Evaluation of biochemical markers in diabetic rats fed diets supplemented with fruit purees

ABSTRACT

In this work, the effect of intake of fruit purees (guava-strawberry, guava-blackberry, guava-soursop, guava-passion fruit) by diabetic rats on reduction of plasma glucose and inflammation biomarkers was evaluated. Consumption of fruit purees in addition to a standard diet was associated with a reduction in body weight (20%), control of glucose metabolism, by decreasing plasma glucose (62.1%). We found a significant reduction in activities of alanine aminotransferase (49.41%), alkaline phosphatase (57.25%) and ϒ-glutamyl transferase (76%), which are useful markers of inflammatory process in the liver. Purees did not alter lipid metabolism and a remarkable improvement in liver morphology was observed. The diets order with the best beneficial effects was diet supplemented with guava-blackberry > guava-strawberry > guava-passion fruit > guava-soursop fruit. Consumption of fruit purees represent a therapeutic alternative by diabetic individuals.

Graphical Abstract

Resumen

En este trabajo, se evaluó el efecto de la ingesta de purés de frutas (guayaba, guayaba, mora, guanábana, guayaba y maracuyá) en ratas diabéticas sobre la reducción de la glucosa plasmática y biomarcadores de inflamación. El consumo de purés de fruta además de una dieta estándar se asoció con una reducción en el peso corporal (20%), control del metabolismo de la glucosa, al disminuir la glucosa en plasma (62,1%). Encontramos una reducción significativa en las actividades de alanina aminotransferasa (49.41%), fosfatasa alcalina (57.25%) y ϓ-glutamil transferasa (76%), que son marcadores útiles del proceso inflamatorio en el hígado. Los purés no alteraron el metabolismo de los lípidos y se observó una mejora notable en la morfología hepática. El orden de las dietas con los mejores efectos beneficiosos fue: dieta suplementada con puré de guayaba-zarzamora > guayaba-fresa, guayaba-maracuyá > guayaba-guanábana. El consumo de purés de frutas representa una alternativa terapéutica para los individuos diabéticos.

KEYWORDS:

• Diabetes mellitus
• Fruit purees
• Hypoglycemic
• biochemical markers

PALABRAS CLAVE:

• Diabetes mellitus
• purés de frutas
• hipoglucémico
• marcadores bioquímicos

Disclosure statement

No potential conflict of interest was reported by the authors.

Acknowledgments

The authors acknowledge CONACYT-Mexico for the student scholarship (U.M. Morales-Ávila). Also, the authors acknowledge at Mr. John Philip Tolman and M.C. Emma Gabriela García López (Purés y Derivados de Nayarit) by the donation of all raw materials and participated directly in the project.

Supplementary material

Supplemental data for this article can be accessed on the publisher’s website.

Additional information

Funding

This work was supported by Consejo Nacional de Ciencia y Tecnología [211953] and Tecnológico Nacional de México [6173.17-P].