gülyüz Öztürk, Hayriye Daloğlu, Suar Çakı Kılıç, Tekin Aksu, Ekrem Ünal, Ülker Koçak, Akif Yeşilipek, Arzu Akçay, Orhan Gürsel, Alphan Küpesiz, Fatma Visal Okur, Talia İleri, Savaş Kansoy, İbrahim Bayram, Barbaros Şahin Karagün, Müge Gökçe, Zühre Kaya, İkbal Ok Bozkaya, Türkan Patıroğlu & Serap Aksoylar
Pages: 1465-1474
Published online: 08 Feb 2020
AbstractforRole of a second transplantation for children with acute leukemia following posttransplantation relapse: a study by the Turkish Bone Marrow Transplantation Study Group | Full Text | References | PDF (916.1 KB) | EPUB
  • 293 Views
  • 2 CrossRef citations
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Article
Achievement of red blood cell transfusion independence in red blood cell transfusion-dependent patients with lower-risk non-del(5q) myelodysplastic syndromes correlates with serum erythropoietin levels
Valeria Santini, Antonio Almeida, Aristoteles Giagounidis, Barry Skikne, CL Beach, Jerry Weaver, Nora Tu & Pierre Fenaux
Pages: 1475-1483
Published online: 17 Feb 2020
AbstractforAchievement of red blood cell transfusion independence in red blood cell transfusion-dependent patients with lower-risk non-del(5q) myelodysplastic syndromes correlates with serum erythropoietin levels | Full Text | References | PDF (854.8 KB) | EPUB | Supplemental
  • 1590 Views
  • 3 CrossRef citations
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Open Access
Article
Phase I study of AR-42 and decitabine in acute myeloid leukemia
Sophia G. Liva, Christopher C. Coss, Jiang Wang, William Blum, Rebecca Klisovic, Bhavana Bhatnagar, Katherine Walsh, Susan Geyer, Qiuhong Zhao, Ramiro Garzon, Guido Marcucci, Mitch A. Phelps & Alison R. Walker
Pages: 1484-1492
Published online: 08 Feb 2020
AbstractforPhase I study of AR-42 and decitabine in acute myeloid leukemia | Full Text | References | PDF (947.6 KB) | EPUB | Supplemental
  • 241 Views
  • 13 CrossRef citations
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Article
LILRB4 expression in chronic myelomonocytic leukemia and myelodysplastic syndrome based on response to hypomethylating agents
Kelly S. Chien, Caleb A. Class, Guillermo Montalban-Bravo, Yue Wei, Koji Sasaki, Kiran Naqvi, Irene Ganan-Gomez, Hui Yang, Kelly A. Soltysiak, Rashmi Kanagal-Shamanna, Kim-Anh Do, Hagop M. Kantarjian & Guillermo Garcia-Manero
Pages: 1493-1499
Published online: 08 Feb 2020
AbstractforLILRB4 expression in chronic myelomonocytic leukemia and myelodysplastic syndrome based on response to hypomethylating agents | Full Text | References | PDF (1.7 MB) | EPUB
  • 429 Views
  • 13 CrossRef citations
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Letters to the Editor

Letter
Grade 3A follicular lymphoma can be effectively controlled with very low-dose radiation therapy
Brandon S. Imber, Karen Chau, Eliana Goldberg, Erel Joffe & Joachim Yahalom
Pages: 1500-1503
Published online: 09 Feb 2020
First Page PreviewforGrade 3A follicular lymphoma can be effectively controlled with very low-dose radiation therapy | Full Text | References | PDF (473.2 KB) | EPUB
  • 269 Views
  • 2 CrossRef citations
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Letter
Epstein-Barr virus-positive diffuse large B-cell lymphoma after sustained remission of T-cell prolymphocytic leukemia with alemtuzumab
Satoshi Ichikawa, Noriko Fukuhara, Kei Saito, Hisayuki Yokoyama, Koichi Onodera, Yasushi Onishi, Ryo Ichinohasama & Hideo Harigae
Pages: 1504-1507
Published online: 21 Jan 2020
First Page PreviewforEpstein-Barr virus-positive diffuse large B-cell lymphoma after sustained remission of T-cell prolymphocytic leukemia with alemtuzumab | Full Text | References | PDF (1.5 MB) | EPUB
  • 138 Views
  • 1 CrossRef citations
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Letter
A retrospective study on prephase therapy prior to definitive multiagent chemotherapy in aggressive lymphomas
Luis Malpica, Bolanle Mufuka, Jonathan Galeotti, Xianming Tan, Natalie Grover, Stephen M. Clark, Anne Beaven, Hyman Muss & Christopher Dittus
Pages: 1508-1511
Published online: 09 Feb 2020
First Page PreviewforA retrospective study on prephase therapy prior to definitive multiagent chemotherapy in aggressive lymphomas | Full Text | References | PDF (577.3 KB) | EPUB
  • 188 Views
  • 2 CrossRef citations
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Letter
Modified CLL International Prognostic Index (CLL-LIPI) using lymphocyte doubling time (LDT) in place of IgHV mutation status in resource-limited settings predicts time to first treatment and overall survival
Deepesh P. Lad, V. Tejaswi, Nishant Jindal, Pankaj Malhotra, Alka Khadwal, Gaurav Prakash, Arihant Jain, Sreejesh Sreedharanunni, Manupdesh Singh Sachdeva, Shano Naseem, Neelam Varma & Subhash Varma
Pages: 1512-1515
Published online: 29 Jan 2020
First Page PreviewforModified CLL International Prognostic Index (CLL-LIPI) using lymphocyte doubling time (LDT) in place of IgHV mutation status in resource-limited settings predicts time to first treatment and overall survival | Full Text | References | PDF (614.2 KB) | EPUB
  • 427 Views
  • 7 CrossRef citations
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Letter
Clinico-pathological characteristics of primary adrenal lymphomas – potential efficacy of autologous stem cell transplantation
Taisuke Narazaki, Motoaki Shiratsuchi, Takamitsu Matsushima, Mariko Tsuda, Yasuhiro Tsukamoto, Hiroki Muta, Toru Masuda, Daisaku Kimura, Akiko Takamatsu, Hidetaka Yamamoto, Yoshinao Oda, Hiroaki Miyoshi, Koichi Ohshima, Yayoi Matsuda, Ryuichi Sakamoto, Yasuhiro Nakashima & Yoshihiro Ogawa
Pages: 1516-1518
Published online: 10 Feb 2020
First Page PreviewforClinico-pathological characteristics of primary adrenal lymphomas – potential efficacy of autologous stem cell transplantation | Full Text | References | PDF (304.1 KB) | EPUB
  • 108 Views
  • 2 CrossRef citations
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Letter
Nivolumab-induced autoantibody negative limbic encephalitis in a patient with Hodgkin lymphoma
Ruziye Erol-Yıldız, Tuğçe Kızılay, Erdem Tüzün, Handan Mısırlı & Recai Türkoğlu
Pages: 1519-1521
Published online: 12 Feb 2020
First Page PreviewforNivolumab-induced autoantibody negative limbic encephalitis in a patient with Hodgkin lymphoma | Full Text | References | PDF (413.5 KB) | EPUB
  • 185 Views
  • 5 CrossRef citations
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